A 1 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen A 2 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen A 3 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen B 4 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen B 5 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen B 6 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen The input data set contained 45101 genes The filtered output data set contains 55 genes 40673 gene rows removed by Include where A-B T-test p-value (two tailed) <= 0.05 4373 gene rows removed by Include where A-B Mean Difference <= -1.0 A A A B B B 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen A-B p-Value A-B Mean Difference A Mean B Mean Well ID Feature ID mgB36 Chr:Start-Stop mgB36 Cytoband Annotation_Src UniGene RefSeq Refseqs_Hit geneIDS_Hit Entrez GeneID Locus Tag Gene Description BioCarta Pathways KEGG Pathways Gene Ontology Terms GO Tier2 Component GO Tier3 Component GO Tier2 Function GO Tier3 Function GO Tier2 Process GO Tier3 Process 1386.2697 1467.3946 1453.1010 3936.4121 3561.2058 2524.2694 0.003657824 -1.19384 10.48698 11.68082 1327556 1415737_at chr19:17461101-17468354 19 B RSQ Mm.7013 NM_019437 1 1 54391 Rfk riboflavin kinase (Rfk), mRNA. Riboflavin metabolism CLASS Metabolism; Metabolism of Cofactors and Vitamins; Riboflavin metabol ATP binding;; cytoplasm;; kinase activity;; magnesium ion binding;; metal ion binding;; nucleotide binding;; riboflavin biosynthetic process;; riboflavin kinase activity;; transferase activity;; zinc ion binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; nucleotide binding;; transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process 170.6334 209.6526 197.3686 329.9748 504.2052 346.9554 0.0088861461 -1.01044 7.58379 8.59423 1327895 1416194_at chr4:115122659-115145637 4 D1 RSQ Mm.1840 NM_007823 1 1 13120 RP23-118K16.5 Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 (Cyp4b1), mRNA. Nuclear Receptors in Lipid Metabolism and Toxicity electron carrier activity;; endoplasmic reticulum;; heme binding;; iron ion binding;; membrane;; metal ion binding;; microsome;; monooxygenase activity;; oxidation reduction;; oxidoreductase activity;; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen cell;; cell part;; organelle cell fraction;; cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane-bounded organelle binding;; catalytic activity;; electron carrier activity ion binding;; oxidoreductase activity;; tetrapyrrole binding metabolic process oxidation reduction 1452.0280 1613.1677 1535.6259 4807.6795 4056.7444 3373.8121 0.00081533267 -1.39775 10.58138 11.97913 1327926 1416229_at chr19:17461101-17468354 19 B RSQ Mm.7013 NM_019437 1 1 54391 Rfk riboflavin kinase (Rfk), mRNA. Riboflavin metabolism CLASS Metabolism; Metabolism of Cofactors and Vitamins; Riboflavin metabol ATP binding;; cytoplasm;; kinase activity;; magnesium ion binding;; metal ion binding;; nucleotide binding;; riboflavin biosynthetic process;; riboflavin kinase activity;; transferase activity;; zinc ion binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; nucleotide binding;; transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process 2504.0857 2997.7266 2299.4119 7748.2930 6620.9434 6476.6427 0.00051560803 -1.42225 11.33559 12.75784 1328061 1416401_at chr2:93219950-93263335 2 E1 RSQ Mm.4261 NM_007656 1 1 12521 RP23-70K10.2 Cd82 CD82 antigen (Cd82), mRNA. p53 signaling pathway CLASS Cellular Processes; Cell Growth and Death; p53 signaling pathway [PA integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 101.8208 116.7051 82.7844 244.2670 228.5044 412.4133 0.0076852461 -1.51615 6.63597 8.15211 1328224 1416619_at chr10:59742260-59768041 10 B4 RSQ Mm.273584 NM_028732 1 1 74048 4632428N05Rik RIKEN cDNA 4632428N05 gene (4632428N05Rik), mRNA. integral to membrane;; membrane;; receptor activity cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity 606.3192 488.4840 643.5140 1158.6073 1697.8070 873.0728 0.025173815 -1.05722 9.16864 10.22586 1329279 1417909_at chr1:162824165-162839687 1 H2.1 RSQ Mm.260770 NM_080844 1 1 11905 Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 (Serpinc1), mRNA. Extrinsic Prothrombin Activation Pathway;; Intrinsic Prothrombin Activation Pathway Complement and coagulation cascades CLASS Cellular Processes; Immune System; Complement and coag blood coagulation;; endopeptidase inhibitor activity;; extracellular region;; heparin binding;; serine-type endopeptidase inhibitor activity extracellular region binding;; enzyme regulator activity carbohydrate binding;; enzyme inhibitor activity;; pattern binding biological regulation;; multicellular organismal process;; response to stimulus coagulation;; regulation of biological quality;; regulation of body fluid levels;; response to external stimulus;; response to stress 18.9432 22.5562 19.8524 50.1924 31.9177 58.8016 0.013527337 -1.15772 4.35010 5.50782 1343687 1418507_s_at chr10:94841297-94841636 10 C2 UGA Mm.4132 216233 Socs2 Suppressor of cytokine signaling 2 Insulin signaling pathway;; Jak-STAT signaling pathway;; Type II diabetes mellitus CLASS Environmental Information Processing; Signal Transduction; Jak-S growth hormone receptor binding;; intracellular signaling cascade;; negative regulation of multicellular organism growth;; negative regulation of multicellular organism growth;; negative regulation of signal transduction;; positive regulation of neuron differentiation;; protein binding;; regulation of cell growth;; regulation of multicellular organism growth;; ubiquitin-dependent protein catabolic process binding protein binding biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure morphogenesis;; catabolic process;; cell communication;; cell development;; cell growth;; cellular component organization;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organism growth;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of growth;; negative regulation of multicellular organismal process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of multicellular organismal process 1099.9002 1639.7109 1260.4125 2727.8972 2919.0286 2524.5448 0.0042936036 -1.04820 10.36069 11.40888 1329833 1418591_at chr9:54497695-54514449 9 A5.3 RSQ Mm.52319 NM_021422 2 2 58233 Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 (Dnaja4), mRNA. heat shock protein binding;; membrane;; metal ion binding;; protein folding;; unfolded protein binding;; zinc ion binding cell;; cell part cell part;; membrane binding ion binding;; protein binding cellular process;; metabolic process cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 106.3525 74.6703 63.8030 260.6996 155.6867 198.1126 0.012218833 -1.32940 6.31691 7.64631 1330507 1419411_at chr10:127127426-127134716 10 D3 RSQ Mm.2374 NM_009312 1 1 21334 Tac2 tachykinin 2 (Tac2), mRNA. extracellular region;; neuropeptide signaling pathway;; tachykinin receptor signaling pathway extracellular region biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 1233.6125 939.7546 722.4706 1504.7965 2746.8315 1727.5588 0.04023504 -1.03061 9.88054 10.91114 1331606 1421008_at chr12:27029020-27042699 12 A2 RSQ Mm.24045 NM_021384 1 1 58185 Rsad2 radical S-adenosyl methionine domain containing 2 (Rsad2), mRNA. catalytic activity;; defense response to virus;; endoplasmic reticulum;; iron ion binding;; iron-sulfur cluster binding;; membrane;; metal ion binding;; response to virus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane-bounded organelle binding;; catalytic activity ion binding;; metal cluster binding immune system process;; multi-organism process;; response to stimulus immune effector process;; immune response;; response to biotic stimulus;; response to other organism;; response to stress 40.5566 42.4201 53.2377 161.3547 136.1898 149.4726 0.00025533159 -1.72146 5.49431 7.21577 1344534 1422103_a_at chr11:100596820-100638607 11 D RSQ Mm.34064 NM_001113563 2 1 20851 RP23-279L23.3 Stat5b signal transducer and activator of transcription 5B (Stat5b), mRNA. Acute myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; ErbB sig;; Chronic myeloid leukemia;; ErbB signaling pathway;; Jak-STAT signaling pathway 2-oxoglutarate metabolic process;; allantoin metabolic process;; calcium ion binding;; citrate metabolic process;; creatine metabolic process;; creatinine metabolic process;; cytokine-mediated signaling pathway;; cytoplasm;; development of secondary female sexual characteristics;; development of secondary male sexual characteristics;; development of secondary male sexual characteristics;; DNA binding;; fatty acid metabolic process;; female pregnancy;; female pregnancy;; isoleucine metabolic process;; JAK-STAT cascade;; lactation;; lipid storage;; luteinization;; natural killer cell differentiation;; negative regulation of apoptosis;; negative regulation of erythrocyte differentiation;; nucleus;; oxaloacetate metabolic process;; Peyer's patch development;; positive regulation of activated T cell proliferation;; positive regulation of B cell differentiation;; positive regulation of cell proliferation;; positive regulation of gamma-delta T cell differentiation;; positive regulation of inflammatory response;; positive regulation of interleukin-2 biosynthetic process;; positive regulation of lymphocyte differentiation;; positive regulation of mitotic cell cycle;; positive regulation of multicellular organism growth;; positive regulation of multicellular organism growth;; positive regulation of survival gene product expression;; positive regulation of transcription from RNA polymerase II promoter;; positive regulation of transcription from RNA polymerase II promoter;; progesterone metabolic process;; protein binding;; regulation of cell adhesion;; regulation of epithelial cell differentiation;; regulation of steroid metabolic process;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; signal transducer activity;; signal transduction;; succinate metabolic process;; T cell differentiation in the thymus;; T cell homeostasis;; taurine metabolic process;; transcription;; transcription factor activity;; valine metabolic process cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; protein binding;; signal transducer activity;; transcription factor activity biological adhesion;; biological regulation;; cellular process;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus;; rhythmic process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell activation;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; death;; female pregnancy;; hormone metabolic process;; immune system development;; leukocyte activation;; leukocyte homeostasis;; macromolecule localization;; macromolecule metabolic process;; multicellular organism growth;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; ovulation cycle;; ovulation cycle process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of growth;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of homeostatic process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; reproductive developmental process;; reproductive process;; reproductive process in a multicellular organism;; response to external stimulus;; response to stress 242.6906 192.3086 259.3436 956.9805 660.4043 955.0673 0.0010440224 -1.88001 7.84299 9.72300 1332863 1422740_at chr17:42480038-42552546 17 B3 RSQ Mm.200792 NM_178589 1 1 94185 Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21), mRNA. Cytokine-cytokine receptor interaction CLASS Environmental Information Processing; Signaling Mol apoptosis;; integral to membrane;; membrane;; protein binding;; receptor activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity biological regulation;; cellular process;; developmental process;; regulation of biological process cell communication;; cell death;; death;; regulation of biological process;; regulation of cellular process 93.4994 88.9667 91.9044 175.2673 128.5930 282.8255 0.0370265 -1.01990 6.51471 7.53462 1333086 1423026_at chr11:87192839-87220634 11 C RSQ Mm.37376 NM_053269 1 1 114714 RP23-209O5.3 Rad51c Rad51 homolog c (S. cerevisiae) (Rad51c), mRNA. Homologous recombination CLASS Genetic Information Processing; Replication and Repair; Homologou crossover junction endodeoxyribonuclease activity;; female meiosis sister chromatid cohesion;; Holliday junction resolvase complex;; male meiosis I;; reciprocal meiotic recombination;; spermatogenesis cell;; cell part;; macromolecular complex cell part;; intracellular;; intracellular part;; protein complex catalytic activity hydrolase activity cellular process;; metabolic process;; reproduction;; reproductive process cell cycle;; cell cycle process;; cellular component organization;; cellular metabolic process;; chromosome segregation;; gamete generation;; macromolecule metabolic process;; primary metabolic process;; reproductive process;; sexual reproduction 294.2015 378.8161 269.9463 1238.8455 1427.6136 1184.7686 0.00026125718 -2.04067 8.28085 10.32152 1333195 1423166_at chr5:17293839-17347520 5 A3 RSQ Mm.18628 NM_007643 1 1 12491 Cd36 CD36 antigen (Cd36), mRNA. TSP-1 Induced Apoptosis in Microvascular Endothelial Cell Adipocytokine signaling pathway CLASS Environmental Information Processing; Signaling Molecules;; ECM-receptor interaction;; Hematopoietic cell lineage;; PPAR signaling pathway apoptotic cell clearance;; cell adhesion;; cholesterol transport;; high-density lipoprotein binding;; integral to membrane;; membrane;; protein binding;; receptor activity;; transport cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity biological adhesion;; biological regulation;; cellular process;; developmental process;; establishment of localization;; localization;; regulation of biological process cell adhesion;; cell communication;; cell death;; cellular component organization;; death;; establishment of localization;; regulation of biological process;; regulation of cellular process;; transport;; vesicle-mediated transport 162.3139 117.1653 186.5718 302.0163 290.2929 404.4944 0.011384883 -1.10706 7.25288 8.35994 1344960 1423924_s_at chr14:39815156-39875520 14 B RSQ Mm.28876 NM_145928 1 1 52588 Tspan14 tetraspanin 14 (Tspan14), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 675.9432 608.3352 900.1322 1926.5642 1743.5282 3381.3755 0.0085626222 -1.64651 9.48782 11.13433 1345554 1425837_a_at chr3:51312375-51339502 3 C RSQ Mm.86541 NM_009834 2 2 12457 Ccrn4l CCR4 carbon catabolite repression 4-like (S. cerevisiae) (Ccrn4l), mRNA. Selective expression of chemokine receptors during T-cell polarization rhythmic process rhythmic process 720.5151 312.0366 346.1574 1479.0113 1458.3312 1786.8520 0.0086912577 -1.87666 8.73791 10.61457 1345980 1426956_a_at chr2:120889691-120962561 2 E5 RSQ Mm.475892 NM_013735 1 1 27223 RP23-437L13.2 Trp53bp1 transformation related protein 53 binding protein 1 (Trp53bp1), mRNA. cellular response to DNA damage stimulus;; damaged DNA binding;; DNA binding;; DNA repair;; intracellular;; kinetochore;; nucleus;; protein binding;; regulation of transcription, DNA-dependent;; replication fork;; response to DNA damage stimulus;; telomeric DNA binding;; transcription;; transcription factor binding cell;; cell part;; macromolecular complex;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; non-membrane-bounded organelle;; organelle part;; protein complex binding nucleic acid binding;; protein binding biological regulation;; cellular process;; metabolic process;; regulation of biological process;; response to stimulus biosynthetic process;; cellular metabolic process;; cellular response to stimulus;; macromolecule metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; response to stress 648.8563 274.4660 426.6448 942.0530 1245.3527 1310.9070 0.02029455 -1.44641 8.72638 10.17278 1335793 1426957_at chr2:120889691-120962561 2 E5 RSQ Mm.475892 NM_013735 1 1 27223 RP23-437L13.2 Trp53bp1 transformation related protein 53 binding protein 1 (Trp53bp1), mRNA. cellular response to DNA damage stimulus;; damaged DNA binding;; DNA binding;; DNA repair;; intracellular;; kinetochore;; nucleus;; protein binding;; regulation of transcription, DNA-dependent;; replication fork;; response to DNA damage stimulus;; telomeric DNA binding;; transcription;; transcription factor binding cell;; cell part;; macromolecular complex;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; non-membrane-bounded organelle;; organelle part;; protein complex binding nucleic acid binding;; protein binding biological regulation;; cellular process;; metabolic process;; regulation of biological process;; response to stimulus biosynthetic process;; cellular metabolic process;; cellular response to stimulus;; macromolecule metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; response to stress 3241.9251 2439.0243 2521.0753 5971.5448 5146.2726 6531.1670 0.0024743973 -1.11059 11.40485 12.51544 1346063 1427364_a_at chr12:17570352-17576982 12 A1.1 RSQ Mm.34102 NM_013614 1 1 18263 Odc1 ornithine decarboxylase, structural 1 (Odc1), mRNA. Glutathione metabolism CLASS Metabolism; Amino Acid Metabolism; Urea cycle and metabolism of ami;; Urea cycle and metabolism of amino groups carboxy-lyase activity;; catalytic activity;; cytosol;; kidney development;; lyase activity;; ornithine decarboxylase activity;; polyamine biosynthetic process;; positive regulation of cell proliferation cell;; cell part cell part;; intracellular;; intracellular part catalytic activity lyase activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; biosynthetic process;; cell proliferation;; cellular metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; primary metabolic process;; regulation of biological process;; regulation of cellular process 134.6094 147.5551 133.1498 374.8288 645.9014 226.6943 0.029258941 -1.45840 7.11155 8.56995 1346744 1431808_a_at chr14:29715521-29730858 14 A3 RSQ Mm.34819 NM_018746 1 1 16427 Itih4 inter alpha-trypsin inhibitor, heavy chain 4 (Itih4), mRNA. calcium ion binding;; cytoplasm;; hyaluronic acid binding;; plasma membrane cell;; cell part cell part;; intracellular;; intracellular part;; membrane binding carbohydrate binding;; ion binding;; pattern binding 588.2632 737.3154 698.1430 1652.1385 1578.4564 1642.2217 0.00022125522 -1.27401 9.39128 10.66528 1337468 1434196_at chr9:54497695-54514449 9 A5.3 RSQ Mm.52319 NM_021422 2 2 58233 Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 (Dnaja4), mRNA. heat shock protein binding;; membrane;; metal ion binding;; protein folding;; unfolded protein binding;; zinc ion binding cell;; cell part cell part;; membrane binding ion binding;; protein binding cellular process;; metabolic process cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 165.3480 132.5216 140.1453 365.3722 530.6304 197.5865 0.046578908 -1.21363 7.18341 8.39704 1337625 1434719_at chr6:121601791-121644857 6 F1 RSQ Mm.30151 NM_175628 2 2 232345 A2m alpha-2-macroglobulin (A2m), mRNA. Complement and coagulation cascades CLASS Cellular Processes; Immune System; Complement and coag endopeptidase inhibitor activity;; extracellular region;; extracellular space;; female pregnancy;; protease inhibitor activity;; protein binding;; serine-type endopeptidase inhibitor activity;; wide-spectrum protease inhibitor activity extracellular region;; extracellular region part extracellular region part;; extracellular space binding;; enzyme regulator activity enzyme inhibitor activity;; protein binding multi-organism process;; reproduction;; reproductive process female pregnancy;; reproductive process 1995.4770 2591.2344 2422.4951 4563.3748 4625.5318 7221.1833 0.0080297984 -1.20170 11.18141 12.38310 1337809 1435458_at chr17:29222522-29223029 17 A3.3 UGA Mm.472907 Transcribed locus 40.6147 34.1719 28.6540 51.4969 89.0537 71.0476 0.020359303 -1.01147 5.09311 6.10458 1347306 1436291_a_at chr15:39612877-39613135 15 B3.1 UG5 Mm.275974 64705 Dpys Dihydropyrimidinase beta-Alanine metabolism;; Drug metabolism - other enzymes CLASS Metabolism; Nucleotide Metabolism; Pyrimidine metabolism [;; Pantothenate and CoA biosynthesis;; Pyrimidine metabolism dihydropyrimidinase activity;; hydrolase activity;; metal ion binding;; zinc ion binding binding;; catalytic activity hydrolase activity;; ion binding 64.7290 66.2339 64.9225 119.5618 225.6051 118.0013 0.019176355 -1.17181 6.02883 7.20064 1347701 1437932_a_at chr16:26271999-26287188 16 B2 RSQ Mm.289441 NM_016674 1 1 12737 Cldn1 claudin 1 (Cldn1), mRNA. Cell adhesion molecules (CAMs);; Leukocyte transendothelial migration CLASS Environmental Information Processing; Signaling Molec;; Tight junction calcium-independent cell-cell adhesion;; cell junction;; identical protein binding;; integral to membrane;; membrane;; plasma membrane;; protein binding;; structural molecule activity;; tight junction cell;; cell part cell part;; membrane;; membrane part binding;; structural molecule activity protein binding biological adhesion;; cellular process cell adhesion 189.4636 106.2524 161.7545 326.9875 397.2981 243.1042 0.027763444 -1.09260 7.21160 8.30420 1339034 1448550_at chr2:157997933-158024293 2 H1 RSQ Mm.218846 NM_008489 1 1 16803 RP23-407H16.4 Lbp lipopolysaccharide binding protein (Lbp), mRNA. Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages Toll-like receptor signaling pathway CLASS Cellular Processes; Immune System; Toll-like receptor acute-phase response;; defense response to bacterium;; defense response to Gram-negative bacterium;; defense response to Gram-positive bacterium;; extracellular region;; extracellular space;; Gram-positive bacterial cell surface binding;; innate immune response;; lipid binding;; lipid transport;; lipopolysaccharide binding;; macrophage activation during immune response;; opsonization;; positive regulation of respiratory burst during acute inflammatory response;; positive regulation of tumor necrosis factor production;; positive regulation of tumor necrosis factor production;; receptor binding;; response to lipopolysaccharide;; transport extracellular region;; extracellular region part extracellular region part;; extracellular space binding bacterial binding;; cell surface binding;; lipid binding;; pattern binding;; protein binding biological regulation;; cellular process;; establishment of localization;; immune system process;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus cell activation;; cellular component organization;; cytokine production;; establishment of localization;; immune effector process;; immune response;; leukocyte activation;; positive regulation of biological process;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; positive regulation of response to stimulus;; regulation of biological process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; respiratory burst;; response to biotic stimulus;; response to chemical stimulus;; response to external stimulus;; response to other organism;; response to stress;; transport;; vesicle-mediated transport 34.6848 46.7492 30.3452 100.6536 79.4318 108.8717 0.0038327523 -1.38163 5.19550 6.57713 1339609 1449248_at chr16:20616508-20629657 16 B1 RSQ Mm.177761 NM_009900 1 1 12724 RP23-101H1.9 Clcn2 chloride channel 2 (Clcn2), mRNA. chloride channel activity;; chloride ion binding;; chloride transport;; integral to membrane;; ion channel activity;; ion transport;; membrane;; transport;; voltage-gated chloride channel activity;; voltage-gated ion channel activity cell;; cell part cell part;; membrane;; membrane part binding;; transporter activity ion binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 17.1345 21.8630 28.7118 86.4222 55.9120 68.4300 0.0042509464 -1.64738 4.46427 6.11166 1348627 1450259_a_at chr11:100675492-100701259 11 D RSQ Mm.277403 NM_011488 1 1 20850 RP23-279L23.4 Stat5a signal transducer and activator of transcription 5A (Stat5a), mRNA. EPO Signaling Pathway;; Growth Hormone Signaling Pathway;; IL 2 signaling pathway;; IL 3 signaling pathway;; IL-2 Receptor Beta Chain in T cell Activation;; IL-7 Signal Transduction;; IL22 Soluble Receptor Signaling Pathway;; Inhibition of Cellular Proliferation by Gleevec;; TPO Signaling Pathway Acute myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; ErbB sig;; Chronic myeloid leukemia;; ErbB signaling pathway;; Jak-STAT signaling pathway 2-oxoglutarate metabolic process;; allantoin metabolic process;; calcium ion binding;; citrate metabolic process;; creatine metabolic process;; creatinine metabolic process;; cytokine-mediated signaling pathway;; cytoplasm;; development of secondary female sexual characteristics;; development of secondary male sexual characteristics;; development of secondary male sexual characteristics;; DNA binding;; fatty acid metabolic process;; female pregnancy;; isoleucine metabolic process;; JAK-STAT cascade;; lactation;; lipid storage;; luteinization;; mammary gland development;; natural killer cell differentiation;; negative regulation of apoptosis;; negative regulation of erythrocyte differentiation;; nucleus;; oxaloacetate metabolic process;; peptidyl-tyrosine phosphorylation;; Peyer's patch development;; phosphate binding;; positive regulation of activated T cell proliferation;; positive regulation of activated T cell proliferation;; positive regulation of B cell differentiation;; positive regulation of cell proliferation;; positive regulation of cell proliferation;; positive regulation of gamma-delta T cell differentiation;; positive regulation of inflammatory response;; positive regulation of interleukin-2 biosynthetic process;; positive regulation of lymphocyte differentiation;; positive regulation of mitotic cell cycle;; positive regulation of multicellular organism growth;; positive regulation of survival gene product expression;; positive regulation of transcription from RNA polymerase II promoter;; positive regulation of transcription from RNA polymerase II promoter;; protein binding;; regulation of cell adhesion;; regulation of epithelial cell differentiation;; regulation of steroid metabolic process;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; response to peptide hormone stimulus;; signal transducer activity;; signal transduction;; succinate metabolic process;; T cell differentiation in the thymus;; T cell homeostasis;; taurine metabolic process;; transcription;; transcription factor activity;; valine metabolic process cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; phosphate binding;; protein binding;; signal transducer activity;; transcription factor activity biological adhesion;; biological regulation;; cellular process;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus;; rhythmic process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell activation;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; death;; female pregnancy;; immune system development;; leukocyte activation;; leukocyte homeostasis;; macromolecule localization;; macromolecule metabolic process;; multicellular organism growth;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; ovulation cycle;; ovulation cycle process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of growth;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of homeostatic process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; reproductive developmental process;; reproductive process;; reproductive process in a multicellular organism;; response to chemical stimulus;; response to endogenous stimulus;; response to external stimulus;; response to stress 209.5626 217.0256 301.9819 1806.8701 1420.2491 2579.6292 0.00059291932 -2.97096 7.90376 10.87472 1348752 1450731_s_at chr17:42480038-42552546 17 B3 RSQ Mm.200792 NM_178589 1 1 94185 Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21), mRNA. Cytokine-cytokine receptor interaction CLASS Environmental Information Processing; Signaling Mol apoptosis;; integral to membrane;; membrane;; protein binding;; receptor activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity biological regulation;; cellular process;; developmental process;; regulation of biological process cell communication;; cell death;; death;; regulation of biological process;; regulation of cellular process 392.4990 337.1887 284.2049 1189.5935 1148.4540 1241.8073 0.00018844893 -1.83174 8.38825 10.21999 1348794 1450883_a_at chr5:17293839-17347520 5 A3 RSQ Mm.18628 NM_007643 1 1 12491 Cd36 CD36 antigen (Cd36), mRNA. TSP-1 Induced Apoptosis in Microvascular Endothelial Cell Adipocytokine signaling pathway CLASS Environmental Information Processing; Signaling Molecules;; ECM-receptor interaction;; Hematopoietic cell lineage;; PPAR signaling pathway apoptotic cell clearance;; cell adhesion;; cholesterol transport;; high-density lipoprotein binding;; integral to membrane;; membrane;; protein binding;; receptor activity;; transport cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity biological adhesion;; biological regulation;; cellular process;; developmental process;; establishment of localization;; localization;; regulation of biological process cell adhesion;; cell communication;; cell death;; cellular component organization;; death;; establishment of localization;; regulation of biological process;; regulation of cellular process;; transport;; vesicle-mediated transport 497.4229 338.5393 359.7968 1273.0686 663.5200 735.1045 0.029877685 -1.11912 8.61752 9.73663 1340886 1451019_at chr19:4855128-4860912 19 A RSQ Mm.29561 NM_019861 1 1 56464 Ctsf cathepsin F (Ctsf), mRNA. cysteine-type endopeptidase activity;; cysteine-type peptidase activity;; hydrolase activity;; lysosome;; peptidase activity;; proteolysis cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle catalytic activity hydrolase activity cellular process;; metabolic process cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 29.3015 32.6675 36.0755 46.2096 91.3841 140.2384 0.044953635 -1.36670 5.02521 6.39191 1342128 1453128_at chr7:110641787-110654134 7 E3 RSQ Mm.396078 NM_053247 1 1 114332 Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 (Lyve1), mRNA. binding;; cell adhesion;; glycosaminoglycan catabolic process;; hyaluronic acid binding;; integral to membrane;; membrane;; plasma membrane;; receptor activity;; transmembrane receptor activity;; transport cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity carbohydrate binding;; pattern binding;; signal transducer activity biological adhesion;; cellular process;; establishment of localization;; localization;; metabolic process catabolic process;; cell adhesion;; cellular metabolic process;; establishment of localization;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; transport 298.8425 390.0409 318.7571 651.5843 682.5647 814.3464 0.001950515 -1.09503 8.38235 9.47738 1342264 1454656_at chr14:59718187-59718635 14 D1 UGA Mm.149776 219140 Spata13 Spermatogenesis associated 13 guanyl-nucleotide exchange factor activity;; intracellular;; intracellular signaling cascade;; regulation of Rho protein signal transduction;; Rho guanyl-nucleotide exchange factor activity cell;; cell part cell part;; intracellular enzyme regulator activity GTPase regulator activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 233.3215 167.4239 145.6579 403.4198 533.3911 363.1839 0.0084570225 -1.25992 7.47999 8.73991 1342479 1455540_at chr1:67163902-67164366 1 C3 UGA Mm.343942 227231 Cps1 Carbamoyl-phosphate synthetase 1 Arginine and proline metabolism;; Glutamate metabolism;; Nitrogen metabolism CLASS Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:mmu00910] Met;; Urea cycle and metabolism of amino groups ATP binding;; carbamoyl-phosphate synthase (ammonia) activity;; carbamoyl-phosphate synthase activity;; catalytic activity;; glutamine metabolic process;; ligase activity;; metabolic process;; mitochondrion;; nitrogen compound metabolic process;; nucleotide binding;; urea cycle cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; catalytic activity ligase activity;; nucleotide binding cellular process;; metabolic process cellular metabolic process;; nitrogen compound metabolic process;; primary metabolic process 28.6192 23.3608 38.9679 313.5983 200.3825 246.2856 0.00041731614 -3.07148 4.88971 7.96119 1349775 1455899_x_at chr11:117782168-117785252 11 E2 RSQ Mm.3468 NM_007707 1 1 12702 RP23-268N22.6 Socs3 suppressor of cytokine signaling 3 (Socs3), mRNA. IL-2 Receptor Beta Chain in T cell Activation;; IL22 Soluble Receptor Signaling Pathway Adipocytokine signaling pathway;; Insulin signaling pathway;; Jak-STAT signaling pathway;; Type II diabetes mellitus CLASS Genetic Information Processing; Folding, Sorting and Degradation;; Ubiquitin mediated proteolysis intracellular signaling cascade;; negative regulation of insulin receptor signaling pathway;; negative regulation of signal transduction;; positive regulation of cell differentiation;; positive regulation of cell differentiation;; protein binding;; regulation of cell growth;; regulation of protein amino acid phosphorylation;; ubiquitin-dependent protein catabolic process binding protein binding biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure morphogenesis;; catabolic process;; cell communication;; cell growth;; cellular component organization;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of metabolic process 40.3955 25.1468 42.6558 290.9594 214.4870 228.8789 0.00054486842 -2.78826 5.13437 7.92262 1349871 1456212_x_at chr11:117782266-117782546 11 E2 IPA Mm.3468 Socs3 Suppressor of cytokine signaling 3 44.7067 26.8367 22.6468 54.5266 89.5313 82.0092 0.024577482 -1.29371 4.90993 6.20364 1350770 1428909_at UGA Mm.291551 Transcribed locus 85.2301 74.4979 143.5144 324.9159 280.3798 196.4605 0.01643653 -1.43193 6.59916 8.03109 1350962 1429184_at chr7:105950183-106008989 7 E3 RSQ Mm.458429 NM_001039160 4 2 74558 Gvin1 GTPase, very large interferon inducible 1 (Gvin1), transcript variant B, mRNA. cytoplasm;; GTP binding;; nucleotide binding;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding nucleotide binding 162.2648 205.7279 123.8159 289.4446 418.7696 298.4972 0.018502339 -1.04329 7.32628 8.36958 1351399 1429808_at chr4:118052608-118067357 4 D2.1 UG5 Mm.256495 68625 1110020C03Rik RIKEN cDNA 1110020C03 gene 249.8168 172.1403 259.4529 529.5208 369.6991 634.0551 0.017457603 -1.15857 7.80383 8.96241 1351978 1430535_at chr3:58503617-58554716 3 D RSQ Mm.218409 NM_001081229 1 1 72033 Tsc22d2 TSC22 domain family, member 2 (Tsc22d2), mRNA. response to osmotic stress response to stimulus response to abiotic stimulus;; response to stress 41.4316 41.5622 31.8616 144.5153 136.2061 172.7514 0.00026502009 -1.98456 5.24787 7.23243 1352813 1431742_at chr16:93232326-93232847 16 C4 UGA Mm.458688 Transcribed locus 32.8024 42.4079 31.9920 60.5147 64.7494 98.3757 0.015174654 -1.03820 5.14721 6.18541 1353556 1432808_at chr11:87158417-87158918 11 C UGA Mm.437551 Transcribed locus 166.3501 126.3319 116.3228 277.5355 412.4605 215.7964 0.023859613 -1.11234 7.07371 8.18606 1354586 1434354_at chrX:15866240-15974323 X A1.2 RSQ Mm.241656 NM_172778 1 1 109731 Maob monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA. Drug metabolism - cytochrome P450 CLASS Metabolism; Amino Acid Metabolism; Glycine, serine and t;; Glycine, serine and threonine metabolism;; Histidine metabolism;; Phenylalanine metabolism;; Tryptophan metabolism;; Tyrosine metabolism;; Urea cycle and metabolism of amino groups amine oxidase activity;; electron carrier activity;; integral to membrane;; membrane;; mitochondrial inner membrane;; mitochondrial outer membrane;; mitochondrion;; oxidation reduction;; oxidoreductase activity cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part catalytic activity;; electron carrier activity oxidoreductase activity metabolic process oxidation reduction 48.1912 47.7595 57.3060 160.2424 121.3844 143.7270 0.00052915439 -1.46857 5.66968 7.13825 1354873 1434909_at chr4:33311610-33350793 4 A5 RSQ Mm.300814 NM_027491 1 1 52187 RP23-360H6.3 Rragd Ras-related GTP binding D (Rragd), mRNA. cytoplasm;; GTP binding;; nucleotide binding;; nucleus;; protein binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding nucleotide binding;; protein binding 18.0648 21.6150 20.0521 70.9323 57.2457 77.7773 0.00029741626 -1.77800 4.31158 6.08958 1354916 1434990_at chr11:87043206-87043606 11 C UG5 Mm.341988 320472 RP23-209O5.1 Ppm1e Protein phosphatase 1E (PP2C domain containing) catalytic activity;; cytoplasm;; hydrolase activity;; magnesium ion binding;; manganese ion binding;; metal ion binding;; nucleus;; phosphoprotein phosphatase activity;; protein amino acid dephosphorylation;; protein serine/threonine phosphatase activity;; protein serine/threonine phosphatase complex cell;; cell part;; macromolecular complex;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle;; protein complex;; protein serine/threonine phosphatase complex binding;; catalytic activity hydrolase activity;; ion binding cellular process;; metabolic process cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 85.0020 72.6713 76.2882 332.5513 236.0254 294.2039 0.00030096598 -1.87159 6.28204 8.15363 1355327 1435657_at chr12:92039028-92039154 12 D3 UGA Mm.23125 Transcribed locus 242.3434 190.9484 208.2868 602.4694 388.6670 338.4460 0.019937555 -1.01318 7.73346 8.74664 1356168 1437087_at chr5:105729936-105730272 5 E5 UGA Mm.439781 Transcribed locus 295.6404 296.4272 220.9260 580.2480 513.2421 544.0262 0.0024126838 -1.02163 8.06888 9.09052 1356572 1437865_at chr14:59588149-59718666 14 D1 RSQ Mm.149776 XM_901902 2 1 219140 Spata13 PREDICTED: spermatogenesis associated 13, transcript variant 7 (Spata13), mRNA. guanyl-nucleotide exchange factor activity;; intracellular;; intracellular signaling cascade;; regulation of Rho protein signal transduction;; Rho guanyl-nucleotide exchange factor activity cell;; cell part cell part;; intracellular enzyme regulator activity GTPase regulator activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 12.1281 11.3011 13.2674 192.7379 322.8622 332.0786 6.9803997e-05 -4.49072 3.60950 8.10022 1371585 1440927_x_at chr15:77461233-77461705 15 E1 UG5 Mm.17957 328563 Apol11b Apolipoprotein L 11b 1362.2464 1398.7466 905.8681 3201.9460 2858.7735 3167.2623 0.002927273 -1.35670 10.22828 11.58498 1361995 1444566_at chr7:100379423-100379754 7 E2 UGA Mm.475949 Transcribed locus 107.1167 104.0379 83.7756 281.9742 204.7312 300.8720 0.0023627451 -1.40585 6.61082 8.01667 1364787 1447485_at chr13:76523030-76523303 13 C1 UGA Mm.167172 238725 Gpr150 G protein-coupled receptor 150 G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; integral to membrane;; membrane;; plasma membrane;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 139.7137 138.5288 112.5585 316.7650 370.6881 478.4893 0.0014788609 -1.56292 7.01830 8.58122 1366993 1455604_at chr1:64664833-64672026 1 C2 RSQ Mm.150813 NM_001042659 2 1 14367 Fzd5 frizzled homolog 5 (Drosophila) (Fzd5), transcript variant 2, mRNA. Basal cell carcinoma CLASS Environmental Information Processing; Signal Transduction; Wnt signal;; Colorectal cancer;; Melanogenesis;; Wnt signaling pathway angiogenesis;; cell differentiation;; cell maturation;; cell surface receptor linked signal transduction;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; Golgi apparatus;; integral to membrane;; membrane;; multicellular organismal development;; non-G-protein coupled 7TM receptor activity;; plasma membrane;; protein binding;; receptor activity;; signal transducer activity;; signal transduction;; Wnt receptor signaling pathway cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding;; molecular transducer activity protein binding;; signal transducer activity biological regulation;; cellular process;; developmental process;; multicellular organismal process;; regulation of biological process anatomical structure development;; anatomical structure formation;; anatomical structure morphogenesis;; cell communication;; cell development;; cell maturation;; cellular developmental process;; developmental maturation;; multicellular organismal development;; regulation of biological process;; regulation of cellular process 225.4844 181.4386 217.6951 464.9850 374.9625 481.9515 0.0019324667 -1.07933 7.69546 8.77480 1367299 1456204_at chr14:29957645-29957756 14 B UG5 Mm.379116 Transcribed locus, strongly similar to XP_001062546.1 PREDICTED: similar to CG32736-PA, isoform A [Rattus norvegicus] 11.1333 11.4301 14.8030 319.8509 376.3062 523.6727 3.4851635e-05 -5.01005 3.62646 8.63651 1368099 1457307_at chr15:77461233-77461523 15 E1 UG5 Mm.17957 328563 Apol11b Apolipoprotein L 11b 136.8828 150.0557 120.6748 514.5404 336.6055 362.7845 0.0017606465 -1.55463 7.08038 8.63501 1369793 1459153_at chr12:92140649-92146209 12 D3 UGA Mm.312234 108800 Ston2 Stonin 2 clathrin adaptor complex;; cytoplasm;; endocytosis;; intracellular protein transport;; membrane;; protein binding;; regulation of endocytosis;; vesicle-mediated transport cell;; cell part;; macromolecular complex cell part;; intracellular;; intracellular part;; membrane;; membrane part;; protein complex binding protein binding biological regulation;; cellular process;; establishment of localization;; localization;; regulation of biological process cellular component organization;; cellular localization;; establishment of localization;; establishment of localization in cell;; establishment of protein localization;; macromolecule localization;; regulation of biological process;; regulation of cellular process;; regulation of localization;; transport;; vesicle-mediated transport