Row
A
A
A
B
B
B
Row
Gene
A-B Mean Difference
A Mean (Stat5MKO-GH)
B Mean (WT-GH)
A-B p-Value
Well ID
Feature ID
Description
EG003.2-01.Muscle.WT.4038WT.noStim
EG003.2-02.Muscle.WT.4060WT.noStim
EG003.2-03.Muscle.WT.4063WT.noStim
EG003.2-04.Muscle.Stat5MKO.4035KO.noStim
EG003.2-05.Muscle.Stat5MKO.4036KO.noStim
EG003.2-06.Muscle.Stat5MKO.4042KO.noStim
Gene Ontology Terms
1
1700001O22Rik
2.89579
9.40274
6.50696
0.0010788846
1345143
1424795_a_at
RIKEN cDNA 1700001O22 gene (1700001O22Rik), mRNA.
555.6433
734.1229
760.2554
124.9346
74.9565
80.3294
2
Stat5b
2.72965
10.48005
7.75040
0.0066651671
1344534
1422103_a_at
signal transducer and activator of transcription 5B (Stat5b), mRNA.
1420.4606
1362.1924
1505.7619
301.7720
176.5317
187.4154
calcium ion binding
cytokine-mediated signaling pathway
cytoplasm
development of secondary female sexual characteristics
development of secondary male sexual characteristics
development of secondary male sexual characteristics
DNA binding
female pregnancy
female pregnancy
JAK-STAT cascade
lactation
lipid storage
luteinization
natural killer cell differentiation
negative regulation of apoptosis
negative regulation of erythrocyte differentiation
nucleus
Peyer's patch development
positive regulation of activated T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of B cell differentiation
positive regulation of cell proliferation
positive regulation of gamma-delta T cell differentiation
positive regulation of inflammatory response
positive regulation of interleukin-2 biosynthetic process
positive regulation of lymphocyte differentiation
positive regulation of mitotic cell cycle
positive regulation of multicellular organism growth
positive regulation of multicellular organism growth
positive regulation of natural killer cell differentiation
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell proliferation
positive regulation of survival gene product expression
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
progesterone metabolic process
protein binding
regulation of cell adhesion
regulation of epithelial cell differentiation
regulation of steroid metabolic process
regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
response to interleukin-15
response to interleukin-2
response to interleukin-4
sex differentiation
signal transducer activity
signal transduction
T cell differentiation in the thymus
T cell homeostasis
transcription
transcription factor activity
3
Cish
2.51205
10.82937
8.31732
0.016365591
1339177
1448724_at
cytokine inducible SH2-containing protein (Cish), mRNA.
1080.4852
1721.8420
3238.0171
495.1049
180.4638
363.2432
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
intracellular signaling cascade
modification-dependent protein catabolic process
negative regulation of signal transduction
plasma membrane
protein binding
regulation of growth
4
Socs2
2.06717
8.67601
6.60884
0.011818782
1343687
1418507_s_at
Suppressor of cytokine signaling 2 (Socs2), mRNA
255.1171
453.8417
590.9852
134.6512
73.0052
94.5830
growth hormone receptor binding
intracellular signaling cascade
lactation
lactation
mammary gland alveolus development
mammary gland alveolus development
modification-dependent protein catabolic process
negative regulation of JAK-STAT cascade
negative regulation of multicellular organism growth
negative regulation of multicellular organism growth
negative regulation of signal transduction
positive regulation of neuron differentiation
regulation of growth
regulation of multicellular organism growth
5
Kcnf1
2.05301
6.62131
4.56831
0.0235545
1366492
1454768_at
potassium voltage-gated channel, subfamily F, member 1 (Kcnf1), mRNA.
68.6281
77.4844
179.4429
28.0236
16.7551
28.4394
integral to membrane
ion channel activity
ion transport
membrane
potassium channel activity
potassium ion binding
potassium ion transport
protein binding
transport
voltage-gated ion channel activity
voltage-gated potassium channel activity
voltage-gated potassium channel complex
6
Socs2
1.95466
9.64328
7.68861
0.0059788138
1339494
1449109_at
suppressor of cytokine signaling 2 (Socs2), mRNA.
597.6048
845.6000
1011.9679
231.8657
185.9429
203.6540
growth hormone receptor binding
intracellular signaling cascade
lactation
lactation
mammary gland alveolus development
mammary gland alveolus development
modification-dependent protein catabolic process
negative regulation of JAK-STAT cascade
negative regulation of multicellular organism growth
negative regulation of multicellular organism growth
negative regulation of signal transduction
positive regulation of neuron differentiation
regulation of growth
regulation of multicellular organism growth
7
Gadl1
1.85758
8.98819
7.13061
0.049384706
1359154
1441384_at
Glutamate decarboxylase-like 1 (Gadl1), mRNA
458.4861
460.1643
620.7335
270.0419
105.7489
96.3556
carboxy-lyase activity
carboxylic acid metabolic process
catalytic activity
lyase activity
pyridoxal phosphate binding
8
Slc15a5
1.80022
5.78354
3.98332
0.044181429
1336340
1427722_at
solute carrier family 15, member 5 (Slc15a5), mRNA.
106.4931
42.3269
37.0779
16.8811
9.8637
23.7602
integral to membrane
membrane
oligopeptide transport
peptide transport
protein transport
symporter activity
transport
transporter activity
9
Casp12
1.76163
8.34531
6.58368
0.0032759493
1339649
1449297_at
caspase 12 (Casp12), mRNA.
298.3186
317.9297
362.7039
116.8754
77.1682
97.8343
apoptosis
apoptosis in response to endoplasmic reticulum stress
cysteine-type endopeptidase activity
cysteine-type peptidase activity
endoplasmic reticulum
endoplasmic reticulum unfolded protein response
hydrolase activity
induction of apoptosis
intracellular
peptidase activity
protein binding
proteolysis
regulation of apoptosis
virus-infected cell apoptosis
10
1.62330
9.19177
7.56847
0.0031722308
1341594
1452106_at
Transcribed locus
558.7154
478.8456
747.4913
220.8808
192.5369
160.8191
11
Casp12
1.60060
9.02264
7.42204
0.00052098409
1330166
1418981_at
caspase 12 (Casp12), mRNA.
502.3105
462.2016
605.9685
176.4864
150.8865
189.4122
apoptosis
apoptosis in response to endoplasmic reticulum stress
cysteine-type endopeptidase activity
cysteine-type peptidase activity
endoplasmic reticulum
endoplasmic reticulum unfolded protein response
hydrolase activity
induction of apoptosis
intracellular
peptidase activity
protein binding
proteolysis
regulation of apoptosis
virus-infected cell apoptosis
12
1.56591
6.58643
5.02052
0.0076407575
1349197
1452107_s_at
Transcribed locus
107.3401
76.1409
108.5822
32.5923
30.6299
34.2547
13
Cd28
1.56502
6.38087
4.81585
0.027523777
1329031
1417597_at
CD28 antigen (Cd28), mRNA.
55.3328
113.4937
92.1606
32.1468
27.0840
25.6622
external side of plasma membrane
external side of plasma membrane
external side of plasma membrane
immune response
induction of apoptosis by extracellular signals
integral to membrane
membrane
negative thymic T cell selection
plasma membrane
positive regulation of alpha-beta T cell proliferation
positive regulation of alpha-beta T cell proliferation
positive regulation of inflammatory response to antigenic stimulus
positive regulation of interleukin-2 biosynthetic process
positive regulation of isotype switching to IgG isotypes
positive regulation of T cell proliferation
positive regulation of T cell proliferation
T cell costimulation
T cell costimulation
14
Stat5b
1.56308
9.30647
7.74340
0.0012332287
1344533
1422102_a_at
signal transducer and activator of transcription 5B (Stat5b), mRNA.
700.2908
558.4112
649.1553
224.4297
204.4297
214.4663
calcium ion binding
cytokine-mediated signaling pathway
cytoplasm
development of secondary female sexual characteristics
development of secondary male sexual characteristics
development of secondary male sexual characteristics
DNA binding
female pregnancy
female pregnancy
JAK-STAT cascade
lactation
lipid storage
luteinization
natural killer cell differentiation
negative regulation of apoptosis
negative regulation of erythrocyte differentiation
nucleus
Peyer's patch development
positive regulation of activated T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of B cell differentiation
positive regulation of cell proliferation
positive regulation of gamma-delta T cell differentiation
positive regulation of inflammatory response
positive regulation of interleukin-2 biosynthetic process
positive regulation of lymphocyte differentiation
positive regulation of mitotic cell cycle
positive regulation of multicellular organism growth
positive regulation of multicellular organism growth
positive regulation of natural killer cell differentiation
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell proliferation
positive regulation of survival gene product expression
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
progesterone metabolic process
protein binding
regulation of cell adhesion
regulation of epithelial cell differentiation
regulation of steroid metabolic process
regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
response to interleukin-15
response to interleukin-2
response to interleukin-4
sex differentiation
signal transducer activity
signal transduction
T cell differentiation in the thymus
T cell homeostasis
transcription
transcription factor activity
15
Acsl3
1.55931
8.37004
6.81073
0.0051952203
1372229
1452771_s_at
acyl-CoA synthetase long-chain family member 3 (Acsl3), transcript variant 3, mRNA.
282.7366
290.2828
441.2631
145.0960
98.2182
99.2781
ATP binding
catalytic activity
endoplasmic reticulum
fatty acid metabolic process
integral to membrane
ligase activity
lipid metabolic process
long-chain-fatty-acid-CoA ligase activity
magnesium ion binding
membrane
metabolic process
microsome
mitochondrial outer membrane
mitochondrion
nucleotide binding
peroxisome
16
Mafb
1.42277
9.62010
8.19733
0.018186563
1341365
1451716_at
V-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA
652.5212
666.6209
1120.3174
341.1308
278.8834
265.8186
brain segmentation
DNA binding
inner ear morphogenesis
nucleus
positive regulation of transcription from RNA polymerase II promoter
protein binding
regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
respiratory gaseous exchange
rhombomere 5 development
rhombomere 6 development
segment specification
sequence-specific DNA binding
transcription
transcription factor activity
transcription factor complex
17
Dkk3
1.41189
7.66216
6.25027
0.019000024
1328794
1417312_at
dickkopf homolog 3 (Xenopus laevis) (Dkk3), mRNA.
157.9852
183.0014
287.4398
85.9731
78.4342
65.4170
extracellular region
extracellular space
multicellular organismal development
negative regulation of Wnt receptor signaling pathway
Wnt receptor signaling pathway
18
Mafb
1.40745
8.24774
6.84029
0.024961307
1341364
1451715_at
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA.
229.7631
276.4024
442.2075
129.3800
117.5628
98.9141
brain segmentation
DNA binding
inner ear morphogenesis
nucleus
positive regulation of transcription from RNA polymerase II promoter
protein binding
regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
respiratory gaseous exchange
rhombomere 5 development
rhombomere 6 development
segment specification
sequence-specific DNA binding
transcription
transcription factor activity
transcription factor complex
19
Socs2
1.31611
6.59017
5.27405
0.0075799986
1356918
1438470_at
Suppressor of cytokine signaling 2, mRNA (cDNA clone IMAGE:1068260)
73.7221
105.0405
115.4938
36.9443
33.9261
46.2234
growth hormone receptor binding
intracellular signaling cascade
lactation
lactation
mammary gland alveolus development
mammary gland alveolus development
modification-dependent protein catabolic process
negative regulation of JAK-STAT cascade
negative regulation of multicellular organism growth
negative regulation of multicellular organism growth
negative regulation of signal transduction
positive regulation of neuron differentiation
regulation of growth
regulation of multicellular organism growth
20
Neto2
1.23588
7.12328
5.88740
0.0088415993
1355746
1436309_at
neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), mRNA.
128.8303
133.1761
157.9499
75.2886
49.8386
55.2788
integral to membrane
membrane
plasma membrane
receptor activity
21
Stat5a
1.21721
7.23537
6.01816
0.0019973238
1348627
1450259_a_at
signal transducer and activator of transcription 5A (Stat5a), mRNA.
166.3186
137.2517
149.8765
74.5429
65.4503
55.7989
calcium ion binding
cytokine-mediated signaling pathway
cytoplasm
development of secondary female sexual characteristics
development of secondary male sexual characteristics
development of secondary male sexual characteristics
DNA binding
epithelial cell differentiation involved in prostate gland development
female pregnancy
JAK-STAT cascade
lactation
lipid storage
luteinization
mammary gland development
natural killer cell differentiation
negative regulation of apoptosis
negative regulation of erythrocyte differentiation
negative regulation of mast cell apoptosis
nucleus
peptidyl-tyrosine phosphorylation
Peyer's patch development
positive regulation of activated T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of B cell differentiation
positive regulation of cell proliferation
positive regulation of cell proliferation
positive regulation of gamma-delta T cell differentiation
positive regulation of inflammatory response
positive regulation of interleukin-2 biosynthetic process
positive regulation of lymphocyte differentiation
positive regulation of mast cell differentiation
positive regulation of mast cell proliferation
positive regulation of mitotic cell cycle
positive regulation of multicellular organism growth
positive regulation of natural killer cell differentiation
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of survival gene product expression
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
prostate gland epithelium morphogenesis
protein binding
regulation of cell adhesion
regulation of epithelial cell differentiation
regulation of steroid metabolic process
regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
response to peptide hormone stimulus
signal transducer activity
signal transduction
T cell differentiation in the thymus
T cell homeostasis
transcription
transcription factor activity
22
1.15876
9.88899
8.73023
0.0024023272
1367020
1455647_at
Transcribed locus
885.6439
1075.1794
895.1835
502.6790
403.8789
377.2622
23
Gadl1
1.13957
7.49263
6.35306
0.02749863
1352211
1430843_at
glutamate decarboxylase-like 1 (Gadl1), mRNA.
179.3990
163.5236
199.1235
104.1016
60.4963
86.7366
carboxy-lyase activity
carboxylic acid metabolic process
catalytic activity
lyase activity
pyridoxal phosphate binding
24
Polk
1.13053
9.04485
7.91431
0.0030263012
1339803
1449483_at
polymerase (DNA directed), kappa (Polk), mRNA.
465.5213
505.1972
626.4852
266.3712
204.3848
257.8708
damaged DNA binding
DNA binding
DNA repair
DNA replication
DNA-directed DNA polymerase activity
magnesium ion binding
metal ion binding
nucleotidyltransferase activity
nucleus
response to DNA damage stimulus
transferase activity
zinc ion binding
25
Odc1
1.13024
10.73701
9.60678
0.033244858
1347648
1437711_x_at
ornithine decarboxylase, structural 1 (Odc1), mRNA.
1810.1088
1270.1519
2162.3660
1041.4852
824.2759
552.1519
carboxy-lyase activity
catalytic activity
cytosol
kidney development
lyase activity
ornithine decarboxylase activity
polyamine biosynthetic process
positive regulation of cell proliferation
26
B130066H01Rik
1.12609
5.18662
4.06053
0.013339111
1363875
1446509_at
RIKEN cDNA B130066H01 gene
35.0984
31.0789
44.2829
13.2299
21.4879
16.3409
27
1.12090
7.84839
6.72749
0.0068605237
1354351
1433898_at
Transcribed locus
246.9030
184.4152
268.8305
125.0574
94.8466
100.3231
28
Armcx4
1.11470
7.44107
6.32637
0.048187743
1335963
1427167_at
Armadillo repeat containing, X-linked 4, mRNA (cDNA clone IMAGE:5374915)
178.8125
152.7356
192.1384
116.8197
74.4440
59.4200
29
1.09288
8.39993
7.30705
0.04783182
1372388
1455966_s_at
Transcribed locus
354.7032
306.4024
354.5955
218.0023
159.4280
114.2602
30
Mchr1
1.07710
7.73639
6.65929
0.0034490492
1336547
1428031_at
melanin-concentrating hormone receptor 1 (Mchr1), mRNA.
200.7433
217.3496
222.2571
107.0690
87.7749
109.8771
G-protein coupled receptor activity
G-protein coupled receptor protein signaling pathway
integral to membrane
melanin-concentrating hormone receptor activity
membrane
neuropeptide signaling pathway
nonmotile primary cilium
plasma membrane
receptor activity
regulation of feeding behavior
signal transducer activity
signal transduction
31
Acsl3
1.07367
5.43131
4.35764
0.0025226076
1350458
1428387_at
acyl-CoA synthetase long-chain family member 3 (Acsl3), transcript variant 3, mRNA.
43.8126
40.1095
45.7212
23.6600
19.1201
19.0474
ATP binding
catalytic activity
endoplasmic reticulum
fatty acid metabolic process
integral to membrane
ligase activity
lipid metabolic process
long-chain-fatty-acid-CoA ligase activity
magnesium ion binding
membrane
metabolic process
microsome
mitochondrial outer membrane
mitochondrion
nucleotide binding
peroxisome
32
Odc1
1.06232
10.55471
9.49239
0.020605427
1346063
1427364_a_at
ornithine decarboxylase, structural 1 (Odc1), mRNA.
1682.9176
1113.2225
1816.3872
845.2527
743.7337
594.4004
carboxy-lyase activity
catalytic activity
cytosol
kidney development
lyase activity
ornithine decarboxylase activity
polyamine biosynthetic process
positive regulation of cell proliferation
33
9130404H23Rik
1.04192
6.25963
5.21771
0.034362544
1368912
1458210_at
PREDICTED: Mus musculus RIKEN cDNA 9130404H23 gene (9130404H23Rik), mRNA
69.7181
70.0735
92.0686
34.4037
28.8514
51.9150
34
Odc1
1.02476
12.35765
11.33289
0.022428023
1347907
1438761_a_at
ornithine decarboxylase, structural 1 (Odc1), mRNA.
5555.4619
3957.2088
6576.0122
2995.5964
2816.5713
2034.2963
carboxy-lyase activity
catalytic activity
cytosol
kidney development
lyase activity
ornithine decarboxylase activity
polyamine biosynthetic process
positive regulation of cell proliferation
35
Slc30a2
1.00905
8.54255
7.53349
0.00048567467
1336101
1427339_at
Solute carrier family 30 (zinc transporter), member 2, mRNA (cDNA clone IMAGE:4239648)
359.7200
350.5555
411.1179
201.9090
174.3739
180.6281
36
8430426J06Rik
1.00876
8.45093
7.44217
0.048013374
1357769
1439844_at
CDNA clone IMAGE:3368992
252.3677
374.0326
453.9504
160.1131
175.2817
187.4064