A 1 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen A 2 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen A 3 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen A 4 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen A 5 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen A 6 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen B 7 02-09-07_Hennighausen_PK_Mouse430_2_M42 GSP-EG003.1 Hennighausen B 8 02-09-07_Hennighausen_PK_Mouse430_2_M43 GSP-EG003.1 Hennighausen B 9 02-09-07_Hennighausen_PK_Mouse430_2_M44 GSP-EG003.1 Hennighausen B 10 02-09-07_Hennighausen_PK_Mouse430_2_M47 GSP-EG003.1 Hennighausen B 11 02-09-07_Hennighausen_PK_Mouse430_2_M48 GSP-EG003.1 Hennighausen B 12 02-09-07_Hennighausen_PK_Mouse430_2_M50 GSP-EG003.1 Hennighausen C 13 06-10-08_Hennighausen_1PK_Mouse430_2_4038WT GSP-EG003.2 Hennighausen C 14 06-10-08_Hennighausen_2PK_Mouse430_2_4060WT GSP-EG003.2 Hennighausen C 15 06-10-08_Hennighausen_3PK_Mouse430_2_4063WT GSP-EG003.2 Hennighausen C 16 06-10-08_Hennighausen_4PK_Mouse430_2_4035KO GSP-EG003.2 Hennighausen C 17 06-10-08_Hennighausen_5PK_Mouse430_2_4036KO GSP-EG003.2 Hennighausen C 18 06-10-08_Hennighausen_6PK_Mouse430_2_4042KO GSP-EG003.2 Hennighausen Gene Property Filtering 18 arrays and 45101 genes in the input dataset 18 arrays and 168 genes in the output dataset. 44933 genes excluded for Well ID not being in local list 'EG3-1-test-1+FC'. A A A A A A B B B B B B C C C C C C 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M42 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M43 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M44 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M47 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M48 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M50 GSP-EG003.1 Hennighausen 06-10-08_Hennighausen_1PK_Mouse430_2_4038WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_2PK_Mouse430_2_4060WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_3PK_Mouse430_2_4063WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_4PK_Mouse430_2_4035KO GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_5PK_Mouse430_2_4036KO GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_6PK_Mouse430_2_4042KO GSP-EG003.2 Hennighausen Well ID Feature ID Map mgB37_Probe Chr:Start-Stop mgB37_Probe Cytoband mgB37_RefSeq Chr:Start-Stop mgB37_RefSeq Cytoband Annotation_Src UniGene RefSeq Refseqs_Hit geneIDS_Hit Entrez GeneID Locus Tag Gene Description BioCarta Pathways KEGG Pathways Gene Ontology Terms GO Tier2 Component GO Tier3 Component GO Tier2 Function GO Tier3 Function GO Tier2 Process GO Tier3 Process 139.0634 147.4432 191.0044 82.2440 90.5323 108.0518 1523.0491 1576.7918 397.0232 395.9849 1560.4356 384.8493 155.4309 209.4098 253.5523 390.0408 477.4949 303.1974 1327679 1415899_at 8 C2-D1|8 38.6 cM chr8:87500883-87501393 8 C3 UGA Mm.1167 16477 Junb Jun-B oncogene, mRNA (cDNA clone MGC:6021 IMAGE:3592704) GATA3 participate in activating the Th2 cytokine genes expression cellular process;; decidualization;; DNA binding;; embryonic process involved in female pregnancy;; in utero embryonic development;; labyrinthine layer blood vessel development;; nucleus;; positive regulation of cell differentiation;; protein dimerization activity;; regulation of cell cycle;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; transcription;; transcription factor activity;; trophectodermal cell differentiation;; trophectodermal cell differentiation;; vasculogenesis cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; protein binding;; transcription factor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; metabolic process;; multi-organism process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; biosynthetic process;; cell cycle;; cellular developmental process;; cellular metabolic process;; embryonic development;; female pregnancy;; macromolecule metabolic process;; multicellular organism reproduction;; multicellular organismal development;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; reproductive process;; reproductive process in a multicellular organism 146.2553 111.0078 120.3167 78.5346 74.8715 76.7035 503.5929 520.5099 168.7229 188.3543 516.2546 190.8918 160.4057 187.4104 178.2143 176.3360 171.2954 133.1809 1343221 1416065_a_at 8 chr8:11611620-11611723 8 A1.1 chr8:11611582-11635689 8 A1.1 RSQ Mm.12459 NM_133971 1 1 102334 Ankrd10 ankyrin repeat domain 10 (Ankrd10), mRNA. 3947.3245 4945.6797 5030.2662 3028.9297 2802.9297 4495.0623 6338.8642 6196.7090 1505.3542 1551.8456 6267.6941 1443.0410 437.4612 663.6470 982.0763 669.4725 1509.8063 737.5304 1327943 1416250_at 1 71.0 cM chr1:135973961-135975525 1 E4 chr1:135971441-135975732 1 E4 RSQ Mm.392646 NM_007570 1 1 12227 Btg2 B-cell translocation gene 2, anti-proliferative (Btg2), mRNA. BTG family proteins and cell cycle regulation anterior/posterior pattern formation;; negative regulation of apoptosis;; neuron differentiation;; protein amino acid methylation;; protein binding;; regulation of transcription, DNA-dependent;; response to DNA damage stimulus;; transcription binding protein binding biological regulation;; cellular process;; death;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; biosynthetic process;; cell death;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; pattern specification process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; response to stress 1388.3992 1437.2428 1340.8979 940.1353 832.1860 980.8734 1763.3867 1666.5310 414.8919 423.1519 1757.0016 399.0408 1091.3115 612.3186 635.9214 1565.4321 2320.3607 1921.4254 1327963 1416273_at 12 56.0 cM chr12:112692639-112692973 12 F1 chr12:112683139-112693229 12 F1 RSQ Mm.255332 NM_009396 1 1 21928 Tnfaip2 tumor necrosis factor, alpha-induced protein 2 (Tnfaip2), mRNA. angiogenesis;; cell differentiation;; multicellular organismal development anatomical structure formation;; cellular process;; developmental process;; multicellular organismal process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cellular developmental process;; multicellular organismal development 24.4466 27.1615 22.7613 28.6837 27.8133 24.6695 273.2035 303.9363 66.7361 63.3636 290.5736 59.8105 74.1940 72.3079 66.3027 182.2095 154.0949 160.2428 1327998 1416318_at 13 12.0 cM chr13:32934621-32937204 13 A3.2 chr13:32933960-32943054 13 A3.2 RSQ Mm.20144 NM_025429 1 1 66222 RP23-427P14.4 Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a (Serpinb1a), mRNA. cytoplasm;; endopeptidase inhibitor activity;; regulation of protein catabolic process;; serine-type endopeptidase inhibitor activity cell;; cell part cell part;; intracellular;; intracellular part enzyme regulator activity enzyme inhibitor activity biological regulation;; metabolic process;; regulation of biological process catabolic process;; macromolecule metabolic process;; primary metabolic process;; regulation of biological process;; regulation of metabolic process 170.1519 153.6519 224.6073 149.6444 217.3747 136.8679 963.3854 916.9217 428.5296 402.8232 957.6589 406.8741 389.4796 328.6911 406.1376 459.9460 380.5199 303.6338 1328081 1416431_at 18 chr18:67561958-67562376 18 E1 chr18:67550384-67562403 18 E1 RSQ Mm.181860 NM_026473 1 1 67951 Tubb6 tubulin, beta 6 (Tubb6), mRNA. Gap junction CLASS Cellular Processes; Cell Communication; Gap junction [PATH:mmu04540] GTP binding;; GTPase activity;; microtubule;; microtubule-based movement;; microtubule-based process;; nucleotide binding;; protein complex;; protein polymerization;; structural molecule activity cell;; cell part;; macromolecular complex;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; non-membrane-bounded organelle;; organelle part;; protein complex binding;; catalytic activity;; structural molecule activity hydrolase activity;; nucleotide binding anatomical structure formation;; cellular component biogenesis;; cellular component organization;; cellular process cellular component assembly;; cellular macromolecular complex subunit organization;; macromolecular complex subunit organization;; microtubule-based process;; protein complex biogenesis 120.5971 155.6736 150.1349 347.2172 257.0916 272.5061 2725.9996 2806.0964 802.0430 734.4321 2673.9977 702.4433 234.9824 228.5365 290.1378 416.5916 379.8765 532.6616 1328194 1416576_at 11 chr11:117827755-117827967 11 E2 chr11:117827392-117830476 11 E2 RSQ Mm.3468 NM_007707 1 1 12702 RP23-268N22.6 Socs3 suppressor of cytokine signaling 3 (Socs3), mRNA. IL-2 Receptor Beta Chain in T cell Activation;; IL22 Soluble Receptor Signaling Pathway Adipocytokine signaling pathway;; Insulin signaling pathway;; Jak-STAT signaling pathway;; Type II diabetes mellitus CLASS Genetic Information Processing; Folding, Sorting and Degradation; Ubiquitin mediated proteolysis [PATH:mmu04120] Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] Cellular Processes; Endocrin;; Ubiquitin mediated proteolysis branching involved in embryonic placenta morphogenesis;; intracellular signaling cascade;; modification-dependent protein catabolic process;; negative regulation of insulin receptor signaling pathway;; negative regulation of signal transduction;; placenta blood vessel development;; positive regulation of cell differentiation;; positive regulation of cell differentiation;; protein binding;; regulation of cell differentiation;; regulation of cell differentiation;; regulation of growth;; regulation of protein amino acid phosphorylation;; spongiotrophoblast differentiation;; spongiotrophoblast differentiation;; trophoblast giant cell differentiation;; trophoblast giant cell differentiation binding protein binding biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; catabolic process;; cell communication;; cellular developmental process;; cellular metabolic process;; cellular response to stimulus;; embryonic development;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of response to stimulus;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of metabolic process;; regulation of response to stimulus;; response to chemical stimulus;; response to endogenous stimulus 818.0788 644.9600 674.9452 994.5523 810.5825 1354.2143 5921.1519 5934.3151 2053.7697 1977.9902 5847.0438 1964.7678 1556.8984 1972.4664 1592.1227 1668.9639 1584.6678 1974.9297 1328407 1416840_at X chrX:10296247-10296743 X A1.1 chrX:10294619-10296823 X A1.1 RSQ Mm.29429 NM_026524 1 1 68041 RP23-130J1.1 Mid1ip1 Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) (Mid1ip1), mRNA. cytoplasm;; microtubule;; microtubule cytoskeleton;; negative regulation of microtubule depolymerization;; nucleus;; protein binding;; protein C-terminus binding cell;; cell part;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; non-membrane-bounded organelle;; organelle part binding protein binding biological regulation;; cellular component organization;; cellular process;; metabolic process;; negative regulation of biological process;; regulation of biological process cellular component disassembly;; cellular macromolecular complex subunit organization;; cellular metabolic process;; macromolecular complex subunit organization;; macromolecule metabolic process;; microtubule-based process;; negative regulation of biological process;; negative regulation of cellular component organization;; negative regulation of cellular process;; negative regulation of metabolic process;; organelle organization;; primary metabolic process;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of metabolic process 144.3203 326.5226 290.0403 112.0430 217.9852 118.8620 4687.2495 4806.2947 509.0127 460.1191 4760.1034 462.8921 487.3561 360.5762 379.0367 280.4741 281.0701 277.9745 1328588 1417065_at 18 16.0 cM chr18:35024067-35024594 18 B1 chr18:35020860-35024610 18 B1 RSQ Mm.181959 NM_007913 1 1 13653 Egr1 early growth response 1 (Egr1), mRNA. Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway Prion diseases CLASS Human Diseases; Neurodegenerative Diseases; Prion diseases [PATH:mmu05020] DNA binding;; intracellular;; metal ion binding;; negative regulation of transcription from RNA polymerase II promoter;; nucleic acid binding;; nucleus;; nucleus;; regulation of transcription, DNA-dependent;; response to protein stimulus;; T cell differentiation;; transcription;; transcription factor activity;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity ion binding;; nucleic acid binding;; transcription factor activity biological regulation;; cellular process;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; biosynthetic process;; cell activation;; cellular developmental process;; cellular metabolic process;; immune system development;; leukocyte activation;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; response to chemical stimulus 724.1850 869.9663 766.3002 637.9374 631.6083 811.4819 1169.8554 1150.9218 388.9852 386.9813 1121.9598 424.5408 329.2930 320.4085 361.0484 377.9926 306.8713 352.0756 1328869 1417406_at 7 chr7:28274785-28275298 7 A3 chr7:28271971-28275333 7 A3 RSQ Mm.153684 NM_018820 1 1 55942 Sertad1 SERTA domain containing 1 (Sertad1), mRNA. cytoplasm;; negative regulation of cell growth;; nucleus;; positive regulation of transcription;; protein binding;; regulation of transcription, DNA-dependent;; transcription;; transcription activator activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity protein binding;; transcription activator activity biological regulation;; cellular process;; growth;; metabolic process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process biosynthetic process;; cell growth;; cellular metabolic process;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of growth;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of growth;; regulation of metabolic process 38969.8570 24517.5964 22101.4526 38617.0964 23638.9611 23632.0964 5984.1681 6025.9914 1095.3497 1299.2783 6056.2174 1321.6060 1890.1404 5885.0765 5689.2352 2662.4852 7325.2117 700.7588 1343546 1417714_x_at 11 16.0 cM RSQ Mm.196110 NM_008218 2 2 15122 Hba-a1 hemoglobin alpha, adult chain 1 (Hba-a1), mRNA. erythrocyte development;; heme binding;; hemoglobin complex;; in utero embryonic development;; iron ion binding;; metal ion binding;; oxygen binding;; oxygen transport;; oxygen transporter activity;; transport cell;; cell part;; macromolecular complex cell part;; intracellular;; intracellular part;; protein complex binding;; transporter activity ion binding;; oxygen binding;; substrate-specific transporter activity;; tetrapyrrole binding biological regulation;; cellular process;; developmental process;; establishment of localization;; immune system process;; localization;; multicellular organismal process anatomical structure development;; cellular developmental process;; embryonic development;; establishment of localization;; immune system development;; multicellular organismal development;; regulation of biological quality;; transport 312.6064 331.4960 363.4239 241.8497 197.2965 316.1721 532.5718 537.7103 236.1525 238.7075 538.7268 257.7410 254.3957 276.2754 279.6740 317.5641 308.2992 247.3426 1329123 1417719_at 8 31.0 cM chr8:59961527-59964341 8 B2 chr8:59961521-59966654 8 B2 RSQ Mm.118 NM_021788 1 1 60406 Sap30 sin3 associated polypeptide (Sap30), mRNA. negative regulation of transcription from RNA polymerase II promoter;; nucleus;; protein binding;; Sin3 complex cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; non-membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding protein binding biological regulation;; cellular process;; metabolic process;; negative regulation of biological process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 1218.4991 1729.1527 701.2075 628.4831 1181.4069 1337.4946 527.4612 515.7743 190.0769 172.2705 537.3162 189.3413 234.5453 220.1125 193.3039 497.3231 165.0399 537.9343 1329183 1417793_at 11 chr11:58035687-58036058 11 B1.3 chr11:58028478-58036285 11 B1.3 RSQ Mm.458517 NM_019440 1 1 54396 RP24-499A8.1 Irgm2 immunity-related GTPase family M member 2 (Irgm2), mRNA. GTPase activity catalytic activity hydrolase activity 68.4305 73.9025 117.4620 49.7991 96.0944 49.9221 865.7190 894.0942 151.2267 124.5341 1034.7201 160.9145 163.7546 154.6498 160.5880 211.8966 166.6975 169.8951 1329299 1417930_at 10 70.0 cM chr10:127098035-127098540 10 D3 chr10:127097973-127103759 10 D3 RSQ Mm.336898 NM_001122895 2 1 17937 Nab2 Ngfi-A binding protein 2 (Nab2), transcript variant 2, mRNA. endochondral ossification;; myelination;; negative regulation of transcription;; nucleus;; regulation of epidermis development;; regulation of transcription;; regulation of transcription, DNA-dependent;; Schwann cell differentiation;; transcription;; transcription regulator activity;; transcription repressor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle transcription regulator activity transcription repressor activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cellular developmental process;; cellular homeostasis;; cellular metabolic process;; ensheathment of neurons;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; ossification;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; system process 77.9668 77.4576 86.9542 82.0591 97.5000 61.4340 1616.0867 1573.0423 400.5288 415.3885 1580.4144 399.0308 170.6553 220.1440 217.9486 192.9692 173.9628 200.9535 1329642 1418349_at 18 15.0 cM chr18:36664709-36665151 18 B2 chr18:36664585-36675428 18 B2 RSQ Mm.289681 NM_010415 1 1 15200 Hbegf heparin-binding EGF-like growth factor (Hbegf), mRNA. NFAT and Hypertrophy of the heart (Transcription in the broken heart) ErbB signaling pathway;; GnRH signaling pathway CLASS Environmental Information Processing; Signal Transduction; ErbB signaling pathway [PATH:mmu04012] Cellular Processes; Endocrine System; GnRH signaling pathway [PATH:mmu04912] epidermal growth factor receptor signaling pathway;; extracellular region;; integral to membrane;; membrane;; plasma membrane;; regulation of heart contraction cell;; cell part;; extracellular region cell part;; membrane;; membrane part biological regulation;; cellular process;; multicellular organismal process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process;; regulation of multicellular organismal process;; system process 80.9814 68.5231 82.1664 67.0932 81.9781 92.3880 4203.5671 4298.9217 1087.2290 1016.1770 4240.6475 1001.6325 229.5814 352.9350 339.5979 314.8332 306.3186 352.1650 1329643 1418350_at 18 15.0 cM chr18:36665688-36667226 18 B2 chr18:36664585-36675428 18 B2 RSQ Mm.289681 NM_010415 1 1 15200 Hbegf heparin-binding EGF-like growth factor (Hbegf), mRNA. NFAT and Hypertrophy of the heart (Transcription in the broken heart) ErbB signaling pathway;; GnRH signaling pathway CLASS Environmental Information Processing; Signal Transduction; ErbB signaling pathway [PATH:mmu04012] Cellular Processes; Endocrine System; GnRH signaling pathway [PATH:mmu04912] epidermal growth factor receptor signaling pathway;; extracellular region;; integral to membrane;; membrane;; plasma membrane;; regulation of heart contraction cell;; cell part;; extracellular region cell part;; membrane;; membrane part biological regulation;; cellular process;; multicellular organismal process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process;; regulation of multicellular organismal process;; system process 80.0634 86.7933 74.3138 82.5224 87.7940 98.3287 1007.5777 1032.5526 468.4987 464.5311 1000.6996 493.8675 1278.8637 712.1853 692.0964 714.5112 685.7494 624.5392 1329700 1418420_at 7 23.5 cM chr7:53633876-53634381 7 B4 chr7:53631843-53634462 7 B4 RSQ Mm.1526 NM_010866 1 1 17927 Myod1 myogenic differentiation 1 (Myod1), mRNA. Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK);; Signal Dependent Regulation of Myogenesis by Corepressor MITR cell differentiation;; DNA binding;; multicellular organismal development;; muscle organ development;; muscle organ development;; myoblast cell fate determination;; myoblast differentiation;; nucleus;; nucleus;; positive regulation of skeletal muscle regeneration;; positive regulation of transcription from RNA polymerase II promoter;; protein binding;; regulation of alternative nuclear mRNA splicing, via spliceosome;; regulation of alternative nuclear mRNA splicing, via spliceosome;; regulation of transcription;; regulation of transcription, DNA-dependent;; RNA polymerase II transcription factor activity, enhancer binding;; skeletal muscle tissue development;; skeletal muscle tissue development;; skeletal muscle tissue development;; striated muscle cell differentiation;; transcription;; transcription activator activity;; transcription factor activity;; transcription factor binding;; transcription factor complex;; transcription regulator activity cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity nucleic acid binding;; protein binding;; RNA polymerase II transcription factor activity;; transcription activator activity;; transcription factor activity biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cellular developmental process;; cellular metabolic process;; developmental growth;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of growth;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; response to external stimulus;; response to stress 465.6154 625.3644 573.1669 566.4796 590.5077 555.1479 4364.5741 4422.7925 1761.4691 1848.3581 4415.6374 1754.2807 946.2518 1214.2661 1261.1007 1240.1825 1600.6565 1290.1840 1329818 1418571_at 17 chr17:23812771-23812982 17 A3.3 chr17:23812411-23814416 17 A3.3 RSQ NM_001161746 2 1 27279 Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a (Tnfrsf12a), transcript variant 2, mRNA. Cytokine-cytokine receptor interaction CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] angiogenesis;; apoptosis;; cell adhesion;; cell death;; cell differentiation;; cell surface;; integral to membrane;; membrane;; multicellular organismal development;; plasma membrane;; positive regulation of axon extension;; protein binding;; receptor activity;; ruffle;; substrate-bound cell migration, cell attachment to substrate cell;; cell part cell leading edge;; cell part;; cell projection;; cell surface;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity anatomical structure formation;; biological adhesion;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; localization;; locomotion;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell adhesion;; cell death;; cell motility;; cell motion;; cell projection organization;; cellular component morphogenesis;; cellular developmental process;; localization of cell;; multicellular organismal development;; positive regulation of biological process;; positive regulation of cellular component organization;; positive regulation of cellular process;; positive regulation of developmental process;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process 180.8886 193.4840 266.8112 195.9640 266.2158 298.5657 3940.8133 4157.4390 1659.0334 1587.8741 4121.4174 1565.2240 760.9914 1043.6241 1071.7630 1005.5524 1363.7326 1130.8393 1343706 1418572_x_at 17 chr17:23812771-23812982 17 A3.3 chr17:23812411-23814416 17 A3.3 RSQ NM_001161746 2 1 27279 Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a (Tnfrsf12a), transcript variant 2, mRNA. Cytokine-cytokine receptor interaction CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] angiogenesis;; apoptosis;; cell adhesion;; cell death;; cell differentiation;; cell surface;; integral to membrane;; membrane;; multicellular organismal development;; plasma membrane;; positive regulation of axon extension;; protein binding;; receptor activity;; ruffle;; substrate-bound cell migration, cell attachment to substrate cell;; cell part cell leading edge;; cell part;; cell projection;; cell surface;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity anatomical structure formation;; biological adhesion;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; localization;; locomotion;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell adhesion;; cell death;; cell motility;; cell motion;; cell projection organization;; cellular component morphogenesis;; cellular developmental process;; localization of cell;; multicellular organismal development;; positive regulation of biological process;; positive regulation of cellular component organization;; positive regulation of cellular process;; positive regulation of developmental process;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process 9.9348 9.1193 9.1344 13.6395 11.2185 9.8972 32.5977 39.1398 16.5060 15.9294 35.6181 15.0100 24.3462 24.9390 22.6573 27.1195 24.0701 17.9505 1329858 1418618_at 1 64.1 cM chr1:122499063-122504568 1 E2.3 RSQ Mm.2657 NM_010133 1 1 13798 En1 engrailed 1 (En1), mRNA. DNA binding;; dorsal/ventral pattern formation;; embryonic forelimb morphogenesis;; embryonic limb morphogenesis;; embryonic limb morphogenesis;; hindbrain development;; midbrain development;; midbrain-hindbrain boundary development;; multicellular organismal development;; neuron development;; neuron differentiation;; nucleus;; pigmentation;; proximal/distal pattern formation;; regulation of transcription;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; transcription factor activity;; transcription regulator activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; transcription factor activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; pigmentation;; regulation of biological process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cellular developmental process;; cellular metabolic process;; embryonic development;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; pattern specification process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 35.7560 61.1456 81.6884 29.1226 50.5230 42.3708 1271.6748 1202.1519 379.9297 321.7813 1217.2630 349.3078 228.0319 274.7113 308.6810 345.4227 341.6724 237.5361 1330049 1418835_at 10 chr10:110945144-110945563 10 D1 chr10:110943341-110945705 10 D1 RSQ Mm.3117 NM_009344 1 1 21664 Phlda1 pleckstrin homology-like domain, family A, member 1 (Phlda1), mRNA. apoptosis;; cytoplasm;; cytoplasmic vesicle;; FasL biosynthetic process;; membrane;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane-bounded organelle;; vesicle cellular process;; death;; metabolic process biosynthetic process;; cell death;; cellular metabolic process;; macromolecule metabolic process 24.3381 26.8275 24.6193 29.1122 30.9426 25.2384 130.8503 132.6910 41.4607 36.8201 138.7248 37.5598 30.1154 38.2075 40.1069 111.3767 89.7235 88.2856 1330250 1419086_at 5 chr5:44370129-44370679 5 B3 chr5:44370098-44373001 5 B3 RSQ Mm.46053 NM_008009 1 1 14181 Fgfbp1 fibroblast growth factor binding protein 1 (Fgfbp1), mRNA. extracellular region;; growth factor binding;; membrane;; plasma membrane cell;; cell part;; extracellular region cell part;; membrane binding protein binding 127.7439 190.8578 128.1612 138.5402 132.5525 120.1342 7353.9914 7360.2075 2638.8732 2549.1249 7427.3301 2603.0837 1057.5133 1109.7197 1362.5183 1067.1625 1922.5705 1670.4169 1330359 1419220_at 9 F4 chr9:119923004-119923392 9 F4 UGA Mm.10117 22437 Xirp1 Xin actin binding;; actin cytoskeleton organization;; cardiac muscle cell development;; cell junction;; cell-cell adherens junction;; fascia adherens;; filamin-C binding;; heart morphogenesis;; intercalated disc;; negative regulation of cell proliferation;; protein binding;; regulation of membrane potential;; sarcomere organization cell;; cell part cell part;; membrane;; membrane part binding protein binding anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; developmental process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process actin filament-based process;; anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell proliferation;; cellular component assembly;; cellular component morphogenesis;; cellular developmental process;; cellular homeostasis;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; organelle organization;; regulation of biological process;; regulation of biological quality;; regulation of cellular process 52.0301 52.7097 50.1741 56.3961 51.7074 55.7210 239.2075 268.7490 123.0307 131.4135 250.1674 123.0197 103.5721 93.0957 104.9362 117.1287 114.0538 108.5997 1330567 1419488_at 5 chr5:34839136-34839321 5 B2 chr5:34838744-34856628 5 B2 RSQ Mm.28615 NM_139064 1 1 231130 Tnip2 TNFAIP3 interacting protein 2 (Tnip2), mRNA. cytoplasm;; I-kappaB kinase/NF-kappaB cascade;; protein binding cell;; cell part cell part;; intracellular;; intracellular part binding protein binding biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 88.5605 116.4067 107.5749 83.1682 128.4041 90.4211 390.5847 413.3741 193.9606 202.7779 403.1652 200.8954 293.2933 246.9340 274.0408 384.5655 311.7714 263.2075 1330644 1419583_at 11 79.5 cM chr11:118941500-118942031 11 E2 chr11:118938884-118947551 11 E2 RSQ Mm.268070 NM_007625 1 1 12418 RP23-458A23.2 Cbx4 chromobox homolog 4 (Drosophila Pc class) (Cbx4), mRNA. The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails chromatin;; chromatin assembly or disassembly;; chromatin binding;; chromatin modification;; modification-dependent protein catabolic process;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; phosphoprotein binding;; regulation of transcription, DNA-dependent;; transcription cell;; cell part;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; non-membrane-bounded organelle;; organelle part binding chromatin binding;; protein binding biological regulation;; cellular component organization;; cellular process;; metabolic process;; negative regulation of biological process;; regulation of biological process biosynthetic process;; catabolic process;; cellular metabolic process;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; organelle organization;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 164.6114 177.0258 125.1797 177.5381 181.1457 134.8442 413.1140 357.2566 147.2615 147.6943 339.3122 153.7539 107.8822 143.2353 137.2016 145.5516 161.9720 175.9615 1331285 1420575_at 8 45.0 cM chr8:96676690-96677865 8 C5 chr8:96676643-96678031 8 C5 RSQ Mm.2064 NM_013603 1 1 17751 Mt3 metallothionein 3 (Mt3), mRNA. cellular metal ion homeostasis;; copper ion binding;; metal ion binding;; negative regulation of neurogenesis;; synaptic vesicle;; zinc ion binding cell;; cell part;; organelle;; synapse;; synapse part cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle;; synapse part;; synaptic vesicle;; vesicle binding ion binding biological regulation;; cellular process;; developmental process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process anatomical structure development;; cellular developmental process;; cellular homeostasis;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process 262.6432 215.6332 306.7156 201.2672 160.3322 165.9770 181.5268 227.7075 97.3248 94.9247 198.9297 100.2819 101.9782 75.2554 80.1076 101.7614 134.7443 89.4351 1331459 1420824_at 13 B1 chr13:51796650-51797202 13 A5 UGA Mm.33903 20354 Sema4d Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (Sema4d), mRNA Axon guidance CLASS Cellular Processes; Development; Axon guidance [PATH:mmu04360] cell differentiation;; integral to membrane;; membrane;; multicellular organismal development;; nervous system development;; positive regulation of axonogenesis;; positive regulation of axonogenesis;; receptor binding cell;; cell part cell part;; membrane;; membrane part binding protein binding biological regulation;; cellular component organization;; cellular process;; developmental process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure morphogenesis;; cell projection organization;; cellular component morphogenesis;; cellular developmental process;; multicellular organismal development;; positive regulation of biological process;; positive regulation of cellular component organization;; positive regulation of cellular process;; positive regulation of developmental process;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process 49.3526 35.9402 26.3882 66.7695 76.2624 51.1329 395.8032 357.7575 158.0785 155.9323 342.2051 135.7749 178.8438 211.0753 231.5755 587.5316 395.1282 487.1988 1331506 1420884_at 9 chr9:53698088-53701597 9 A5.3 chr9:53698057-53701656 9 A5.3 RSQ Mm.29132 NM_025540 1 1 66402 Sln sarcolipin (Sln), mRNA. enzyme regulator activity;; integral to membrane;; membrane;; sarcoplasmic reticulum cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle enzyme regulator activity 42.5751 29.2195 43.7361 44.0788 58.1670 36.5856 1973.5586 1927.1863 760.4818 719.8664 1967.2630 695.0346 200.7800 141.9667 190.8598 284.3779 173.0591 137.4432 1331591 1420991_at 19 chr19:36187159-36191361 19 C2 chr19:36186454-36194334 19 C2 RSQ Mm.10279 NM_013468 1 1 107765 Ankrd1 ankyrin repeat domain 1 (cardiac muscle) (Ankrd1), mRNA. cytoplasm;; I band;; nucleus;; protein binding;; regulation of transcription from RNA polymerase II promoter;; transcription corepressor activity;; transcription factor complex cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity protein binding;; transcription cofactor activity;; transcription repressor activity biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 31.9519 41.9799 27.5361 44.6846 32.7657 32.2877 1537.9415 1602.5127 543.4858 572.1462 1537.0619 552.3462 150.5234 110.2621 120.1813 182.5408 134.9352 92.3970 1331592 1420992_at 19 chr19:36186663-36186994 19 C2 chr19:36186454-36194334 19 C2 RSQ Mm.10279 NM_013468 1 1 107765 Ankrd1 ankyrin repeat domain 1 (cardiac muscle) (Ankrd1), mRNA. cytoplasm;; I band;; nucleus;; protein binding;; regulation of transcription from RNA polymerase II promoter;; transcription corepressor activity;; transcription factor complex cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity protein binding;; transcription cofactor activity;; transcription repressor activity biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 109.1165 94.0396 122.5535 114.1721 114.3106 107.1515 246.8676 247.9234 104.3040 91.4115 243.2141 99.3919 113.1034 81.5462 77.9860 162.8186 218.5802 179.4852 1332186 1421830_at 4 47.6 cM chr4:101139016-101139266 4 C6 chr4:101092363-101139600 4 C6 RSQ Mm.42040 NM_009647 2 2 11639 RP23-301M3.3 Ak3l1 adenylate kinase 3-like 1 (Ak3l1), nuclear gene encoding mitochondrial protein, mRNA. Metabolic pathways CLASS Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:mmu00230];; Purine metabolism adenylate kinase activity;; ATP binding;; GTP binding;; kinase activity;; mitochondrion;; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;; nucleobase, nucleoside, nucleotide kinase activity;; nucleotide binding;; nucleotide kinase activity;; phosphotransferase activity, phosphate group as acceptor;; transferase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; catalytic activity nucleoside binding;; nucleotide binding;; transferase activity cellular process;; metabolic process cellular metabolic process;; nitrogen compound metabolic process;; primary metabolic process 49.8934 45.4001 38.3019 53.7737 45.8045 31.3861 63.4071 57.6838 20.1484 30.0719 47.4780 26.7651 26.4630 20.5917 24.7008 22.3499 25.1900 34.8383 1332410 1422134_at 7 5.0 cM chr7:19888336-19888846 7 A3 chr7:19888044-19895394 7 A3 RSQ Mm.248335 NM_008036 1 1 14282 Fosb FBJ osteosarcoma oncogene B (Fosb), mRNA. FOSB gene expression and drug abuse DNA binding;; nucleus;; protein dimerization activity;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; protein binding;; transcription factor activity biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 125.9710 111.9947 127.9352 124.5198 136.1381 90.3107 221.6347 221.3106 102.9984 109.5603 230.6212 110.9439 142.4867 117.5727 175.3741 164.9301 147.2075 138.4859 1344583 1422286_a_at 17 chr17:71193992-71194330 17 E1.3 chr17:71193554-71200538 17 E1.3 RSQ Mm.101034 NM_009372 1 1 21815 Tgif1 TGFB-induced factor homeobox 1 (Tgif1), mRNA. chromatin binding;; determination of left/right symmetry;; DNA binding;; dorsal/ventral pattern formation;; JUN kinase binding;; negative regulation of cell proliferation;; negative regulation of retinoic acid receptor signaling pathway;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription from RNA polymerase II promoter;; neural tube closure;; nucleus;; positive regulation of fibroblast proliferation;; positive regulation of neuron differentiation;; protein binding;; regulation of transcription;; regulation of transcription, DNA-dependent;; retina development in camera-type eye;; sequence-specific DNA binding;; specific transcriptional repressor activity;; transcription;; transcription factor activity;; transcription regulator activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity chromatin binding;; nucleic acid binding;; protein binding;; transcription factor activity;; transcription repressor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; biosynthetic process;; cell communication;; cell proliferation;; cellular developmental process;; cellular metabolic process;; embryonic development;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; pattern specification process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process 48.6110 79.2411 44.6101 54.2329 61.0357 46.4758 431.8676 406.3101 166.8186 159.2236 418.1212 166.4457 171.0548 180.6047 181.6076 230.8524 312.7947 241.9590 1332530 1422300_at 11 50.5 cM chr11:89161951-89163873 11 C RSQ Mm.135266 NM_008711 1 1 18121 RP23-205A9.1 Nog noggin (Nog), mRNA. TGF-beta signaling pathway CLASS Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway [PATH:mmu04350] anatomical structure formation involved in morphogenesis;; anatomical structure formation involved in morphogenesis;; BMP signaling pathway;; brain development;; cartilage development;; cell differentiation;; central nervous system development;; extracellular region;; extracellular space;; mesenchymal cell differentiation;; multicellular organismal development;; negative regulation of cell differentiation;; notochord morphogenesis;; pattern specification process;; positive regulation of epithelial cell proliferation;; positive regulation of epithelial cell proliferation;; prostatic bud formation;; skeletal system development;; ureteric bud development;; urogenital system development extracellular region;; extracellular region part extracellular region part;; extracellular space anatomical structure formation;; biological regulation;; cellular process;; developmental process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell communication;; cell proliferation;; cellular developmental process;; embryonic development;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; pattern specification process;; positive regulation of biological process;; positive regulation of cellular process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; reproductive developmental process;; reproductive process 109.5733 74.7981 111.1564 140.1180 170.6508 133.3669 1016.4785 1042.1023 491.3976 518.2960 997.3018 473.5159 517.6892 585.7949 674.0960 1349.6060 1406.0643 1441.9590 1332719 1422558_at 10 43.0 cM chr10:79721002-79722530 10 C1 chr10:79720895-79723713 10 C1 RSQ Mm.7329 NM_010255 1 1 14431 Gamt guanidinoacetate methyltransferase (Gamt), mRNA. Arginine and proline metabolism;; Glycine, serine and threonine metabolism;; Metabolic pathways CLASS Metabolism; Amino Acid Metabolism; Glycine, serine and threonine metabolism [PATH:mmu00260] Metabolism; Amino Acid Metabolism; Arginine and proline metabolism [PATH:mmu00330] creatine biosynthetic process;; guanidinoacetate N-methyltransferase activity;; methyltransferase activity;; organ morphogenesis;; regulation of multicellular organism growth;; spermatogenesis;; transferase activity catalytic activity transferase activity biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; regulation of biological process;; reproduction;; reproductive process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cellular metabolic process;; gamete generation;; multicellular organism growth;; multicellular organismal development;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of growth;; regulation of multicellular organismal process;; reproductive process;; sexual reproduction 36.8026 39.0115 31.9439 34.7910 45.0480 34.5834 2728.9297 2861.6266 105.0458 103.2849 2879.3005 109.6757 72.0823 76.6715 94.1597 73.1061 89.8435 88.0124 1332723 1422562_at 8 D3 chr8:107152017-107152528 8 D3 UG5 Mm.29467 56437 Rrad Ras-related associated with diabetes (Rrad), mRNA calmodulin binding;; GTP binding;; nucleotide binding;; small GTPase mediated signal transduction binding nucleotide binding;; protein binding biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 73.6421 66.5187 60.5837 50.6283 56.7876 51.7154 254.4957 249.7773 60.3312 54.6500 262.9522 47.9001 46.4272 45.4087 46.6956 45.4336 38.7496 33.1057 1332965 1422864_at 16 62.2 cM chr16:92603923-92604494 16 C4 chr16:92601710-92826311 16 C4 RSQ Mm.4081 NM_001111022 4 1 12394 Runx1 runt related transcription factor 1 (Runx1), transcript variant 2, mRNA. Acute myeloid leukemia CLASS Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221] Human Diseases; Cancers; Chronic myeloid leukemia [PATH:mmu05220];; Chronic myeloid leukemia;; Pathways in cancer ATP binding;; behavioral response to pain;; central nervous system development;; definitive hemopoiesis;; DNA binding;; embryonic hemopoiesis;; in utero embryonic development;; liver development;; neuron development;; neuron differentiation;; nucleus;; positive regulation of angiogenesis;; protein binding;; regulation of transcription, DNA-dependent;; response to retinoic acid;; skeletal system development;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; nucleoside binding;; nucleotide binding;; protein binding;; transcription factor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; behavior;; biosynthetic process;; cellular developmental process;; cellular metabolic process;; embryonic development;; immune system development;; macromolecule metabolic process;; multicellular organismal development;; multicellular organismal response to stress;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; response to chemical stimulus;; response to external stimulus;; response to stress 50.0494 37.4260 36.7061 32.5908 39.9413 31.9876 72.8341 113.7913 25.8690 30.4685 99.7284 27.2434 40.8410 22.3955 32.5159 32.7863 33.6534 31.1564 1332966 1422865_at 16 62.2 cM chr16:92601710-92826311 16 C4 RSQ Mm.4081 NM_001111022 4 1 12394 Runx1 runt related transcription factor 1 (Runx1), transcript variant 2, mRNA. Acute myeloid leukemia CLASS Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221] Human Diseases; Cancers; Chronic myeloid leukemia [PATH:mmu05220];; Chronic myeloid leukemia;; Pathways in cancer ATP binding;; behavioral response to pain;; central nervous system development;; definitive hemopoiesis;; DNA binding;; embryonic hemopoiesis;; in utero embryonic development;; liver development;; neuron development;; neuron differentiation;; nucleus;; positive regulation of angiogenesis;; protein binding;; regulation of transcription, DNA-dependent;; response to retinoic acid;; skeletal system development;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; nucleoside binding;; nucleotide binding;; protein binding;; transcription factor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; behavior;; biosynthetic process;; cellular developmental process;; cellular metabolic process;; embryonic development;; immune system development;; macromolecule metabolic process;; multicellular organismal development;; multicellular organismal response to stress;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; response to chemical stimulus;; response to external stimulus;; response to stress 387.8434 392.6048 652.6372 164.1993 162.4652 252.8820 587.2702 627.0421 281.4281 320.4872 634.7980 278.4209 361.6557 207.6187 496.2613 633.7762 831.9966 757.8855 1333142 1423100_at 12 40.0 cM chr12:86817651-86818190 12 D2 chr12:86814850-86818219 12 D2 RSQ Mm.246513 NM_010234 1 1 14281 Fos FBJ osteosarcoma oncogene (Fos), mRNA. B Cell Survival Pathway;; BCR Signaling Pathway;; Cadmium induces DNA synthesis and proliferation in macrophages;; EGF Signaling Pathway;; EPO Signaling Pathway;; Fc Epsilon Receptor I Signaling in Mast Cells;; IGF-1 Signaling Pathway;; IL 2 signaling pathway;; IL 3 signaling pathway;; IL 6 signaling pathway;; IL-2 Receptor Beta Chain in T cell Activation;; Inhibition of Cellular Proliferation by Gleevec;; Insulin Signaling Pathway;; MAPKinase Signaling Pathway;; METS affect on Macrophage Differentiation;; Nerve growth factor pathway (NGF);; Oxidative Stress Induced Gene Expression Via Nrf2;; PDGF Signaling Pathway;; Pertussis toxin-insensitive CCR5 Signaling in Macrophage;; Repression of Pain Sensation by the Transcriptional Regulator DREAM;; Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy;; Signaling Pathway from G-Protein Families;; T Cell Receptor Signaling Pathway;; Toll-Like Receptor Pathway;; TPO Signaling Pathway;; TSP-1 Induced Apoptosis in Microvascular Endothelial Cell B cell receptor signaling pathway;; Colorectal cancer CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Cellular Processes; Immune System; Toll-like receptor signaling pathway [PATH:mmu04620] Cellular Processes; Immune System; T cell receptor signaling pathway [PATH:mmu04660] Cellular Processes; Immune System; B cell receptor signaling;; MAPK signaling pathway;; Pathways in cancer;; T cell receptor signaling pathway;; Toll-like receptor signaling pathway cellular response to extracellular stimulus;; DNA binding;; nervous system development;; nucleus;; nucleus;; nucleus;; positive regulation of transcription from RNA polymerase II promoter;; protein dimerization activity;; regulation of transcription, DNA-dependent;; regulation of transcription, DNA-dependent;; response to drug;; response to protein stimulus;; sequence-specific DNA binding;; transcription factor activity;; transcription factor activity;; transcription factor complex cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity nucleic acid binding;; protein binding;; transcription factor activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; biosynthetic process;; cell communication;; cellular metabolic process;; cellular response to stimulus;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; response to chemical stimulus;; response to external stimulus 30.5858 52.9669 24.7400 43.8570 52.6204 38.2665 1038.9927 993.4050 297.7718 351.5543 1090.4613 347.0248 207.4718 312.4297 215.8886 256.3508 270.4106 278.2632 1344806 1423250_a_at 1 101.5 cM chr1:188449250-188454584 1 H5 chr1:188447064-188529871 1 H5 RSQ Mm.18213 NM_009367 1 1 21808 Tgfb2 transforming growth factor, beta 2 (Tgfb2), mRNA. Cell cycle;; Chronic myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway [PATH:mmu04350] Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu0;; Colorectal cancer;; Cytokine-cytokine receptor interaction;; MAPK signaling pathway;; Pancreatic cancer;; Pathways in cancer;; Renal cell carcinoma;; TGF-beta signaling pathway activation-induced cell death of T cells;; axon;; axon guidance;; blood vessel development;; blood vessel remodeling;; cartilage condensation;; cell growth;; cell proliferation;; cell soma;; dopamine biosynthetic process;; extracellular matrix organization;; extracellular region;; extracellular space;; growth;; growth factor activity;; hair follicle development;; hair follicle morphogenesis;; heart development;; hemopoiesis;; induction of apoptosis;; negative regulation of keratinocyte differentiation;; neuron development;; neuron fate commitment;; pathway-restricted SMAD protein phosphorylation;; positive regulation of cell cycle;; protein binding;; regulation of apoptosis;; skeletal system development;; somatic stem cell division;; transforming growth factor beta receptor binding cell;; cell part;; extracellular region;; extracellular region part cell part;; cell projection;; cell soma;; extracellular region part;; extracellular space binding protein binding biological adhesion;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process alcohol metabolic process;; anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell division;; cell growth;; cell motion;; cell projection organization;; cell proliferation;; cellular component morphogenesis;; cellular developmental process;; cellular metabolic process;; extracellular structure organization;; immune system development;; leukocyte homeostasis;; localization of cell;; macromolecule metabolic process;; molting cycle;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process;; tissue remodeling 45.8718 57.9982 62.7149 55.8175 102.1063 68.3169 1152.7744 1257.5812 596.5964 580.2489 1188.8881 557.7999 623.4348 503.6819 714.1072 857.7630 1299.2639 885.0571 1344811 1423269_a_at 18 chr18:65369304-65372623 18 E1 chr18:65047409-65377480 18 E1 RSQ Mm.98668 NM_001114386 2 1 83814 Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l), transcript variant 1, mRNA. Endocytosis CLASS Genetic Information Processing; Folding, Sorting and Degradation; Ubiquitin mediated proteolysis [PATH:mmu04120] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144];; Ubiquitin mediated proteolysis acid-amino acid ligase activity;; cytoplasm;; intracellular;; ligase activity;; modification-dependent protein catabolic process;; negative regulation of sodium ion transport;; negative regulation of sodium ion transport;; protein binding;; protein modification process;; sodium channel inhibitor activity cell;; cell part cell part;; intracellular;; intracellular part auxiliary transport protein activity;; binding;; catalytic activity channel regulator activity;; ligase activity;; protein binding biological regulation;; cellular process;; establishment of localization;; localization;; metabolic process;; negative regulation of biological process;; regulation of biological process catabolic process;; cellular metabolic process;; establishment of localization;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of transport;; primary metabolic process;; regulation of biological process;; regulation of localization;; transport 78.3211 101.5516 72.1706 92.3712 100.3271 122.7175 573.6519 535.9750 247.1863 267.1123 559.6519 267.9297 225.3732 296.0625 243.7436 299.5894 284.6599 280.9907 1333719 1423835_at 14 A3|14 9.0 cM chr14:22803395-22803774 14 A3 UGA Mm.292401 218820 Zfp503 Zinc finger protein 503 (Zfp503), mRNA intracellular;; metal ion binding;; nucleus;; regulation of transcription, DNA-dependent;; transcription;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding ion binding biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 48.1551 56.9653 44.2522 41.1921 70.2249 56.5030 475.5408 438.8135 189.3307 207.1326 414.0580 182.9776 201.4095 319.5666 222.0233 319.8112 288.9660 279.4301 1333720 1423836_at 14 A3|14 9.0 cM UG5 Mm.292401 218820 Zfp503 Zinc finger protein 503 (Zfp503), mRNA intracellular;; metal ion binding;; nucleus;; regulation of transcription, DNA-dependent;; transcription;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding ion binding biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 72.4751 57.3254 100.6724 66.3773 59.3008 97.5288 359.2630 335.4632 168.5426 158.8153 318.5213 173.1870 499.2630 170.5778 325.4619 297.8810 429.4789 185.5430 1334327 1424615_at 7 E3 chr7:109386887-109386989 7 E3 UGA Mm.302013 233575 Frag1 FGF receptor activating protein 1 (Frag1), mRNA anti-apoptosis;; DNA damage response, signal transduction;; endoplasmic reticulum;; Golgi apparatus;; GPI anchor biosynthetic process;; integral to membrane;; membrane;; nucleus;; protein binding;; response to DNA damage stimulus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding protein binding biological regulation;; cellular process;; death;; developmental process;; metabolic process;; negative regulation of biological process;; regulation of biological process;; response to stimulus biosynthetic process;; cell communication;; cell death;; cellular metabolic process;; cellular response to stimulus;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; organophosphate metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; response to stress 72.5225 79.8201 116.7529 54.1395 70.6199 59.5141 81.1661 92.4310 26.0938 29.8064 80.0747 29.5848 102.6029 29.8331 55.4116 68.6650 81.2033 31.7792 1345166 1424857_a_at 7 chr7:111410157-111410731 7 E3 chr7:111392970-111410753 7 E3 RSQ Mm.326945 NM_030684 1 1 94094 Trim34 tripartite motif-containing 34 (Trim34), mRNA. intracellular;; metal ion binding;; protein binding;; zinc ion binding cell;; cell part cell part;; intracellular binding ion binding;; protein binding 93.7954 103.1435 120.3654 100.6305 118.1854 90.4441 489.8741 531.3741 232.4833 188.1905 449.5627 180.6749 188.3757 146.9147 177.8221 146.8204 163.7786 190.4401 1334833 1425351_at 2 chr2:151935679-151936227 2 G3 chr2:151931465-151937089 2 G3 RSQ Mm.218639 NM_029688 1 1 76650 Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) (Srxn1), mRNA. antioxidant activity;; ATP binding;; cytoplasm;; cytosol;; magnesium ion binding;; nucleotide binding;; oxidation reduction;; oxidoreductase activity;; response to oxidative stress;; sulfiredoxin activity cell;; cell part cell part;; intracellular;; intracellular part antioxidant activity;; binding;; catalytic activity ion binding;; nucleoside binding;; nucleotide binding;; oxidoreductase activity metabolic process;; response to stimulus oxidation reduction;; response to chemical stimulus;; response to stress 241.2972 253.9852 275.1031 228.6464 185.7103 242.6804 2348.5110 2284.7302 476.8720 418.9297 2262.4852 430.5461 372.0408 365.2395 501.1094 298.5240 403.2400 434.4057 1345965 1426875_s_at 2 chr2:151936530-151936918 2 G3 chr2:151931465-151937089 2 G3 RSQ Mm.218639 NM_029688 1 1 76650 Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) (Srxn1), mRNA. antioxidant activity;; ATP binding;; cytoplasm;; cytosol;; magnesium ion binding;; nucleotide binding;; oxidation reduction;; oxidoreductase activity;; response to oxidative stress;; sulfiredoxin activity cell;; cell part cell part;; intracellular;; intracellular part antioxidant activity;; binding;; catalytic activity ion binding;; nucleoside binding;; nucleotide binding;; oxidoreductase activity metabolic process;; response to stimulus oxidation reduction;; response to chemical stimulus;; response to stress 258.7929 189.7630 205.2907 144.1863 144.0992 146.3564 824.8623 881.4139 389.4293 438.4977 880.7285 454.6771 284.3186 311.7026 343.2075 275.9297 305.0408 210.5749 1335747 1426900_at 10 chr10:66718474-66719018 10 B5.1 chr10:66590005-66719074 10 B5.1 RSQ NM_207221 1 1 108829 Jmjd1c jumonji domain containing 1C (Jmjd1c), mRNA. chromatin modification;; iron ion binding;; metal ion binding;; nucleus;; oxidation reduction;; oxidoreductase activity;; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;; regulation of transcription, DNA-dependent;; transcription;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; catalytic activity ion binding;; oxidoreductase activity biological regulation;; cellular component organization;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; organelle organization;; oxidation reduction;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 68.3817 75.7531 70.7989 77.5854 61.9560 63.0952 216.9852 218.3053 84.5870 97.1554 220.3186 103.2695 118.1407 96.8461 127.1373 109.6967 105.6673 104.8300 1336880 1429033_at 6 chr6:28366904-28367275 6 A3.3 chr6:28366690-28371724 6 A3.3 RSQ Mm.332950 NM_028900 1 1 74375 Gcc1 golgi coiled coil 1 (Gcc1), mRNA. cytoplasm;; Golgi apparatus;; membrane cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane-bounded organelle 126.0769 154.8025 157.0144 165.7961 185.6361 131.9556 502.5408 505.8241 233.3687 203.4130 461.3280 212.4986 519.5960 494.7121 413.1456 554.3083 596.5308 518.3302 1346671 1431469_a_at 18 chr18:36018867-36020465 18 B2 chr18:35989471-36021342 18 B2 RSQ Mm.94560 NM_133687 1 1 67393 Cxxc5 CXXC finger 5 (Cxxc5), mRNA. cytoplasm;; DNA binding;; metal ion binding;; nucleus;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding ion binding;; nucleic acid binding 64.9313 51.3365 54.3049 46.3284 66.6448 65.4937 548.4110 562.9852 173.7850 186.0676 567.2907 176.3957 286.6712 337.7839 299.8345 344.3611 319.6608 266.6235 1337282 1433575_at 13 chr13:29041009-29041491 13 A3.1 UGA Mm.455819 Transcribed locus, strongly similar to NP_033264.2 SRY-box containing gene 4 [Mus musculus] 69.0613 54.7757 79.8890 41.0723 28.3100 64.5118 964.1025 891.5964 264.1499 251.8186 967.6248 260.8223 183.2523 248.0304 215.4297 263.7380 272.2267 230.5185 1337418 1434025_at 14 chr14:99713709-99714191 14 E2.2 UGA Mm.441332 Transcribed locus 13336.5696 13691.0964 14106.8327 15429.4706 15637.5408 16432.8785 533.5974 489.0088 247.8597 273.8260 539.4488 249.0817 183.0323 185.6627 160.0508 174.5533 198.2024 154.3803 1347098 1434773_a_at 4 52.0 cM chr4:118809715-118809927 4 D2.1 chr4:118781349-118809935 4 D2.1 RSQ Mm.21002 NM_011400 1 1 20525 RP23-344D2.2 Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 (Slc2a1), mRNA. Vitamin C in the Brain Adipocytokine signaling pathway;; Pathways in cancer;; Renal cell carcinoma CLASS Cellular Processes; Endocrine System; Adipocytokine signaling pathway [PATH:mmu04920] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Renal cell carcinoma [PATH:mmu05211] basolateral plasma membrane;; carbohydrate transport;; cytoplasm;; glucose transmembrane transporter activity;; glucose transport;; integral to membrane;; intracellular;; membrane;; plasma membrane;; protein binding;; substrate-specific transmembrane transporter activity;; sugar:hydrogen symporter activity;; transmembrane transport;; transport;; transporter activity cell;; cell part cell part;; intracellular;; intracellular part;; membrane;; membrane part binding;; transporter activity protein binding;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization establishment of localization;; transmembrane transport;; transport 1940.5295 1857.2588 1995.7352 1046.5408 924.9715 1194.3566 3396.0841 3344.4747 607.3380 666.1293 3253.4297 620.1634 1937.2358 1153.9852 1051.9975 2594.0235 3370.5477 2549.9669 1347930 1438855_x_at 12 56.0 cM chr12:112692993-112693192 12 F1 IPA Tnfaip2 tumor necrosis factor, alpha-induced protein 2 283.1711 188.8646 206.2546 176.7213 152.1201 191.0621 1031.9227 1059.9033 475.4297 411.3906 1031.4726 424.1817 439.5980 460.4725 424.3343 428.3029 427.6436 395.6834 1338758 1448199_at 8 chr8:11611781-11612172 8 A1.1 chr8:11611582-11635689 8 A1.1 RSQ Mm.12459 NM_133971 1 1 102334 Ankrd10 ankyrin repeat domain 10 (Ankrd10), mRNA. 3681.5429 3601.3019 3294.2607 2269.3582 2323.6005 2945.9026 4229.9804 4101.1907 751.5744 789.5818 3888.3464 784.9710 671.4587 576.7557 781.9805 722.9115 1312.3741 874.7988 1338812 1448272_at 1 71.0 cM chr1:135972093-135972484 1 E4 chr1:135971441-135975732 1 E4 RSQ Mm.392646 NM_007570 1 1 12227 Btg2 B-cell translocation gene 2, anti-proliferative (Btg2), mRNA. BTG family proteins and cell cycle regulation anterior/posterior pattern formation;; negative regulation of apoptosis;; neuron differentiation;; protein amino acid methylation;; protein binding;; regulation of transcription, DNA-dependent;; response to DNA damage stimulus;; transcription binding protein binding biological regulation;; cellular process;; death;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; biosynthetic process;; cell death;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; pattern specification process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; response to stress 15.3995 15.2600 17.2604 16.6503 14.7459 14.5189 29.7899 26.8275 14.7072 17.4374 42.2828 16.3057 17.6800 20.0860 18.1564 22.1579 22.1939 22.4371 1348199 1448301_s_at 13 12.0 cM chr13:32933960-32943054 13 A3.2 RSQ Mm.20144 NM_025429 1 1 66222 RP23-427P14.4 Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a (Serpinb1a), mRNA. cytoplasm;; endopeptidase inhibitor activity;; regulation of protein catabolic process;; serine-type endopeptidase inhibitor activity cell;; cell part cell part;; intracellular;; intracellular part enzyme regulator activity enzyme inhibitor activity biological regulation;; metabolic process;; regulation of biological process catabolic process;; macromolecule metabolic process;; primary metabolic process;; regulation of biological process;; regulation of metabolic process 126.3926 107.3345 130.0289 82.6578 89.9170 97.4635 639.9896 589.0408 170.9235 152.1751 676.0721 144.0514 146.1972 101.1525 133.2009 143.7794 116.8419 143.0304 1338857 1448328_at 5 chr5:34905699-34906233 5 B2 chr5:34892336-34906288 5 B2 RSQ Mm.5012 NM_001136088 4 1 24055 Sh3bp2 SH3-domain binding protein 2 (Sh3bp2), transcript variant d, mRNA. Natural killer cell mediated cytotoxicity CLASS Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] protein binding;; SH3 domain binding binding protein binding 21.8832 20.9009 34.8389 21.1226 28.7822 27.8114 1709.4891 1715.6037 665.8675 653.2635 1689.0408 647.8035 773.4528 606.3355 755.8846 614.3341 808.7623 584.2388 1339017 1448529_at 2 84.0 cM chr2:148230231-148230761 2 G3 chr2:148230206-148233924 2 G3 RSQ Mm.24096 NM_009378 1 1 21824 RP23-70N3.2 Thbd thrombomodulin (Thbd), mRNA. Complement and coagulation cascades CLASS Cellular Processes; Immune System; Complement and coagulation cascades [PATH:mmu04610] binding;; blood coagulation;; calcium ion binding;; embryonic development;; female pregnancy;; integral to membrane;; membrane;; negative regulation of coagulation;; plasma membrane;; receptor activity cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity ion binding;; signal transducer activity biological regulation;; developmental process;; multi-organism process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus coagulation;; embryonic development;; female pregnancy;; multicellular organismal development;; negative regulation of biological process;; negative regulation of multicellular organismal process;; regulation of biological process;; regulation of biological quality;; regulation of body fluid levels;; regulation of multicellular organismal process;; reproductive process;; response to external stimulus;; response to stress 199.1057 232.8577 171.3741 182.0050 283.5341 142.4327 774.6110 780.8944 415.2784 347.3741 781.1279 359.5941 721.6461 704.6519 597.8448 881.8391 940.8186 745.1499 1339375 1448960_at 18 chr18:36020796-36021211 18 B2 chr18:35989471-36021342 18 B2 RSQ Mm.94560 NM_133687 1 1 67393 Cxxc5 CXXC finger 5 (Cxxc5), mRNA. cytoplasm;; DNA binding;; metal ion binding;; nucleus;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding ion binding;; nucleic acid binding 149.8091 168.3629 151.8444 173.8040 170.0663 131.0352 5293.7720 5588.1837 2723.6911 2687.9347 5506.6385 2686.9769 1663.9508 1535.2982 1763.5608 1854.0559 2458.4886 1991.9136 1339463 1449073_at 6 8.5 cM chr6:29411311-29411636 6 A3.3 chr6:29383152-29411888 6 A3.3 RSQ Mm.39046 NM_001081185 1 1 68794 Flnc filamin C, gamma (Flnc), mRNA. Focal adhesion CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Cellular Processes; Cell Communication; Focal adhesion [PATH:mmu04510];; MAPK signaling pathway actin binding;; actin cytoskeleton;; actin filament-based process;; cytoplasm;; cytoskeleton;; membrane;; muscle fiber development cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; non-membrane-bounded organelle binding protein binding cellular process;; developmental process;; multicellular organismal process actin filament-based process;; anatomical structure development;; cellular developmental process;; multicellular organismal development 100.1828 102.3653 119.3668 101.7410 108.5241 125.9359 780.2635 668.3992 215.9840 229.7588 692.9613 214.4440 125.9893 181.2372 249.4372 256.3480 266.2402 213.4880 1339561 1449188_at 10 chr10:79620535-79621046 10 C1 chr10:79611034-79621112 10 C1 RSQ Mm.143813 NM_021565 1 1 59090 Midn midnolin (Midn), mRNA. nucleolus;; nucleus cell;; cell part;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; non-membrane-bounded organelle;; organelle lumen;; organelle part 187.3361 236.7103 284.8186 222.6017 221.7619 173.2208 2059.0425 2041.1732 432.2075 397.1113 1989.7122 428.8662 293.0243 405.6677 510.0572 329.2998 907.7075 586.1713 1339701 1449363_at 1 103.2 cM chr1:192994277-192994768 1 H6 chr1:192994174-193007212 1 H6 RSQ Mm.2706 NM_007498 1 1 11910 Atf3 activating transcription factor 3 (Atf3), mRNA. DNA binding;; gluconeogenesis;; nucleus;; protein dimerization activity;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; transcription;; transcription factor activity;; transcription factor complex;; transcription repressor activity cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity nucleic acid binding;; protein binding;; transcription factor activity;; transcription repressor activity biological regulation;; cellular process;; metabolic process;; regulation of biological process alcohol metabolic process;; biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 86.7903 85.9943 106.6160 99.2313 96.7008 68.6743 793.5231 775.6884 316.7158 339.4873 828.7525 360.0368 367.3348 354.7348 379.7472 406.8015 482.2134 393.4220 1339763 1449433_at 11 B5 chr11:72985602-72986081 11 B4 UGA Mm.156893 94045 RP23-263M10.2 P2rx5 Purinergic receptor P2X, ligand-gated ion channel, 5 (P2rx5), mRNA Calcium signaling pathway;; Neuroactive ligand-receptor interaction CLASS Environmental Information Processing; Signal Transduction; Calcium signaling pathway [PATH:mmu04020] Environmental Information Processing; Signaling Molecules and Interaction; Neuroactive ligand-receptor interaction [PATH:mmu04080] ATP-gated cation channel activity;; cell surface receptor linked signal transduction;; integral to membrane;; integral to plasma membrane;; ion channel activity;; ion transport;; receptor activity;; transport cell;; cell part cell part;; membrane;; membrane part molecular transducer activity;; transporter activity signal transducer activity;; substrate-specific transporter activity;; transmembrane transporter activity biological regulation;; cellular process;; establishment of localization;; localization;; regulation of biological process cell communication;; establishment of localization;; regulation of biological process;; regulation of cellular process;; transport 2086.4922 2226.2006 2350.4653 2403.8186 2334.4604 2586.7770 1441.2160 1450.5048 700.1195 685.0384 1459.3252 707.7250 300.1185 337.7652 297.3741 419.6539 284.7226 238.2511 1339832 1449519_at 6 chr6:66985453-66985671 6 C1 chr6:66985089-66987401 6 C1 RSQ Mm.389750 NM_007836 1 1 13197 Gadd45a growth arrest and DNA-damage-inducible 45 alpha (Gadd45a), mRNA. ATM Signaling Pathway;; Cell Cycle: G2/M Checkpoint;; p53 Signaling Pathway Cell cycle;; MAPK signaling pathway;; p53 signaling pathway CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Cellular Processes; Cell Growth and Death; Cell cycle [PATH:mmu04110] Cellular Processes; Cell Growth and Death; p53 signaling pathway [PATH:mmu04115] cell cycle;; cell cycle arrest;; centrosome cycle;; negative regulation of protein kinase activity;; nucleus;; protein binding;; regulation of cell cycle;; response to DNA damage stimulus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding protein binding biological regulation;; cellular component organization;; cellular process;; metabolic process;; regulation of biological process;; response to stimulus cell cycle;; cell cycle process;; cellular metabolic process;; microtubule-based process;; organelle organization;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; regulation of molecular function;; response to stress 163.9360 153.6870 172.3335 143.5078 126.6825 193.2007 884.7538 894.2427 446.4948 424.1280 905.2729 432.2580 461.5324 425.3228 425.1778 533.3548 445.4728 449.5408 1348500 1449852_a_at 2 chr2:119915222-119980311 2 E5 RSQ Mm.132226 NM_133838 1 1 98878 RP23-348L16.8 Ehd4 EH-domain containing 4 (Ehd4), mRNA. Endocytosis CLASS Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] ATP binding;; calcium ion binding;; endosome;; GTP binding;; GTPase activity;; membrane;; nucleotide binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane-bounded organelle binding;; catalytic activity hydrolase activity;; ion binding;; nucleoside binding;; nucleotide binding 20.4229 17.9741 17.2063 23.5891 21.1161 20.8167 40.5499 57.1793 18.7394 19.8731 33.6230 17.0824 13.5026 13.0007 14.6378 15.0211 16.1647 18.6145 1340126 1449984_at 5 E1|5 51.0 cM UGA Mm.4979 20310 Cxcl2 Chemokine (C-X-C motif) ligand 2 (Cxcl2), mRNA Chemokine signaling pathway CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] Cellular Processes; Immune System; Chemokine signaling pathway [PATH:mmu04062];; Cytokine-cytokine receptor interaction chemokine activity;; chemotaxis;; cytokine activity;; extracellular region;; extracellular space;; immune response;; inflammatory response extracellular region;; extracellular region part extracellular region part;; extracellular space binding protein binding immune system process;; locomotion;; response to stimulus behavior;; immune response;; response to chemical stimulus;; response to external stimulus;; response to stress;; taxis 138.3914 144.3297 176.2277 148.0226 176.4317 142.9258 405.0296 451.2680 157.1633 164.0247 397.8170 167.1677 218.2075 134.3381 114.9569 315.7167 362.3709 375.1926 1348663 1450387_s_at 4 47.6 cM chr4:101139123-101139504 4 C6 chr4:101092363-101139600 4 C6 RSQ Mm.42040 NM_009647 2 2 11639 RP23-301M3.3 Ak3l1 adenylate kinase 3-like 1 (Ak3l1), nuclear gene encoding mitochondrial protein, mRNA. Metabolic pathways CLASS Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:mmu00230];; Purine metabolism adenylate kinase activity;; ATP binding;; GTP binding;; kinase activity;; mitochondrion;; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;; nucleobase, nucleoside, nucleotide kinase activity;; nucleotide binding;; nucleotide kinase activity;; phosphotransferase activity, phosphate group as acceptor;; transferase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; catalytic activity nucleoside binding;; nucleotide binding;; transferase activity cellular process;; metabolic process cellular metabolic process;; nitrogen compound metabolic process;; primary metabolic process 48.2518 57.5122 45.9360 67.7827 61.5466 74.4156 213.8440 205.5096 122.2039 95.8878 223.6587 83.7410 186.8965 134.5573 201.0623 225.5720 235.0632 208.5767 1340425 1450413_at 15 46.8 cM chr15:79826303-79845238 15 E1 RSQ Mm.144089 NM_011057 1 1 18591 Pdgfb platelet derived growth factor, B polypeptide (Pdgfb), mRNA. Transcriptional activation of dbpb from mRNA Cytokine-cytokine receptor interaction;; Focal adhesion;; Gap junction;; Glioma;; MAPK signaling pathway;; Melanoma CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] Cellular Processes; Cell Motility; Regulation of actin cytoskeleton [PATH:mmu04810] Cellular Processes; Cell Com;; Pathways in cancer;; Prostate cancer;; Regulation of actin cytoskeleton;; Renal cell carcinoma actin cytoskeleton organization;; branching involved in salivary gland morphogenesis;; cell projection assembly;; cell proliferation;; collagen binding;; epithelial cell proliferation involved in salivary gland morphogenesis;; extracellular region;; growth factor activity;; membrane;; negative regulation of cell migration;; positive regulation of endothelial cell proliferation;; positive regulation of fibroblast growth factor receptor signaling pathway;; regulation of peptidyl-tyrosine phosphorylation;; substrate-bound cell migration cell;; cell part;; extracellular region cell part;; membrane binding protein binding anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; developmental process;; localization;; locomotion;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process actin filament-based process;; anatomical structure development;; anatomical structure morphogenesis;; cell communication;; cell motility;; cell motion;; cell projection organization;; cell proliferation;; cellular component assembly;; cellular metabolic process;; localization of cell;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; organelle organization;; positive regulation of biological process;; positive regulation of cellular process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of localization;; regulation of locomotion;; regulation of metabolic process 225.1010 304.8633 226.5616 260.5595 340.0900 250.4133 714.1649 737.7814 267.9678 265.8354 749.2230 292.3871 561.1455 363.7501 455.3950 690.0399 661.1091 570.6475 1340426 1450414_at 15 46.8 cM chr15:79826551-79826877 15 E1 chr15:79826303-79845238 15 E1 RSQ Mm.144089 NM_011057 1 1 18591 Pdgfb platelet derived growth factor, B polypeptide (Pdgfb), mRNA. Transcriptional activation of dbpb from mRNA Cytokine-cytokine receptor interaction;; Focal adhesion;; Gap junction;; Glioma;; MAPK signaling pathway;; Melanoma CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] Cellular Processes; Cell Motility; Regulation of actin cytoskeleton [PATH:mmu04810] Cellular Processes; Cell Com;; Pathways in cancer;; Prostate cancer;; Regulation of actin cytoskeleton;; Renal cell carcinoma actin cytoskeleton organization;; branching involved in salivary gland morphogenesis;; cell projection assembly;; cell proliferation;; collagen binding;; epithelial cell proliferation involved in salivary gland morphogenesis;; extracellular region;; growth factor activity;; membrane;; negative regulation of cell migration;; positive regulation of endothelial cell proliferation;; positive regulation of fibroblast growth factor receptor signaling pathway;; regulation of peptidyl-tyrosine phosphorylation;; substrate-bound cell migration cell;; cell part;; extracellular region cell part;; membrane binding protein binding anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; developmental process;; localization;; locomotion;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process actin filament-based process;; anatomical structure development;; anatomical structure morphogenesis;; cell communication;; cell motility;; cell motion;; cell projection organization;; cell proliferation;; cellular component assembly;; cellular metabolic process;; localization of cell;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; organelle organization;; positive regulation of biological process;; positive regulation of cellular process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of localization;; regulation of locomotion;; regulation of metabolic process 240.8982 285.0826 215.2245 298.3130 300.1510 231.5983 358.2277 371.8831 119.9162 129.2152 344.6403 95.1542 137.7630 99.5618 107.4891 101.7634 102.7790 125.7799 1340635 1450698_at 2 chr2:127163556-127163826 2 F1 chr2:127161894-127164113 2 F1 RSQ Mm.4729 NM_010090 1 1 13537 RP23-206D14.6 Dusp2 dual specificity phosphatase 2 (Dusp2), mRNA. Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases MAPK signaling pathway CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] dephosphorylation;; hydrolase activity;; MAP kinase tyrosine/serine/threonine phosphatase activity;; mitogen-activated protein kinase binding;; nucleus;; phosphatase activity;; phosphoprotein phosphatase activity;; protein amino acid dephosphorylation;; protein tyrosine phosphatase activity;; protein tyrosine/serine/threonine phosphatase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; catalytic activity hydrolase activity;; protein binding cellular process;; metabolic process cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 74.9699 82.2538 85.5747 73.8890 104.2891 89.7941 1411.9536 1425.8560 514.0150 493.8949 1435.1444 460.5803 459.4852 349.8540 403.7416 462.7012 460.5133 568.4920 1340651 1450716_at 16 53.4 cM chr16:85794592-85794942 16 C3.3 chr16:85794071-85803360 16 C3.3 RSQ Mm.1421 NM_009621 1 1 11504 Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 (Adamts1), mRNA. basement membrane;; cytoplasmic vesicle;; extracellular matrix;; extracellular region;; heart trabecula formation;; heparin binding;; hydrolase activity;; kidney development;; metal ion binding;; metalloendopeptidase activity;; metalloendopeptidase activity;; metalloendopeptidase activity;; metallopeptidase activity;; negative regulation of angiogenesis;; ovulation from ovarian follicle;; peptidase activity;; protein binding;; proteinaceous extracellular matrix;; proteolysis;; zinc ion binding cell;; cell part;; extracellular region;; extracellular region part;; organelle cell part;; extracellular matrix;; extracellular matrix part;; extracellular region part;; intracellular;; intracellular organelle;; intracellular part;; vesicle binding;; catalytic activity carbohydrate binding;; hydrolase activity;; ion binding;; pattern binding;; protein binding anatomical structure formation;; biological regulation;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; rhythmic process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; catabolic process;; gamete generation;; macromolecule metabolic process;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of developmental process;; ovulation cycle;; ovulation cycle process;; primary metabolic process;; regulation of biological process;; regulation of developmental process;; regulation of multicellular organismal process;; reproductive developmental process;; reproductive process;; reproductive process in a multicellular organism;; sexual reproduction 179.9260 163.5532 170.0524 205.4264 197.4873 158.1706 647.2192 579.5104 198.7296 227.3866 701.8720 220.6812 178.9236 220.2075 184.2630 188.9717 183.5334 181.4054 1348775 1450826_a_at 7 23.5 cM chr7:53967388-53967984 7 B4 chr7:53967367-53971046 7 B4 RSQ Mm.14277 NM_011315 1 1 20210 Saa3 serum amyloid A 3 (Saa3), mRNA. acute-phase response;; extracellular region;; high-density lipoprotein particle extracellular region;; extracellular region part;; macromolecular complex extracellular region part;; extracellular space;; plasma lipoprotein particle;; protein-lipid complex response to stimulus response to external stimulus;; response to stress 32.3186 35.6890 37.4516 36.8118 55.5847 29.7553 627.2333 643.6571 146.3624 186.1569 628.5221 160.6176 123.8658 199.3186 150.6199 191.6381 211.9297 180.3432 1348802 1450922_a_at 1 101.5 cM chr1:188448391-188448651 1 H5 chr1:188447064-188529871 1 H5 RSQ Mm.18213 NM_009367 1 1 21808 Tgfb2 transforming growth factor, beta 2 (Tgfb2), mRNA. Cell cycle;; Chronic myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway [PATH:mmu04350] Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu0;; Colorectal cancer;; Cytokine-cytokine receptor interaction;; MAPK signaling pathway;; Pancreatic cancer;; Pathways in cancer;; Renal cell carcinoma;; TGF-beta signaling pathway activation-induced cell death of T cells;; axon;; axon guidance;; blood vessel development;; blood vessel remodeling;; cartilage condensation;; cell growth;; cell proliferation;; cell soma;; dopamine biosynthetic process;; extracellular matrix organization;; extracellular region;; extracellular space;; growth;; growth factor activity;; hair follicle development;; hair follicle morphogenesis;; heart development;; hemopoiesis;; induction of apoptosis;; negative regulation of keratinocyte differentiation;; neuron development;; neuron fate commitment;; pathway-restricted SMAD protein phosphorylation;; positive regulation of cell cycle;; protein binding;; regulation of apoptosis;; skeletal system development;; somatic stem cell division;; transforming growth factor beta receptor binding cell;; cell part;; extracellular region;; extracellular region part cell part;; cell projection;; cell soma;; extracellular region part;; extracellular space binding protein binding biological adhesion;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process alcohol metabolic process;; anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell division;; cell growth;; cell motion;; cell projection organization;; cell proliferation;; cellular component morphogenesis;; cellular developmental process;; cellular metabolic process;; extracellular structure organization;; immune system development;; leukocyte homeostasis;; localization of cell;; macromolecule metabolic process;; molting cycle;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process;; tissue remodeling 23.3814 30.9604 31.8256 34.3968 26.9039 29.5003 301.1696 351.7740 142.8969 148.5418 350.3053 142.5996 100.5343 146.2188 126.5967 129.8592 139.3636 145.2075 1340805 1450923_at 1 101.5 cM chr1:188447467-188447940 1 H5 chr1:188447064-188529871 1 H5 RSQ Mm.18213 NM_009367 1 1 21808 Tgfb2 transforming growth factor, beta 2 (Tgfb2), mRNA. Cell cycle;; Chronic myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway [PATH:mmu04350] Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu0;; Colorectal cancer;; Cytokine-cytokine receptor interaction;; MAPK signaling pathway;; Pancreatic cancer;; Pathways in cancer;; Renal cell carcinoma;; TGF-beta signaling pathway activation-induced cell death of T cells;; axon;; axon guidance;; blood vessel development;; blood vessel remodeling;; cartilage condensation;; cell growth;; cell proliferation;; cell soma;; dopamine biosynthetic process;; extracellular matrix organization;; extracellular region;; extracellular space;; growth;; growth factor activity;; hair follicle development;; hair follicle morphogenesis;; heart development;; hemopoiesis;; induction of apoptosis;; negative regulation of keratinocyte differentiation;; neuron development;; neuron fate commitment;; pathway-restricted SMAD protein phosphorylation;; positive regulation of cell cycle;; protein binding;; regulation of apoptosis;; skeletal system development;; somatic stem cell division;; transforming growth factor beta receptor binding cell;; cell part;; extracellular region;; extracellular region part cell part;; cell projection;; cell soma;; extracellular region part;; extracellular space binding protein binding biological adhesion;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process alcohol metabolic process;; anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell division;; cell growth;; cell motion;; cell projection organization;; cell proliferation;; cellular component morphogenesis;; cellular developmental process;; cellular metabolic process;; extracellular structure organization;; immune system development;; leukocyte homeostasis;; localization of cell;; macromolecule metabolic process;; molting cycle;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process;; tissue remodeling 117.7246 111.5530 174.8044 123.2636 111.0290 114.5969 1911.5043 1968.7630 646.5049 652.4852 1895.6206 628.8909 389.9490 487.6805 425.8164 490.9640 531.4408 556.4862 1348818 1451021_a_at 14 chr14:99701186-99702697 14 E2.2 chr14:99697909-99712631 14 E2.2 RSQ Mm.30262 NM_009769 1 1 12224 Klf5 Kruppel-like factor 5 (Klf5), mRNA. angiogenesis;; DNA binding;; DNA binding;; intracellular;; metal ion binding;; microvillus assembly;; nucleic acid binding;; nucleus;; positive regulation of transcription;; protein binding;; regulation of transcription, DNA-dependent;; transcription;; transcription factor activity;; transcription factor activity;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity ion binding;; nucleic acid binding;; protein binding;; transcription factor activity anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; biosynthetic process;; cell projection organization;; cellular component assembly;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 87.2932 98.6059 104.5640 96.9999 113.8648 83.4396 1140.7718 1061.0782 496.5102 551.8252 1070.2930 539.2844 591.9750 511.4956 565.9577 616.1417 640.4331 588.2791 1341053 1451264_at 12 chr12:72002571-72003037 12 C3 chr12:71926500-72003221 12 C3 RSQ Mm.2962 NM_028127 1 1 319710 Frmd6 FERM domain containing 6 (Frmd6), mRNA. binding;; cytoplasm;; cytoskeleton;; membrane;; plasma membrane cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; non-membrane-bounded organelle binding 61.3686 58.2960 51.6118 49.0922 59.0973 61.7359 130.0492 131.6540 51.8906 62.8610 106.4405 64.9589 57.4229 67.2280 59.0973 74.3495 65.1570 75.4760 1341254 1451538_at 11 69.5 cM chr11:112646659-112647196 11 E2 chr11:112643523-112649071 11 E2 RSQ Mm.286407 NM_011448 1 1 20682 RP23-36D5.1 Sox9 SRY-box containing gene 9 (Sox9), mRNA. cartilage condensation;; cartilage development;; cell differentiation;; cell fate commitment;; cell fate specification;; DNA binding;; endochondral bone morphogenesis;; epithelial cell proliferation involved in prostatic bud elongation;; epithelial to mesenchymal transition;; hair follicle development;; heart development;; male germ-line sex determination;; male gonad development;; male sex determination;; negative regulation of bone mineralization;; negative regulation of chondrocyte differentiation;; negative regulation of transcription, DNA-dependent;; neural crest cell development;; nucleus;; positive regulation of transcription from RNA polymerase II promoter;; positive regulation of transcription from RNA polymerase II promoter;; prostate gland morphogenesis;; protein binding;; regulation of apoptosis;; regulation of cell proliferation;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; transcription;; transcription activator activity;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; protein binding;; transcription activator activity;; transcription factor activity biological adhesion;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell adhesion;; cell death;; cell proliferation;; cellular component morphogenesis;; cellular developmental process;; cellular metabolic process;; developmental growth;; macromolecule metabolic process;; molting cycle;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; negative regulation of metabolic process;; negative regulation of multicellular organismal process;; nitrogen compound metabolic process;; ossification;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; reproductive developmental process;; reproductive process;; tissue remodeling 171.3843 350.6214 304.9308 139.6874 165.4960 147.2833 491.4297 469.7440 200.9062 245.3227 450.4501 241.3579 51.8993 43.7403 53.0672 58.3130 60.2290 52.2288 1341305 1451612_at 8 C5|8 45.0 cM chr8:96703143-96703979 8 C5 UGA Mm.192991 17748 Mt1 Metallothionein 1, mRNA (cDNA clone MGC:47147 IMAGE:4990006) cellular metal ion homeostasis;; cellular zinc ion homeostasis;; copper ion binding;; cytosol;; detoxification of copper ion;; lysosome;; metal ion binding;; nitric oxide mediated signal transduction;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding ion binding biological regulation;; cellular process;; regulation of biological process;; response to stimulus cell communication;; cellular homeostasis;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; response to chemical stimulus 66.1253 91.6568 119.0715 40.9817 73.5519 22.5173 403.4822 430.6428 206.4480 192.5464 413.8841 205.5454 124.7292 134.0040 115.0063 137.4298 156.3615 151.3066 1341319 1451634_at 17 7.36 cM chr17:13007636-13008080 17 A1 chr17:12934176-13008423 17 A1 RSQ NR_002853 2 1 104103 Airn antisense Igf2r RNA (Airn), transcript variant 1, non-coding RNA. genetic imprinting biological regulation;; cellular process;; metabolic process;; regulation of biological process cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of metabolic process 497.5964 483.9577 657.9760 542.6473 458.4137 428.6389 4180.2906 4203.4998 981.1130 911.4083 4195.7075 951.8186 796.5192 656.3186 907.1161 582.9237 744.5343 839.1176 1341347 1451680_at 2 chr2:151935283-151935614 2 G3 chr2:151931465-151937089 2 G3 RSQ Mm.218639 NM_029688 1 1 76650 Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) (Srxn1), mRNA. antioxidant activity;; ATP binding;; cytoplasm;; cytosol;; magnesium ion binding;; nucleotide binding;; oxidation reduction;; oxidoreductase activity;; response to oxidative stress;; sulfiredoxin activity cell;; cell part cell part;; intracellular;; intracellular part antioxidant activity;; binding;; catalytic activity ion binding;; nucleoside binding;; nucleotide binding;; oxidoreductase activity metabolic process;; response to stimulus oxidation reduction;; response to chemical stimulus;; response to stress 29.0020 18.8280 18.9560 20.9392 22.3075 21.3986 94.6380 103.1296 37.4327 42.5624 95.0330 46.4850 58.6847 119.5754 71.5862 75.6753 140.5655 24.2559 1342006 1452677_at 11 A4 UGA Mm.211131 71701 RP23-313I4.2 Pnpt1 Polynucleotide phosphorylase-like protein (PNPASE gene) Purine metabolism;; Pyrimidine metabolism CLASS Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:mmu00230] Metabolism; Nucleotide Metabolism; Pyrimidine metabolism [PATH:mmu00240] mitochondrial intermembrane space cell;; cell part;; envelope;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle envelope;; organelle envelope lumen;; organelle part 22.6423 20.6528 36.1766 242.2528 152.9323 183.5801 3532.9631 3291.2873 758.4727 901.1034 3378.5646 879.0435 175.8772 212.4538 268.9634 380.5947 288.2147 403.0422 1349775 1455899_x_at 11 chr11:117827463-117827587 11 E2 chr11:117827392-117830476 11 E2 RSQ Mm.3468 NM_007707 1 1 12702 RP23-268N22.6 Socs3 suppressor of cytokine signaling 3 (Socs3), mRNA. IL-2 Receptor Beta Chain in T cell Activation;; IL22 Soluble Receptor Signaling Pathway Adipocytokine signaling pathway;; Insulin signaling pathway;; Jak-STAT signaling pathway;; Type II diabetes mellitus CLASS Genetic Information Processing; Folding, Sorting and Degradation; Ubiquitin mediated proteolysis [PATH:mmu04120] Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] Cellular Processes; Endocrin;; Ubiquitin mediated proteolysis branching involved in embryonic placenta morphogenesis;; intracellular signaling cascade;; modification-dependent protein catabolic process;; negative regulation of insulin receptor signaling pathway;; negative regulation of signal transduction;; placenta blood vessel development;; positive regulation of cell differentiation;; positive regulation of cell differentiation;; protein binding;; regulation of cell differentiation;; regulation of cell differentiation;; regulation of growth;; regulation of protein amino acid phosphorylation;; spongiotrophoblast differentiation;; spongiotrophoblast differentiation;; trophoblast giant cell differentiation;; trophoblast giant cell differentiation binding protein binding biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; catabolic process;; cell communication;; cellular developmental process;; cellular metabolic process;; cellular response to stimulus;; embryonic development;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of response to stimulus;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of metabolic process;; regulation of response to stimulus;; response to chemical stimulus;; response to endogenous stimulus 48.9595 27.6735 54.1104 297.7746 226.1876 240.6310 2547.2819 2516.3176 501.8186 599.3431 2565.6128 644.3749 154.3001 149.3006 177.7507 288.0805 200.8621 249.8199 1349871 1456212_x_at 11 E2 chr11:117827490-117827770 11 E2 IPA Mm.3468 Socs3 Suppressor of cytokine signaling 3 (Socs3), mRNA 296.0767 276.1814 341.6162 243.6939 311.9855 224.9269 2130.3466 1995.0602 718.2331 749.8354 1993.9678 693.5062 563.5964 511.8688 736.6675 1215.0369 1560.5489 1229.2415 1343080 1460700_at 11 60.5 cM chr11:100748149-100748711 11 D chr11:100748123-100800825 11 D RSQ Mm.249934 NM_011486 3 1 20848 RP23-279L23.5 Stat3 signal transducer and activator of transcription 3 (Stat3), transcript variant 3, mRNA. EGF Signaling Pathway;; Erk1/Erk2 Mapk Signaling pathway;; IL 6 signaling pathway;; IL22 Soluble Receptor Signaling Pathway;; PDGF Signaling Pathway;; Role of ERBB2 in Signal Transduction and Oncology;; Signaling of Hepatocyte Growth Factor Receptor;; Stat3 Signaling Pathway;; TPO Signaling Pathway Acute myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Endocrine System; Adipocytokine signaling pathway [PATH:mmu04920] Cellular Processes; Immune System; Chemokine signaling pathway [PATH:mmu04062] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200];; Adipocytokine signaling pathway;; Chemokine signaling pathway;; Jak-STAT signaling pathway;; Pancreatic cancer;; Pathways in cancer acute-phase response;; calcium ion binding;; cytokine-mediated signaling pathway;; cytoplasm;; DNA binding;; eating behavior;; eye photoreceptor cell differentiation;; glucose homeostasis;; JAK-STAT cascade involved in growth hormone signaling pathway;; nucleus;; plasma membrane;; positive regulation of transcription from RNA polymerase II promoter;; protein binding;; protein dimerization activity;; protein kinase binding;; regulation of multicellular organism growth;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; sexual reproduction;; signal transducer activity;; signal transduction;; temperature homeostasis;; transcription;; transcription activator activity;; transcription factor activity;; transcription from RNA polymerase II promoter cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; protein binding;; signal transducer activity;; transcription activator activity;; transcription factor activity biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; reproduction;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; behavior;; biosynthetic process;; cell communication;; cellular developmental process;; cellular metabolic process;; cellular response to stimulus;; macromolecule metabolic process;; multicellular organism growth;; multicellular organismal development;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of growth;; regulation of metabolic process;; regulation of multicellular organismal process;; response to chemical stimulus;; response to endogenous stimulus;; response to external stimulus;; response to stress;; sexual reproduction;; temperature homeostasis 39.3749 42.7705 39.8018 37.5248 31.3502 33.7200 326.7330 293.5599 153.1382 148.9297 317.4286 128.5013 296.8894 284.2300 301.5964 437.2503 366.9948 232.7425 1370785 1419985_s_at 11 28.5 cM chr11:54863346-54863586 11 B1.3 chr11:54863239-54891633 11 B1.3 RSQ Mm.22361 NM_177471 1 1 52570 Ccdc69 coiled-coil domain containing 69 (Ccdc69), mRNA. 92.3235 97.2647 96.0092 77.5455 129.5897 78.3745 491.9852 522.7671 170.5748 171.2306 497.5964 166.8491 208.0928 181.2786 169.2994 576.1519 675.4474 1166.6011 1370826 1428420_a_at 12 chr12:112667670-112669350 12 F1 chr12:112655640-112669394 12 F1 RSQ Mm.248640 NM_028807 1 1 74190 1200009I06Rik RIKEN cDNA 1200009I06 gene (1200009I06Rik), mRNA. 9.9121 10.4848 11.7271 12.6391 16.1590 11.3901 149.7921 171.9226 9.9889 10.1801 159.7830 12.0198 17.4422 15.3314 18.6598 22.1049 22.4992 14.7266 1350626 1428663_at 3 chr3:131021980-131022466 3 G3 chr3:131021902-131047841 3 G3 RSQ Mm.273360 NM_028943 1 1 74442 Sgms2 sphingomyelin synthase 2 (Sgms2), mRNA. Metabolic pathways CLASS Metabolism; Lipid Metabolism; Sphingolipid metabolism [PATH:mmu00600];; Sphingolipid metabolism ceramide cholinephosphotransferase activity;; Golgi apparatus;; integral to Golgi membrane;; integral to membrane;; integral to plasma membrane;; kinase activity;; lipid metabolic process;; membrane;; plasma membrane;; sphingolipid metabolic process;; sphingomyelin biosynthetic process;; sphingomyelin synthase activity;; transferase activity cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part catalytic activity transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; organophosphate metabolic process;; primary metabolic process 98.5206 75.4052 96.4418 95.1631 114.5071 101.0187 176.0733 163.8612 75.5555 59.0052 185.4764 64.4003 59.0838 66.2389 69.7412 56.7982 66.7099 85.5941 1350856 1429029_at 3 G3 chr3:131025716-131026224 3 G3 UGA Mm.273360 74442 Sgms2 Sphingomyelin synthase 2 (Sgms2), mRNA Metabolic pathways CLASS Metabolism; Lipid Metabolism; Sphingolipid metabolism [PATH:mmu00600];; Sphingolipid metabolism ceramide cholinephosphotransferase activity;; Golgi apparatus;; integral to Golgi membrane;; integral to membrane;; integral to plasma membrane;; kinase activity;; lipid metabolic process;; membrane;; plasma membrane;; sphingolipid metabolic process;; sphingomyelin biosynthetic process;; sphingomyelin synthase activity;; transferase activity cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part catalytic activity transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; organophosphate metabolic process;; primary metabolic process 190.8614 194.7173 181.3911 222.3591 191.2890 185.3195 490.1945 545.4885 275.6434 242.9132 531.4098 238.5964 206.6664 212.6453 198.3132 189.8447 211.8299 242.2117 1351042 1429304_at 8 A1.1 chr8:11614351-11614743 8 A1.1 UGA Mm.12459 102334 Ankrd10 Ankyrin repeat domain 10 (Ankrd10), mRNA 77.2439 66.8769 80.2440 59.8078 99.2277 57.3331 678.4476 670.4325 295.5887 322.3900 601.6635 337.6717 837.8303 1440.6726 1744.2968 2267.7608 1755.8989 1723.4822 1370950 1430584_s_at 3 A2|3 11.7 cM chr3:14865376-14865506 3 A1 UGA Mm.300 12350 Car3 Carbonic anhydrase 3, mRNA (cDNA clone MGC:18583 IMAGE:4195712) Nitrogen metabolism CLASS Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:mmu00910] carbonate dehydratase activity;; cytoplasm;; lyase activity;; metal ion binding;; nickel ion binding;; one-carbon metabolic process;; zinc ion binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; lyase activity cellular process;; metabolic process cellular metabolic process 94.0203 110.0590 102.9780 51.3227 106.4492 66.0184 383.6388 365.6560 102.3978 157.1999 313.3908 115.8699 87.4356 87.4703 101.3218 95.4936 103.2550 91.5338 1352101 1430702_at 15 chr15:98590670-98590993 15 F1 chr15:98590568-98592483 15 F1 RSQ Mm.441883 NM_175232 1 1 76061 5830427D03Rik RIKEN cDNA 5830427D03 gene (5830427D03Rik), mRNA. 78.0017 80.7801 87.0123 117.6287 102.0694 87.7343 366.4738 387.5431 186.7610 154.8753 410.2278 176.1028 155.7427 168.3723 162.3121 148.2475 159.4852 198.2542 1353535 1432787_at 5 chr5:15476262-15476595 5 A2 UGA Mm.446079 Transcribed locus 240.4071 198.8506 136.6932 270.0408 229.2630 189.9322 480.9297 406.7912 253.5099 189.5964 408.0565 197.6784 342.0356 312.4297 206.8748 419.9750 432.7099 448.0889 1353754 1433023_at chr12:82344479-82345008 12 D1 IPA 2310068G24Rik RIKEN cDNA 2310068G24 gene 31.6241 46.2381 40.9647 44.7342 45.6192 36.6474 378.8243 386.7983 114.3324 125.0738 360.1435 123.1345 109.8215 127.8969 84.2638 140.6818 223.7344 220.8705 1353838 1433110_at chr1:21942230-21942722 1 A4 IPA 5830474E16Rik RIKEN cDNA 5830474E16 gene 80.8570 110.0959 120.5971 114.5913 163.4852 107.4891 676.2764 650.8316 329.7820 301.6641 622.3986 325.4220 518.9613 356.5548 435.9500 520.9412 492.3128 383.3739 1354264 1433742_at 19 chr19:25508401-25508603 19 B chr19:25311691-25508986 19 B RSQ Mm.260722 NM_181404 1 1 107351 Kank1 KN motif and ankyrin repeat domains 1 (Kank1), mRNA. negative regulation of actin filament polymerization anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; metabolic process;; negative regulation of biological process;; regulation of biological process actin filament-based process;; cellular component assembly;; cellular macromolecular complex subunit organization;; cellular metabolic process;; macromolecular complex subunit organization;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular component organization;; negative regulation of cellular process;; negative regulation of metabolic process;; organelle organization;; primary metabolic process;; protein complex biogenesis;; regulation of biological process;; regulation of biological quality;; regulation of cellular component biogenesis;; regulation of cellular component organization;; regulation of cellular process;; regulation of metabolic process 143.7630 198.9096 179.8356 107.8176 122.4852 150.4094 178.0881 205.8361 90.9325 93.0366 191.7651 79.5979 85.5747 91.2586 110.2189 114.8555 99.5080 95.8594 1355094 1435284_at 11 chr11:29596168-29596644 11 A3.3 UGA Mm.440639 Transcribed locus 42.0445 40.6199 43.2130 48.0355 39.5856 43.5057 931.9759 886.6027 353.2630 358.3860 838.7075 351.4852 154.9209 386.5522 286.4813 552.7356 849.0978 517.0878 1355281 1435585_at X F1 chrX:132760192-132760615 X F1 UGA Mm.18125 100040972 RP23-105O4.2 RP23-105O4.2 Transcription elongation factor A (SII)-like 7 (Tceal7), mRNA 55.7275 62.5357 64.4856 62.4571 71.2860 59.8466 138.7144 159.2392 70.2057 78.0851 161.6378 67.6771 85.2744 57.3360 72.3285 97.6229 97.6947 82.7421 1355674 1436196_at 11 chr11:23637084-23637417 11 A3.2 UGA Mm.30811 Transcribed locus 48.0602 60.7246 90.9560 59.1889 100.3941 68.1786 190.8741 164.4699 71.2665 72.2493 176.2763 67.3830 64.3878 63.0337 59.7811 56.0655 53.6770 63.5241 1355677 1436200_at X A2 chrX:33906277-33906788 X A3.3 UGA Mm.327654 74365 RP23-145O4.1 Lonrf3 LON peptidase N-terminal domain and ring finger 3, mRNA (cDNA clone MGC:155927 IMAGE:40129613) ATP-dependent peptidase activity;; binding;; metal ion binding;; protein binding;; proteolysis;; zinc ion binding binding;; catalytic activity hydrolase activity;; ion binding;; protein binding metabolic process catabolic process;; macromolecule metabolic process;; primary metabolic process 12.0111 11.3855 12.3273 14.3516 14.9853 16.5376 37.6151 41.8791 16.9192 17.1773 37.5185 20.3450 25.4257 28.0884 35.6445 58.6382 37.7164 26.3083 1371257 1436203_a_at 15 chr15:55468259-55468349 15 D1 UGA Mm.478132 Transcribed locus 200.2527 194.1171 198.2281 224.6582 179.3055 181.3313 338.4798 390.2439 109.5856 124.5128 380.8212 112.6363 113.5809 115.7160 104.9710 110.4357 104.9347 136.2076 1356231 1437199_at 19 D2 chr19:53615956-53616474 19 D2 UGA Mm.52043 240672 Dusp5 Dual specificity phosphatase 5 (Dusp5), mRNA MAPK signaling pathway CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] hydrolase activity;; MAP kinase tyrosine/serine/threonine phosphatase activity catalytic activity hydrolase activity 161.9271 168.0678 223.9118 124.5361 115.0289 129.9790 456.9299 401.8184 210.9452 215.6551 460.9338 196.2728 189.6101 202.4398 152.5113 193.3496 197.5964 170.2855 1356245 1437224_at 11 chr11:29606699-29607240 11 A3.3 chr11:29593773-29642916 11 A3.3 RSQ Mm.192580 NM_194051 2 1 68585 RP23-176O5.4 Rtn4 reticulon 4 (Rtn4), transcript variant 5, mRNA. angiogenesis;; cell projection;; cell soma;; endoplasmic reticulum;; integral to endoplasmic reticulum membrane;; integral to membrane;; membrane;; negative regulation of anti-apoptosis;; negative regulation of axon extension;; nervous system development;; nuclear envelope;; regulation of cell migration cell;; cell part;; envelope;; organelle;; organelle part cell part;; cell projection;; cell soma;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part anatomical structure formation;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; localization;; locomotion;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell death;; cell motility;; cell motion;; cell projection organization;; cellular component morphogenesis;; cellular developmental process;; localization of cell;; multicellular organismal development;; negative regulation of anti-apoptosis;; negative regulation of biological process;; negative regulation of cellular component organization;; negative regulation of cellular process;; negative regulation of developmental process;; regulation of anti-apoptosis;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of developmental process;; regulation of localization;; regulation of locomotion;; regulation of multicellular organismal process 13.8524 9.9088 12.1013 12.3008 12.9610 13.3979 82.1644 66.3981 21.0455 23.2087 73.2373 25.8606 18.4211 28.7155 22.3317 29.0849 21.7617 20.6855 1356563 1437833_at 19 B|19 2.0 cM chr19:5752075-5752356 19 A UG5 Mm.182396 16998 Ltbp3 Latent transforming growth factor beta binding protein 3 (Ltbp3), mRNA binding;; calcium ion binding;; extracellular region;; growth factor binding;; proteinaceous extracellular matrix;; skeletal system development;; transforming growth factor beta receptor signaling pathway;; transforming growth factor beta receptor signaling pathway extracellular region;; extracellular region part extracellular matrix;; extracellular region part binding ion binding;; protein binding biological regulation;; cellular process;; developmental process;; multicellular organismal process;; regulation of biological process anatomical structure development;; cell communication;; multicellular organismal development;; regulation of biological process;; regulation of cellular process 138.6243 139.4821 133.3794 120.0130 131.7362 137.6639 149.0140 185.8659 58.7507 54.4041 189.3443 47.5234 71.2096 71.9502 50.3067 93.4615 220.8211 122.6019 1356745 1438185_at 7 chr7:83378532-83379004 7 D2 UGA Mm.370825 Transcribed locus 192.0784 196.5402 174.9915 141.5821 167.0264 102.0103 885.8741 970.5680 305.2089 321.3774 947.4409 304.7462 235.1214 268.1741 257.1782 302.6816 274.2473 253.1274 1356892 1438429_at 8 chr8:11622380-11622942 8 A1.1 UGA Mm.441154 Transcribed locus 28.2679 28.1583 23.9776 27.8952 30.4114 31.2833 205.9640 186.2001 26.6215 29.4348 225.0207 26.4638 26.4986 22.3955 26.5741 27.8535 75.4844 35.8652 1357431 1439412_at chr9:112004583-112004658 9 F3 IPA ESTs 21.1869 24.5289 21.5442 13.4531 16.0800 16.1197 35.6331 50.8499 23.5011 20.2428 44.9737 19.3242 15.7658 19.9397 19.1116 17.9056 19.6579 16.9175 1357586 1439638_at 13 chr13:104615681-104616180 13 D1 UGA Mm.442245 Transcribed locus 532.9716 327.0775 379.7571 393.2864 236.4347 281.1978 734.1372 741.5407 301.3544 327.6984 600.4444 269.4208 315.6313 229.7804 274.7018 280.0701 234.0150 203.0847 1371475 1439740_s_at 1 H2.3 chr1:169153282-169153392 1 H2.3 UGA Mm.440156 80914 Uck2 Uridine-cytidine kinase 2, mRNA (cDNA clone IMAGE:3493906) Drug metabolism - other enzymes;; Metabolic pathways CLASS Metabolism; Nucleotide Metabolism; Pyrimidine metabolism [PATH:mmu00240] Metabolism; Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes [PATH:mmu00983];; Pyrimidine metabolism ATP binding;; kinase activity;; metabolic process;; nucleotide binding;; phosphotransferase activity, alcohol group as acceptor;; transferase activity;; uridine kinase activity binding;; catalytic activity nucleoside binding;; nucleotide binding;; transferase activity metabolic process 18.3358 20.9009 15.1513 15.0926 17.6165 17.7355 305.5309 299.4029 81.3517 88.1226 318.1556 64.1841 44.7398 64.0387 47.2593 64.0072 65.2502 54.0433 1357961 1440051_at IPA Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230017C05 product:hypothetical protein, full insert sequence. 81.7648 94.0162 70.5022 86.0359 82.9972 64.3833 124.9121 111.1290 43.9675 52.0680 85.0647 31.6576 38.1460 45.9452 38.2211 44.0676 50.3311 48.5479 1358405 1440543_at 12 C1 chr12:53010825-53011204 12 C1 UGA Mm.131941 320487 Heatr5a HEAT repeat containing 5A, mRNA (cDNA clone MGC:99412 IMAGE:30544145) 69.9459 56.1909 93.1692 88.5572 98.4091 62.9310 403.3556 533.3844 139.3842 134.4529 408.7996 127.6467 62.4265 59.6349 66.7521 62.5685 100.1319 105.9936 1358631 1440776_at 5 C3.1 chr5:67139353-67139604 5 C3.1 UGA Mm.374778 77569 Limch1 LIM and calponin homology domains 1 (Limch1), mRNA actin binding;; actomyosin structure organization;; metal ion binding;; zinc ion binding binding ion binding;; protein binding cellular component organization;; cellular process actin filament-based process;; organelle organization 46.2480 47.9352 50.0380 40.5686 35.7659 41.5656 96.5529 96.5024 48.9456 42.3024 103.6766 37.2512 43.2313 24.6753 37.4727 60.6681 39.3869 42.1065 1358691 1440878_at 16 62.2 cM chr16:92601752-92602086 16 C4 chr16:92601710-92826311 16 C4 RSQ Mm.4081 NM_001111022 4 1 12394 Runx1 runt related transcription factor 1 (Runx1), transcript variant 2, mRNA. Acute myeloid leukemia CLASS Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221] Human Diseases; Cancers; Chronic myeloid leukemia [PATH:mmu05220];; Chronic myeloid leukemia;; Pathways in cancer ATP binding;; behavioral response to pain;; central nervous system development;; definitive hemopoiesis;; DNA binding;; embryonic hemopoiesis;; in utero embryonic development;; liver development;; neuron development;; neuron differentiation;; nucleus;; positive regulation of angiogenesis;; protein binding;; regulation of transcription, DNA-dependent;; response to retinoic acid;; skeletal system development;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; nucleoside binding;; nucleotide binding;; protein binding;; transcription factor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; behavior;; biosynthetic process;; cellular developmental process;; cellular metabolic process;; embryonic development;; immune system development;; macromolecule metabolic process;; multicellular organismal development;; multicellular organismal response to stress;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; response to chemical stimulus;; response to external stimulus;; response to stress 18.8450 20.4321 18.3331 20.8158 21.8440 20.5486 63.4025 82.1758 25.8771 30.6025 77.4065 32.7379 22.3609 21.9864 20.5486 21.4368 26.5328 20.5512 1358927 1441129_at 5 chr5:93535215-93535741 5 E2 UGA Mm.450589 Transcribed locus 32.7576 52.7279 58.6116 33.3005 40.2190 61.6467 350.0812 335.9187 88.8867 95.1042 360.3314 102.5755 80.0099 75.1502 87.8925 87.3463 84.5908 84.5109 1359131 1441360_at chrX:155711702-155712021 X F4 IPA ESTs, Moderately similar to S12207 hypothetical protein (B2 element) - mouse [M.musculus] 24.0581 20.1228 19.7115 23.9333 24.6617 21.8393 110.9231 122.6275 47.6703 30.3079 113.0433 37.7028 36.1230 48.1580 43.3726 40.2513 37.9703 49.8934 1359142 1441372_at 18 chr18:68108128-68108625 18 E2 UGA Mm.446015 Transcribed locus 93.6632 118.0632 81.4527 121.7616 99.9804 105.8245 86.6902 102.3660 50.1883 44.1120 115.2089 48.4722 54.4436 49.1334 57.3374 36.9799 58.6760 51.3774 1359292 1441529_at chr11:22757572-22758125 11 A3.2 IPA ESTs 79.6653 118.8354 86.1274 43.0355 73.8019 36.9330 239.3613 262.9002 141.0580 105.6996 207.8978 109.1112 78.2709 106.1127 96.1726 110.6297 145.8393 113.0559 1359309 1441546_at 6 chr6:50063213-50063735 6 B2.3 chr6:50060284-50063960 6 B2.3 RSQ XM_898388 1 1 624524 LOC624524 PREDICTED: hypothetical LOC624524 (LOC624524), mRNA. 47.5057 76.4959 71.9274 32.7984 55.9516 35.3354 157.2023 157.9271 65.0842 60.3673 156.1753 62.0749 21.0842 25.0583 23.2114 20.3063 20.1412 27.7300 1359586 1441858_at IPA Unknown 12.9543 23.0601 13.2495 13.4318 11.2614 15.1046 65.5719 61.6627 31.5659 29.0734 60.3553 29.8183 16.0786 18.5773 18.1671 21.1196 17.6383 18.1671 1371720 1441956_s_at 5 G2|5 78.0 cM chr5:136958783-136958847 5 G2 UGA Mm.320317 13047 Cux1 CDNA fis, clone TRACH2005314,highly similar to Mus musculus mCASP (cux) mRNA auditory receptor cell differentiation;; chromatin binding;; DNA binding;; Golgi apparatus;; integral to Golgi membrane;; integral to membrane;; intra-Golgi vesicle-mediated transport;; lung development;; membrane;; multicellular organismal development;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; regulation of transcription;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; transcription;; transcription factor activity;; transcription regulator activity;; transcription repressor activity;; transport cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part binding;; transcription regulator activity chromatin binding;; nucleic acid binding;; transcription factor activity;; transcription repressor activity biological regulation;; cellular process;; developmental process;; establishment of localization;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process anatomical structure development;; biosynthetic process;; cellular developmental process;; cellular localization;; cellular metabolic process;; establishment of localization;; establishment of localization in cell;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; transport;; vesicle-mediated transport 133.2076 136.2076 134.8545 133.7076 139.2075 129.7672 304.1689 325.3140 117.4413 129.7672 353.0964 139.3029 107.2127 123.7363 126.2557 110.9662 114.2588 115.7375 1359813 1442176_at 10 chr10:67558667-67559135 10 B5.1 chr10:67558340-67741474 10 B5.1 RSQ Mm.440357 NM_023598 1 1 71371 Arid5b AT rich interactive domain 5B (MRF1-like) (Arid5b), mRNA. DNA binding;; face morphogenesis;; fibroblast migration;; intracellular;; kidney development;; multicellular organism growth;; muscle organ morphogenesis;; nitrogen compound metabolic process;; nucleus;; palate development;; platelet-derived growth factor receptor signaling pathway;; post-embryonic development;; regulation of transcription, DNA-dependent;; skeletal system morphogenesis;; transcription cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding nucleic acid binding biological regulation;; cellular process;; developmental process;; growth;; localization;; locomotion;; metabolic process;; multicellular organismal process;; regulation of biological process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell communication;; cell motility;; cell motion;; cellular metabolic process;; localization of cell;; macromolecule metabolic process;; multicellular organism growth;; multicellular organismal development;; nitrogen compound metabolic process;; post-embryonic development;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 53.3554 55.8814 48.8607 58.5858 53.4364 49.7721 140.4297 115.5820 62.5478 64.1097 141.8017 52.2731 44.9433 51.4150 47.3439 51.4498 54.6219 71.2926 1359876 1442241_at 5 chr5:23092186-23092646 5 A3 UGA Mm.443009 Transcribed locus 137.2893 129.5261 136.6520 138.5126 149.3308 125.5206 486.8951 448.0872 175.8048 169.7432 449.9860 170.8648 146.1695 178.4269 187.8989 184.1371 184.4923 222.1304 1359922 1442288_at 11 B1.3|11 29.5 cM chr11:54844602-54845026 11 B1.3 UGA Mm.265347 11749 Anxa6 Annexin A6, mRNA (cDNA clone MGC:6574 IMAGE:3482035) calcium ion binding;; calcium ion transport;; calcium-dependent phospholipid binding;; cytoplasm;; perinuclear region of cytoplasm;; regulation of muscle contraction cell;; cell part cell part;; intracellular;; intracellular part binding ion binding;; lipid binding biological regulation;; establishment of localization;; localization;; multicellular organismal process;; regulation of biological process establishment of localization;; regulation of biological process;; regulation of multicellular organismal process;; system process;; transport 69.8319 79.6665 69.3949 89.6888 79.1577 82.8510 352.1864 379.1085 195.0077 170.2395 349.1038 171.1519 126.9555 139.9446 115.8756 129.0508 139.6671 156.4074 1360008 1442382_at 13 D1 chr13:103559646-103562570 13 D1 UGA Mm.202606 328329 Mast4 MKIAA0303 protein ATP binding;; cytoplasm;; kinase activity;; magnesium ion binding;; metal ion binding;; nucleotide binding;; protein amino acid phosphorylation;; protein binding;; protein kinase activity;; protein serine/threonine kinase activity;; transferase activity cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; nucleoside binding;; nucleotide binding;; protein binding;; transferase activity cellular process;; metabolic process cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 56.1113 75.2179 61.8412 64.3822 64.7708 55.2873 635.3268 556.4423 321.3202 260.5442 554.1874 255.1722 80.0638 81.4781 69.1425 67.0231 172.8667 154.7860 1360020 1442395_at 1 chr1:34085393-34085906 1 B UGA Mm.436779 Transcribed locus 35.7960 33.2435 30.3480 32.4821 40.4434 33.2840 810.7263 796.9055 293.4851 260.3700 809.7142 269.9265 292.8195 244.7075 183.8901 403.2840 306.6368 398.7561 1360303 1442700_at 4 C6|4 46.8 cM chr4:102243528-102243998 4 C6 UGA Mm.20181 18578 RP23-57D24.1 Pde4b Phosphodiesterase 4B, cAMP specific, mRNA (cDNA clone IMAGE:5354427) Purine metabolism CLASS Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:mmu00230] 3',5'-cyclic-AMP phosphodiesterase activity;; smooth muscle contraction catalytic activity hydrolase activity multicellular organismal process system process 12.1277 15.8776 7.8481 13.9860 13.5791 10.7008 254.5513 247.0487 121.4411 111.2129 248.1182 112.5854 141.9146 162.7194 157.7832 164.1207 203.0418 163.2137 1360318 1442715_at X UGA Mm.411941 Transcribed locus 104.7989 113.5929 115.0585 56.7930 93.4735 99.1187 190.0408 204.3828 107.9015 95.2722 202.6011 94.8209 78.9430 96.8740 94.4275 93.3454 97.1084 97.3405 1371742 1442760_x_at chr11:29616149-29616353 11 A3.3 IPA ESTs 85.8647 115.5948 75.2801 81.9977 68.8210 79.7756 236.1724 255.5325 74.6728 81.5836 243.2201 88.4012 90.4556 58.8192 92.6217 71.4720 100.2443 83.6406 1360727 1443159_at 10 C1 chr10:82357178-82357468 10 C1 UGA Mm.210155 50493 Txnrd1 Thioredoxin reductase 1, mRNA (cDNA clone MGC:46868 IMAGE:5059831) Pyrimidine metabolism CLASS Metabolism; Nucleotide Metabolism; Pyrimidine metabolism [PATH:mmu00240] cell proliferation;; cell redox homeostasis;; cytoplasm;; cytosol;; FAD binding;; gastrulation;; mesoderm formation;; NADP or NADPH binding;; nucleus;; oxidation reduction;; oxidoreductase activity;; selenium binding;; thioredoxin-disulfide reductase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle antioxidant activity;; binding;; catalytic activity cofactor binding;; nucleoside binding;; nucleotide binding;; oxidoreductase activity;; selenium binding;; thioredoxin-disulfide reductase activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell proliferation;; cellular homeostasis;; embryonic development;; multicellular organismal development;; oxidation reduction;; regulation of biological process;; regulation of biological quality;; regulation of cellular process 21.9055 29.5991 25.0553 19.4371 22.8072 23.7948 85.4342 95.8322 30.7800 35.1871 90.8806 39.0084 14.0207 18.2806 13.0802 17.2148 22.3893 21.5777 1360780 1443212_at chr8:75853675-75854162 8 B3.3 IPA ESTs 112.9604 123.7113 92.3539 142.6121 151.5722 142.2446 1352.6141 1341.0749 428.6160 422.2975 1312.3666 401.8301 490.1917 462.8785 522.9428 553.2205 721.0148 717.3226 1360866 1443299_at 8 B1.1 chr8:46988445-46988717 8 B1.1 UGA Mm.282900 53318 Pdlim3 PDZ and LIM domain 3 (Pdlim3), mRNA actin cytoskeleton;; actin filament organization;; cytoplasm;; cytoskeletal protein binding;; heart development;; metal ion binding;; protein binding;; skeletal muscle tissue development;; structural constituent of muscle;; structural constituent of muscle;; Z disc;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; non-membrane-bounded organelle binding;; structural molecule activity ion binding;; protein binding;; structural constituent of muscle cellular component organization;; cellular process;; developmental process;; multicellular organismal process actin filament-based process;; anatomical structure development;; multicellular organismal development;; organelle organization 51.4337 55.7294 48.2578 51.5856 59.3598 52.2725 119.9270 158.5883 63.1307 63.1218 164.7428 61.4676 49.7017 49.9433 50.1462 75.3302 65.3387 74.2698 1361083 1443544_at chr18:68137416-68137770 18 E2 IPA ESTs 45.9321 51.7952 59.8965 45.1365 60.4401 49.0968 74.4958 82.3863 30.3315 29.3568 65.4243 31.1417 26.1463 22.6142 21.6869 17.8622 21.3373 27.4897 1361128 1443593_at chr16:22134185-22134615 16 B1 IPA Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430085A14 product:unknown EST, full insert sequence. 14.7971 13.1123 12.1640 13.4911 15.1542 12.8222 69.8172 64.1338 17.5608 19.8101 70.7098 22.6311 16.6605 24.4844 13.1610 22.9933 18.6346 16.6335 1361161 1443630_at chr3:136399370-136399659 3 G3 IPA ESTs, Weakly similar to RIKEN cDNA 5730493B19 [Mus musculus] [M.musculus] 72.3164 78.8400 66.7947 82.8281 86.3495 83.7449 144.7766 153.0817 59.1054 67.2717 115.2967 60.6281 61.3586 47.8035 52.1692 43.3699 54.6411 49.9505 1362068 1444645_at 11 chr11:20451270-20451705 11 A3.1 UG5 Mm.449965 Transcribed locus 31.4181 30.9426 28.3249 31.8258 34.1119 33.3926 100.3992 94.9140 46.6336 43.6106 98.7907 52.9237 33.2002 36.1695 30.6217 34.1323 33.0605 34.5397 1362606 1445200_at chr14:121449800-121450181 14 E5 IPA ESTs, Moderately similar to RIKEN cDNA 5730493B19 [Mus musculus] [M.musculus] 37.2838 36.1768 34.7662 45.7472 49.8620 44.2828 351.0118 343.7526 157.5952 129.5364 347.9196 127.2414 61.1687 60.7533 67.3254 78.4704 83.7358 76.9620 1362800 1445398_at 5 chr5:67306909-67307387 5 C3.1 UGA Mm.454791 Transcribed locus 33.1396 37.3050 33.9569 27.7166 35.3308 35.0760 386.1633 352.0731 119.4993 130.6484 311.2328 133.8825 76.0883 95.6880 65.3746 80.9814 94.9356 85.5210 1363243 1445866_at chr13:103556977-103557456 13 D1 IPA ESTs 169.0864 197.3862 204.6977 163.3357 189.4367 134.4596 449.1228 455.1874 217.0408 195.7547 446.7451 231.9444 100.0485 124.6387 105.0303 107.9912 133.3187 110.7071 1363341 1445966_at 17 chr17:12945147-12945628 17 A1 UGA Mm.411497 Transcribed locus 111.4455 118.5272 109.8047 147.9853 118.5611 114.8303 435.5323 428.8620 92.5009 122.8117 401.3469 102.5630 88.6989 93.4698 88.0464 90.0582 91.8387 103.4748 1363514 1446141_at chr1:188503427-188503922 1 H5 IPA Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130049J04 product:unclassifiable, full insert sequence. 24.3326 26.0907 30.2963 23.0076 34.0040 28.6995 55.0511 66.3343 24.3339 23.4325 56.0986 21.8537 36.4253 32.2755 33.0450 44.2561 53.6034 58.8944 1363581 1446212_at chr1:21847057-21847588 1 A4 IPA Mus musculus 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430057L14 product:unknown EST, full insert sequence. 39.7213 42.6001 45.1463 48.1033 49.5944 48.3309 107.6002 111.5327 40.3370 41.1548 116.1609 38.6118 30.7893 36.0396 32.3135 31.5076 28.9785 35.8248 1363593 1446224_at 19 C2 chr19:36665196-36665583 19 C2 UGA Mm.61107 226098 Hectd2 HECT domain containing 2, mRNA (cDNA clone MGC:178371 IMAGE:9053363) acid-amino acid ligase activity;; intracellular;; ligase activity;; modification-dependent protein catabolic process;; protein modification process cell;; cell part cell part;; intracellular catalytic activity ligase activity cellular process;; metabolic process catabolic process;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 44.2522 68.5129 81.0723 62.1293 80.7815 76.0069 680.0408 669.7630 304.6117 274.9567 722.5169 298.4341 241.5243 232.4202 233.2687 219.8846 322.6587 305.4064 1363692 1446324_at 5 chr5:15445246-15445625 5 A2 UGA Mm.445336 Transcribed locus 54.9445 76.9694 60.7650 51.8095 70.4527 54.5835 174.1644 194.5886 93.4229 81.1616 170.9723 93.6470 138.6520 154.2012 128.8140 237.7243 285.3335 303.1523 1363903 1446537_at IPA ESTs 78.2224 89.5263 88.2972 62.5557 98.5742 51.2105 288.3186 271.1169 110.9322 102.4294 286.9852 101.5482 72.4002 62.4886 64.8428 71.0462 90.3918 87.1506 1364275 1446921_at 11 chr11:11901351-11901733 11 A1 UGA Mm.438641 Transcribed locus 19.8139 26.4231 27.8198 21.9803 21.2348 21.0276 3872.9896 3869.2951 1616.6509 1907.4264 3842.8185 1945.8741 306.4852 413.5158 330.5900 680.4346 707.2991 497.9465 1364970 1447891_at IPA Unknown 192.8256 157.7290 163.7672 89.1949 82.7376 131.3366 484.8186 501.9665 137.2189 154.7326 493.2433 165.5505 210.8462 215.7630 218.0549 459.4518 757.4940 561.2626 1365310 1453119_at 2 chr2:19581695-19582189 2 A3 UGA Mm.470264 Transcribed locus 50.9889 40.8515 42.7761 46.5630 47.1827 47.0286 78.5470 90.8349 36.2054 41.7512 74.9660 37.5504 39.1490 49.9390 48.5028 40.1339 48.7957 37.2682 1365458 1453323_at 9 chr9:112138041-112138459 9 F3 chr9:112136775-112138524 9 F3 RSQ XM_001478934 1 1 331033 2900079G21Rik PREDICTED: RIKEN cDNA 2900079G21 gene (2900079G21Rik), mRNA. 14.5047 15.7451 15.8219 16.2321 12.7804 15.2208 136.7060 136.9914 60.9511 61.6777 131.1691 59.4235 52.1219 47.6307 57.4979 82.1287 102.0878 79.2958 1365662 1453595_at IPA 2900064B18Rik RIKEN cDNA 2900064B18 gene 42.9236 30.9332 52.1277 37.1310 61.4818 40.9233 324.1517 317.4300 157.3879 157.2841 324.7969 146.3491 245.8452 327.2464 232.8481 404.8186 229.3469 217.2518 1366506 1454799_at 5 E4 chr5:101327556-101328077 5 E4 UGA Mm.271911 231510 Agpat9 1-acylglycerol-3-phosphate O-acyltransferase 9, mRNA (cDNA clone MGC:169852 IMAGE:8861247) acyltransferase activity;; endoplasmic reticulum;; glycerol-3-phosphate O-acyltransferase activity;; integral to membrane;; membrane;; metabolic process;; phospholipid biosynthetic process;; transferase activity;; triglyceride biosynthetic process cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle catalytic activity transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; organic ether metabolic process;; organophosphate metabolic process;; primary metabolic process 1089.0427 1154.7506 1140.0997 919.8712 758.4837 879.9882 1427.8668 1434.6579 580.7016 576.4393 1327.5698 541.0930 574.0584 397.0730 482.5597 619.5136 968.3232 815.0641 1372358 1455157_a_at 8 chr8:125005638-125005952 8 E1 chr8:125005196-125075229 8 E1 RSQ XM_001481316 1 1 234839 BC039210 PREDICTED: cDNA sequence BC039210 (BC039210), mRNA. 29.8304 24.6569 24.7358 23.9866 22.7097 27.2480 59.5033 50.0037 26.4679 26.5642 53.2814 24.0971 26.4164 26.1879 24.6323 29.6041 24.4181 27.4337 1366906 1455468_at 7 chr7:36470549-36470974 7 B2 chr7:36470518-36539473 7 B2 RSQ Mm.257808 NM_178704 1 1 233115 Dpy19l3 dpy-19-like 3 (C. elegans) (Dpy19l3), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 71.1006 82.0897 93.4089 58.8460 99.5620 80.8065 818.7012 769.6025 307.8794 293.9297 721.9888 334.8463 212.2075 194.9854 249.1519 239.0936 236.5545 241.3855 1367261 1456139_at chr17:12960003-12960449 17 A1 IPA Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130073E08 product:unknown EST, full insert sequence. 7.4116 7.5204 7.3875 7.7881 8.2728 7.5448 41.0669 66.6873 18.7084 22.4825 54.4917 22.8474 9.0663 10.5879 10.0793 9.9795 10.1156 9.1523 1367837 1457018_at 14 A3 chr14:24240872-24241001 14 A3 UGA Mm.343607 16531 Kcnma1 Calcium-activated potassium channel SLO1 mRNA, complete cds, alternatively spliced Vascular smooth muscle contraction CLASS Cellular Processes; Circulatory System; Vascular smooth muscle contraction [PATH:mmu04270] adult walking behavior;; apical plasma membrane;; auditory receptor cell differentiation;; binding;; calcium ion binding;; calcium-activated potassium channel activity;; calcium-activated potassium channel activity;; calcium-activated potassium channel activity;; catalytic activity;; cell maturation;; circadian rhythm;; cytoplasmic part;; endoplasmic reticulum;; external side of plasma membrane;; eye blink reflex;; integral to membrane;; integral to membrane;; ion channel activity;; ion transport;; large conductance calcium-activated potassium channel activity;; large conductance calcium-activated potassium channel activity;; locomotor rhythm;; magnesium ion binding;; membrane;; metabolic process;; metal ion binding;; micturition;; negative regulation of cell volume;; neuromuscular process controlling balance;; plasma membrane;; postsynaptic membrane;; potassium channel activity;; potassium channel activity;; potassium ion binding;; potassium ion transport;; protein binding;; protein homooligomerization;; regulation of action potential in neuron;; regulation of aldosterone metabolic process;; regulation of membrane potential;; regulation of membrane potential;; relaxation of vascular smooth muscle;; response to hypoxia;; saliva secretion;; sensory perception of sound;; sensory perception of sound;; smooth muscle contraction involved in micturition;; synaptic transmission;; terminal button;; transport;; vasodilation;; voltage-gated ion channel activity;; voltage-gated potassium channel activity;; voltage-gated potassium channel activity;; voltage-gated potassium channel complex cell;; cell part;; macromolecular complex;; organelle;; synapse;; synapse part apical part of cell;; cell part;; cell projection;; cell projection part;; cell surface;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; postsynaptic membrane;; protein complex;; synapse part binding;; catalytic activity;; transporter activity ion binding;; protein binding;; substrate-specific transporter activity;; transmembrane transporter activity anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; developmental process;; establishment of localization;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; response to stimulus;; rhythmic process adult behavior;; anatomical structure development;; behavior;; biosynthetic process;; cell communication;; cellular component assembly;; cellular developmental process;; cellular homeostasis;; cellular metabolic process;; circadian rhythm;; developmental maturation;; digestion;; establishment of localization;; hormone metabolic process;; macromolecular complex subunit organization;; multicellular organismal development;; negative regulation of biological process;; negative regulation of multicellular organismal process;; primary metabolic process;; protein complex biogenesis;; regulation of biological process;; regulation of biological quality;; regulation of body fluid levels;; regulation of cellular process;; regulation of metabolic process;; regulation of multicellular organismal process;; response to chemical stimulus;; response to external stimulus;; response to stress;; rhythmic behavior;; system process;; transport 95.9433 103.9207 103.9941 85.3006 133.9083 88.6332 710.9297 660.0291 287.0627 299.5895 684.7195 275.0964 183.9402 162.9894 167.9704 201.1853 210.2235 174.3493 1368145 1457356_at 17 chr17:12946045-12946480 17 A1 UGA Mm.411497 Transcribed locus 41.1486 45.8676 53.0783 63.5536 43.8824 29.7995 387.0921 359.7645 151.6204 144.5705 320.9852 138.5039 99.7705 86.3105 107.3991 128.9364 143.8182 150.0465 1368162 1457374_at 18 E1 chr18:65329357-65329745 18 E1 UGA Mm.98668 83814 Nedd4l Neural precursor cell expressed, developmentally down-regulated gene 4-like, mRNA (cDNA clone MGC:49433 IMAGE:3157137) Endocytosis CLASS Genetic Information Processing; Folding, Sorting and Degradation; Ubiquitin mediated proteolysis [PATH:mmu04120] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144];; Ubiquitin mediated proteolysis acid-amino acid ligase activity;; cytoplasm;; intracellular;; ligase activity;; modification-dependent protein catabolic process;; negative regulation of sodium ion transport;; negative regulation of sodium ion transport;; protein binding;; protein modification process;; sodium channel inhibitor activity cell;; cell part cell part;; intracellular;; intracellular part auxiliary transport protein activity;; binding;; catalytic activity channel regulator activity;; ligase activity;; protein binding biological regulation;; cellular process;; establishment of localization;; localization;; metabolic process;; negative regulation of biological process;; regulation of biological process catabolic process;; cellular metabolic process;; establishment of localization;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of transport;; primary metabolic process;; regulation of biological process;; regulation of localization;; transport 18.0055 26.1125 28.2646 23.9333 27.2862 32.4118 62.6033 66.3902 31.2947 29.0169 71.1858 32.4858 24.1135 21.6690 25.6185 20.5309 21.0899 21.1488 1368397 1457637_at 15 chr15:93423954-93424139 15 E3 UGA Mm.447383 Transcribed locus 15.4410 15.8883 11.6122 15.0671 15.1962 13.1410 30.2738 34.9679 15.6410 16.8742 41.9520 18.9736 18.0705 18.8217 17.5184 16.0047 19.6150 15.3816 1372499 1457656_s_at 17 chr17:51896651-51896813 17 C UGA Mm.477120 Transcribed locus 15.4707 19.0396 28.6795 20.5792 20.0454 17.8683 112.8032 138.9829 52.2279 58.2650 132.2151 59.5010 96.7861 97.6396 99.0503 160.0612 186.3186 149.0014 1368615 1457898_at 1 chr1:21809222-21809675 1 A4 UGA Mm.434527 Transcribed locus 36.6653 48.8734 37.2443 37.8986 37.5324 40.2838 68.5118 85.7406 23.0482 31.0767 86.4653 25.8177 31.6866 34.7647 32.0440 106.5041 232.3178 226.1078 1368821 1458115_at 8 chr8:64401070-64401578 8 B3.1 UGA Mm.440931 Transcribed locus 19.0319 24.4772 34.4748 19.4102 32.6149 19.7736 213.3292 205.3803 66.6755 70.5184 219.3551 69.2101 28.8129 42.1917 34.7669 33.9863 38.4372 39.5957 1368884 1458179_at chr17:12967927-12968457 17 A1 IPA ESTs 51.2114 61.0989 51.8781 42.2410 34.2315 45.4013 64.2993 73.0743 39.6953 29.6983 76.9292 33.5145 26.5036 17.9928 33.8745 23.3472 25.7181 31.1733 1369097 1458432_at 1 chr1:43511003-43511494 1 B UG5 Mm.447891 Transcribed locus 46.3716 66.1323 82.1425 55.0781 72.1394 47.4199 305.6319 320.9574 153.9128 139.1235 325.0850 142.0834 150.0043 143.2353 146.3694 158.3590 181.5445 142.6669 1369597 1458947_at chr13:63347049-63347523 13 B3 IPA ESTs 136.0124 128.2310 120.2960 129.0244 134.1324 89.8691 683.1283 722.5378 206.0403 213.7492 673.8883 200.2739 198.9487 216.8741 228.7833 380.7653 316.2834 341.1993 1369653 1459003_at X A6-A7.1 chrX:54043834-54044264 X A5 UGA Mm.3126 14199 RP23-71G11.1 Fhl1 Four and a half LIM domains 1, mRNA (cDNA clone MGC:32284 IMAGE:5012394) cell differentiation;; cytoplasm;; metal ion binding;; multicellular organismal development;; nucleus;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding ion binding cellular process;; developmental process;; multicellular organismal process cellular developmental process;; multicellular organismal development 33.9470 23.1913 23.2523 29.5502 24.7873 20.8216 115.0192 101.7045 51.1925 57.0026 109.4645 46.6056 44.6025 42.5304 51.5298 54.3720 54.3224 52.8791 1369844 1459205_at chr7:88577467-88577894 7 D3 IPA ESTs 34.8808 45.2815 42.0601 28.3054 35.7266 31.3399 366.7719 358.6909 90.3209 103.9826 391.7159 83.6722 60.8922 55.5802 49.4398 81.8156 94.4264 83.4715 1370044 1459409_at chr10:59030775-59031053 10 B4 IPA Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130014A12 product:unclassifiable, full insert sequence. 52.0823 59.2469 70.1517 79.7844 53.8949 71.1556 73.2407 96.3366 37.5792 42.5913 95.0563 43.5559 25.6455 24.4830 25.2491 35.4571 33.8204 35.0140 1370101 1459467_at chr14:25054971-25055453 14 A3 IPA ESTs 100.1356 107.9099 115.2749 125.9679 98.8447 140.8163 129.3122 96.7926 37.1947 35.8740 116.4645 34.4233 40.6220 35.8935 27.0394 34.2207 31.0515 38.7872 1370104 1459470_at chr16:92615772-92616302 16 C4 IPA ESTs