Trans-NIH Jak-Stat Initiative - Muscle: Stat5MKO-GH vs WT-GH

Changes in comparison: All samples for Muscle: Stat5MKO-GH vs WT-GH

Muscle cells from Stat5-null and control 15-week mice without GH treatment. This used mAdb test: EG3.2-test-1-FC-ALL.

Muscle: EG003.2
(T2-)  Stat5MKO-GH vs WT-GH --- fold changes < 2X and p-Value<0.05.

This mAdb-derived analysis report compares two groups of samples (A and B) using the paired t-test followed by a fold-change test with the threshold values listed above. The t-test is only done if are at least two samples/condition. It performs fold-change thresholding in either case. The mean A and mean B values are shown as log2 values in the following table as A Mean and B Mean. If there are not enough samples in either condition A or condition B, it only compares the fold-change (mean A/mean B) computed as the difference between the log2 means shown as A-B Mean Difference in this report - see Data Analysis Methods for more discussion. If the t-test is performed, the p-Value is reported as A-B p-Value. Individual sample expression values are reported as the RMA normalized values not using the log2. The tests, thresholding and mAdb Retrieval Report were generated on the mAdb system for the GSP data and subsequently converted to this Web page.

Clicking on the table entries for Gene, Well ID, and Feature ID will go to the GeneCard, mAdb Feature Report, and Affymetrix probe database Web page for that entry. The genes are sorted by A-B Mean Difference with:
   (A) Samples[Stat5MKO-GH]: EG003.2-04, EG003.2-05, EG003.2-06
   (B) Samples[WT-GH]: EG003.2-01, EG003.2-02, EG003.2-03.

mAdb Microarray Retrieval Report - All Samples

Preface to table

Row                 A A A A A A B B B B B B C C C C C C  
Row Gene A-B Mean Difference A Mean (Stat5MKO-GH) B Mean (WT-GH) A-B p-Value Well ID Feature ID Description EG001-01.Erythroid.Stat5KO.br1.noStim EG001-02.Erythroid.Stat5KO.br2.noStim EG001-03.Erythroid.Stat5KO.br3.noStim EG001-04.Erythroid.WT.br1.noStim EG001-05.Erythroid.WT.br2.noStim EG001-06.Erythroid.WT.br3.noStim EG003.1-01.Muscle.Stat5MKO.42.GH EG003.1-02.Muscle.Stat5MKO.43.GH EG003.1-03.Muscle.WT.44.GH EG003.1-04.Muscle.WT.47.GH EG003.1-05.Muscle.Stat5MKO.48.GH EG003.1-06.Muscle.WT.50.GH EG003.2-01.Muscle.WT.4038WT.noStim EG003.2-02.Muscle.WT.4060WT.noStim EG003.2-03.Muscle.WT.4063WT.noStim EG003.2-04.Muscle.Stat5MKO.4035KO.noStim EG003.2-05.Muscle.Stat5MKO.4036KO.noStim EG003.2-06.Muscle.Stat5MKO.4042KO.noStim Gene Ontology Terms
1 Ak3l1 -1.05022 6.48540 7.53562 0.0093021397 1332186 1421830_at adenylate kinase 3-like 1 (Ak3l1), nuclear gene encoding mitochondrial protein, mRNA. 109.1165 94.0396 122.5535 114.1721 114.3106 107.1515 246.8676 247.9234 104.3040 91.4115 243.2141 99.3919 113.1034 81.5462 77.9860 162.8186 218.5802 179.4852
2 Mustn1 -1.06881 10.41685 11.48566 0.018573107 1335990 1427201_at musculoskeletal, embryonic nuclear protein 1 (Mustn1), mRNA. 89.6202 100.3193 119.3163 125.0710 118.8532 117.4835 3774.1063 3798.2257 2516.2359 2468.5727 3992.7806 2416.3270 1112.3910 1549.3411 1482.3400 3852.3579 2425.2815 2524.0403 nucleus
3 Tnfaip2 -1.08163 10.37704 11.45867 0.040723537 1347930 1438855_x_at tumor necrosis factor, alpha-induced protein 2 1940.5295 1857.2588 1995.7352 1046.5408 924.9715 1194.3566 3396.0841 3344.4747 607.3380 666.1293 3253.4297 620.1634 1937.2358 1153.9852 1051.9975 2594.0235 3370.5477 2549.9669  
4 Serpina1c -1.14894 4.84929 5.99823 0.010746921 1339138 1448680_at serine (or cysteine) peptidase inhibitor, clade A, member 1C (Serpina1c), mRNA. 605.4722 797.3774 241.9977 1044.7616 2713.7768 856.5815 60.0072 57.7634 126.2640 107.7231 56.7346 117.4833 35.0984 23.1433 29.4871 67.2878 68.1489 56.9569
5 Stat3 -1.15172 9.22101 10.37272 0.0053308228 1343080 1460700_at signal transducer and activator of transcription 3 (Stat3), transcript variant 3, mRNA. 296.0767 276.1814 341.6162 243.6939 311.9855 224.9269 2130.3466 1995.0602 718.2331 749.8354 1993.9678 693.5062 563.5964 511.8688 736.6675 1215.0369 1560.5489 1229.2415
6 Serpinb1a -1.22031 6.14677 7.36708 0.00034890631 1327998 1416318_at serine (or cysteine) peptidase inhibitor, clade B, member 1a (Serpinb1a), mRNA. 24.4466 27.1615 22.7613 28.6837 27.8133 24.6695 273.2035 303.9363 66.7361 63.3636 290.5736 59.8105 74.1940 72.3079 66.3027 182.2095 154.0949 160.2428
7 Ak3l1 -1.22369 7.22808 8.45177 0.040083447 1348663 1450387_s_at adenylate kinase 3-like 1 (Ak3l1), nuclear gene encoding mitochondrial protein, mRNA. 138.3914 144.3297 176.2277 148.0226 176.4317 142.9258 405.0296 451.2680 157.1633 164.0247 397.8170 167.1677 218.2075 134.3381 114.9569 315.7167 362.3709 375.1926
8 Sln -1.23119 7.68650 8.91769 0.0054222097 1331506 1420884_at sarcolipin (Sln), mRNA. 49.3526 35.9402 26.3882 66.7695 76.2624 51.1329 395.8032 357.7575 158.0785 155.9323 342.2051 135.7749 178.8438 211.0753 231.5755 587.5316 395.1282 487.1988
9   -1.24487 7.35232 8.59718 0.0037471724 1367914 1457102_at Transcribed locus 56.9843 51.1179 53.7367 62.7476 55.2265 55.1888 80.3621 93.2247 99.7970 79.2927 81.0504 93.5868 195.5695 138.2218 161.4077 393.0408 457.7161 322.8464  
10 Gamt -1.24753 9.20233 10.44986 0.0052749455 1332719 1422558_at guanidinoacetate methyltransferase (Gamt), mRNA. 109.5733 74.7981 111.1564 140.1180 170.6508 133.3669 1016.4785 1042.1023 491.3976 518.2960 997.3018 473.5159 517.6892 585.7949 674.0960 1349.6060 1406.0643 1441.9590
11 Tnfaip2 -1.34592 9.55423 10.90015 0.019383957 1327963 1416273_at tumor necrosis factor, alpha-induced protein 2 (Tnfaip2), mRNA. 1388.3992 1437.2428 1340.8979 940.1353 832.1860 980.8734 1763.3867 1666.5310 414.8919 423.1519 1757.0016 399.0408 1091.3115 612.3186 635.9214 1565.4321 2320.3607 1921.4254
12 Fgfbp1 -1.41894 5.16466 6.58361 0.0011928135 1330250 1419086_at fibroblast growth factor binding protein 1 (Fgfbp1), mRNA. 24.3381 26.8275 24.6193 29.1122 30.9426 25.2384 130.8503 132.6910 41.4607 36.8201 138.7248 37.5598 30.1154 38.2075 40.1069 111.3767 89.7235 88.2856
13   -1.43316 7.74730 9.18046 0.020322115 1365310 1453119_at Transcribed locus 192.8256 157.7290 163.7672 89.1949 82.7376 131.3366 484.8186 501.9665 137.2189 154.7326 493.2433 165.5505 210.8462 215.7630 218.0549 459.4518 757.4940 561.2626  
14 1200009I06Rik -2.05051 7.53553 9.58603 0.016057694 1370826 1428420_a_at RIKEN cDNA 1200009I06 gene (1200009I06Rik), mRNA. 92.3235 97.2647 96.0092 77.5455 129.5897 78.3745 491.9852 522.7671 170.5748 171.2306 497.5964 166.8491 208.0928 181.2786 169.2994 576.1519 675.4474 1166.6011  
15 Myh7 -2.16573 7.41775 9.58347 0.049555307 1348252 1448554_s_at myosin, heavy polypeptide 7, cardiac muscle, beta (Myh7), mRNA. 16.5279 18.6388 18.3893 19.6150 27.5955 20.6975 895.3741 917.2365 676.7113 598.8186 927.1719 615.1178 98.3841 328.7075 154.5816 769.0408 813.4041 721.9121
16 Tpm3 -2.38939 8.57935 10.96874 0.035580778 1340138 1449997_at Tropomyosin 3, gamma, mRNA (cDNA clone MGC:36031 IMAGE:4502880) 111.0782 114.5469 89.8428 131.3188 125.2634 161.9665 1616.6321 1516.8238 1056.8315 1009.4378 1470.3815 982.6807 249.1013 748.7493 300.0638 1856.5197 1897.4333 2285.0254
17 Tnni1 -2.40297 7.86608 10.26905 0.028790526 1348770 1450813_a_at troponin I, skeletal, slow 1 (Tnni1), transcript variant 2, mRNA. 118.4341 88.0124 124.0556 150.9327 170.7027 88.0575 982.1189 1039.9147 567.6175 559.6030 1021.2107 564.2468 146.8151 436.8152 198.0208 1158.1453 1100.0280 1474.7292
18   -2.43608 5.03578 7.47186 0.021004874 1368821 1458115_at Transcribed locus 36.6653 48.8734 37.2443 37.8986 37.5324 40.2838 68.5118 85.7406 23.0482 31.0767 86.4653 25.8177 31.6866 34.7647 32.0440 106.5041 232.3178 226.1078  
19 Tnnc1 -2.54042 8.50746 11.04788 0.040945566 1329660 1418370_at troponin C, cardiac/slow skeletal (Tnnc1), mRNA. 103.8266 101.6423 94.7859 125.5332 190.5004 104.6094 1898.0111 1970.2178 1179.6578 1179.6042 1988.1943 1133.8942 269.9078 781.6517 228.4423 2008.4111 1945.6615 2428.3396


This Web page was derived in collaboration with GSP consortium members.

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Revised: Mon Sep 28 13:56:56 EDT 2009