Trans-NIH Jak-Stat Initiative - Muscle: Stat5MKO+GH vs WT+GH

Changes in comparison: Test samples for Muscle: Stat5MKO+GH vs WT+GH

Muscle cells from Stat5-null and control 12-week mice with GH treatment. This used mAdb test: EG3.1-test-1-FC.

Muscle: EG003.1
(T1-)  Stat5MKO+GH vs WT+GH --- fold changes < 2X and p-Value<0.05.

This mAdb-derived analysis report compares two groups of samples (A and B) using the paired t-test followed by a fold-change test with the threshold values listed above. The t-test is only done if are at least two samples/condition. It performs fold-change thresholding in either case. The mean A and mean B values are shown as log2 values in the following table as A Mean and B Mean. If there are not enough samples in either condition A or condition B, it only compares the fold-change (mean A/mean B) computed as the difference between the log2 means shown as A-B Mean Difference in this report - see Data Analysis Methods for more discussion. If the t-test is performed, the p-Value is reported as A-B p-Value. Individual sample expression values are reported as the RMA normalized values not using the log2. The tests, thresholding and mAdb Retrieval Report were generated on the mAdb system for the GSP data and subsequently converted to this Web page.

Clicking on the table entries for Gene, Well ID, and Feature ID will go to the GeneCard, mAdb Feature Report, and Affymetrix probe database Web page for that entry. The genes are sorted by A-B Mean Difference with:
   (A) Samples[Stat5MKO+GH]: EG003.1-01, EG003.1-02, EG003.1-05
   (B) Samples[WT+GH]: EG003.1-03, EG003.1-04, EG003.1-06.

mAdb Microarray Retrieval Report - Test Samples

Preface to table

Row                  
Row Gene A-B Mean Difference A Mean (Stat5MKO+GH) B Mean (WT+GH) A-B p-Value Well ID Feature ID Description Gene Ontology Terms
1   -1.00577 4.47558 5.48135 0.00030523845 1363507 1446134_at ESTs  
2 Serpina1c -1.00750 5.86177 6.86927 0.0018003748 1339138 1448680_at serine (or cysteine) peptidase inhibitor, clade A, member 1C (Serpina1c), mRNA.
3 Cited4 -1.00847 8.10305 9.11152 4.3575697e-05 1345355 1425400_a_at Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4, mRNA (cDNA clone IMAGE:3670674)
4 Adamts9 -1.02266 7.42303 8.44569 0.0014195701 1351838 1430352_at MKIAA1312 protein
5 Armcx4 -1.02696 6.47434 7.50130 0.00012462914 1335963 1427167_at Armadillo repeat containing, X-linked 4, mRNA (cDNA clone IMAGE:5374915)  
6   -1.02716 5.66278 6.68994 0.00025077457 1363186 1445809_at Transcribed locus  
7 Dkk3 -1.02749 6.77564 7.80313 0.017327606 1339128 1448669_at dickkopf homolog 3 (Xenopus laevis) (Dkk3), mRNA.
8 Frat2 -1.02764 8.76971 9.79735 7.1981979e-06 1342410 1455220_at frequently rearranged in advanced T-cell lymphomas 2 (Frat2), mRNA.
9 Tob1 -1.03762 9.48397 10.52159 3.4408054e-05 1358662 1440844_at transducer of ErbB-2.1 (Tob1), mRNA.
10 Bdh1 -1.05719 6.16453 7.22172 0.0023140757 1335795 1426959_at 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.
11 Fbxo32 -1.06572 10.25504 11.32077 0.0005490209 1339195 1448747_at F-box protein 32 (Fbxo32), mRNA.
12   -1.06722 4.84376 5.91097 0.0032645792 1357927 1440016_at ESTs  
13 Ucp3 -1.07093 10.49335 11.56428 0.00017987325 1331338 1420657_at uncoupling protein 3 (mitochondrial, proton carrier) (Ucp3), nuclear gene encoding mitochondrial protein, mRNA.
14 Bdh1 -1.07231 8.77250 9.84481 9.6843356e-05 1341716 1452257_at 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.
15 Socs2 -1.08119 8.84492 9.92611 7.1381435e-05 1339494 1449109_at suppressor of cytokine signaling 2 (Socs2), mRNA.
16 Apbb3 -1.09638 9.49820 10.59459 0.0006813956 1334205 1424457_at Amyloid beta (A4) precursor protein-binding, family B, member 3 (Apbb3), mRNA
17 BC002189 -1.10136 6.77786 7.87922 0.011894786 1341465 1451883_at CDNA sequence BC002189, mRNA (cDNA clone MGC:7386 IMAGE:3487872)  
18   -1.10573 7.86850 8.97423 0.00028336503 1362558 1445148_at Mus musculus 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230091K16 product:unknown EST, full insert sequence.  
19 Igh-6 -1.11070 8.46175 9.57245 2.65514e-05 1346060 1427351_s_at Immunoglobulin heavy chain complex, mRNA (cDNA clone MGC:28019 IMAGE:3660622)
20 Gm129 -1.11738 7.35202 8.46939 0.00095723691 1355034 1435188_at predicted gene 129 (Gm129), mRNA.  
21 Neto2 -1.13171 5.28173 6.41344 0.0097901312 1355746 1436309_at neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), mRNA.
22 Gpr177 -1.13778 7.14735 8.28513 0.0033455627 1333713 1423825_at G protein-coupled receptor 177 (Gpr177), mRNA
23 Apold1 -1.13785 7.39455 8.53240 0.00011455178 1359017 1441228_at Apolipoprotein L domain containing 1 (Apold1), mRNA  
24 Ppargc1a -1.13858 6.95255 8.09113 0.00093133607 1342923 1460336_at peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (Ppargc1a), transcript variant 1, mRNA.
25 Casp12 -1.14336 7.44898 8.59234 0.00050990983 1330166 1418981_at caspase 12 (Casp12), mRNA.
26 Amd1 -1.14668 11.55101 12.69769 7.1412985e-05 1343385 1416835_s_at S-adenosylmethionine decarboxylase 1 (Amd1), mRNA.
27   -1.15584 4.75702 5.91286 0.013258111 1352872 1431869_at Transcribed locus  
28 Rgs2 -1.16736 7.61139 8.77875 0.00066732964 1372117 1447830_s_at regulator of G-protein signaling 2 (Rgs2), mRNA.
29 Zfp462 -1.16884 6.29959 7.46844 0.00016520924 1367622 1456789_at zinc finger protein 462 (Zfp462), mRNA.
30   -1.18391 5.15256 6.33647 0.0014605726 1353251 1432461_at Transcribed locus  
31 Ttr -1.19392 3.35731 4.55123 0.0020615281 1349780 1455913_x_at transthyretin (Ttr), mRNA.
32 Gramd1a -1.19860 8.64527 9.84388 4.1399609e-06 1343360 1416708_a_at GRAM domain containing 1A (Gramd1a), mRNA.
33 Ttr -1.19950 4.35913 5.55863 0.004162931 1349572 1454608_x_at transthyretin (Ttr), mRNA.
34 Inhbb -1.20941 6.38489 7.59430 0.00050009481 1335714 1426858_at Inhibin beta-B subunit
35 2310003H01Rik -1.21346 7.18196 8.39542 0.00022867201 1365491 1453368_at RIKEN cDNA 2310003H01 gene, mRNA (cDNA clone MGC:37540 IMAGE:4986832)
36 Tsc22d1 -1.21729 4.04999 5.26728 0.030392382 1364676 1447360_at TSC22-related inducible leucine zipper 1b (Tilz1b)
37 Tcfcp2l1 -1.23042 7.82647 9.05689 0.00013744918 1329435 1418091_at transcription factor CP2-like 1 (Tcfcp2l1), mRNA.
38 Mras -1.24367 6.71447 7.95814 0.012297776 1348434 1449590_a_at muscle and microspikes RAS (Mras), mRNA.
39   -1.24403 6.22486 7.46889 0.00025802251 1364374 1447023_at ESTs  
40 9130404H23Rik -1.26640 5.32932 6.59572 0.011571678 1368912 1458210_at PREDICTED: Mus musculus RIKEN cDNA 9130404H23 gene (9130404H23Rik), mRNA  
41 Casp12 -1.27366 6.69284 7.96650 0.00012121675 1339649 1449297_at caspase 12 (Casp12), mRNA.
42 Igh-6 -1.28640 10.37595 11.66235 9.9677398e-05 1346052 1427329_a_at Immunoglobulin heavy chain complex, mRNA (cDNA clone MGC:28019 IMAGE:3660622)
43 Klf15 -1.29186 10.11271 11.40456 0.00042828507 1338746 1448181_at Kruppel-like factor 15 (Klf15), mRNA.
44 Arrdc2 -1.29315 9.47776 10.77091 0.0016019058 1350443 1428352_at arrestin domain containing 2 (Arrdc2), mRNA.  
45 Acsl3 -1.30294 7.30039 8.60333 0.00064747098 1372229 1452771_s_at acyl-CoA synthetase long-chain family member 3 (Acsl3), transcript variant 3, mRNA.
46 Kcnf1 -1.32182 6.63304 7.95486 0.00014807324 1359079 1441300_at Potassium voltage-gated channel, subfamily F, member 1 (Kcnf1), mRNA
47 Cd28 -1.37695 5.80231 7.17926 0.00020118959 1338084 1437025_at CD28 antigen (Cd28), mRNA.
48 Stat5a -1.40167 4.88226 6.28392 0.000711184 1348627 1450259_a_at signal transducer and activator of transcription 5A (Stat5a), mRNA.
49 Fbxo32 -1.40226 9.26325 10.66551 6.1049745e-05 1328966 1417522_at F-box protein 32 (Fbxo32), mRNA.
50 Socs2 -1.40391 7.99067 9.39457 6.3920059e-05 1343687 1418507_s_at Suppressor of cytokine signaling 2 (Socs2), mRNA
51 Slc25a25 -1.46113 9.95830 11.41944 4.1933681e-06 1334422 1424735_at solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 (Slc25a25), nuclear gene encoding mitochondrial protein, mRNA.
52   -1.46205 7.10259 8.56464 0.000107031 1360668 1443100_at Transcribed locus  
53 Dkk3 -1.48988 6.40382 7.89370 0.00013983873 1328794 1417312_at dickkopf homolog 3 (Xenopus laevis) (Dkk3), mRNA.
54 Slc7a8 -1.49984 7.96062 9.46046 0.00020570579 1329298 1417929_at solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (Slc7a8), mRNA.
55 Tm6sf2 -1.51615 5.36625 6.88239 0.0030043878 1334673 1425079_at transmembrane 6 superfamily member 2 (Tm6sf2), mRNA.
56 Stat5b -1.55482 7.49408 9.04890 0.00031706532 1344533 1422102_a_at signal transducer and activator of transcription 5B (Stat5b), mRNA.
57 Chd6 -1.55773 6.99415 8.55188 0.00030105915 1336133 1427384_at Chromodomain helicase DNA binding protein 6, mRNA (cDNA clone IMAGE:3597702)
58 Gadl1 -1.58941 6.83063 8.42004 0.0054594723 1359154 1441384_at Glutamate decarboxylase-like 1 (Gadl1), mRNA
59   -1.60369 7.91103 9.51472 0.00074085621 1369075 1458409_at ESTs  
60 Ddit4 -1.70136 11.00698 12.70834 5.2878803e-06 1336689 1428306_at DNA-damage-inducible transcript 4 (Ddit4), mRNA.
61 LOC100048105 -1.72338 6.23069 7.95408 0.00050866253 1335161 1425965_at PREDICTED: similar to Ubc protein, transcript variant 2 (LOC100048105), mRNA.  
62 Cish -1.85801 10.20218 12.06020 2.3745585e-06 1339177 1448724_at cytokine inducible SH2-containing protein (Cish), mRNA.
63 Aldh9a1 -1.98268 7.97343 9.95611 8.6036817e-05 1347565 1437398_a_at aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA.
64 Aldh9a1 -1.99216 9.07099 11.06315 0.00018455543 1347360 1436689_a_at aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA.
65 Mafb -2.00842 9.43076 11.43918 8.6868417e-05 1341365 1451716_at V-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA
66 Cd28 -2.07162 4.76589 6.83751 0.0045513571 1329031 1417597_at CD28 antigen (Cd28), mRNA.
67 Pnmt -2.12516 6.92598 9.05114 6.0248296e-05 1340562 1450606_at phenylethanolamine-N-methyltransferase (Pnmt), mRNA.
68 Stat5b -2.23420 7.57364 9.80783 5.4362387e-05 1344534 1422103_a_at signal transducer and activator of transcription 5B (Stat5b), mRNA.
69   -2.25013 8.31204 10.56217 0.00037745141 1342536 1455869_at Transcribed locus, moderately similar to XP_001477892.1 PREDICTED: hypothetical protein [Mus musculus]  
70 Slc15a5 -2.26503 4.41609 6.68113 0.0014649411 1336340 1427722_at solute carrier family 15, member 5 (Slc15a5), mRNA.
71 Mafb -2.28473 8.49461 10.77934 9.287748e-06 1341364 1451715_at v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA.
72   -2.39750 8.06657 10.46408 2.9695035e-06 1346626 1431213_a_at Transcribed locus, weakly similar to XP_001379802.1 PREDICTED: similar to pol protein [Monodelphis domestica]  
73   -2.43276 6.00594 8.43870 4.5809926e-05 1369924 1459289_at Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630027C04 product:unknown EST, full insert sequence.  
74 Gdpd3 -2.57115 6.08938 8.66052 5.1116691e-07 1348421 1449526_a_at glycerophosphodiester phosphodiesterase domain containing 3 (Gdpd3), mRNA.
75 Kcnf1 -2.75248 5.74620 8.49868 6.0764879e-05 1366492 1454768_at potassium voltage-gated channel, subfamily F, member 1 (Kcnf1), mRNA.
76 1700001O22Rik -2.98010 5.76955 8.74965 0.00018664134 1345143 1424795_a_at RIKEN cDNA 1700001O22 gene (1700001O22Rik), mRNA.  

This Web page was derived in collaboration with GSP consortium members.

Home: jak-stat.nih.gov
Home: Jak-Stat Prospector

Revised: Mon Sep 28 13:56:56 EDT 2009