Trans-NIH Jak-Stat Initiative - Muscle: Stat5MKO-GH vs WT-GH

Changes in comparison: All samples for Muscle: Stat5MKO-GH vs WT-GH

Muscle cells from Stat5-null and control 15-week mice without GH treatment. This used mAdb test: EG3.2-test-1+FC-ALL.

Muscle: EG003.2
(T2+)  Stat5MKO-GH vs WT-GH --- fold changes > 2X and p-Value<0.05.

This mAdb-derived analysis report compares two groups of samples (A and B) using the paired t-test followed by a fold-change test with the threshold values listed above. The t-test is only done if are at least two samples/condition. It performs fold-change thresholding in either case. The mean A and mean B values are shown as log2 values in the following table as A Mean and B Mean. If there are not enough samples in either condition A or condition B, it only compares the fold-change (mean A/mean B) computed as the difference between the log2 means shown as A-B Mean Difference in this report - see Data Analysis Methods for more discussion. If the t-test is performed, the p-Value is reported as A-B p-Value. Individual sample expression values are reported as the RMA normalized values not using the log2. The tests, thresholding and mAdb Retrieval Report were generated on the mAdb system for the GSP data and subsequently converted to this Web page.

Clicking on the table entries for Gene, Well ID, and Feature ID will go to the GeneCard, mAdb Feature Report, and Affymetrix probe database Web page for that entry. The genes are sorted by A-B Mean Difference with:
   (A) Samples[Stat5MKO-GH]: EG003.2-04, EG003.2-05, EG003.2-06
   (B) Samples[WT-GH]: EG003.2-01, EG003.2-02, EG003.2-03.

mAdb Microarray Retrieval Report - All Samples

Preface to table

Row                 A A A A A A B B B B B B C C C C C C  
Row Gene A-B Mean Difference A Mean (Stat5MKO-GH) B Mean (WT-GH) A-B p-Value Well ID Feature ID Description EG001-01.Erythroid.Stat5KO.br1.noStim EG001-02.Erythroid.Stat5KO.br2.noStim EG001-03.Erythroid.Stat5KO.br3.noStim EG001-04.Erythroid.WT.br1.noStim EG001-05.Erythroid.WT.br2.noStim EG001-06.Erythroid.WT.br3.noStim EG003.1-01.Muscle.Stat5MKO.42.GH EG003.1-02.Muscle.Stat5MKO.43.GH EG003.1-03.Muscle.WT.44.GH EG003.1-04.Muscle.WT.47.GH EG003.1-05.Muscle.Stat5MKO.48.GH EG003.1-06.Muscle.WT.50.GH EG003.2-01.Muscle.WT.4038WT.noStim EG003.2-02.Muscle.WT.4060WT.noStim EG003.2-03.Muscle.WT.4063WT.noStim EG003.2-04.Muscle.Stat5MKO.4035KO.noStim EG003.2-05.Muscle.Stat5MKO.4036KO.noStim EG003.2-06.Muscle.Stat5MKO.4042KO.noStim Gene Ontology Terms
1 1700001O22Rik 2.89579 9.40274 6.50696 0.0010788846 1345143 1424795_a_at RIKEN cDNA 1700001O22 gene (1700001O22Rik), mRNA. 48.3118 50.5877 59.0861 49.5796 80.8323 49.3861 67.1359 51.3696 489.9384 431.6515 47.0724 377.0922 555.6433 734.1229 760.2554 124.9346 74.9565 80.3294  
2 Stat5b 2.72965 10.48005 7.75040 0.0066651671 1344534 1422103_a_at signal transducer and activator of transcription 5B (Stat5b), mRNA. 36.8179 32.6977 47.5826 137.0905 121.0724 106.5132 195.1879 183.1424 842.1944 887.5067 193.3896 963.3258 1420.4606 1362.1924 1505.7619 301.7720 176.5317 187.4154
3 Cish 2.51205 10.82937 8.31732 0.016365591 1339177 1448724_at cytokine inducible SH2-containing protein (Cish), mRNA. 228.0238 398.3964 283.2197 495.2884 453.0797 551.0824 1230.2147 1169.5646 4293.6797 4113.7206 1136.2792 4409.4028 1080.4852 1721.8420 3238.0171 495.1049 180.4638 363.2432
4 Socs2 2.06717 8.67601 6.60884 0.011818782 1343687 1418507_s_at Suppressor of cytokine signaling 2 (Socs2), mRNA 17.8044 20.1361 18.3384 49.2846 28.3416 46.7672 248.9299 268.4852 653.5010 643.1115 246.2027 725.4607 255.1171 453.8417 590.9852 134.6512 73.0052 94.5830
5 Kcnf1 2.05301 6.62131 4.56831 0.0235545 1366492 1454768_at potassium voltage-gated channel, subfamily F, member 1 (Kcnf1), mRNA. 18.4807 20.3811 22.2198 28.8419 17.5167 18.4864 56.6816 47.6452 379.9297 338.0776 57.2635 368.4297 68.6281 77.4844 179.4429 28.0236 16.7551 28.4394
6 Socs2 1.95466 9.64328 7.68861 0.0059788138 1339494 1449109_at suppressor of cytokine signaling 2 (Socs2), mRNA. 38.4313 29.2628 32.6417 62.9996 52.0411 64.4851 472.4270 433.4186 1003.3441 981.8046 474.8078 934.7482 597.6048 845.6000 1011.9679 231.8657 185.9429 203.6540
7 Gadl1 1.85758 8.98819 7.13061 0.049384706 1359154 1441384_at Glutamate decarboxylase-like 1 (Gadl1), mRNA 49.2502 53.4814 51.5917 43.7548 43.0360 46.1209 114.4313 113.9699 304.5925 328.7047 113.0672 401.3536 458.4861 460.1643 620.7335 270.0419 105.7489 96.3556
8 Slc15a5 1.80022 5.78354 3.98332 0.044181429 1336340 1427722_at solute carrier family 15, member 5 (Slc15a5), mRNA. 20.4691 19.6137 19.8437 20.8589 19.1393 20.3895 20.9009 20.5427 93.2300 94.2457 22.6625 122.9824 106.4931 42.3269 37.0779 16.8811 9.8637 23.7602
9 Casp12 1.76163 8.34531 6.58368 0.0032759493 1339649 1449297_at caspase 12 (Casp12), mRNA. 24.8068 23.7843 23.5432 29.1122 27.2175 25.4449 101.0482 111.2058 258.5023 239.1447 98.5324 253.1287 298.3186 317.9297 362.7039 116.8754 77.1682 97.8343
10   1.62330 9.19177 7.56847 0.0031722308 1341594 1452106_at Transcribed locus 19.7915 27.3467 17.8997 16.1982 17.9287 18.4070 161.5834 168.0249 324.3930 305.3578 180.7075 308.0631 558.7154 478.8456 747.4913 220.8808 192.5369 160.8191  
11 Casp12 1.60060 9.02264 7.42204 0.00052098409 1330166 1418981_at caspase 12 (Casp12), mRNA. 42.1646 37.8794 50.0380 57.8193 76.5623 68.3550 164.7075 175.9609 413.8376 349.4793 184.0654 397.5633 502.3105 462.2016 605.9685 176.4864 150.8865 189.4122
12   1.56591 6.58643 5.02052 0.0076407575 1349197 1452107_s_at Transcribed locus 12.1140 15.0824 14.0361 14.9930 13.5626 12.1668 31.0002 34.1491 63.7421 59.9165 33.2156 59.6938 107.3401 76.1409 108.5822 32.5923 30.6299 34.2547  
13 Cd28 1.56502 6.38087 4.81585 0.027523777 1329031 1417597_at CD28 antigen (Cd28), mRNA. 22.9933 21.2014 23.2580 23.9194 26.5585 26.6697 26.8275 24.5152 152.6904 106.3417 30.6207 92.1240 55.3328 113.4937 92.1606 32.1468 27.0840 25.6622
14 Stat5b 1.56308 9.30647 7.74340 0.0012332287 1344533 1422102_a_at signal transducer and activator of transcription 5B (Stat5b), mRNA. 214.4234 228.9297 176.0408 297.3186 279.9465 252.4171 200.1609 167.7075 560.8443 521.5580 174.5408 507.9575 700.2908 558.4112 649.1553 224.4297 204.4297 214.4663
15 Acsl3 1.55931 8.37004 6.81073 0.0051952203 1372229 1452771_s_at acyl-CoA synthetase long-chain family member 3 (Acsl3), transcript variant 3, mRNA. 86.1739 64.0624 91.3430 102.6487 106.3951 105.2779 163.2630 149.6342 431.9551 370.4974 160.3225 367.5856 282.7366 290.2828 441.2631 145.0960 98.2182 99.2781
16 Mafb 1.42277 9.62010 8.19733 0.018186563 1341365 1451716_at V-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA 104.7092 115.8596 130.8743 90.6181 117.8875 143.2256 715.7394 690.2579 2766.2138 2808.5714 665.3594 2755.7235 652.5212 666.6209 1120.3174 341.1308 278.8834 265.8186
17 Dkk3 1.41189 7.66216 6.25027 0.019000024 1328794 1417312_at dickkopf homolog 3 (Xenopus laevis) (Dkk3), mRNA. 53.9805 60.7781 50.3236 51.8402 50.3162 40.0145 76.3389 89.8983 262.7482 224.6651 88.4559 227.8496 157.9852 183.0014 287.4398 85.9731 78.4342 65.4170
18 Mafb 1.40745 8.24774 6.84029 0.024961307 1341364 1451715_at v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA. 55.6164 55.6164 58.3606 49.0425 52.2882 62.2736 351.4852 390.0426 1629.9509 1790.5964 342.2789 1860.1253 229.7631 276.4024 442.2075 129.3800 117.5628 98.9141
19 Socs2 1.31611 6.59017 5.27405 0.0075799986 1356918 1438470_at Suppressor of cytokine signaling 2, mRNA (cDNA clone IMAGE:1068260) 36.4542 34.6507 23.9269 42.2096 32.5182 37.4998 88.5275 76.0028 188.1409 120.8790 82.3322 111.8483 73.7221 105.0405 115.4938 36.9443 33.9261 46.2234
20 Neto2 1.23588 7.12328 5.88740 0.0088415993 1355746 1436309_at neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), mRNA. 43.1165 38.6592 45.2781 29.9397 41.5449 43.3398 30.9623 42.6913 94.6231 83.2493 44.5354 78.6205 128.8303 133.1761 157.9499 75.2886 49.8386 55.2788
21 Stat5a 1.21721 7.23537 6.01816 0.0019973238 1348627 1450259_a_at signal transducer and activator of transcription 5A (Stat5a), mRNA. 13.8932 16.3582 22.5512 59.7969 39.8737 43.7828 25.8331 31.5116 82.9659 78.6861 31.5116 72.4687 166.3186 137.2517 149.8765 74.5429 65.4503 55.7989
22   1.15876 9.88899 8.73023 0.0024023272 1367020 1455647_at Transcribed locus 29.4400 21.9108 29.1606 30.2491 29.6021 22.3630 660.4493 581.2630 1215.7705 1152.0391 613.9852 1120.9556 885.6439 1075.1794 895.1835 502.6790 403.8789 377.2622  
23 Gadl1 1.13957 7.49263 6.35306 0.02749863 1352211 1430843_at glutamate decarboxylase-like 1 (Gadl1), mRNA. 79.3460 65.0256 68.5228 95.1100 81.6388 78.1968 90.4863 80.8346 130.5659 120.6834 89.4227 111.2311 179.3990 163.5236 199.1235 104.1016 60.4963 86.7366
24 Polk 1.13053 9.04485 7.91431 0.0030263012 1339803 1449483_at polymerase (DNA directed), kappa (Polk), mRNA. 292.3919 271.6886 245.1151 274.8274 326.9900 256.0853 233.8353 225.3646 345.6923 333.0883 222.1680 327.0964 465.5213 505.1972 626.4852 266.3712 204.3848 257.8708
25 Odc1 1.13024 10.73701 9.60678 0.033244858 1347648 1437711_x_at ornithine decarboxylase, structural 1 (Odc1), mRNA. 6687.3671 6043.3741 5708.4380 6664.1734 7009.6519 8174.1733 1520.5682 1560.5462 1424.5334 1909.5881 1560.3095 1934.8143 1810.1088 1270.1519 2162.3660 1041.4852 824.2759 552.1519
26 B130066H01Rik 1.12609 5.18662 4.06053 0.013339111 1363875 1446509_at RIKEN cDNA B130066H01 gene 50.9236 75.2505 59.7120 46.6197 65.4652 70.6477 66.3173 65.7148 135.2879 117.4626 77.2464 108.7614 35.0984 31.0789 44.2829 13.2299 21.4879 16.3409  
27   1.12090 7.84839 6.72749 0.0068605237 1354351 1433898_at Transcribed locus 117.3344 65.6846 91.9802 59.1016 57.0308 54.3299 222.2389 264.1762 268.3589 294.0615 259.0106 344.8308 246.9030 184.4152 268.8305 125.0574 94.8466 100.3231  
28 Armcx4 1.11470 7.44107 6.32637 0.048187743 1335963 1427167_at Armadillo repeat containing, X-linked 4, mRNA (cDNA clone IMAGE:5374915) 16.7457 23.9955 18.2506 22.0354 22.0988 37.2792 92.0472 89.8266 191.7828 181.2917 85.0148 171.0661 178.8125 152.7356 192.1384 116.8197 74.4440 59.4200  
29   1.09288 8.39993 7.30705 0.04783182 1372388 1455966_s_at Transcribed locus 170.5508 199.1926 124.1036 156.1014 132.5101 153.5051 124.3757 139.9304 166.0027 143.3408 128.7360 143.8669 354.7032 306.4024 354.5955 218.0023 159.4280 114.2602  
30 Mchr1 1.07710 7.73639 6.65929 0.0034490492 1336547 1428031_at melanin-concentrating hormone receptor 1 (Mchr1), mRNA. 84.1527 69.4702 94.8623 86.1372 56.1097 56.2483 141.9958 142.2075 170.4603 184.8394 155.6311 169.9445 200.7433 217.3496 222.2571 107.0690 87.7749 109.8771
31 Acsl3 1.07367 5.43131 4.35764 0.0025226076 1350458 1428387_at acyl-CoA synthetase long-chain family member 3 (Acsl3), transcript variant 3, mRNA. 15.9337 20.8409 19.6265 20.2143 18.3331 17.6289 22.4003 22.3235 28.8001 31.5855 19.9450 44.8858 43.8126 40.1095 45.7212 23.6600 19.1201 19.0474
32 Odc1 1.06232 10.55471 9.49239 0.020605427 1346063 1427364_a_at ornithine decarboxylase, structural 1 (Odc1), mRNA. 2469.0588 1833.6796 2089.5172 5094.7275 4581.5947 5555.6635 758.9211 784.7345 1125.1624 1045.3071 789.7075 1049.0672 1682.9176 1113.2225 1816.3872 845.2527 743.7337 594.4004
33 9130404H23Rik 1.04192 6.25963 5.21771 0.034362544 1368912 1458210_at PREDICTED: Mus musculus RIKEN cDNA 9130404H23 gene (9130404H23Rik), mRNA 67.4383 71.8530 68.2470 75.3261 71.5535 54.9563 42.0233 40.3867 118.1431 94.5930 38.2933 80.9575 69.7181 70.0735 92.0686 34.4037 28.8514 51.9150  
34 Odc1 1.02476 12.35765 11.33289 0.022428023 1347907 1438761_a_at ornithine decarboxylase, structural 1 (Odc1), mRNA. 10735.8480 10602.4838 9343.8561 11600.0707 11040.1486 13638.8741 3180.6963 3246.2949 4260.7474 4387.6364 3321.6179 4521.6353 5555.4619 3957.2088 6576.0122 2995.5964 2816.5713 2034.2963
35 Slc30a2 1.00905 8.54255 7.53349 0.00048567467 1336101 1427339_at Solute carrier family 30 (zinc transporter), member 2, mRNA (cDNA clone IMAGE:4239648) 74.1144 84.8762 61.9197 57.8193 82.1259 42.7128 361.9962 351.5033 591.9471 620.0180 368.9119 622.0585 359.7200 350.5555 411.1179 201.9090 174.3739 180.6281  
36 8430426J06Rik 1.00876 8.45093 7.44217 0.048013374 1357769 1439844_at CDNA clone IMAGE:3368992 254.6228 234.4385 205.0104 313.7068 256.9484 251.2402 178.5510 144.3592 266.8818 306.7982 184.2070 315.0408 252.3677 374.0326 453.9504 160.1131 175.2817 187.4064  


This Web page was derived in collaboration with GSP consortium members.

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Revised: Mon Sep 28 13:56:56 EDT 2009