A 1 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen A 2 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen A 3 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen A 4 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen A 5 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen A 6 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen B 7 02-09-07_Hennighausen_PK_Mouse430_2_M42 GSP-EG003.1 Hennighausen B 8 02-09-07_Hennighausen_PK_Mouse430_2_M43 GSP-EG003.1 Hennighausen B 9 02-09-07_Hennighausen_PK_Mouse430_2_M44 GSP-EG003.1 Hennighausen B 10 02-09-07_Hennighausen_PK_Mouse430_2_M47 GSP-EG003.1 Hennighausen B 11 02-09-07_Hennighausen_PK_Mouse430_2_M48 GSP-EG003.1 Hennighausen B 12 02-09-07_Hennighausen_PK_Mouse430_2_M50 GSP-EG003.1 Hennighausen C 13 06-10-08_Hennighausen_1PK_Mouse430_2_4038WT GSP-EG003.2 Hennighausen C 14 06-10-08_Hennighausen_2PK_Mouse430_2_4060WT GSP-EG003.2 Hennighausen C 15 06-10-08_Hennighausen_3PK_Mouse430_2_4063WT GSP-EG003.2 Hennighausen C 16 06-10-08_Hennighausen_4PK_Mouse430_2_4035KO GSP-EG003.2 Hennighausen C 17 06-10-08_Hennighausen_5PK_Mouse430_2_4036KO GSP-EG003.2 Hennighausen C 18 06-10-08_Hennighausen_6PK_Mouse430_2_4042KO GSP-EG003.2 Hennighausen Gene Property Filtering 18 arrays and 45101 genes in the input dataset 18 arrays and 130 genes in the output dataset. 44971 genes excluded for Well ID not being in local list 'EG3-1-test-3-FC'. A A A A A A B B B B B B C C C C C C 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M42 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M43 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M44 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M47 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M48 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M50 GSP-EG003.1 Hennighausen 06-10-08_Hennighausen_1PK_Mouse430_2_4038WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_2PK_Mouse430_2_4060WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_3PK_Mouse430_2_4063WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_4PK_Mouse430_2_4035KO GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_5PK_Mouse430_2_4036KO GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_6PK_Mouse430_2_4042KO GSP-EG003.2 Hennighausen Well ID Feature ID Map mgB37_Probe Chr:Start-Stop mgB37_Probe Cytoband mgB37_RefSeq Chr:Start-Stop mgB37_RefSeq Cytoband Annotation_Src UniGene RefSeq Refseqs_Hit geneIDS_Hit Entrez GeneID Locus Tag Gene Description BioCarta Pathways KEGG Pathways Gene Ontology Terms GO Tier2 Component GO Tier3 Component GO Tier2 Function GO Tier3 Function GO Tier2 Process GO Tier3 Process 504.9534 293.7807 391.4360 589.2380 575.4937 788.2860 114.2676 126.1762 127.4476 134.5965 132.9854 133.5763 329.8339 245.4086 368.3903 232.2447 224.8760 224.5115 1327621 1415823_at 19 C3|19 43.0 cM chr19:44379503-44380037 19 C3 UG5 Mm.477490 20250 Scd2 Fatty acid desaturase (Scd3) Biosynthesis of unsaturated fatty acids;; PPAR signaling pathway CLASS Metabolism; Lipid Metabolism; Biosynthesis of unsaturated fatty acids [PATH:mmu01040] Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] endoplasmic reticulum;; fatty acid biosynthetic process;; integral to membrane;; iron ion binding;; lipid biosynthetic process;; lipid metabolic process;; membrane;; oxidation reduction;; oxidoreductase activity;; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;; stearoyl-CoA 9-desaturase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding;; catalytic activity ion binding;; oxidoreductase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; oxidation reduction;; primary metabolic process 242.3054 143.6519 225.2155 214.5646 324.4665 273.3409 133.7686 144.7697 109.5534 108.8453 144.3710 81.1374 350.2630 290.2975 369.8186 213.3794 276.1477 105.3334 1327622 1415824_at 19 43.0 cM chr19:44377854-44378358 19 C3 chr19:44368165-44381354 19 C3 RSQ Mm.477490 NM_009128 1 1 20250 Scd2 stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA. Biosynthesis of unsaturated fatty acids;; PPAR signaling pathway CLASS Metabolism; Lipid Metabolism; Biosynthesis of unsaturated fatty acids [PATH:mmu01040] Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] endoplasmic reticulum;; fatty acid biosynthetic process;; integral to membrane;; iron ion binding;; lipid biosynthetic process;; lipid metabolic process;; membrane;; oxidation reduction;; oxidoreductase activity;; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;; stearoyl-CoA 9-desaturase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding;; catalytic activity ion binding;; oxidoreductase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; oxidation reduction;; primary metabolic process 442.6437 495.1519 496.5210 376.2766 734.4557 569.8191 272.7580 282.5272 251.0264 256.1806 260.3645 254.3658 637.3946 542.8403 551.2780 595.2583 608.4431 497.4458 1327729 1415971_at 10 22.0 cM chr10:36854908-36855205 10 B1 chr10:36853048-36858732 10 B1 RSQ Mm.477725 NM_008538 1 1 17118 Marcks myristoylated alanine rich protein kinase C substrate (Marcks), mRNA. Effects of calcineurin in Keratinocyte Differentiation actin binding;; calmodulin binding;; cell cortex;; centrosome;; cytoplasm;; cytoskeleton;; germinal vesicle;; membrane;; protein kinase C binding cell;; cell part;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane-bounded organelle;; non-membrane-bounded organelle;; organelle part binding protein binding 141.8742 112.9872 135.4853 122.1526 149.0408 178.0408 133.8309 145.8577 173.2686 165.9393 139.6460 167.2719 368.5746 295.4993 383.2267 236.9852 271.8674 179.4852 1327861 1416147_at 11 29.0 cM chr11:53073951-53074494 11 B1.3 chr11:53073315-53113981 11 B1.3 RSQ Mm.239865 NM_008300 1 1 15525 RP23-337J7.3 Hspa4 heat shock protein 4 (Hspa4), mRNA. Antigen processing and presentation CLASS Environmental Information Processing; Membrane Transport; Pores ion channels Cellular Processes; Immune System; Antigen processing and presentation [PATH:mmu04612] ATP binding;; cytoplasm;; nucleotide binding;; response to stress cell;; cell part cell part;; intracellular;; intracellular part binding nucleoside binding;; nucleotide binding response to stimulus response to stress 15.0948 19.8653 27.8242 14.4647 24.6474 22.2518 237.1320 239.5493 191.8662 214.7191 226.6632 201.0615 435.0964 555.8798 471.5711 541.4883 438.8333 243.2075 1343325 1416514_a_at 5 86.0 cM chr5:143722033-143734868 5 G2 RSQ Mm.289707 NM_007984 1 1 14086 Fscn1 fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) (Fscn1), mRNA. actin binding;; actin filament binding;; filopodium;; protein binding, bridging cell;; cell part cell part;; cell projection binding protein binding 93.8312 116.3330 114.3274 118.8291 105.2733 123.1567 61.6673 67.4182 58.1149 67.8136 67.0724 74.3360 124.4942 175.2179 152.0450 175.0784 125.3745 129.8743 1328142 1416515_at 5 86.0 cM chr5:143731618-143733619 5 G2 chr5:143722033-143734868 5 G2 RSQ Mm.289707 NM_007984 1 1 14086 Fscn1 fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) (Fscn1), mRNA. actin binding;; actin filament binding;; filopodium;; protein binding, bridging cell;; cell part cell part;; cell projection binding protein binding 42.0490 48.3984 72.6117 63.9720 56.7183 76.7595 176.6266 173.3296 123.7982 124.1524 168.1330 117.2949 215.7185 258.5713 302.3976 281.9482 332.9091 243.2627 1328185 1416564_at 14 C3 chr14:64569018-64569492 14 D1 UGA Mm.42162 20680 Sox7 SRY-box containing gene 7 (Sox7), mRNA DNA binding;; nucleus;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; transcription factor activity biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 58.4167 69.8954 52.1538 58.7805 60.8997 43.5015 126.0487 140.3186 109.5986 114.2619 137.8460 116.4307 270.3911 201.6884 249.4264 221.0056 174.7375 164.2928 1328664 1417163_at 1 chr1:185898879-185899173 1 H5 chr1:185858339-185899515 1 H5 RSQ Mm.404024 NM_022019 1 1 63953 Dusp10 dual specificity phosphatase 10 (Dusp10), mRNA. MAPK signaling pathway CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] cytoplasm;; dephosphorylation;; hydrolase activity;; MAP kinase tyrosine/serine/threonine phosphatase activity;; nucleus;; phosphatase activity;; phosphoprotein phosphatase activity;; protein amino acid dephosphorylation;; protein tyrosine phosphatase activity;; protein tyrosine/serine/threonine phosphatase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle catalytic activity hydrolase activity cellular process;; metabolic process cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 65.2607 80.4752 108.8667 81.9309 98.1727 84.5432 169.3758 176.8072 141.3951 136.9296 166.7358 125.7281 327.0306 551.5224 735.4410 613.8217 267.9948 174.1124 1328866 1417403_at 3 chr3:129337407-129337843 3 G3 chr3:129235303-129341413 3 G3 RSQ Mm.314113 NM_130450 1 1 170439 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA. Biosynthesis of unsaturated fatty acids CLASS Metabolism; Lipid Metabolism; Biosynthesis of unsaturated fatty acids [PATH:mmu01040] endoplasmic reticulum;; fatty acid biosynthetic process;; fatty acid elongation;; integral to endoplasmic reticulum membrane;; integral to membrane;; lipid biosynthetic process;; membrane;; mitochondrion;; transferase activity, transferring acyl groups other than amino-acyl groups cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part catalytic activity transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; primary metabolic process 143.6870 144.8967 174.7075 166.3123 193.6343 164.9981 236.8413 244.4948 202.0844 199.0892 241.5013 197.3741 600.9026 708.1519 1092.3741 883.8801 383.3393 276.8487 1328867 1417404_at 3 chr3:129340915-129341301 3 G3 chr3:129235303-129341413 3 G3 RSQ Mm.314113 NM_130450 1 1 170439 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA. Biosynthesis of unsaturated fatty acids CLASS Metabolism; Lipid Metabolism; Biosynthesis of unsaturated fatty acids [PATH:mmu01040] endoplasmic reticulum;; fatty acid biosynthetic process;; fatty acid elongation;; integral to endoplasmic reticulum membrane;; integral to membrane;; lipid biosynthetic process;; membrane;; mitochondrion;; transferase activity, transferring acyl groups other than amino-acyl groups cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part catalytic activity transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; primary metabolic process 272.9234 280.6981 227.8221 303.8922 266.4039 233.1008 369.7774 356.9297 342.7886 346.2920 347.5898 353.7801 852.4274 647.2951 700.3186 786.0408 715.1519 560.0347 1328897 1417439_at 19 chr19:5070090-5070618 19 A chr19:5068077-5070640 19 A RSQ Mm.29597 NM_054042 1 1 70445 Cd248 CD248 antigen, endosialin (Cd248), mRNA. binding;; calcium ion binding;; cytoplasm;; integral to membrane;; membrane;; plasma membrane;; sugar binding cell;; cell part cell part;; intracellular;; intracellular part;; membrane;; membrane part binding carbohydrate binding;; ion binding 775.2785 568.8912 873.9718 1042.3186 1323.9230 899.2955 501.5542 496.3197 555.8741 541.4600 518.7847 496.5945 891.2093 1085.3978 1454.5039 2089.7250 1627.1519 769.3820 1329001 1417561_at 7 4.0 cM chr7:20277334-20277835 7 A3 chr7:20274829-20278007 7 A3 RSQ Mm.182440 NM_001110009 2 1 11812 Apoc1 apolipoprotein C-I (Apoc1), transcript variant 2, mRNA. cholesterol metabolic process;; extracellular region;; lipid transport;; lipoprotein metabolic process;; transport;; triglyceride metabolic process;; very-low-density lipoprotein particle extracellular region;; extracellular region part;; macromolecular complex extracellular region part;; extracellular space;; plasma lipoprotein particle;; protein-lipid complex cellular process;; establishment of localization;; localization;; metabolic process alcohol metabolic process;; biosynthetic process;; cellular metabolic process;; establishment of localization;; macromolecule metabolic process;; organic ether metabolic process;; primary metabolic process;; transport 68.4757 82.9054 78.5187 56.9123 83.2880 58.6642 156.5564 162.6991 178.5692 173.6488 154.7741 176.8683 290.4721 451.9635 485.1519 499.3186 364.0039 208.2075 1329842 1418601_at 19 20.0 cM chr19:20767471-20767872 19 B chr19:20767442-20802046 19 B RSQ Mm.14609 NM_011921 1 1 26358 Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 (Aldh1a7), mRNA. Metabolic pathways CLASS Metabolism; Metabolism of Cofactors and Vitamins; Retinol metabolism [PATH:mmu00830];; Retinol metabolism aldehyde dehydrogenase (NAD) activity;; cytoplasm;; metabolic process;; oxidation reduction;; oxidoreductase activity;; retinal metabolic process;; retinoic acid metabolic process cell;; cell part cell part;; intracellular;; intracellular part catalytic activity oxidoreductase activity biological regulation;; cellular process;; metabolic process cellular metabolic process;; hormone metabolic process;; oxidation reduction;; primary metabolic process;; regulation of biological quality;; secondary metabolic process 45.4666 50.2162 56.3268 56.4023 44.0432 49.4824 54.8566 49.6595 57.2328 44.4773 51.9172 51.5856 86.7933 157.9122 145.1077 116.2222 92.8658 78.3050 1330128 1418937_at 12 chr12:91963030-91963530 12 D3 chr12:91962991-91976878 12 D3 RSQ Mm.21389 NM_010050 1 1 13371 Dio2 deiodinase, iodothyronine, type II (Dio2), mRNA. hormone biosynthetic process;; integral to membrane;; membrane;; oxidation reduction;; oxidoreductase activity;; selenium binding;; thyroid hormone catabolic process;; thyroxine 5'-deiodinase activity cell;; cell part cell part;; membrane;; membrane part binding;; catalytic activity oxidoreductase activity;; selenium binding biological regulation;; cellular process;; metabolic process biosynthetic process;; catabolic process;; cellular metabolic process;; hormone metabolic process;; nitrogen compound metabolic process;; oxidation reduction;; primary metabolic process;; regulation of biological quality 408.4960 364.3741 400.3741 466.8766 636.6980 410.2014 776.8052 796.1330 713.0390 677.1720 787.7251 651.1900 2091.5578 2143.0032 2260.8741 3234.9852 2402.4730 1924.6148 1330167 1418982_at 7 12.0 cM chr7:35906421-35906839 7 B1 chr7:35904311-35906947 7 B1 RSQ Mm.349667 NM_007678 1 1 12606 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha (Cebpa), mRNA. Keratinocyte Differentiation;; MAPKinase Signaling Pathway Acute myeloid leukemia CLASS Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221];; Pathways in cancer brown fat cell differentiation;; cell maturation;; cytokine-mediated signaling pathway;; DNA binding;; embryonic placenta development;; fat cell differentiation;; liver development;; lung development;; macrophage differentiation;; mitochondrion organization;; myeloid cell differentiation;; negative regulation of cell proliferation;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; positive regulation of specific transcription from RNA polymerase II promoter;; positive regulation of transcription;; promoter binding;; protein binding;; protein dimerization activity;; protein homodimerization activity;; regulation of cell proliferation;; regulation of transcription, DNA-dependent;; RNA polymerase II transcription factor activity, enhancer binding;; sequence-specific DNA binding;; specific RNA polymerase II transcription factor activity;; transcription;; transcription factor activity;; transcription factor complex;; urea cycle cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity nucleic acid binding;; protein binding;; RNA polymerase II transcription factor activity;; transcription factor activity biological regulation;; cellular component organization;; cellular process;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; biosynthetic process;; cell communication;; cell proliferation;; cellular developmental process;; cellular metabolic process;; developmental maturation;; embryonic development;; immune system development;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; organelle organization;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 104.9347 81.5200 115.2089 125.9878 99.4754 133.7737 195.8584 208.6519 190.8741 195.6832 199.5964 207.9852 458.7796 369.1894 408.2042 371.7781 295.4313 237.5042 1330199 1419024_at 1 B UGA Mm.374437 19243 Ptp4a1 Protein tyrosine phosphatase 4a1 (Ptp4a1), mRNA cell cycle;; cytoplasm;; dephosphorylation;; endoplasmic reticulum;; endosome;; hydrolase activity;; membrane;; multicellular organismal development;; phosphatase activity;; phosphoprotein phosphatase activity;; plasma membrane;; positive regulation of cell migration;; prenylated protein tyrosine phosphatase activity;; protein amino acid dephosphorylation;; protein tyrosine phosphatase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane-bounded organelle catalytic activity hydrolase activity biological regulation;; cellular process;; developmental process;; localization;; locomotion;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process cell cycle;; cell motility;; cell motion;; cellular metabolic process;; localization of cell;; macromolecule metabolic process;; multicellular organismal development;; positive regulation of biological process;; positive regulation of cellular process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of localization;; regulation of locomotion 105.7469 106.1762 89.2710 196.3104 159.5869 141.0591 59.6538 57.8696 50.2953 56.1507 57.5145 54.8053 112.1468 109.7212 129.4230 77.7745 78.6716 68.0342 1330207 1419033_at X chrX:48245741-48246226 X A5 UGA Mm.46254 Transcribed locus, strongly similar to XP_001477930.1 PREDICTED: FERM domain containing 7 [Mus musculus] 41.1126 42.0200 43.2000 41.1212 43.7632 35.9874 102.4654 109.8335 63.7211 59.8912 110.9545 64.4887 149.3739 189.7943 145.9489 152.2630 114.2096 167.7368 1343807 1419186_a_at 1 chr1:97484294-97484817 1 D chr1:97484258-97564171 1 D RSQ Mm.306228 NM_009183 1 1 20452 St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (St8sia4), transcript variant 1, mRNA. Steps in the Glycosylation of Mammalian N-linked Oligosaccarides alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;; Golgi apparatus;; integral to Golgi membrane;; integral to membrane;; membrane;; protein amino acid glycosylation;; sialyltransferase activity;; transferase activity;; transferase activity, transferring glycosyl groups cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part catalytic activity transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 1250.8328 1299.6686 1146.1338 983.6584 757.3699 897.0128 181.2150 128.8461 128.3149 139.0049 159.1940 161.2752 241.5994 299.3996 368.5408 346.0408 268.3964 246.6519 1330770 1419742_at 2 chr2:130972272-130972647 2 F1 chr2:130972060-130985756 2 F1 RSQ Mm.27711 NM_026091 1 1 67326 RP23-32L15.2 1700037H04Rik RIKEN cDNA 1700037H04 gene (1700037H04Rik), mRNA. 40.0453 40.9138 43.4818 49.5780 56.7271 57.8220 167.7865 147.4773 145.6945 164.9446 157.1092 162.3797 361.2231 461.2620 475.8007 380.6723 492.9228 260.1455 1344152 1420715_a_at 6 52.7 cM chr6:115439974-115440254 6 E3 chr6:115372083-115440419 6 E3 RSQ Mm.3020 NM_011146 2 1 19016 Pparg peroxisome proliferator activated receptor gamma (Pparg), transcript variant 2, mRNA. Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression;; Nuclear Receptors in Lipid Metabolism and Toxicity;; Role of PPAR-gamma Coactivators in Obesity and Thermogenesis;; Visceral Fat Deposits and the Metabolic Syndrome Huntington's disease;; Pathways in cancer;; PPAR signaling pathway;; Thyroid cancer CLASS Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Thyroid Cancer [PATH:mmu05216] Human Diseases; Neurodegenerative Diseases; Huntington's disease [PATH:mmu05016] arachidonic acid binding;; brown fat cell differentiation;; cell fate commitment;; chromatin binding;; cytosol;; DNA binding;; DNA binding;; epithelial cell differentiation;; fat cell differentiation;; fat cell differentiation;; inflammatory response;; ligand-dependent nuclear receptor activity;; long-chain fatty acid transport;; metal ion binding;; negative regulation of cell proliferation;; negative regulation of cytokine production;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription, DNA-dependent;; nucleus;; placenta development;; positive regulation of fat cell differentiation;; positive regulation of fat cell differentiation;; positive regulation of transcription;; positive regulation of transcription from RNA polymerase II promoter;; protein binding;; receptor activity;; regulation of fat cell differentiation;; regulation of fat cell differentiation;; regulation of transcription;; regulation of transcription, DNA-dependent;; response to lipid;; sequence-specific DNA binding;; steroid hormone receptor activity;; transcription;; transcription activator activity;; transcription factor activity;; transcription repressor activity;; transcription repressor activity;; transcriptional repressor complex;; white fat cell differentiation;; white fat cell differentiation;; zinc ion binding cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; molecular transducer activity;; transcription regulator activity carboxylic acid binding;; chromatin binding;; ion binding;; lipid binding;; nucleic acid binding;; protein binding;; signal transducer activity;; transcription activator activity;; transcription factor activity;; transcription repressor activity biological regulation;; cellular process;; developmental process;; establishment of localization;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; establishment of localization;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; negative regulation of multicellular organismal process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; response to chemical stimulus;; response to external stimulus;; response to stress;; transport 51.1920 59.7151 46.5958 49.4246 66.8533 41.4296 125.8152 149.8666 133.1177 120.7424 147.7845 117.1975 191.5096 252.4297 332.6812 292.2765 305.8123 254.2576 1344266 1421149_a_at 6 60.21 cM chr6:124692719-124693272 6 F2 chr6:124692561-124706505 6 F2 RSQ Mm.333380 NM_007881 2 2 13498 Atn1 atrophin 1 (Atn1), mRNA. cytoplasm;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; nucleus;; protein binding;; toxin metabolic process;; toxin receptor binding;; transcription corepressor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity protein binding;; transcription cofactor activity;; transcription repressor activity biological regulation;; cellular process;; metabolic process;; negative regulation of biological process;; regulation of biological process;; response to stimulus biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; response to chemical stimulus;; secondary metabolic process 41.3713 40.9726 42.5488 50.9825 54.1880 33.1228 54.2888 51.1518 43.9413 49.2716 53.7399 55.1182 119.5417 124.2635 156.3065 166.3437 119.7170 138.9096 1331990 1421555_at 8 10.0 cM chr8:28337294-28338230 8 A2 chr8:28336247-28340060 8 A2 RSQ Mm.278475 NM_013462 1 1 11556 Adrb3 adrenergic receptor, beta 3 (Adrb3), mRNA. Calcium signaling pathway;; Endocytosis CLASS Environmental Information Processing; Signal Transduction; Calcium signaling pathway [PATH:mmu04020] Environmental Information Processing; Signaling Molecules and Interaction; Neuroactive ligand-receptor interaction [PATH:mmu04080] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144];; Neuroactive ligand-receptor interaction activation of adenylate cyclase activity by G-protein signaling pathway;; adrenoceptor activity;; beta-3 adrenergic receptor binding;; beta-adrenergic receptor activity;; brown fat cell differentiation;; diet induced thermogenesis;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; heat generation;; integral to membrane;; membrane;; membrane fraction;; negative regulation of multicellular organism growth;; plasma membrane;; receptor activity;; response to cold;; signal transducer activity;; signal transduction;; vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure cell;; cell part cell fraction;; cell part;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus biosynthetic process;; cell communication;; cellular developmental process;; cellular metabolic process;; multicellular organism growth;; multicellular organismal metabolic process;; negative regulation of biological process;; negative regulation of growth;; negative regulation of multicellular organismal process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of growth;; regulation of metabolic process;; regulation of molecular function;; regulation of multicellular organismal process;; response to abiotic stimulus;; response to dietary excess;; response to stress;; system process;; temperature homeostasis 36.8887 33.7820 33.4435 46.6734 40.6512 45.6915 108.5243 89.0018 62.6017 69.2477 85.3186 64.4220 130.6714 199.6548 222.0753 227.7912 189.1142 172.9099 1332082 1421681_at 9 chr9:55069139-55090023 9 B chr9:55068028-55131432 9 B RSQ Mm.443874 NM_032002 1 1 83961 Nrg4 neuregulin 4 (Nrg4), mRNA. g-Secretase mediated ErbB4 Signaling Pathway ErbB signaling pathway CLASS Environmental Information Processing; Signal Transduction; ErbB signaling pathway [PATH:mmu04012] extracellular region;; growth factor activity;; integral to membrane;; membrane;; plasma membrane cell;; cell part;; extracellular region cell part;; membrane;; membrane part binding protein binding 291.6817 217.4220 332.6520 215.6481 246.5698 301.4006 225.8039 230.3638 238.7650 240.0570 217.9269 217.1702 504.0869 512.8958 551.5580 609.0543 542.5672 371.5695 1332679 1422508_at 16 chr16:44085965-44086095 16 B4 chr16:44085516-44139132 16 B4 RSQ Mm.217787 NM_007508 1 1 11964 Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A (Atp6v1a), mRNA. Metabolic pathways CLASS Metabolism; Energy Metabolism; Oxidative phosphorylation [PATH:mmu00190];; Oxidative phosphorylation ATP binding;; ATP metabolic process;; ATP synthesis coupled proton transport;; cytosol;; hydrogen ion transmembrane transporter activity;; hydrogen ion transporting ATP synthase activity, rotational mechanism;; hydrolase activity;; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;; ion transport;; mitochondrion;; nucleotide binding;; plasma membrane;; proton transport;; proton-transporting ATPase activity, rotational mechanism;; proton-transporting two-sector ATPase complex;; proton-transporting two-sector ATPase complex, catalytic domain;; proton-transporting V-type ATPase, V1 domain;; transport cell;; cell part;; macromolecular complex;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; protein complex binding;; catalytic activity;; transporter activity hydrolase activity;; nucleoside binding;; nucleotide binding;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process biosynthetic process;; cellular metabolic process;; establishment of localization;; nitrogen compound metabolic process;; primary metabolic process;; transmembrane transport;; transport 65.6184 66.9161 92.3954 82.6846 113.9920 67.1412 1115.1471 1122.1519 1283.0679 1238.9763 1133.3741 1194.2830 2213.8986 2651.0081 2870.6519 2856.3862 1759.5224 1417.5295 1344742 1422973_a_at 7 chr7:104565546-104565932 7 E1 chr7:104561466-104566020 7 E1 RSQ Mm.28585 NM_009381 1 1 21835 Thrsp thyroid hormone responsive SPOT14 homolog (Rattus) (Thrsp), mRNA. nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle 298.6907 255.2800 334.6550 270.3364 296.5339 331.3904 382.5947 379.6587 444.5087 404.5952 384.7874 412.7075 873.6589 720.5835 1082.9938 814.1603 944.1261 528.5260 1333185 1423152_at 2 103.0 cM chr2:173604288-173604593 2 H4 chr2:173563071-173609837 2 H4 RSQ Mm.260456 NM_019806 1 1 56491 RP23-383L13.1 Vapb vesicle-associated membrane protein, associated protein B and C (Vapb), mRNA. integral to membrane;; membrane;; membrane fraction;; plasma membrane;; structural molecule activity cell;; cell part cell fraction;; cell part;; membrane;; membrane part structural molecule activity 101.4994 97.0605 123.9014 134.8187 119.0697 115.2748 430.9837 461.9510 491.7432 463.1621 451.1126 482.0518 1215.1582 1098.1363 1109.8630 1429.3547 1241.7630 943.0829 1333463 1423488_at 11 chr11:90138754-90139257 11 C chr11:90110789-90139887 11 C RSQ Mm.277518 NM_026178 2 2 67468 RP23-220F20.1 Mmd monocyte to macrophage differentiation-associated (Mmd), mRNA. cytolysis;; endosome;; integral to membrane;; lysosome;; membrane;; receptor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle molecular transducer activity signal transducer activity cellular process;; death cell death 74.1885 76.6516 84.3829 147.3703 118.1957 139.5693 731.6965 677.8186 843.3732 796.3962 697.7075 784.2800 1854.2693 1607.5960 1746.0964 2053.1093 1748.9408 1418.2271 1333464 1423489_at 11 chr11:90139426-90139743 11 C chr11:90110789-90139887 11 C RSQ Mm.277518 NM_026178 2 2 67468 RP23-220F20.1 Mmd monocyte to macrophage differentiation-associated (Mmd), mRNA. cytolysis;; endosome;; integral to membrane;; lysosome;; membrane;; receptor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle molecular transducer activity signal transducer activity cellular process;; death cell death 398.2649 354.4645 604.7498 387.0430 345.8485 366.2875 425.1519 405.7905 434.6932 414.6661 425.2620 400.0567 807.0964 820.1449 1059.4223 939.7279 632.8079 495.2075 1344891 1423706_a_at 4 77.6 cM chr4:148524331-148524689 4 E2 chr4:148524093-148540816 4 E2 RSQ Mm.252080 NM_001081274 1 1 110208 RP23-249G3.4 Pgd phosphogluconate dehydrogenase (Pgd), mRNA. Glutathione metabolism;; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Pentose phosphate pathway [PATH:mmu00030] Metabolism; Metabolism of Other Amino Acids; Glutathione metabolism [PATH:mmu00480];; Pentose phosphate pathway binding;; catalytic activity;; coenzyme binding;; metabolic process;; NADP or NADPH binding;; oxidation reduction;; oxidoreductase activity;; pentose biosynthetic process;; pentose-phosphate shunt;; phosphogluconate 2-dehydrogenase activity;; phosphogluconate dehydrogenase (decarboxylating) activity binding;; catalytic activity cofactor binding;; nucleotide binding;; oxidoreductase activity cellular process;; metabolic process alcohol metabolic process;; biosynthetic process;; catabolic process;; cellular metabolic process;; nitrogen compound metabolic process;; oxidation reduction;; primary metabolic process;; secondary metabolic process 345.0830 343.4514 459.1384 300.6372 362.7199 316.3819 2444.8689 2463.7089 2416.3855 2357.6985 2420.7245 2369.9274 5288.7935 5716.0919 7418.1797 6699.1718 4293.0610 3490.4512 1333715 1423828_at 11 72.0 cM chr11:120668427-120668973 11 E2 chr11:120667271-120685861 11 E2 RSQ Mm.236443 NM_007988 1 1 14104 RP23-99M13.6 Fasn fatty acid synthase (Fasn), mRNA. Fatty acid biosynthesis;; Insulin signaling pathway CLASS Metabolism; Lipid Metabolism; Fatty acid biosynthesis [PATH:mmu00061] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910];; Metabolic pathways 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity;; 3-oxoacyl-[acyl-carrier-protein] reductase activity;; 3-oxoacyl-[acyl-carrier-protein] synthase activity;; [acyl-carrier-protein] S-acetyltransferase activity;; [acyl-carrier-protein] S-malonyltransferase activity;; acyl carrier activity;; acyltransferase activity;; binding;; biosynthetic process;; catalytic activity;; cofactor binding;; cytoplasm;; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity;; fatty acid biosynthetic process;; fatty-acid synthase activity;; glycogen granule;; hydrolase activity;; hydrolase activity, acting on ester bonds;; lipid biosynthetic process;; lyase activity;; metabolic process;; oleoyl-[acyl-carrier-protein] hydrolase activity;; oxidation reduction;; oxidoreductase activity;; phosphopantetheine binding;; transferase activity;; zinc ion binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity;; transporter activity amine binding;; carboxylic acid binding;; cofactor binding;; hydrolase activity;; ion binding;; lyase activity;; oxidoreductase activity;; substrate-specific transporter activity;; transferase activity;; vitamin binding cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; oxidation reduction;; primary metabolic process 597.3471 536.6259 648.2379 344.4637 307.7104 368.7197 298.9244 295.5625 302.4900 263.0497 309.9131 290.3726 612.7475 607.2283 535.0130 698.1968 705.3741 527.4491 1333913 1424086_at 9 23.0 cM chr9:43030228-43030494 9 A5.1 chr9:43029360-43047899 9 A5.1 RSQ Mm.246479 NM_178644 1 1 102644 Oaf OAF homolog (Drosophila) (Oaf), mRNA. 170.2747 153.1697 180.5408 281.1828 192.9606 133.0409 418.2227 431.9268 579.7830 553.0904 423.1519 530.0941 1348.9521 1126.1295 1110.0311 1808.6801 1451.1741 1111.9595 1334125 1424357_at 9 chr9:31233861-31234366 9 A4 chr9:31233780-31271823 9 A4 RSQ Mm.390134 NM_144936 1 1 235135 Tmem45b transmembrane protein 45b (Tmem45b), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 20.8585 28.2289 20.2412 22.4874 25.2847 41.4439 65.5969 72.8266 45.2415 46.0675 63.6211 51.6878 97.0399 109.8771 138.2075 143.4794 130.3298 123.9134 1334291 1424567_at 3 chr3:102574564-102574656 3 F2.2 chr3:102538692-102576215 3 F2.2 RSQ Mm.477505 NM_027533 1 1 70747 Tspan2 tetraspanin 2 (Tspan2), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 189.6004 124.4826 105.3736 196.7640 94.1117 110.6966 364.1001 354.1012 353.2630 356.2427 357.5293 388.5157 916.5180 626.8934 740.6832 1079.8715 711.2379 950.1731 1345191 1424948_x_at 17 B1|17 18.44 cM chr17:34133284-34134088 17 B1 UG5 Mm.422886 14972 H2-K1 Histocompatibility 2, K1, K region, mRNA (cDNA clone MGC:7052 IMAGE:3156482) Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class I;; antigen processing and presentation of peptide antigen via MHC class I;; defense response to bacterium;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; peptide antigen binding;; positive regulation of T cell mediated cytotoxicity cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding antigen binding;; peptide binding biological regulation;; cell killing;; cellular process;; death;; developmental process;; immune system process;; multi-organism process;; positive regulation of biological process;; regulation of biological process;; response to stimulus antigen processing and presentation;; cell death;; immune effector process;; immune response;; leukocyte mediated cytotoxicity;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of response to stimulus;; regulation of biological process;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of response to stimulus;; response to biotic stimulus;; response to other organism;; response to stress 94.2148 106.2434 95.5878 135.9853 108.9330 110.0957 106.9119 114.7452 86.5724 113.9313 102.7695 95.1100 182.9297 193.0831 218.4320 363.0408 241.3464 198.1519 1334756 1425216_at 7 chr7:31603441-31603954 7 B1 chr7:31603375-31608794 7 B1 RSQ Mm.97338 NM_146187 1 1 233079 Ffar2 free fatty acid receptor 2 (Ffar2), mRNA. G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; integral to membrane;; lipid binding;; membrane;; plasma membrane;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity lipid binding;; signal transducer activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 240.9897 177.8380 217.9988 184.2871 236.5745 210.4774 361.3149 328.1365 425.1647 387.1497 360.9431 374.6671 1180.6126 1000.0470 1757.5787 1645.2399 710.0312 552.8795 1334817 1425326_at 11 chr11:100338538-100342819 11 D chr11:100337669-100389215 11 D RSQ Mm.282039 NM_134037 1 1 104112 RP23-392I3.9 Acly ATP citrate lyase (Acly), mRNA. Shuttle for transfer of acetyl groups from mitochondria to the cytosol Citrate cycle (TCA cycle);; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Citrate cycle (TCA cycle) [PATH:mmu00020] Metabolism; Energy Metabolism; Reductive carboxylate cycle (CO2 fixation) [PATH:mmu00720];; Reductive carboxylate cycle (CO2 fixation) acetyl-CoA biosynthetic process;; ATP binding;; ATP citrate synthase activity;; binding;; catalytic activity;; cellular carbohydrate metabolic process;; cytoplasm;; intracellular;; lipid biosynthetic process;; lyase activity;; magnesium ion binding;; metabolic process;; metal ion binding;; nucleotide binding;; protein binding;; succinate-CoA ligase (ADP-forming) activity;; transferase activity;; transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; ligase activity;; lyase activity;; nucleoside binding;; nucleotide binding;; protein binding;; transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; primary metabolic process 150.2630 143.6542 150.1506 170.7959 164.7851 150.0141 37.1927 51.5099 62.8204 65.2644 58.8237 55.5615 187.8805 189.8574 131.0361 129.8743 181.8186 86.3434 1345371 1425436_x_at 6 62.69 cM chr6:130128783-130128874 6 F3 chr6:130128699-130143130 6 F3 RSQ Mm.457996 NM_010651 2 2 16640 Klra9 killer cell lectin-like receptor subfamily A, member 9 (Klra9), mRNA. Graft-versus-host disease CLASS Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Human Diseases; Immune Disorders; Graft-versus-host disease [PATH:mmu05332];; Natural killer cell mediated cytotoxicity plasma membrane;; receptor activity;; sugar binding cell;; cell part cell part;; membrane binding;; molecular transducer activity carbohydrate binding;; signal transducer activity 62.5129 51.0376 45.2336 63.6684 47.9478 43.5173 107.9864 115.8312 123.8346 107.5586 111.0735 104.3988 241.5908 228.4367 251.2003 362.3639 255.8382 281.1665 1345392 1425477_x_at 17 B1|17 18.64 cM UG5 Mm.254067 14961 H2-Ab1 Histocompatibility 2, class II antigen A, beta 1, mRNA (cDNA clone MGC:6297 IMAGE:2651058) Allograft rejection;; Antigen processing and presentation;; Asthma;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Immune System; Antigen processing and presentation [PATH:mmu04612] Human Diseases; Immune Disorders; Asthma [PATH:mmu05310] Human Diseases; Immune Disorders; Systemic lupus erythema;; Systemic lupus erythematosus;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class II;; antigen processing and presentation of peptide antigen;; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;; early endosome;; external side of plasma membrane;; Golgi apparatus;; immune response;; integral to membrane;; intracellular;; membrane;; MHC class II protein complex;; multivesicular body;; peptide antigen binding;; plasma membrane;; protein binding cell;; cell part;; macromolecular complex;; organelle cell part;; cell surface;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; protein complex binding antigen binding;; peptide binding;; protein binding immune system process;; response to stimulus antigen processing and presentation;; immune response 105.9246 91.1126 81.7356 134.9744 99.5136 86.6249 760.5655 738.2776 831.1004 771.4788 776.9735 776.3932 1441.7902 1547.4986 1889.1281 1860.8291 1657.7775 1883.9420 1345403 1425519_a_at 18 32.0 cM chr18:60963502-60972306 18 E1 RSQ Mm.439737 NM_010545 2 1 16149 Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 2, mRNA. Antigen processing and presentation CLASS Cellular Processes; Immune System; Antigen processing and presentation [PATH:mmu04612] antigen processing and presentation;; antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class II;; chaperone mediated protein folding requiring cofactor;; chaperone mediated protein folding requiring cofactor;; defense response;; endoplasmic reticulum;; external side of plasma membrane;; Golgi apparatus;; immune response;; immunoglobulin mediated immune response;; integral to membrane;; integral to plasma membrane;; intracellular protein transport;; intracellular protein transport;; late endosome;; lysosome;; membrane;; MHC class II protein binding;; multivesicular body;; negative regulation of T cell differentiation;; negative thymic T cell selection;; plasma membrane;; plasma membrane;; positive regulation of T cell differentiation;; positive thymic T cell selection;; protein binding;; protein complex assembly cell;; cell part;; organelle cell part;; cell surface;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding protein binding anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; developmental process;; establishment of localization;; immune system process;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; antigen processing and presentation;; cell activation;; cellular component assembly;; cellular developmental process;; cellular localization;; cellular metabolic process;; establishment of localization;; establishment of localization in cell;; establishment of protein localization;; immune effector process;; immune response;; immune system development;; leukocyte activation;; macromolecular complex subunit organization;; macromolecule localization;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; negative regulation of immune system process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; primary metabolic process;; protein complex biogenesis;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of multicellular organismal process;; response to stress;; T cell selection;; transport 56.3972 49.8934 56.0193 75.5043 73.5799 63.8537 91.5403 74.1721 91.2814 86.8904 86.9727 85.8613 194.3674 160.2018 216.4238 193.3400 321.1805 131.1521 1345423 1425559_a_at 7 chr7:126924372-126927888 7 F2 chr7:126904436-126928407 7 F2 RSQ Mm.334199 NM_212442 3 1 20216 Acsm3 acyl-CoA synthetase medium-chain family member 3 (Acsm3), transcript variant 3, mRNA. Butanoate metabolism;; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Butanoate metabolism [PATH:mmu00650] ATP binding;; butyrate-CoA ligase activity;; catalytic activity;; fatty acid biosynthetic process;; fatty acid metabolic process;; fatty-acid ligase activity;; ligase activity;; lipid metabolic process;; magnesium ion binding;; metabolic process;; metal ion binding;; mitochondrial matrix;; mitochondrion;; nucleotide binding cell;; cell part;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part binding;; catalytic activity ion binding;; ligase activity;; nucleoside binding;; nucleotide binding cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; primary metabolic process 36.4130 31.8877 29.8493 28.1904 34.9389 34.2960 45.4444 46.1193 45.0858 42.1229 41.6469 43.3421 96.5529 83.6218 87.4996 69.7518 80.6031 53.3730 1334972 1425596_at 10 B1 chr10:39722016-39722362 10 B1 UGA Mm.55513 215929 AI317395 Expressed sequence AI317395 (AI317395), mRNA carbohydrate transport;; integral to membrane;; ion transport;; membrane;; plasma membrane;; sodium ion binding;; sodium ion transport;; sugar:hydrogen symporter activity;; symporter activity;; transport cell;; cell part cell part;; membrane;; membrane part binding;; transporter activity ion binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 54.7268 58.8042 60.5520 52.3582 63.7786 49.4040 127.6109 123.7621 105.8898 111.8599 131.2870 130.1395 279.6696 248.2999 360.8186 311.3841 275.3032 274.3376 1345622 1425967_a_at 14 20.0 cM chr14:56679515-56680545 14 C3 chr14:56678580-56681147 14 C3 RSQ Mm.439684 NM_010779 1 1 17227 Mcpt4 mast cell protease 4 (Mcpt4), mRNA. hydrolase activity;; intracellular;; peptidase activity;; proteolysis;; serine-type endopeptidase activity;; serine-type peptidase activity cell;; cell part cell part;; intracellular catalytic activity hydrolase activity metabolic process catabolic process;; macromolecule metabolic process;; primary metabolic process 18.6375 28.1476 24.1307 25.3642 22.2049 22.3780 27.3614 33.7180 30.2736 23.3141 31.5978 24.0641 54.8253 86.5457 82.5615 64.8568 69.6521 69.6668 1335414 1426433_at 10 chr10:4739751-4752813 10 A1 RSQ Mm.338242 NM_026793 1 1 68632 Myct1 myc target 1 (Myct1), mRNA. integral to membrane;; membrane;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle 219.9349 200.8214 233.7962 280.6139 228.2809 211.8808 409.4345 390.2151 726.4197 716.0649 379.0538 686.5129 1384.7015 1458.9940 1471.5683 1921.9176 1727.5791 1434.1089 1335439 1426464_at 11 chr11:98629636-98631067 11 D chr11:98629248-98636556 11 D RSQ Mm.390397 NM_145434 1 1 217166 RP23-395E10.7 Nr1d1 nuclear receptor subfamily 1, group D, member 1 (Nr1d1), mRNA. Circadian rhythm - mammal CLASS Cellular Processes; Behavior; Circadian rhythm - mammal [PATH:mmu04710] circadian rhythm;; DNA binding;; ligand-dependent nuclear receptor activity;; metal ion binding;; nucleus;; receptor activity;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; steroid hormone receptor activity;; transcription;; transcription factor activity;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; signal transducer activity;; transcription factor activity biological regulation;; cellular process;; metabolic process;; regulation of biological process;; rhythmic process biosynthetic process;; cellular metabolic process;; circadian rhythm;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 15.5544 14.9119 14.7383 15.5750 19.6150 20.1143 675.2075 631.7201 388.6323 404.7875 608.7075 385.6577 706.6519 904.8291 902.4952 476.8533 657.9226 506.5770 1335537 1426607_at 13 chr13:120276845-120284312 13 D2.3 RSQ Mm.46679 NM_001039244 1 1 633640 Gm7120 predicted gene 7120 (Gm7120), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 61.6777 45.9887 44.9898 44.6424 49.2933 50.2043 49.4645 53.5100 45.0397 35.6668 50.9649 37.3841 89.9039 94.0006 65.0130 138.6294 77.6867 75.9451 1335789 1426952_at 10 chr10:26637764-26638019 10 A4 chr10:26492317-26638454 10 A4 RSQ Mm.356496 NM_176837 1 1 73910 Arhgap18 Rho GTPase activating protein 18 (Arhgap18), mRNA. GTPase activator activity;; intracellular;; signal transduction cell;; cell part cell part;; intracellular enzyme regulator activity enzyme activator activity;; nucleoside-triphosphatase regulator activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 67.6781 69.2316 103.5210 51.1385 64.7516 74.4164 34.5471 36.4241 33.3882 27.1549 34.6428 37.2293 88.1138 73.8195 84.3237 97.6690 84.5894 66.6934 1336073 1427301_at 1 93.3 cM chr1:173629579-173629781 1 H3 chr1:173612185-173635388 1 H3 RSQ Mm.1738 NM_007649 1 1 12506 Cd48 CD48 antigen (Cd48), mRNA. Natural killer cell mediated cytotoxicity CLASS Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] anchored to membrane;; eukaryotic cell surface binding;; external side of plasma membrane;; membrane;; plasma membrane;; protein binding;; response to protein stimulus;; signal transduction;; T cell activation cell;; cell part cell part;; cell surface;; membrane;; membrane part binding cell surface binding;; protein binding biological regulation;; cellular process;; immune system process;; regulation of biological process;; response to stimulus cell activation;; cell communication;; leukocyte activation;; regulation of biological process;; regulation of cellular process;; response to chemical stimulus 189.9950 227.1694 161.3251 204.7630 208.9297 177.3937 139.3123 146.8561 82.3272 86.3048 159.1842 97.0230 555.4214 205.7242 292.5824 355.1519 424.9447 274.6168 1336105 1427343_at 8 C1 chr8:77747442-77747638 8 C1 UG5 Mm.179267 75141 Rasd2 RASD family, member 2, mRNA (cDNA clone IMAGE:4988981) GTP binding;; intracellular;; locomotory behavior;; membrane;; nucleotide binding;; small GTPase mediated signal transduction cell;; cell part cell part;; intracellular;; membrane binding nucleotide binding biological regulation;; cellular process;; regulation of biological process;; response to stimulus behavior;; cell communication;; regulation of biological process;; regulation of cellular process 13.3368 13.4083 14.3698 14.5828 13.5678 12.8152 35.4354 34.0058 27.5186 19.7115 35.6158 20.5339 72.4086 48.3279 40.2444 72.0648 70.4924 54.1449 1336159 1427426_at 1 A5 chr1:21391726-21392265 1 A4 UGA Mm.336519 226922 Kcnq5 Voltage-gated potassium channel KCNQ5 (Kcnq5) integral to membrane;; ion channel activity;; ion transport;; membrane;; potassium channel activity;; potassium ion binding;; potassium ion transport;; transport;; voltage-gated ion channel activity;; voltage-gated potassium channel activity;; voltage-gated potassium channel complex cell;; cell part;; macromolecular complex cell part;; membrane;; membrane part;; protein complex binding;; transporter activity ion binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 129.0853 172.3680 191.6693 116.2091 239.8115 114.3516 62.3188 68.9018 59.4201 60.2677 56.9014 63.4561 108.7576 116.4071 146.1604 88.4254 95.6729 68.1262 1346139 1427580_a_at 12 F1|12 54.5 cM chr12:110889243-110890147 12 F1 UGA Mm.293263 75745 Rian MRNA, MBII-343 snoRNA nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle 68.6288 52.1698 50.4855 80.2437 121.2316 74.6533 14.8688 17.2169 19.0506 19.4800 13.8207 17.8298 61.5157 58.4955 78.0293 111.8407 41.7438 39.2783 1336527 1428005_at 1 chr1:186611301-186611707 1 H5 chr1:186610645-186635192 1 H5 RSQ Mm.272457 NM_001081361 3 2 66112 Mosc1 MOCO sulphurase C-terminal domain containing 1 (Mosc1), mRNA. catalytic activity;; mitochondrial inner membrane;; mitochondrion;; molybdenum ion binding;; oxidation reduction;; oxidoreductase activity;; pyridoxal phosphate binding cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding;; catalytic activity cofactor binding;; ion binding;; lipid binding;; oxidoreductase activity;; vitamin binding metabolic process oxidation reduction 41.1814 28.4530 54.2822 33.6180 40.7460 43.1529 199.2955 219.6081 173.2343 166.9675 188.9681 179.0341 339.5461 350.6263 385.0895 462.4362 369.8574 220.1742 1336703 1428333_at X chrX:132529324-132529820 X F1 chrX:132528369-132529894 X F1 RSQ NR_003642 1 1 76976 2900062L11Rik RIKEN cDNA 2900062L11 gene (2900062L11Rik), non-coding RNA. 126.0769 154.8025 157.0144 165.7961 185.6361 131.9556 502.5408 505.8241 233.3687 203.4130 461.3280 212.4986 519.5960 494.7121 413.1456 554.3083 596.5308 518.3302 1346671 1431469_a_at 18 chr18:36018867-36020465 18 B2 chr18:35989471-36021342 18 B2 RSQ Mm.94560 NM_133687 1 1 67393 Cxxc5 CXXC finger 5 (Cxxc5), mRNA. cytoplasm;; DNA binding;; metal ion binding;; nucleus;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding ion binding;; nucleic acid binding 119.2512 116.4326 65.4153 128.9913 92.3403 85.4145 580.9299 546.4297 888.8382 813.7706 586.3542 841.9954 2348.5575 2883.4864 2884.6519 2902.7281 2711.3186 1294.5176 1337510 1434340_at 11 A1 UGA Mm.269736 66152 RP23-280J3.4 1110020P15Rik RIKEN cDNA 1110020P15 gene, mRNA (cDNA clone MGC:37480 IMAGE:4984172) Alzheimer's disease;; Cardiac muscle contraction;; Huntington's disease CLASS Metabolism; Energy Metabolism; Oxidative phosphorylation [PATH:mmu00190] Cellular Processes; Circulatory System; Cardiac muscle contraction [PATH:mmu04260] Human Diseases; Neurodegenerative Diseases; Alzheimer's disease [PATH:mmu05010] Human Diseases; Neurodegenerative Diseases; Parkinson's disease [PATH:mmu05012] Human Diseas;; Metabolic pathways;; Oxidative phosphorylation;; Parkinson's disease electron transport chain;; membrane;; mitochondrial electron transport, ubiquinol to cytochrome c;; mitochondrial envelope;; mitochondrial inner membrane;; mitochondrion;; respiratory chain;; transport;; ubiquinol-cytochrome-c reductase activity cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part catalytic activity;; transporter activity oxidoreductase activity;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process cellular metabolic process;; establishment of localization;; oxidation reduction;; transport 220.2867 189.0393 209.8279 202.5118 166.5932 203.8637 859.9223 744.9613 1146.2013 1059.3887 843.5532 1048.0854 2212.6519 2347.4852 2083.9050 2190.5964 2002.7089 1345.5922 1347039 1434341_x_at 11 A1 chr11:4602128-4604281 11 A1 UGA Mm.269736 66152 RP23-280J3.4 1110020P15Rik RIKEN cDNA 1110020P15 gene, mRNA (cDNA clone MGC:37480 IMAGE:4984172) Alzheimer's disease;; Cardiac muscle contraction;; Huntington's disease CLASS Metabolism; Energy Metabolism; Oxidative phosphorylation [PATH:mmu00190] Cellular Processes; Circulatory System; Cardiac muscle contraction [PATH:mmu04260] Human Diseases; Neurodegenerative Diseases; Alzheimer's disease [PATH:mmu05010] Human Diseases; Neurodegenerative Diseases; Parkinson's disease [PATH:mmu05012] Human Diseas;; Metabolic pathways;; Oxidative phosphorylation;; Parkinson's disease electron transport chain;; membrane;; mitochondrial electron transport, ubiquinol to cytochrome c;; mitochondrial envelope;; mitochondrial inner membrane;; mitochondrion;; respiratory chain;; transport;; ubiquinol-cytochrome-c reductase activity cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part catalytic activity;; transporter activity oxidoreductase activity;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process cellular metabolic process;; establishment of localization;; oxidation reduction;; transport 118.8747 114.3894 176.4850 106.0946 176.3910 112.9872 187.6925 206.4016 109.9901 124.5968 204.2005 152.9095 252.9448 249.8993 275.7422 297.5795 283.0592 154.1908 1347882 1438634_x_at 11 56.0 cM chr11:97699966-97700055 11 D chr11:97660985-97700078 11 D RSQ Mm.271967 NM_010688 1 1 16796 RP23-386E10.6 Lasp1 LIM and SH3 protein 1 (Lasp1), mRNA. actin binding;; actin filament binding;; cytoplasm;; cytoskeleton;; focal adhesion;; ion transport;; metal ion binding;; protein binding;; transport;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; non-membrane-bounded organelle binding ion binding;; protein binding establishment of localization;; localization establishment of localization;; transport 19.2529 21.0685 20.0486 25.9965 32.0529 33.8040 412.2642 418.7965 210.4487 201.0995 401.5277 235.8607 616.4443 845.5585 685.2976 674.9947 666.9638 651.4852 1347891 1438651_a_at 2 chr2:84979971-84980073 2 D chr2:84976516-84980080 2 D RSQ Mm.29368 NM_011784 1 1 23796 RP23-366I14.3 Aplnr apelin receptor (Aplnr), mRNA. Neuroactive ligand-receptor interaction CLASS Environmental Information Processing; Signaling Molecules and Interaction; Neuroactive ligand-receptor interaction [PATH:mmu04080] G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; integral to membrane;; membrane;; plasma membrane;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 5220.2989 5107.3014 6289.0052 4157.6966 2701.6356 4600.0014 2756.1517 2746.5379 2311.3927 2247.3099 2734.9869 2254.7075 5004.1541 5097.7609 6287.6519 6421.6146 4152.8251 2777.0780 1348090 1439443_x_at 14 chr14:31386607-31386776 14 B chr14:31362334-31387908 14 B RSQ Mm.290692 NM_009388 1 1 21881 Tkt transketolase (Tkt), mRNA. Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Pentose phosphate pathway [PATH:mmu00030] Metabolism; Biosynthesis of Polyketides and Nonribosomal Peptides; Biosynthesis of ansamycins;; Pentose phosphate pathway calcium ion binding;; catalytic activity;; metabolic process;; metal ion binding;; regulation of growth;; transferase activity;; transketolase activity binding;; catalytic activity ion binding;; transferase activity biological regulation;; growth;; metabolic process;; regulation of biological process regulation of biological process;; regulation of growth 446.0278 265.5999 540.9061 304.7221 374.1249 374.3630 755.0670 778.6959 752.3772 798.7728 776.1798 797.7909 1704.9347 1367.9235 2415.7804 2415.7804 987.5337 763.5192 1348104 1439459_x_at 11 chr11:100337689-100337814 11 D chr11:100337669-100389215 11 D RSQ Mm.282039 NM_134037 1 1 104112 RP23-392I3.9 Acly ATP citrate lyase (Acly), mRNA. Shuttle for transfer of acetyl groups from mitochondria to the cytosol Citrate cycle (TCA cycle);; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Citrate cycle (TCA cycle) [PATH:mmu00020] Metabolism; Energy Metabolism; Reductive carboxylate cycle (CO2 fixation) [PATH:mmu00720];; Reductive carboxylate cycle (CO2 fixation) acetyl-CoA biosynthetic process;; ATP binding;; ATP citrate synthase activity;; binding;; catalytic activity;; cellular carbohydrate metabolic process;; cytoplasm;; intracellular;; lipid biosynthetic process;; lyase activity;; magnesium ion binding;; metabolic process;; metal ion binding;; nucleotide binding;; protein binding;; succinate-CoA ligase (ADP-forming) activity;; transferase activity;; transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; ligase activity;; lyase activity;; nucleoside binding;; nucleotide binding;; protein binding;; transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; primary metabolic process 53.0054 48.4751 38.9348 48.4171 33.3155 33.1101 82.0365 94.6227 125.2912 125.7983 83.9711 110.5522 364.1519 246.6005 358.7981 266.7688 249.7060 162.2068 1338760 1448201_at 3 38.5 cM chr3:83577660-83577987 3 E3 chr3:83570242-83578236 3 E3 RSQ Mm.19155 NM_009144 1 1 20319 Sfrp2 secreted frizzled-related protein 2 (Sfrp2), mRNA. Wnt signaling pathway CLASS Environmental Information Processing; Signal Transduction; Wnt signaling pathway [PATH:mmu04310] anterior/posterior pattern formation;; cell differentiation;; cellular response to extracellular stimulus;; extracellular region;; multicellular organismal development;; somitogenesis;; Wnt receptor signaling pathway extracellular region biological regulation;; cellular process;; developmental process;; multicellular organismal process;; regulation of biological process;; response to stimulus cell communication;; cellular developmental process;; cellular response to stimulus;; embryonic development;; multicellular organismal development;; pattern specification process;; regulation of biological process;; regulation of cellular process;; response to external stimulus 70.3510 72.9219 68.4044 62.6213 75.5634 63.3622 141.4692 139.7701 198.9852 174.2487 164.5932 180.8634 425.2079 343.8897 423.5509 399.0937 417.4943 272.0202 1338998 1448507_at 1 chr1:89206841-89207235 1 D chr1:89160938-89207366 1 D RSQ Mm.247951 NM_028889 1 1 98363 Efhd1 EF hand domain containing 1 (Efhd1), mRNA. calcium ion binding;; mitochondrial inner membrane;; neuron projection development cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding ion binding cellular component organization;; cellular process;; developmental process;; multicellular organismal process anatomical structure development;; cell projection organization;; cellular developmental process;; multicellular organismal development 27.0208 25.6126 20.0667 26.9888 29.0471 20.8333 32.9122 39.8214 41.1549 37.0941 33.4596 38.7050 87.9308 108.7108 137.4182 124.7565 89.9551 77.7158 1339165 1448710_at 1 67.4 cM chr1:130485067-130485335 1 E4 chr1:130484775-130488876 1 E4 RSQ Mm.1401 NM_009911 1 1 12767 Cxcr4 chemokine (C-X-C motif) receptor 4 (Cxcr4), mRNA. CXCR4 Signaling Pathway;; Pertussis toxin-insensitive CCR5 Signaling in Macrophage;; Selective expression of chemokine receptors during T-cell polarization Axon guidance;; Chemokine signaling pathway;; Cytokine-cytokine receptor interaction;; Endocytosis;; Leukocyte transendothelial migration CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Leukocyte transendothelial migration [PATH:mmu04670] Cellular Processes; ameboidal cell migration;; brain development;; C-C chemokine receptor activity;; C-X-C chemokine receptor activity;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; germ cell development;; germ cell migration;; growth cone;; integral to membrane;; membrane;; motor axon guidance;; nervous system development;; neuron migration;; organ morphogenesis;; patterning of blood vessels;; plasma membrane;; receptor activity;; regulation of cell migration;; regulation of cell migration;; signal transducer activity;; signal transduction;; T cell proliferation cell;; cell part cell part;; cell projection;; membrane;; membrane part;; site of polarized growth binding;; molecular transducer activity peptide binding;; protein binding;; signal transducer activity anatomical structure formation;; biological regulation;; cellular component organization;; cellular process;; developmental process;; immune system process;; localization;; locomotion;; multicellular organismal process;; regulation of biological process;; reproduction;; reproductive process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell activation;; cell communication;; cell motility;; cell motion;; cell projection organization;; cell proliferation;; cellular component morphogenesis;; cellular developmental process;; gamete generation;; leukocyte activation;; localization of cell;; multicellular organismal development;; pattern specification process;; regulation of biological process;; regulation of cellular process;; regulation of localization;; regulation of locomotion;; reproductive process;; sexual reproduction 176.7124 166.9367 190.8121 213.6433 313.8973 190.5791 1096.4961 1077.7291 1110.5736 1127.1830 1060.0210 1101.2584 2421.6436 2282.7075 2597.6344 3056.5408 2552.7630 1618.5442 1339273 1448842_at 18 23.0 cM chr18:46873195-46875358 18 C chr18:46872858-46887996 18 C RSQ Mm.241056 NM_033037 1 1 12583 Cdo1 cysteine dioxygenase 1, cytosolic (Cdo1), mRNA. Cysteine and methionine metabolism;; Cysteine metabolism;; Metabolic pathways CLASS Metabolism; Amino Acid Metabolism; Cysteine and methionine metabolism [PATH:mmu00270] Metabolism; Amino Acid Metabolism; Cysteine metabolism [PATH:mmu00272] Metabolism; Metabolism of Other Amino Acids; Taurine and hypotaurine metabolism [PATH:mmu00430];; Taurine and hypotaurine metabolism cysteine dioxygenase activity;; cytosol;; iron ion binding;; L-cysteine catabolic process to taurine;; L-cysteine metabolic process;; metal ion binding;; oxidation reduction;; oxidoreductase activity;; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;; taurine metabolic process cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; oxidoreductase activity cellular process;; metabolic process catabolic process;; cellular metabolic process;; nitrogen compound metabolic process;; oxidation reduction;; primary metabolic process 27.6922 25.3944 36.3122 40.7499 36.5841 25.3552 75.6617 78.9085 68.7690 80.2497 73.5243 68.5947 151.8920 156.7557 174.0615 154.0920 136.0370 127.8542 1339320 1448901_at 2 chr2:130217001-130218931 2 F1 chr2:130216510-130223365 2 F1 RSQ Mm.112701 NM_019696 1 1 56264 RP23-29K12.2 Cpxm1 carboxypeptidase X 1 (M14 family) (Cpxm1), mRNA. carboxypeptidase activity;; cell adhesion;; extracellular region;; extracellular space;; hydrolase activity;; metal ion binding;; metallocarboxypeptidase activity;; metallopeptidase activity;; peptidase activity;; proteolysis;; zinc ion binding extracellular region;; extracellular region part extracellular region part;; extracellular space binding;; catalytic activity hydrolase activity;; ion binding biological adhesion;; cellular process;; metabolic process catabolic process;; cell adhesion;; macromolecule metabolic process;; primary metabolic process 336.5107 265.5324 254.9800 312.4020 294.8403 259.2164 1555.8117 1495.8398 1398.3183 1424.3730 1482.3883 1359.0964 2605.0688 3613.9115 4098.4646 5533.2047 3669.5042 3767.4064 1339421 1449015_at 16 B5|16 32.6 cM chr16:48842672-48844529 16 B5 UGA Mm.441868 57262 Retnla Resistin like alpha, mRNA (cDNA clone MGC:35890 IMAGE:4189285) extracellular region;; hormone activity extracellular region binding protein binding 150.7879 220.5041 256.5993 225.1770 247.7991 381.4441 449.5478 444.4970 441.7566 405.5964 463.9825 364.7840 664.5258 885.3742 1041.5601 1127.9783 1337.0408 798.6034 1339514 1449135_at 2 96.0 cM chr2:181404769-181405114 2 H4 chr2:181404541-181406345 2 H4 RSQ Mm.264904 NM_009236 1 1 20672 Sox18 SRY-box containing gene 18 (Sox18), mRNA. angiogenesis;; DNA binding;; nucleus;; regulation of transcription, DNA-dependent;; transcription;; transcription factor activity;; vasculogenesis cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; transcription factor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; biosynthetic process;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 87.7158 88.8376 93.1275 95.3777 116.0027 65.4573 187.0391 208.3156 178.8339 177.2192 187.1516 177.4457 369.8286 370.8415 350.7776 494.7371 397.4913 348.9612 1339524 1449147_at 2 chr2:92454920-92455309 2 E1 chr2:92439863-92455409 2 E1 RSQ Mm.38021 NM_023850 1 1 76969 RP23-165L23.5 Chst1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (Chst1), mRNA. Keratan sulfate biosynthesis;; Metabolic pathways CLASS Metabolism; Glycan Biosynthesis and Metabolism; Keratan sulfate biosynthesis [PATH:mmu00533] carbohydrate metabolic process;; Golgi apparatus;; Golgi membrane;; inflammatory response;; integral to membrane;; keratan sulfotransferase activity;; membrane;; sulfotransferase activity;; transferase activity cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part catalytic activity transferase activity metabolic process;; response to stimulus primary metabolic process;; response to external stimulus;; response to stress 84.3235 61.1323 67.9024 77.0656 106.4749 78.2709 120.4960 135.3124 105.0715 98.6059 126.0537 100.4643 243.4689 263.4501 262.9191 246.6519 306.4654 218.4156 1339578 1449211_at 1 chr1:187181209-187181563 1 H5 chr1:187156037-187181648 1 H5 RSQ Mm.227549 NM_011794 1 1 23827 Bpnt1 bisphosphate 3'-nucleotidase 1 (Bpnt1), mRNA. Sulfur metabolism CLASS Metabolism; Energy Metabolism; Sulfur metabolism [PATH:mmu00920] 3'(2'),5'-bisphosphate nucleotidase activity;; hydrolase activity;; inositol or phosphatidylinositol phosphatase activity;; lithium ion binding;; magnesium ion binding;; metal ion binding binding;; catalytic activity hydrolase activity;; ion binding 85.9458 108.3219 94.2228 70.3351 67.4182 68.4010 60.5250 70.2196 73.5858 72.4736 68.2558 73.4358 143.3363 174.3599 156.7431 164.5877 134.1586 136.2064 1339828 1449514_at 19 55.0 cM chr19:61166433-61168180 19 D3 chr19:60965651-61168459 19 D3 RSQ Mm.279400 NM_018869 1 1 14773 Grk5 G protein-coupled receptor kinase 5 (Grk5), mRNA. Chemokine signaling pathway;; Endocytosis CLASS Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Chemokine signaling pathway [PATH:mmu04062] ATP binding;; G-protein coupled receptor kinase activity;; kinase activity;; nucleotide binding;; protein amino acid phosphorylation;; protein kinase activity;; protein serine/threonine kinase activity;; signal transducer activity;; signal transduction;; transferase activity binding;; catalytic activity;; molecular transducer activity nucleoside binding;; nucleotide binding;; signal transducer activity;; transferase activity biological regulation;; cellular process;; metabolic process;; regulation of biological process cell communication;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process 40.8925 53.7244 59.3642 51.5844 51.3486 45.4847 53.4231 53.0479 35.5649 51.1640 53.2635 42.8819 87.9043 111.6607 95.4965 93.0789 92.2823 103.4354 1339853 1449545_at 11 chr11:33017469-33017991 11 A4 chr11:33017429-33047400 11 A4 RSQ Mm.339812 NM_008005 1 1 14172 RP23-413O19.3 Fgf18 fibroblast growth factor 18 (Fgf18), mRNA. MAPK signaling pathway;; Melanoma CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Cellular Processes; Cell Motility; Regulation of actin cytoskeleton [PATH:mmu04810] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Melanoma [PATH:mmu05218];; Pathways in cancer;; Regulation of actin cytoskeleton angiogenesis;; chondrocyte development;; endochondral ossification;; extracellular region;; fibroblast growth factor receptor binding;; growth factor activity;; intramembranous ossification;; lung development;; ossification;; positive regulation of cell proliferation;; positive regulation of vascular endothelial growth factor receptor signaling pathway;; signal transduction extracellular region binding protein binding anatomical structure formation;; biological regulation;; cellular process;; developmental process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell communication;; cell proliferation;; cellular developmental process;; multicellular organismal development;; ossification;; positive regulation of biological process;; positive regulation of cellular process;; regulation of biological process;; regulation of cellular process 1194.4071 861.3918 914.9395 476.5737 367.5408 322.1530 100.2600 94.8244 59.9717 58.7340 86.5221 64.1202 146.6837 133.7965 128.3416 161.4045 130.5110 122.5946 1340027 1449839_at 8 B1.1|8 26.0 cM chr8:47724466-47724986 8 B1.1 UGA Mm.34405 12367 Casp3 Caspase 3, mRNA (cDNA clone MGC:46907 IMAGE:4482368) Apoptotic DNA fragmentation and tissue homeostasis;; Apoptotic Signaling in Response to DNA Damage;; B Cell Survival Pathway;; Caspase Cascade in Apoptosis;; D4-GDI Signaling Pathway;; FAS signaling pathway ( CD95 );; HIV-I Nef: negative effector of Fas and TNF;; Induction of apoptosis through DR3 and DR4/5 Death Receptors;; Role of Mitochondria in Apoptotic Signaling;; Stress Induction of HSP Regulation;; TNFR1 Signaling Pathway;; TSP-1 Induced Apoptosis in Microvascular Endothelial Cell Alzheimer's disease;; Amyotrophic lateral sclerosis (ALS);; Apoptosis;; Colorectal cancer CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Cellular Processes; Cell Growth and Death; Apoptosis [PATH:mmu04210] Cellular Processes; Cell Growth and Death; p53 signaling pathway [PATH:mmu04115] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:;; Huntington's disease;; MAPK signaling pathway;; Natural killer cell mediated cytotoxicity;; p53 signaling pathway;; Parkinson's disease;; Pathways in cancer apoptosis;; apoptosis;; apoptosis;; B cell homeostasis;; cell fate commitment;; cyclin-dependent protein kinase inhibitor activity;; cysteine-type endopeptidase activity;; cysteine-type peptidase activity;; cytoplasm;; DNA fragmentation involved in apoptosis;; heart development;; hydrolase activity;; induction of apoptosis;; induction of apoptosis;; induction of apoptosis;; induction of apoptosis;; induction of apoptosis by oxidative stress;; induction of apoptosis via death domain receptors;; keratinocyte differentiation;; negative regulation of activated T cell proliferation;; negative regulation of apoptosis;; negative regulation of B cell proliferation;; negative regulation of cell cycle;; negative regulation of cyclin-dependent protein kinase activity;; neuron apoptosis;; peptidase activity;; peptidase activity;; peptidase activity;; peptidase activity;; proteolysis;; release of cytochrome c from mitochondria;; response to DNA damage stimulus;; response to UV;; response to UV;; response to wounding;; sensory perception of sound;; T cell homeostasis cell;; cell part cell part;; intracellular;; intracellular part catalytic activity;; enzyme regulator activity enzyme inhibitor activity;; hydrolase activity;; kinase regulator activity biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; catabolic process;; cell activation;; cell cycle;; cell death;; cell proliferation;; cellular component disassembly;; cellular developmental process;; cellular metabolic process;; leukocyte activation;; leukocyte homeostasis;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; negative regulation of immune system process;; nitrogen compound metabolic process;; organelle organization;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of metabolic process;; regulation of molecular function;; response to abiotic stimulus;; response to external stimulus;; response to stress;; system process 55.2462 60.5614 44.2123 55.7385 58.7242 63.8055 92.4788 97.7903 89.0266 85.9540 100.0781 84.4725 168.7150 199.3186 213.6166 229.0526 202.8142 255.7643 1340086 1449918_at 8 chr8:4136365-4137667 8 A1.1 chr8:4134245-4137707 8 A1.1 RSQ Mm.390006 XM_284376 2 1 70192 Cd209g PREDICTED: CD209g antigen (Cd209g), mRNA. integral to membrane;; membrane;; sugar binding cell;; cell part cell part;; membrane;; membrane part binding carbohydrate binding 105.7091 79.8201 102.1115 41.6861 43.0829 35.1840 230.7630 242.3235 167.7622 180.9728 241.0001 191.8741 414.8807 401.2452 324.6121 520.1367 550.0026 458.3301 1340171 1450044_at 1 30.1 cM chr1:59543258-59543780 1 C1.3 chr1:59538990-59543799 1 C1.3 RSQ Mm.297906 NM_008057 1 1 14369 Fzd7 frizzled homolog 7 (Drosophila) (Fzd7), mRNA. Basal cell carcinoma CLASS Environmental Information Processing; Signal Transduction; Wnt signaling pathway [PATH:mmu04310] Cellular Processes; Endocrine System; Melanogenesis [PATH:mmu04916] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Colorectal cancer [PATH:mmu05210] Human Diseases; Cancers; Basal cell carcinom;; Colorectal cancer;; Melanogenesis;; Pathways in cancer;; Wnt signaling pathway cell surface receptor linked signal transduction;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; integral to membrane;; membrane;; multicellular organismal development;; non-G-protein coupled 7TM receptor activity;; receptor activity;; signal transducer activity;; signal transduction;; transmembrane receptor activity;; Wnt receptor signaling pathway cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity biological regulation;; cellular process;; developmental process;; multicellular organismal process;; regulation of biological process cell communication;; multicellular organismal development;; regulation of biological process;; regulation of cellular process 513.4762 356.8073 412.0435 139.1363 78.0887 147.5433 17.5503 17.4648 18.6625 20.5990 21.3868 19.4384 51.5856 40.7220 43.1129 54.3777 41.1417 31.2346 1340189 1450065_at 8 40.0 cM chr8:90853286-90853457 8 C3 chr8:90806890-90853861 8 C3 RSQ Mm.288206 NM_001109756 4 1 11513 Adcy7 adenylate cyclase 7 (Adcy7), transcript variant 4, mRNA. Calcium signaling pathway;; Chemokine signaling pathway;; Gap junction;; GnRH signaling pathway;; Melanogenesis CLASS Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:mmu00230] Environmental Information Processing; Signal Transduction; Calcium signaling pathway [PATH:mmu04020] Cellular Processes; Cell Communication; Gap junction [PATH:mmu04540] Cellular Processes; Circulatory System; Vascular smooth muscle contraction [PATH:mmu04270] Cellu;; Purine metabolism;; Vascular smooth muscle contraction activation of adenylate cyclase activity;; adenylate cyclase activity;; ATP binding;; cAMP biosynthetic process;; cyclic nucleotide biosynthetic process;; integral to membrane;; intracellular signaling cascade;; lyase activity;; magnesium ion binding;; membrane;; metal ion binding;; nucleotide binding;; phosphorus-oxygen lyase activity;; plasma membrane cell;; cell part cell part;; membrane;; membrane part binding;; catalytic activity cyclase activity;; ion binding;; lyase activity;; nucleoside binding;; nucleotide binding biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cell communication;; cellular metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; regulation of molecular function 95.7308 90.1043 96.1439 112.1050 99.1985 102.6012 114.6100 105.5720 116.9665 117.9322 117.5526 117.8219 247.1964 253.1895 284.3426 357.0918 268.9733 326.9686 1340228 1450130_at 1 81.6 cM chr1:157126726-157127275 1 G3 chr1:157122786-157264574 1 G3 RSQ Mm.266215 NM_011273 1 1 19775 Xpr1 xenotropic and polytropic retrovirus receptor 1 (Xpr1), mRNA. integral to membrane;; membrane;; plasma membrane;; receptor activity;; response to virus;; response to virus cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity multi-organism process;; response to stimulus response to biotic stimulus;; response to other organism 80.6420 99.7018 122.8120 61.0042 91.8994 94.0006 74.7081 72.6452 58.8742 61.2051 72.1458 70.7522 165.0964 155.4819 153.3741 207.8186 160.4300 119.2498 1348619 1450241_a_at 11 46.13 cM chr11:79340425-79340856 11 B5 chr11:79340061-79344111 11 B5 RSQ Mm.439665 NM_010161 2 1 14017 RP23-271B20.1 Evi2a ecotropic viral integration site 2a (Evi2a), transcript variant 2, mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 16.0762 14.6973 13.8208 17.1377 15.7443 16.0506 34.0331 35.0447 37.7950 28.2764 35.2623 33.1230 90.4048 83.3322 128.0871 115.8169 103.5314 81.5511 1348652 1450344_a_at 3 82.0 cM chr3:157307126-157307682 3 H4 chr3:157229855-157307722 3 H4 RSQ Mm.30424 NM_011196 1 1 19218 Ptger3 prostaglandin E receptor 3 (subtype EP3) (Ptger3), mRNA. Eicosanoid Metabolism Calcium signaling pathway;; Neuroactive ligand-receptor interaction CLASS Environmental Information Processing; Signal Transduction; Calcium signaling pathway [PATH:mmu04020] Environmental Information Processing; Signaling Molecules and Interaction; Neuroactive ligand-receptor interaction [PATH:mmu04080] activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger;; bicarbonate transport;; diuresis;; elevation of cytosolic calcium ion concentration;; fever;; fever;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; G-protein signaling, coupled to cAMP nucleotide second messenger;; integral to membrane;; membrane;; plasma membrane;; prostaglandin E receptor activity;; prostaglandin E receptor activity;; prostaglandin receptor activity;; protein binding;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity biological regulation;; cellular process;; establishment of localization;; localization;; multicellular organismal process;; regulation of biological process;; response to stimulus cell communication;; cellular homeostasis;; establishment of localization;; regulation of biological process;; regulation of biological quality;; regulation of body fluid levels;; regulation of cellular process;; regulation of molecular function;; response to external stimulus;; response to stress;; system process;; temperature homeostasis;; transport 2699.6470 2682.8536 3317.6165 2207.0245 1416.8734 2233.5763 1202.7133 1218.0440 1071.1847 1089.5250 1221.4562 1010.0007 2497.9299 2426.5297 3175.8699 3125.0432 2036.3336 1436.8131 1340882 1451015_at 14 chr14:31383452-31386610 14 B chr14:31362334-31387908 14 B RSQ Mm.290692 NM_009388 1 1 21881 Tkt transketolase (Tkt), mRNA. Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Pentose phosphate pathway [PATH:mmu00030] Metabolism; Biosynthesis of Polyketides and Nonribosomal Peptides; Biosynthesis of ansamycins;; Pentose phosphate pathway calcium ion binding;; catalytic activity;; metabolic process;; metal ion binding;; regulation of growth;; transferase activity;; transketolase activity binding;; catalytic activity ion binding;; transferase activity biological regulation;; growth;; metabolic process;; regulation of biological process regulation of biological process;; regulation of growth 26.2228 20.3998 23.0118 18.9906 23.2025 21.2481 140.1282 140.1705 151.9955 167.2135 132.6631 163.0853 250.2095 346.0062 433.6498 476.9395 317.8186 199.8216 1340915 1451054_at 4 31.4 cM chr4:63005700-63007115 4 B3 chr4:63005599-63009196 4 B3 RSQ Mm.4777 NM_008768 1 1 18405 Orm1 orosomucoid 1 (Orm1), mRNA. acute-phase response;; binding;; extracellular region;; extracellular space;; regulation of immune system process;; transport;; transporter activity extracellular region;; extracellular region part extracellular region part;; extracellular space binding;; transporter activity biological regulation;; establishment of localization;; immune system process;; localization;; regulation of biological process;; response to stimulus establishment of localization;; regulation of biological process;; regulation of immune system process;; response to external stimulus;; response to stress;; transport 818.6467 620.8565 1056.0459 750.0964 882.4852 744.7226 877.3376 871.7034 997.4611 919.0831 868.7271 887.0660 2245.5578 2050.1021 3328.9561 3038.8076 1485.5514 1168.5277 1341334 1451666_at 11 chr11:100337916-100338433 11 D chr11:100337669-100389215 11 D RSQ Mm.282039 NM_134037 1 1 104112 RP23-392I3.9 Acly ATP citrate lyase (Acly), mRNA. Shuttle for transfer of acetyl groups from mitochondria to the cytosol Citrate cycle (TCA cycle);; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Citrate cycle (TCA cycle) [PATH:mmu00020] Metabolism; Energy Metabolism; Reductive carboxylate cycle (CO2 fixation) [PATH:mmu00720];; Reductive carboxylate cycle (CO2 fixation) acetyl-CoA biosynthetic process;; ATP binding;; ATP citrate synthase activity;; binding;; catalytic activity;; cellular carbohydrate metabolic process;; cytoplasm;; intracellular;; lipid biosynthetic process;; lyase activity;; magnesium ion binding;; metabolic process;; metal ion binding;; nucleotide binding;; protein binding;; succinate-CoA ligase (ADP-forming) activity;; transferase activity;; transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; ligase activity;; lyase activity;; nucleoside binding;; nucleotide binding;; protein binding;; transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; primary metabolic process 67.6767 69.1694 85.6233 70.0928 105.4587 82.4959 70.5197 72.6250 57.6680 62.2610 65.6650 78.6925 120.6347 169.9424 195.6806 198.1038 140.5059 109.2421 1341346 1451679_at X chrX:132568984-132569483 X F1 chrX:132567905-132569483 X F1 RSQ NR_003641 1 1 76219 6530401D17Rik RIKEN cDNA 6530401D17 gene (6530401D17Rik), non-coding RNA. 164.1317 107.6868 190.2088 83.8730 82.1665 121.4835 363.0902 416.5964 327.9297 381.4167 403.1389 391.3918 858.9852 657.3160 727.5383 1039.9632 729.0964 1088.6519 1349018 1451683_x_at 17 B1|17 18.44 cM UG5 Mm.439675 14972 H2-K1 MRNA similar to histocompatibility 2, D region locus 1 (cDNA clone MGC:25703 IMAGE:3675316) Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class I;; antigen processing and presentation of peptide antigen via MHC class I;; defense response to bacterium;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; peptide antigen binding;; positive regulation of T cell mediated cytotoxicity cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding antigen binding;; peptide binding biological regulation;; cell killing;; cellular process;; death;; developmental process;; immune system process;; multi-organism process;; positive regulation of biological process;; regulation of biological process;; response to stimulus antigen processing and presentation;; cell death;; immune effector process;; immune response;; leukocyte mediated cytotoxicity;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of response to stimulus;; regulation of biological process;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of response to stimulus;; response to biotic stimulus;; response to other organism;; response to stress 1221.3782 681.2041 1159.7546 724.7925 1044.7360 671.9647 782.7702 747.6665 1170.2803 1025.6796 741.3321 1004.8186 1601.8713 3039.6844 2725.6312 1668.6856 1546.5644 1361.1412 1349251 1452406_x_at RSQ Mm.391385 NM_133362 1 1 170942 Erdr1 erythroid differentiation regulator 1 (Erdr1), mRNA. 124.8385 100.2431 98.0736 119.8471 120.4317 111.1593 214.6368 226.5161 261.2908 217.2031 223.7999 246.6519 939.6733 724.9297 829.1106 1419.6960 859.9257 1380.3186 1349261 1452431_s_at 17 B1|17 18.65 cM UGA Mm.235338 14960 H2-Aa Histocompatibility 2, class II antigen A, alpha, mRNA (cDNA clone MGC:25391 IMAGE:3670758) Allograft rejection;; Antigen processing and presentation;; Asthma;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Immune System; Antigen processing and presentation [PATH:mmu04612] Human Diseases; Immune Disorders; Asthma [PATH:mmu05310] Human Diseases; Immune Disorders; Systemic lupus erythema;; Systemic lupus erythematosus;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class II;; antigen processing and presentation of peptide antigen;; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;; external side of plasma membrane;; immune response;; integral to membrane;; lysosome;; membrane;; MHC class II protein complex;; peptide antigen binding;; plasma membrane;; positive regulation of T cell differentiation;; protein binding cell;; cell part;; macromolecular complex;; organelle cell part;; cell surface;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; protein complex binding antigen binding;; peptide binding;; protein binding biological regulation;; cellular process;; developmental process;; immune system process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; antigen processing and presentation;; cell activation;; cellular developmental process;; immune response;; immune system development;; leukocyte activation;; multicellular organismal development;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of multicellular organismal process 49.1773 36.3141 52.2845 47.4812 46.7342 43.0335 47.7586 50.6814 44.7097 48.4795 50.2179 47.4463 92.4934 108.4380 86.5265 97.2823 78.4135 62.9860 1349327 1452583_s_at 17 chr17:80584095-80584282 17 E3 chr17:80526810-80584372 17 E3 RSQ Mm.29098 NM_176963 1 1 319625 Galm galactose mutarotase (Galm), mRNA. Glycolysis / Gluconeogenesis CLASS Metabolism; Carbohydrate Metabolism; Glycolysis / Gluconeogenesis [PATH:mmu00010] aldose 1-epimerase activity;; carbohydrate binding;; carbohydrate metabolic process;; catalytic activity;; cytoplasm;; hexose metabolic process;; isomerase activity;; protein homodimerization activity cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity carbohydrate binding;; isomerase activity;; protein binding metabolic process alcohol metabolic process;; primary metabolic process 81.0131 81.5997 106.6401 88.7994 114.6259 104.3173 82.6416 76.4676 81.5042 91.0702 83.5325 93.8270 175.9797 191.9577 235.9697 132.9854 157.4349 67.0832 1342085 1452899_at 12 F1|12 54.5 cM UGA Mm.293263 75745 Rian MRNA, MBII-343 snoRNA nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle 70.3646 95.6575 59.8008 62.1087 79.6220 63.8157 176.5201 192.0631 140.5245 139.6971 172.9784 127.6174 625.5690 704.2230 826.8130 1153.4187 783.4692 523.2278 1342546 1455918_at 8 10.0 cM chr8:28336344-28336821 8 A2 IPA Adrb3 adrenergic receptor, beta 3 244.4320 185.9174 283.1040 196.7393 277.2630 219.3594 291.7551 293.1663 214.2176 215.9003 264.2600 238.9542 493.6886 411.4053 502.5414 475.8003 477.7630 363.7318 1342795 1460173_at 11 56.0 cM chr11:97699504-97699690 11 D chr11:97660985-97700078 11 D RSQ Mm.271967 NM_010688 1 1 16796 RP23-386E10.6 Lasp1 LIM and SH3 protein 1 (Lasp1), mRNA. actin binding;; actin filament binding;; cytoplasm;; cytoskeleton;; focal adhesion;; ion transport;; metal ion binding;; protein binding;; transport;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; non-membrane-bounded organelle binding ion binding;; protein binding establishment of localization;; localization establishment of localization;; transport 39.3749 42.7705 39.8018 37.5248 31.3502 33.7200 326.7330 293.5599 153.1382 148.9297 317.4286 128.5013 296.8894 284.2300 301.5964 437.2503 366.9948 232.7425 1370785 1419985_s_at 11 28.5 cM chr11:54863346-54863586 11 B1.3 chr11:54863239-54891633 11 B1.3 RSQ Mm.22361 NM_177471 1 1 52570 Ccdc69 coiled-coil domain containing 69 (Ccdc69), mRNA. 280.2741 250.5465 290.8617 232.2791 223.7356 228.3715 494.3567 510.0672 474.2630 477.2828 507.5340 472.6945 1113.3022 904.7566 1598.5856 1953.3744 920.3831 730.9813 1350368 1428190_at 16 10.65 cM chr16:17925667-17925845 16 A3 chr16:17925303-17928312 16 A3 RSQ Mm.229291 NM_153150 1 1 13358 Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 (Slc25a1), nuclear gene encoding mitochondrial protein, mRNA. Shuttle for transfer of acetyl groups from mitochondria to the cytosol integral to membrane;; membrane;; mitochondrial inner membrane;; mitochondrion;; transport cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part establishment of localization;; localization establishment of localization;; transport 120.5971 106.9891 94.2228 132.1419 140.3186 100.8211 520.3902 505.8652 526.5408 545.4004 554.6801 553.0658 1091.2918 1637.4404 1664.8059 1550.7658 1140.0075 894.9635 1350720 1428821_at 2 A3 chr2:26448641-26449174 2 A3 UGA Mm.24244 67512 RP23-125H15.1 Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (Agpat2), mRNA Ether lipid metabolism;; Glycerolipid metabolism;; Glycerophospholipid metabolism;; Metabolic pathways CLASS Metabolism; Lipid Metabolism; Glycerolipid metabolism [PATH:mmu00561] Metabolism; Lipid Metabolism; Glycerophospholipid metabolism [PATH:mmu00564] Metabolism; Lipid Metabolism; Ether lipid metabolism [PATH:mmu00565] 1-acylglycerol-3-phosphate O-acyltransferase activity;; acyltransferase activity;; endoplasmic reticulum;; integral to membrane;; membrane;; metabolic process;; phospholipid biosynthetic process;; transferase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle catalytic activity transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; organophosphate metabolic process;; primary metabolic process 34.1932 31.5363 31.1925 45.2684 40.1620 35.6289 72.5825 69.4762 83.4715 77.0000 71.8190 72.4800 173.2064 154.9167 172.0175 181.6473 162.1715 141.3742 1351306 1429679_at 5 chr5:21080798-21081258 5 A3 chr5:21049344-21081729 5 A3 RSQ Mm.439963 NM_028977 1 1 74511 Lrrc17 leucine rich repeat containing 17 (Lrrc17), mRNA. protein binding binding protein binding 62.9027 64.6006 91.9871 40.4775 71.9532 76.8953 32.7652 33.0183 35.5440 31.2393 30.8769 35.1483 92.3557 67.4359 70.8265 76.4882 66.6538 67.4182 1351521 1429954_at 6 chr6:122917515-122919822 6 F2 chr6:122902661-122919892 6 F2 RSQ Mm.25684 NM_153197 1 1 73149 Clec4a3 C-type lectin domain family 4, member a3 (Clec4a3), mRNA. integral to membrane;; membrane;; receptor activity;; sugar binding cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity carbohydrate binding;; signal transducer activity 77.2439 66.8769 80.2440 59.8078 99.2277 57.3331 678.4476 670.4325 295.5887 322.3900 601.6635 337.6717 837.8303 1440.6726 1744.2968 2267.7608 1755.8989 1723.4822 1370950 1430584_s_at 3 A2|3 11.7 cM chr3:14865376-14865506 3 A1 UGA Mm.300 12350 Car3 Carbonic anhydrase 3, mRNA (cDNA clone MGC:18583 IMAGE:4195712) Nitrogen metabolism CLASS Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:mmu00910] carbonate dehydratase activity;; cytoplasm;; lyase activity;; metal ion binding;; nickel ion binding;; one-carbon metabolic process;; zinc ion binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; lyase activity cellular process;; metabolic process cellular metabolic process 78.5246 72.0006 67.1761 77.6311 50.3412 69.3224 70.4277 72.2671 95.2206 74.5342 75.1252 80.9407 130.5938 183.7836 207.7039 146.0130 202.0696 143.5506 1371114 1432489_a_at 15 chr15:57979902-57985205 15 D1 chr15:57972990-57990209 15 D1 RSQ Mm.26771 NM_029734 1 1 76773 Wdyhv1 WDYHV motif containing 1 (Wdyhv1), mRNA. cytosol;; nucleus;; protein catabolic process;; protein modification process;; protein N-terminal glutamine amidohydrolase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle catalytic activity hydrolase activity cellular process;; metabolic process catabolic process;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 57.2775 48.5935 75.3733 37.8108 64.6067 57.5236 32.6064 32.8980 26.9117 32.0852 43.4580 35.0977 57.9109 66.5614 66.3859 64.1220 44.2523 42.2938 1371142 1433716_x_at 14 D3-E1 chr14:71379255-71379626 14 D2 UG5 Mm.32619 14586 Gfra2 Glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2), mRNA anchored to membrane;; membrane;; nervous system development;; plasma membrane;; receptor activity;; transmembrane receptor protein tyrosine kinase signaling pathway cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity biological regulation;; cellular process;; developmental process;; multicellular organismal process;; regulation of biological process anatomical structure development;; cell communication;; multicellular organismal development;; regulation of biological process;; regulation of cellular process 656.0566 928.1674 598.8363 494.7198 611.9779 320.1715 90.4765 90.3731 102.6417 97.0494 94.5032 92.2826 235.8176 229.9281 309.1894 152.0792 202.7666 154.5896 1354344 1433885_at 13 47.01 cM chr13:96397192-96397709 13 D1 chr13:96397131-96661877 13 D1 RSQ Mm.38878 NM_027711 1 1 544963 Iqgap2 IQ motif containing GTPase activating protein 2 (Iqgap2), mRNA. calmodulin binding;; GTPase activator activity;; intracellular;; protein binding;; regulation of small GTPase mediated signal transduction cell;; cell part cell part;; intracellular binding;; enzyme regulator activity enzyme activator activity;; nucleoside-triphosphatase regulator activity;; protein binding biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 196.7172 150.0596 198.5249 205.0865 172.5536 245.2504 835.6576 747.3160 814.3356 767.7958 786.5238 731.3685 1546.9073 1505.3570 2000.9759 2165.1519 1411.6086 1031.4746 1354501 1434185_at 11 chr11:84214703-84215129 11 C chr11:84008939-84215153 11 C RSQ Mm.31374 NM_133360 2 2 107476 RP23-123O10.1 Acaca acetyl-Coenzyme A carboxylase alpha (Acaca), mRNA. Fatty acid biosynthesis;; Insulin signaling pathway CLASS Metabolism; Carbohydrate Metabolism; Pyruvate metabolism [PATH:mmu00620] Metabolism; Carbohydrate Metabolism; Propanoate metabolism [PATH:mmu00640] Metabolism; Lipid Metabolism; Fatty acid biosynthesis [PATH:mmu00061] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910];; Metabolic pathways;; Propanoate metabolism;; Pyruvate metabolism acetyl-CoA carboxylase activity;; ATP binding;; biotin binding;; biotin carboxylase activity;; catalytic activity;; cytoplasm;; fatty acid biosynthetic process;; ligase activity;; lipid biosynthetic process;; lipid homeostasis;; lipid metabolic process;; manganese ion binding;; metabolic process;; metal ion binding;; multicellular organismal protein metabolic process;; nucleotide binding;; protein binding;; tissue homeostasis cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity carboxylic acid binding;; ion binding;; ligase activity;; nucleoside binding;; nucleotide binding;; protein binding;; vitamin binding biological regulation;; cellular process;; metabolic process;; multicellular organismal process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal homeostasis;; multicellular organismal metabolic process;; primary metabolic process;; regulation of biological quality 24.3334 29.5543 37.5928 28.2745 39.9864 31.3059 61.3094 61.3094 41.6835 44.6629 55.9766 35.8108 84.0888 96.8739 116.9309 103.4111 96.0813 83.5661 1354564 1434301_at 15 chr15:60650930-60651452 15 D1 chr15:60650550-60656635 15 D1 RSQ NM_001162926 1 1 399603 D330050I23Rik RIKEN cDNA D330050I23 gene (D330050I23Rik), mRNA. 73.1297 100.1883 99.4728 93.3139 111.2275 62.3294 275.6704 277.5559 247.0080 249.6608 286.4208 232.8227 454.1377 488.5551 518.3594 633.4586 537.1972 431.5536 1354940 1435031_at 5 chr5:136211374-136212331 5 G2 chr5:136211359-136220042 5 G2 RSQ Mm.11688 NM_172541 1 1 215210 Tmem120a transmembrane protein 120A (Tmem120a), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 66.4941 61.7880 65.9845 52.6976 66.2017 64.8973 73.6325 63.5213 50.9001 52.2348 58.3002 54.1234 98.9947 197.6991 244.4297 111.0507 120.7972 61.7854 1355930 1436590_at 8 chr8:36450642-36451011 8 A4 chr8:36438794-36451193 8 A4 RSQ Mm.247126 NM_177741 1 1 244416 Ppp1r3b protein phosphatase 1, regulatory (inhibitor) subunit 3B (Ppp1r3b), mRNA. Insulin signaling pathway CLASS Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] carbohydrate metabolic process;; glycogen metabolic process cellular process;; metabolic process cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 39.1504 35.6535 24.5213 53.0596 38.9904 32.3142 62.3328 59.0888 67.2663 71.3168 66.6229 70.0025 104.6075 180.3644 172.4665 161.8556 125.6705 88.4424 1356002 1436702_at 5 chr5:34338632-34348565 5 B2 RSQ Mm.274610 NM_001001985 1 1 269642 Nat8l N-acetyltransferase 8-like (Nat8l), mRNA. acyltransferase activity;; integral to membrane;; membrane;; metabolic process;; N-acetyltransferase activity;; transferase activity cell;; cell part cell part;; membrane;; membrane part catalytic activity transferase activity metabolic process 87.6041 64.6707 83.4437 74.3321 100.5191 94.6485 41.6413 39.8215 44.4701 36.4406 58.4072 38.4622 113.6123 82.3965 102.5717 107.7774 89.8428 93.8447 1356037 1436779_at X chrX:9013285-9013716 X A1.1 chrX:9012377-9046450 X A1.1 RSQ Mm.200362 NM_007807 1 1 13058 RP23-243O4.1 Cybb cytochrome b-245, beta polypeptide (Cybb), mRNA. Leukocyte transendothelial migration CLASS Cellular Processes; Immune System; Leukocyte transendothelial migration [PATH:mmu04670] cytoplasm;; electron carrier activity;; electron transport chain;; FAD binding;; hydrogen peroxide biosynthetic process;; integral to membrane;; ion channel activity;; ion transport;; iron ion binding;; membrane;; metal ion binding;; mitochondrion;; oxidation reduction;; oxidoreductase activity;; plasma membrane;; transport;; voltage-gated ion channel activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding;; catalytic activity;; electron carrier activity;; transporter activity cofactor binding;; ion binding;; nucleoside binding;; nucleotide binding;; oxidoreductase activity;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process biosynthetic process;; cellular metabolic process;; establishment of localization;; oxidation reduction;; transport 34.8593 41.7565 28.9996 43.5775 37.2970 37.3739 48.5704 46.5877 48.3358 47.2480 35.0170 52.0885 112.1908 115.9695 128.2543 79.1953 44.1081 42.1422 1356239 1437213_at 8 chr8:96542029-96542261 8 C5 UG5 Mm.432689 Transcribed locus 35.1895 36.3663 37.1285 33.0210 39.4357 28.8077 68.3821 78.6239 68.5479 59.5045 80.1455 63.3984 121.9304 136.0256 201.8644 177.3186 226.7170 185.6567 1371329 1437479_x_at 5 65.0 cM chr5:120134159-120134242 5 F chr5:120120677-120134610 5 F RSQ Mm.219139 NM_198052 2 1 21386 Tbx3 T-box 3 (Tbx3), transcript variant 2, mRNA. blood vessel development;; branching involved in mammary gland duct morphogenesis;; cell aging;; DNA binding;; forelimb morphogenesis;; heart looping;; heart morphogenesis;; in utero embryonic development;; limb morphogenesis;; limbic system development;; mammary gland development;; mammary placode formation;; mammary placode formation;; multicellular organismal development;; negative regulation of transcription;; negative regulation of transcription, DNA-dependent;; nucleus;; organ morphogenesis;; positive regulation of transcription, DNA-dependent;; regulation of cell proliferation;; regulation of transcription, DNA-dependent;; specification of organ position;; transcription;; transcription factor activity;; transcription repressor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; transcription factor activity;; transcription repressor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process aging;; anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; biosynthetic process;; cell aging;; cell proliferation;; cellular metabolic process;; embryonic development;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; pattern specification process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 137.2095 139.8477 195.0530 92.1530 108.7446 127.4097 30.6346 32.2628 26.7341 27.4372 33.5844 27.1340 58.6026 57.1946 58.9143 88.5367 50.0461 46.6358 1371345 1437811_x_at 8 E1 UGA Mm.393405 72042 Cotl1 Coactosin-like 1 (Dictyostelium) (Cotl1), mRNA actin binding;; cytoplasm;; cytoskeleton;; intracellular;; protein binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; non-membrane-bounded organelle binding protein binding 87.2932 106.9891 71.4332 59.8199 104.6569 62.1052 178.7950 177.0408 219.4476 189.3013 174.1481 182.7630 501.5173 602.0631 612.3131 559.0248 596.4027 311.3603 1356810 1438285_at 11 A1 chr11:5681352-5681850 11 A1 UGA Mm.260203 76508 2210015D19Rik PREDICTED: Mus musculus RIKEN cDNA 2210015D19 gene, transcript variant 2 (2210015D19Rik), mRNA 12.8698 10.0902 12.7866 10.2657 11.3753 10.0578 20.0888 21.5472 17.9538 18.2423 20.1267 20.8772 31.6523 45.1828 46.2399 58.8077 46.4092 31.7372 1356824 1438309_at 2 C1.1 chr2:58120038-58120425 2 C1.1 UG5 Mm.77751 269275 RP23-100B18.1 Acvr1c Activin A receptor, type IC, mRNA (cDNA clone IMAGE:1196242) Adherens junction;; Chronic myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway [PATH:mmu04350] Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu0;; Colorectal cancer;; Endocytosis;; MAPK signaling pathway;; Pancreatic cancer;; Pathways in cancer;; TGF-beta signaling pathway activin binding;; apoptosis;; ATP binding;; cell surface;; determination of left/right symmetry;; in utero embryonic development;; integral to membrane;; kinase activity;; lipid storage;; magnesium ion binding;; manganese ion binding;; membrane;; metal ion binding;; negative regulation of insulin secretion;; nucleotide binding;; positive regulation of apoptosis;; protein amino acid phosphorylation;; protein kinase activity;; protein serine/threonine kinase activity;; receptor activity;; response to dietary excess;; response to glucose stimulus;; response to insulin stimulus;; transferase activity;; transforming growth factor beta receptor activity;; transmembrane receptor protein serine/threonine kinase activity;; trophectodermal cell proliferation cell;; cell part cell part;; cell surface;; membrane;; membrane part binding;; catalytic activity;; molecular transducer activity ion binding;; nucleoside binding;; nucleotide binding;; protein binding;; signal transducer activity;; transferase activity biological regulation;; cellular process;; death;; developmental process;; establishment of localization;; growth;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; cell communication;; cell death;; cell proliferation;; cellular localization;; cellular metabolic process;; developmental growth;; embryonic development;; establishment of localization;; establishment of localization in cell;; generation of a signal involved in cell-cell signaling;; macromolecule localization;; macromolecule metabolic process;; multicellular organism growth;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of transport;; pattern specification process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of localization;; regulation of multicellular organismal process;; response to chemical stimulus;; response to dietary excess;; response to endogenous stimulus;; secretion by cell;; transport 62.9455 57.0845 62.1621 67.7553 87.0791 66.5989 89.8063 84.9958 92.0541 79.6849 87.6471 100.0685 144.2529 185.0408 226.9684 268.4778 226.0482 134.7953 1356879 1438411_at 5 chr5:124327047-124327571 5 F chr5:124326986-124330012 5 F RSQ Mm.33362 NM_175520 1 1 243270 Gpr81 G protein-coupled receptor 81 (Gpr81), mRNA. G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; integral to membrane;; membrane;; plasma membrane;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 1224.9865 942.5342 990.7780 760.1954 497.5521 1047.2392 197.8528 221.9590 164.5932 184.6137 196.8600 207.6188 326.1093 438.2180 438.9162 466.4601 391.3584 229.5794 1357007 1438664_at 12 chr12:32643802-32643933 12 A3 chr12:32643343-32746144 12 A3 RSQ Mm.476869 NM_011158 1 1 19088 RP23-193M19.1 Prkar2b protein kinase, cAMP dependent regulatory, type II beta (Prkar2b), mRNA. AKAP95 role in mitosis and chromosome dynamics;; Protein Kinase A at the Centrosome;; Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation Apoptosis;; Insulin signaling pathway CLASS Cellular Processes; Cell Growth and Death; Apoptosis [PATH:mmu04210] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] cAMP binding;; cAMP-dependent protein kinase complex;; cAMP-dependent protein kinase regulator activity;; cell proliferation;; fatty acid metabolic process;; kinase activity;; learning;; nucleotide binding;; organ morphogenesis;; protein amino acid phosphorylation;; regulation of protein amino acid phosphorylation;; signal transduction cell;; cell part;; macromolecular complex cell part;; intracellular;; intracellular part;; protein complex binding;; catalytic activity;; enzyme regulator activity kinase regulator activity;; nucleoside binding;; nucleotide binding;; transferase activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; behavior;; cell communication;; cell proliferation;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal development;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; system process 42.9154 42.7486 41.5104 47.5794 45.3061 41.5104 93.0273 94.5577 106.3928 109.4516 91.4119 109.5074 313.2228 238.8955 280.8846 289.8741 355.7855 368.1383 1357038 1438720_at 10 chr10:28949419-28949955 10 A4 UG5 Mm.379334 Transcribed locus 24.2744 35.1691 23.8178 27.8935 31.5916 34.4874 18.2361 24.5305 22.5993 22.3923 22.3719 18.8778 40.9233 80.3196 74.9426 91.7171 46.6512 34.1821 1357453 1439489_at 19 chr19:38188168-38188602 19 C3 chr19:38171568-38188753 19 C2 RSQ Mm.35288 NM_181748 1 1 107221 Gpr120 G protein-coupled receptor 120 (Gpr120), mRNA. endocytic vesicle;; fatty acid binding;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; hormone secretion;; integral to membrane;; lipid binding;; membrane;; plasma membrane;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; vesicle binding;; molecular transducer activity carboxylic acid binding;; lipid binding;; signal transducer activity biological regulation;; cellular process;; establishment of localization;; localization;; regulation of biological process cell communication;; cellular localization;; establishment of localization;; establishment of localization in cell;; generation of a signal involved in cell-cell signaling;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; secretion by cell;; transport 11.5885 12.2132 10.3956 12.3344 12.0056 11.1948 13.9023 14.8394 15.0958 13.2232 14.3938 14.5463 88.3494 153.0361 154.0390 140.4818 11.9123 143.8742 1357529 1439575_at 17 chr17:65605344-65890122 17 E1.1 RSQ Mm.141275 NM_001008973 1 1 381107 E130009J12Rik RIKEN cDNA E130009J12 gene (E130009J12Rik), mRNA. 23.1772 25.1969 19.3721 21.5145 27.6557 22.6325 436.1894 444.1576 556.9391 549.7219 456.1765 553.4852 1556.7029 1156.1628 1112.1309 1277.4385 1184.3762 985.9630 1357783 1439859_at 6 chr6:127035208-127035696 6 F3 chr6:127035139-127059554 6 F3 RSQ Mm.101836 NM_177003 2 2 319801 9630033F20Rik RIKEN cDNA 9630033F20 gene (9630033F20Rik), mRNA. catalytic activity;; fructose-2,6-bisphosphate 2-phosphatase activity;; hydrolase activity;; metabolic process catalytic activity hydrolase activity metabolic process 73.9094 80.1256 79.8033 90.8834 69.8477 74.7880 76.1774 82.7353 58.7067 51.7139 83.1828 47.5119 119.9255 112.5955 92.1749 120.0248 247.4485 274.1412 1358871 1441071_at 1 chr1:21950022-21950404 1 A4 UG5 Mm.403737 Transcribed locus, strongly similar to XP_532200.2 PREDICTED: similar to potassium voltage-gated channel, KQT-like subfamily, member 5 isoform 1 [Canis familiaris] 42.6322 52.5959 57.2313 48.5342 44.9461 37.5364 185.8055 205.8552 186.1101 193.3616 201.8787 192.3153 416.1203 548.2478 539.1323 510.0122 511.6171 437.9437 1358895 1441096_at 11 chr11:76511606-76512085 11 B5 chr11:76493374-76512164 11 B5 RSQ Mm.127006 NM_177709 1 1 237858 RP23-343C18.2 Tusc5 tumor suppressor candidate 5 (Tusc5), mRNA. integral to membrane;; membrane;; response to biotic stimulus cell;; cell part cell part;; membrane;; membrane part response to stimulus response to biotic stimulus 108.9174 99.7707 102.6227 114.1744 96.3412 112.4124 69.9177 71.4308 68.6128 64.9249 63.4307 62.4214 177.0561 146.8189 190.7301 103.0599 87.9395 108.6681 1360916 1443353_at chr15:12060176-12060481 15 A1 IPA ESTs, Weakly similar to RIKEN cDNA 5730493B19 [Mus musculus] [M.musculus] 67.7580 70.4822 69.1916 58.6109 59.6901 66.1641 265.2489 306.8512 177.1850 168.0816 291.6786 178.2110 420.4297 438.7405 396.6601 598.9852 513.6349 347.7445 1362970 1445574_at 18 chr18:61451167-61451464 18 E1 UGA Mm.25466 Transcribed locus 23.5466 22.4119 23.6547 22.6779 23.8188 28.2987 43.9421 44.8791 28.8852 26.2278 47.7576 36.4593 57.5168 83.0667 58.6735 39.7635 47.1858 60.0734 1364513 1447174_at 14 chr14:98494912-98495320 14 E2.1 UGA Mm.416176 Transcribed locus 22.1603 34.3627 28.0312 35.8429 42.4061 45.6915 116.4206 125.1553 73.4950 77.6659 116.8879 68.1541 177.1183 253.5899 217.0947 194.9725 200.3176 160.0031 1371969 1447584_s_at 10 chr10:4739804-4739954 10 A1 chr10:4739751-4752813 10 A1 RSQ Mm.338242 NM_026793 1 1 68632 Myct1 myc target 1 (Myct1), mRNA. integral to membrane;; membrane;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle 11.0714 11.5426 8.2560 9.4512 18.0168 8.3447 85.4085 79.1631 49.1210 44.3139 78.3204 41.1772 92.0591 144.0671 189.2351 235.4825 156.1519 93.7401 1365656 1453588_at 3 A2|3 11.7 cM chr3:14865268-14865776 3 A1 UGA Mm.300 12350 Car3 Carbonic anhydrase 3, mRNA (cDNA clone MGC:18583 IMAGE:4195712) Nitrogen metabolism CLASS Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:mmu00910] carbonate dehydratase activity;; cytoplasm;; lyase activity;; metal ion binding;; nickel ion binding;; one-carbon metabolic process;; zinc ion binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; lyase activity cellular process;; metabolic process cellular metabolic process 12.4669 15.1677 14.1052 14.4843 13.6009 11.7941 32.2548 33.5263 27.5075 23.9333 28.0018 27.4346 68.3508 54.4139 63.0029 47.7694 49.9289 37.1277 1365660 1453593_at 16 chr16:65861625-65861853 16 C1.3 chr16:65815877-65863311 16 C1.3 RSQ Mm.25670 XM_283372 2 1 73569 Vgll3 PREDICTED: vestigial like 3 (Drosophila) (Vgll3), mRNA. nucleus;; regulation of transcription;; regulation of transcription, DNA-dependent;; transcription;; transcription regulator activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle transcription regulator activity biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 87.5931 118.5999 199.6626 112.8699 134.1194 142.8336 170.5124 159.4852 160.4480 173.8766 168.7280 180.2793 370.8558 344.0756 389.4342 376.4359 381.9244 253.0988 1366445 1454671_at 5 B1 chr5:28404633-28405164 5 B1 UG5 Mm.30221 231070 Insig1 Insulin induced gene 1 (Insig1), mRNA cholesterol biosynthetic process;; cholesterol metabolic process;; cranial suture morphogenesis;; endoplasmic reticulum;; inner ear morphogenesis;; integral to membrane;; lipid metabolic process;; membrane;; middle ear morphogenesis;; negative regulation of fat cell differentiation;; negative regulation of fatty acid biosynthetic process;; negative regulation of steroid biosynthetic process;; palate development;; protein binding;; response to sterol depletion;; steroid metabolic process;; sterol biosynthetic process;; triglyceride metabolic process cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding protein binding biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; response to stimulus alcohol metabolic process;; anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cellular developmental process;; cellular metabolic process;; embryonic development;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; negative regulation of metabolic process;; organic ether metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; response to stress 17.5669 16.1162 14.2134 20.9689 34.5109 20.7271 57.6233 55.0794 46.1979 36.3080 49.8583 43.9885 123.3106 117.1716 126.1256 145.7923 156.1046 129.0346 1366550 1454877_at 1 chr1:194670735-194671190 1 H6 chr1:194670681-194681915 1 H6 RSQ Mm.22806 NM_198247 1 1 214791 RP23-381K21.1 Sertad4 SERTA domain containing 4 (Sertad4), mRNA. 30.8403 29.3702 32.6575 38.7248 34.9009 34.6269 33.1191 30.8079 31.5324 33.4904 34.5619 29.9236 81.8681 65.0026 53.3577 74.0869 69.5986 47.6369 1366597 1454965_at 2 chr2:83723050-83723465 2 D chr2:83649896-83723691 2 D RSQ XM_922613 1 1 634842 LOC634842 PREDICTED: similar to D430039N05Rik protein, transcript variant 2 (LOC634842), mRNA. 170.5508 199.1926 124.1036 156.1014 132.5101 153.5051 124.3757 139.9304 166.0027 143.3408 128.7360 143.8669 354.7032 306.4024 354.5955 218.0023 159.4280 114.2602 1372388 1455966_s_at 8 chr8:96541804-96542041 8 C5 UGA Mm.432689 Transcribed locus 1247.3422 1004.5408 904.2063 870.9066 534.4989 1112.3613 183.5235 180.6241 131.5357 156.7280 175.1948 165.4637 245.9247 373.0138 374.7883 437.2241 377.8960 202.3109 1372415 1456475_s_at 12 chr12:32643573-32643806 12 A3 chr12:32643343-32746144 12 A3 RSQ Mm.476869 NM_011158 1 1 19088 RP23-193M19.1 Prkar2b protein kinase, cAMP dependent regulatory, type II beta (Prkar2b), mRNA. AKAP95 role in mitosis and chromosome dynamics;; Protein Kinase A at the Centrosome;; Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation Apoptosis;; Insulin signaling pathway CLASS Cellular Processes; Cell Growth and Death; Apoptosis [PATH:mmu04210] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] cAMP binding;; cAMP-dependent protein kinase complex;; cAMP-dependent protein kinase regulator activity;; cell proliferation;; fatty acid metabolic process;; kinase activity;; learning;; nucleotide binding;; organ morphogenesis;; protein amino acid phosphorylation;; regulation of protein amino acid phosphorylation;; signal transduction cell;; cell part;; macromolecular complex cell part;; intracellular;; intracellular part;; protein complex binding;; catalytic activity;; enzyme regulator activity kinase regulator activity;; nucleoside binding;; nucleotide binding;; transferase activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; behavior;; cell communication;; cell proliferation;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal development;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; system process 27.5039 29.4911 29.6984 25.4969 33.9101 23.4102 317.6519 342.3578 160.4410 163.4505 297.0408 162.1254 526.1544 357.2980 340.6341 538.9245 590.5401 455.4938 1368361 1457587_at 1 chr1:21388534-21388877 1 A4 chr1:21388483-21952023 1 A4 RSQ Mm.336519 NM_023872 2 1 226922 Kcnq5 potassium voltage-gated channel, subfamily Q, member 5 (Kcnq5), mRNA. integral to membrane;; ion channel activity;; ion transport;; membrane;; potassium channel activity;; potassium ion binding;; potassium ion transport;; transport;; voltage-gated ion channel activity;; voltage-gated potassium channel activity;; voltage-gated potassium channel complex cell;; cell part;; macromolecular complex cell part;; membrane;; membrane part;; protein complex binding;; transporter activity ion binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 65.2184 60.0845 59.9820 70.3081 83.6936 72.0392 71.3279 76.1458 67.4694 81.8275 75.0932 72.7446 183.5943 170.8214 134.1250 205.5359 163.9676 155.2833 1369047 1458379_at 10 A4 chr10:28947684-28948074 10 A4 UGA Mm.132789 212448 9330159F19Rik RIKEN cDNA 9330159F19 gene, mRNA (cDNA clone IMAGE:8861298) 11.4186 9.8245 12.0426 14.2529 12.2284 13.6593 14.3405 12.9307 10.4432 15.4484 15.7488 13.6507 33.3623 17.8815 32.1740 35.0650 24.9624 17.4669 1372680 1459973_x_at 2 C2-D|2 35.0 cM UG5 Mm.1151 13482 RP23-87G8.2 Dpp4 Dipeptidylpeptidase 4, mRNA (cDNA clone MGC:14076 IMAGE:3982742) aminopeptidase activity;; extracellular region;; hydrolase activity;; integral to membrane;; intercellular canaliculus;; membrane;; peptidase activity;; plasma membrane;; proteolysis;; serine-type endopeptidase activity;; serine-type peptidase activity cell;; cell part;; extracellular region cell part;; membrane;; membrane part catalytic activity hydrolase activity metabolic process catabolic process;; macromolecule metabolic process;; primary metabolic process