Trans-NIH Jak-Stat Initiative - Muscle: WT+GH vs WT-GH

Changes in comparison: Test samples for Muscle: WT+GH vs WT-GH

Muscle cells from WT 12-week mice with GH treatment and 15 week WT without GT treatment. This used mAdb test: EG3.1-test-3-FC.

Muscle: EG003.1+EG003.2
(T4-)  WT+GH vs WT-GH --- fold changes < 2X and p-Value<0.05.

This mAdb-derived analysis report compares two groups of samples (A and B) using the paired t-test followed by a fold-change test with the threshold values listed above. The t-test is only done if are at least two samples/condition. It performs fold-change thresholding in either case. The mean A and mean B values are shown as log2 values in the following table as A Mean and B Mean. If there are not enough samples in either condition A or condition B, it only compares the fold-change (mean A/mean B) computed as the difference between the log2 means shown as A-B Mean Difference in this report - see Data Analysis Methods for more discussion. If the t-test is performed, the p-Value is reported as A-B p-Value. Individual sample expression values are reported as the RMA normalized values not using the log2. The tests, thresholding and mAdb Retrieval Report were generated on the mAdb system for the GSP data and subsequently converted to this Web page.

Clicking on the table entries for Gene, Well ID, and Feature ID will go to the GeneCard, mAdb Feature Report, and Affymetrix probe database Web page for that entry. The genes are sorted by A-B Mean Difference with:
   (A) Samples[WT+GH]: EG003.1-03, EG003.1-04, EG003.1-06
   (B) Samples[WT-GH]: EG003.2-01, EG003.2-02, EG003.2-03.

mAdb Microarray Retrieval Report - Test Samples

Preface to table

Row                  
Row Gene A-B Mean Difference A Mean (WT+GH) B Mean (WT-GH) A-B p-Value Well ID Feature ID Description Gene Ontology Terms
1 Tmem120a -1.00061 7.92511 8.92572 0.00040703644 1354940 1435031_at transmembrane protein 120A (Tmem120a), mRNA.
2 Rian -1.00851 5.93129 6.93981 0.012721137 1346139 1427580_a_at MRNA, MBII-343 snoRNA nucleus
3 Ffar2 -1.01329 6.61313 7.62642 0.0032909694 1334756 1425216_at free fatty acid receptor 2 (Ffar2), mRNA.
4 Gpr81 -1.01500 6.49516 7.51017 0.017782834 1356879 1438411_at G protein-coupled receptor 81 (Gpr81), mRNA.
5 Lasp1 -1.01872 6.99963 8.01835 0.011764243 1347882 1438634_x_at LIM and SH3 protein 1 (Lasp1), mRNA.
6 Nr1d1 -1.01917 9.47058 10.48975 1.1290479e-05 1335439 1426464_at nuclear receptor subfamily 1, group D, member 1 (Nr1d1), mRNA.
7 H2-K1 -1.02296 8.51498 9.53794 0.0026324184 1349018 1451683_x_at MRNA similar to histocompatibility 2, D region locus 1 (cDNA clone MGC:25703 IMAGE:3675316)
8 Galm -1.02568 5.55001 6.57569 0.0043629784 1349327 1452583_s_at galactose mutarotase (Galm), mRNA.
9 Gfra2 -1.02596 4.96243 5.98839 0.0032457903 1371142 1433716_x_at Glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2), mRNA
10 Cd74 -1.02729 9.63034 10.65762 0.0083341282 1345403 1425519_a_at CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 2, mRNA.
11 1110020P15Rik -1.02944 10.08173 11.11118 0.00011356004 1347039 1434341_x_at RIKEN cDNA 1110020P15 gene, mRNA (cDNA clone MGC:37480 IMAGE:4984172)
12 Atn1 -1.03129 6.94838 7.97967 0.039907141 1344266 1421149_a_at atrophin 1 (Atn1), mRNA.
13 Chst1 -1.03223 7.47437 8.50659 0.00048840277 1339524 1449147_at carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (Chst1), mRNA.
14 AI317395 -1.03381 5.44294 6.47675 0.00083713221 1334972 1425596_at Expressed sequence AI317395 (AI317395), mRNA
15 Oaf -1.03566 8.15390 9.18956 0.00029017291 1333913 1424086_at OAF homolog (Drosophila) (Oaf), mRNA.  
16   -1.03638 5.71272 6.74910 0.0025297024 1358871 1441071_at Transcribed locus, strongly similar to XP_532200.2 PREDICTED: similar to potassium voltage-gated channel, KQT-like subfamily, member 5 isoform 1 [Canis familiaris]  
17 Wdyhv1 -1.03912 6.37728 7.41640 0.019220843 1371114 1432489_a_at WDYHV motif containing 1 (Wdyhv1), mRNA.
18 Hspa4 -1.03915 7.39914 8.43829 0.010798742 1327861 1416147_at heat shock protein 4 (Hspa4), mRNA.
19 Ccdc69 -1.03945 7.16094 8.20039 0.0029006027 1370785 1419985_s_at coiled-coil domain containing 69 (Ccdc69), mRNA.  
20 H2-K1 -1.04055 8.51438 9.55494 0.016792167 1345191 1424948_x_at Histocompatibility 2, K1, K region, mRNA (cDNA clone MGC:7052 IMAGE:3156482)
21 Dpp4 -1.04119 3.70159 4.74279 0.049283963 1372680 1459973_x_at Dipeptidylpeptidase 4, mRNA (cDNA clone MGC:14076 IMAGE:3982742)
22 2900062L11Rik -1.04874 7.43470 8.48343 0.00040067965 1336703 1428333_at RIKEN cDNA 2900062L11 gene (2900062L11Rik), non-coding RNA.  
23 Thrsp -1.04987 10.27408 11.32395 0.0075397023 1344742 1422973_a_at thyroid hormone responsive SPOT14 homolog (Rattus) (Thrsp), mRNA. nucleus
24 Ptp4a1 -1.05128 7.62973 8.68101 0.0029653493 1330199 1419024_at Protein tyrosine phosphatase 4a1 (Ptp4a1), mRNA
25 LOC634842 -1.05588 4.98255 6.03843 0.021579116 1366597 1454965_at PREDICTED: similar to D430039N05Rik protein, transcript variant 2 (LOC634842), mRNA.  
26 Orm1 -1.05971 7.32764 8.38734 0.040411285 1340915 1451054_at orosomucoid 1 (Orm1), mRNA.
27 Arhgap18 -1.06452 5.29133 6.35586 0.0094807321 1335789 1426952_at Rho GTPase activating protein 18 (Arhgap18), mRNA.
28 Vapb -1.06646 8.71513 9.78159 0.019607669 1333185 1423152_at vesicle-associated membrane protein, associated protein B and C (Vapb), mRNA.
29 Cd248 -1.06728 8.44124 9.50853 0.011237348 1328897 1417439_at CD248 antigen, endosialin (Cd248), mRNA.
30 Lasp1 -1.06908 7.79925 8.86832 0.0017413234 1342795 1460173_at LIM and SH3 protein 1 (Lasp1), mRNA.
31 1700037H04Rik -1.07072 7.15197 8.22269 0.011764295 1330770 1419742_at RIKEN cDNA 1700037H04 gene (1700037H04Rik), mRNA.  
32 Fzd7 -1.07118 7.49131 8.56249 0.0034468784 1340171 1450044_at frizzled homolog 7 (Drosophila) (Fzd7), mRNA.
33 Dusp10 -1.07392 6.82520 7.89912 0.011016504 1328664 1417163_at dual specificity phosphatase 10 (Dusp10), mRNA.
34 Sox7 -1.07531 6.92727 8.00258 0.014218672 1328185 1416564_at SRY-box containing gene 7 (Sox7), mRNA
35 Sox18 -1.07632 8.65397 9.73029 0.017757859 1339514 1449135_at SRY-box containing gene 18 (Sox18), mRNA.
36 Apoc1 -1.07823 9.05175 10.12998 0.02881953 1329001 1417561_at apolipoprotein C-I (Apoc1), transcript variant 2, mRNA.
37 Gm7120 -1.08322 8.61815 9.70138 0.0098337064 1335537 1426607_at predicted gene 7120 (Gm7120), mRNA.
38 Acvr1c -1.09124 4.24643 5.33767 0.01540413 1356824 1438309_at Activin A receptor, type IC, mRNA (cDNA clone IMAGE:1196242)
39 Nat8l -1.09216 6.11911 7.21126 0.048054528 1356002 1436702_at N-acetyltransferase 8-like (Nat8l), mRNA.
40 Pgd -1.09389 8.70124 9.79513 0.0092673261 1344891 1423706_a_at phosphogluconate dehydrogenase (Pgd), mRNA.
41 Efhd1 -1.10131 7.52676 8.62807 0.002014924 1338998 1448507_at EF hand domain containing 1 (Efhd1), mRNA.
42 Insig1 -1.10152 7.42066 8.52218 0.00010721953 1366445 1454671_at Insulin induced gene 1 (Insig1), mRNA
43 Mmd -1.10155 9.65753 10.75908 0.00045441942 1333464 1423489_at monocyte to macrophage differentiation-associated (Mmd), mRNA.
44 Acsm3 -1.10226 6.45910 7.56137 0.010393606 1345423 1425559_a_at acyl-CoA synthetase medium-chain family member 3 (Acsm3), transcript variant 3, mRNA.
45 Lrrc17 -1.10287 6.27650 7.37937 0.0001655887 1351306 1429679_at leucine rich repeat containing 17 (Lrrc17), mRNA. protein binding
46 Tmem45b -1.10344 9.11362 10.21705 0.0025442389 1334125 1424357_at transmembrane protein 45b (Tmem45b), mRNA.
47 Cotl1 -1.10352 4.76023 5.86375 5.2734902e-07 1371345 1437811_x_at Coactosin-like 1 (Dictyostelium) (Cotl1), mRNA
48 Prkar2b -1.10453 7.52964 8.63417 0.0046496634 1357007 1438664_at protein kinase, cAMP dependent regulatory, type II beta (Prkar2b), mRNA.
49 H2-Ab1 -1.10585 6.80240 7.90826 0.00097306656 1345392 1425477_x_at Histocompatibility 2, class II antigen A, beta 1, mRNA (cDNA clone MGC:6297 IMAGE:2651058)
50 Grk5 -1.10743 6.19305 7.30048 0.0051432031 1339828 1449514_at G protein-coupled receptor kinase 5 (Grk5), mRNA.
51 Prkar2b -1.11110 7.23393 8.34503 0.016848462 1372415 1456475_s_at protein kinase, cAMP dependent regulatory, type II beta (Prkar2b), mRNA.
52   -1.11441 4.91783 6.03225 0.0082293457 1364513 1447174_at Transcribed locus  
53 Acaca -1.11635 9.58950 10.70585 0.0078644728 1354501 1434185_at acetyl-Coenzyme A carboxylase alpha (Acaca), mRNA.
54   -1.12102 5.74661 6.86763 0.00055010378 1330207 1419033_at Transcribed locus, strongly similar to XP_001477930.1 PREDICTED: FERM domain containing 7 [Mus musculus]  
55 Cdo1 -1.12692 10.12018 11.24709 0.0017236298 1339273 1448842_at cysteine dioxygenase 1, cytosolic (Cdo1), mRNA.
56 9330159F19Rik -1.12957 6.20515 7.33472 0.0044111187 1369047 1458379_at RIKEN cDNA 9330159F19 gene, mRNA (cDNA clone IMAGE:8861298)  
57 Cxxc5 -1.13205 7.75535 8.88740 0.0017181017 1346671 1431469_a_at CXXC finger 5 (Cxxc5), mRNA.
58 Cpxm1 -1.15086 6.17671 7.32758 0.00036202459 1339320 1448901_at carboxypeptidase X 1 (M14 family) (Cpxm1), mRNA.
59 Xpr1 -1.15095 6.87741 8.02836 0.0028395642 1340228 1450130_at xenotropic and polytropic retrovirus receptor 1 (Xpr1), mRNA.
60 Erdr1 -1.15330 10.05591 11.20921 0.049327614 1349251 1452406_x_at erythroid differentiation regulator 1 (Erdr1), mRNA.  
61 Cd209g -1.15806 6.43402 7.59209 0.0056205618 1340086 1449918_at PREDICTED: CD209g antigen (Cd209g), mRNA.
62 Casp3 -1.15976 5.92835 7.08810 0.00017685077 1340027 1449839_at Caspase 3, mRNA (cDNA clone MGC:46907 IMAGE:4482368)
63   -1.16427 7.23565 8.39993 0.00029954228 1372388 1455966_s_at Transcribed locus  
64 Clec4a3 -1.16620 5.08407 6.25026 0.0067677331 1351521 1429954_at C-type lectin domain family 4, member a3 (Clec4a3), mRNA.
65 Fscn1 -1.16699 6.05344 7.22043 0.0037455593 1328142 1416515_at fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) (Fscn1), mRNA.
66 Rian -1.17224 6.46988 7.64212 0.0039618965 1342085 1452899_at MRNA, MBII-343 snoRNA nucleus
67 Atp6v1a -1.17269 7.85645 9.02914 5.4384816e-05 1332679 1422508_at ATPase, H+ transporting, lysosomal V1 subunit A (Atp6v1a), mRNA.
68 Aldh1a7 -1.17924 7.46230 8.64154 0.036152453 1329842 1418601_at aldehyde dehydrogenase family 1, subfamily A7 (Aldh1a7), mRNA.
69 Marcks -1.18120 7.98782 9.16902 0.0035071278 1327729 1415971_at myristoylated alanine rich protein kinase C substrate (Marcks), mRNA.
70 Acly -1.18491 9.61227 10.79718 0.036689836 1348104 1439459_x_at ATP citrate lyase (Acly), mRNA.
71 9630033F20Rik -1.18739 9.11211 10.29951 0.016155043 1357783 1439859_at RIKEN cDNA 9630033F20 gene (9630033F20Rik), mRNA.
72 Fgf18 -1.19549 5.41725 6.61274 0.0044434268 1339853 1449545_at fibroblast growth factor 18 (Fgf18), mRNA.
73 Adcy7 -1.19976 4.28914 5.48889 0.0029695897 1340189 1450065_at adenylate cyclase 7 (Adcy7), transcript variant 4, mRNA.
74 Kcnq5 -1.22012 4.48108 5.70120 0.020892518 1336159 1427426_at Voltage-gated potassium channel KCNQ5 (Kcnq5)
75 Tbx3 -1.23152 5.99345 7.22496 0.024362556 1371329 1437479_x_at T-box 3 (Tbx3), transcript variant 2, mRNA.
76 Vgll3 -1.23250 4.71354 5.94604 0.00083551192 1365660 1453593_at PREDICTED: vestigial like 3 (Drosophila) (Vgll3), mRNA.
77 Scd2 -1.23398 7.04259 8.27658 0.017924848 1327621 1415823_at Fatty acid desaturase (Scd3)
78 Mmd -1.25125 8.90339 10.15465 0.00013137363 1333463 1423488_at monocyte to macrophage differentiation-associated (Mmd), mRNA.
79 Tspan2 -1.25798 5.57233 6.83031 0.0068574794 1334291 1424567_at tetraspanin 2 (Tspan2), mRNA.
80 Tkt -1.25854 11.14908 12.40762 0.006354349 1348090 1439443_x_at transketolase (Tkt), mRNA.
81 Fscn1 -1.26113 7.66059 8.92172 0.002204768 1343325 1416514_a_at fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) (Fscn1), mRNA.
82   -1.26171 7.44652 8.70823 5.5423271e-05 1362970 1445574_at Transcribed locus  
83   -1.27006 5.62003 6.89009 0.00011130469 1356239 1437213_at Transcribed locus  
84 6530401D17Rik -1.27588 6.03604 7.31192 0.010009851 1341346 1451679_at RIKEN cDNA 6530401D17 gene (6530401D17Rik), non-coding RNA.  
85 Retnla -1.27777 10.44467 11.72244 0.021562107 1339421 1449015_at Resistin like alpha, mRNA (cDNA clone MGC:35890 IMAGE:4189285)
86 D330050I23Rik -1.27889 5.34158 6.62046 0.0025357662 1354564 1434301_at RIKEN cDNA D330050I23 gene (D330050I23Rik), mRNA.  
87 Slc25a1 -1.30386 8.89100 10.19487 0.032205525 1350368 1428190_at solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 (Slc25a1), nuclear gene encoding mitochondrial protein, mRNA.
88 Kcnq5 -1.30428 7.33986 8.64414 0.022270292 1368361 1457587_at potassium voltage-gated channel, subfamily Q, member 5 (Kcnq5), mRNA.
89 Dio2 -1.30694 5.66756 6.97449 0.027489775 1330128 1418937_at deiodinase, iodothyronine, type II (Dio2), mRNA.
90 Cybb -1.31512 5.30920 6.62432 0.0025047374 1356037 1436779_at cytochrome b-245, beta polypeptide (Cybb), mRNA.
91 Evi2a -1.31628 5.98662 7.30289 0.0012303923 1348619 1450241_a_at ecotropic viral integration site 2a (Evi2a), transcript variant 2, mRNA.
92 Bpnt1 -1.33936 6.66312 8.00248 1.9084413e-05 1339578 1449211_at bisphosphate 3'-nucleotidase 1 (Bpnt1), mRNA.
93 Cd48 -1.34077 5.01426 6.35503 0.0024981736 1336073 1427301_at CD48 antigen (Cd48), mRNA.
94 Mcpt4 -1.34092 6.85196 8.19288 0.0044352497 1345622 1425967_a_at mast cell protease 4 (Mcpt4), mRNA.
95 Tkt -1.34317 10.04487 11.38804 0.0054799905 1340882 1451015_at transketolase (Tkt), mRNA.
96   -1.34761 6.76076 8.10837 0.0064046775 1357038 1438720_at Transcribed locus  
97 Fasn -1.35132 11.21748 12.56880 0.011395055 1333715 1423828_at fatty acid synthase (Fasn), mRNA.
98 St8sia4 -1.35715 5.96965 7.32680 0.0051116231 1343807 1419186_a_at ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (St8sia4), transcript variant 1, mRNA.
99 Tusc5 -1.38385 7.57417 8.95801 0.0076936342 1358895 1441096_at tumor suppressor candidate 5 (Tusc5), mRNA.
100   -1.38542 6.02836 7.41378 0.0031168307 1360916 1443353_at ESTs, Weakly similar to RIKEN cDNA 5730493B19 [Mus musculus] [M.musculus]  
101 Iqgap2 -1.39627 6.60337 7.99964 0.0054191919 1354344 1433885_at IQ motif containing GTPase activating protein 2 (Iqgap2), mRNA.
102 Sfrp2 -1.40292 6.91090 8.31382 0.010551215 1338760 1448201_at secreted frizzled-related protein 2 (Sfrp2), mRNA.
103 Agpat2 -1.40910 9.08096 10.49006 0.018493841 1350720 1428821_at 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (Agpat2), mRNA
104 Acly -1.41204 9.86636 11.27840 0.018062669 1341334 1451666_at ATP citrate lyase (Acly), mRNA.
105 Adrb3 -1.42741 5.62155 7.04895 0.00096338252 1331990 1421555_at adrenergic receptor, beta 3 (Adrb3), mRNA.
106 Pparg -1.44818 7.29862 8.74680 0.0025828068 1344152 1420715_a_at peroxisome proliferator activated receptor gamma (Pparg), transcript variant 2, mRNA.
107 Klra9 -1.45296 5.93247 7.38542 0.0072815974 1345371 1425436_x_at killer cell lectin-like receptor subfamily A, member 9 (Klra9), mRNA.
108 Nrg4 -1.45825 6.03043 7.48869 0.02172261 1332082 1421681_at neuregulin 4 (Nrg4), mRNA.
109 Cxcr4 -1.49151 5.28352 6.77503 0.011811138 1339165 1448710_at chemokine (C-X-C motif) receptor 4 (Cxcr4), mRNA.
110 Myct1 -1.50921 4.68398 6.19319 0.0069344917 1335414 1426433_at myc target 1 (Myct1), mRNA.
111 2210015D19Rik -1.53532 7.61870 9.15402 0.00025841882 1356810 1438285_at PREDICTED: Mus musculus RIKEN cDNA 2210015D19 gene, transcript variant 2 (2210015D19Rik), mRNA  
112 Sertad4 -1.54211 5.39034 6.93245 0.0025980339 1366550 1454877_at SERTA domain containing 4 (Sertad4), mRNA.  
113 Myct1 -1.54920 6.18984 7.73903 0.0046209341 1371969 1447584_s_at myc target 1 (Myct1), mRNA.
114 Gpr120 -1.56283 4.40725 5.97008 0.02976068 1357453 1439489_at G protein-coupled receptor 120 (Gpr120), mRNA.
115 Ptger3 -1.58957 5.03714 6.62670 0.0038734357 1348652 1450344_a_at prostaglandin E receptor 3 (subtype EP3) (Ptger3), mRNA.
116 Car3 -1.60246 5.48391 7.08637 0.02824509 1365656 1453588_at Carbonic anhydrase 3, mRNA (cDNA clone MGC:18583 IMAGE:4195712)
117 1110020P15Rik -1.66781 9.72731 11.39511 0.0012940561 1337510 1434340_at RIKEN cDNA 1110020P15 gene, mRNA (cDNA clone MGC:37480 IMAGE:4984172)
118 Cebpa -1.67010 9.40938 11.07948 5.8370473e-06 1330167 1418982_at CCAAT/enhancer binding protein (C/EBP), alpha (Cebpa), mRNA.
119 Ppp1r3b -1.68500 5.71157 7.39657 0.049937484 1355930 1436590_at protein phosphatase 1, regulatory (inhibitor) subunit 3B (Ppp1r3b), mRNA.
120 Acly -1.69082 8.62603 10.31685 0.016002772 1334817 1425326_at ATP citrate lyase (Acly), mRNA.
121 Aplnr -1.72043 7.75029 9.47072 0.0014878131 1347891 1438651_a_at apelin receptor (Aplnr), mRNA.
122 Scd2 -1.76015 6.62797 8.38812 0.00086884444 1327622 1415824_at stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA.
123 H2-Aa -1.77813 7.91292 9.69104 0.00031471617 1349261 1452431_s_at Histocompatibility 2, class II antigen A, alpha, mRNA (cDNA clone MGC:25391 IMAGE:3670758)
124 Mosc1 -1.80239 4.23064 6.03303 0.0027802828 1336527 1428005_at MOCO sulphurase C-terminal domain containing 1 (Mosc1), mRNA.
125 Rasd2 -1.86659 6.46497 8.33157 0.043595931 1336105 1427343_at RASD family, member 2, mRNA (cDNA clone IMAGE:4988981)
126 Elovl6 -1.92266 7.07168 8.99434 0.028053415 1328866 1417403_at ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA.
127 Elovl6 -1.95709 7.64029 9.59738 0.016719341 1328867 1417404_at ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA.
128 Car3 -2.01063 8.31320 10.32382 0.021204072 1370950 1430584_s_at Carbonic anhydrase 3, mRNA (cDNA clone MGC:18583 IMAGE:4195712)
129 Adrb3 -2.39460 7.08551 9.48011 0.00074486461 1342546 1455918_at adrenergic receptor, beta 3  
130 E130009J12Rik -3.16212 3.83455 6.99668 0.00527146 1357529 1439575_at RIKEN cDNA E130009J12 gene (E130009J12Rik), mRNA.  


This Web page was derived in collaboration with GSP consortium members.

Home: jak-stat.nih.gov
Home: Jak-Stat Prospector

Revised: Mon Sep 28 13:56:56 EDT 2009