A 1 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen A 2 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen A 3 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen A 4 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen A 5 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen A 6 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen B 7 02-09-07_Hennighausen_PK_Mouse430_2_M42 GSP-EG003.1 Hennighausen B 8 02-09-07_Hennighausen_PK_Mouse430_2_M43 GSP-EG003.1 Hennighausen B 9 02-09-07_Hennighausen_PK_Mouse430_2_M44 GSP-EG003.1 Hennighausen B 10 02-09-07_Hennighausen_PK_Mouse430_2_M47 GSP-EG003.1 Hennighausen B 11 02-09-07_Hennighausen_PK_Mouse430_2_M48 GSP-EG003.1 Hennighausen B 12 02-09-07_Hennighausen_PK_Mouse430_2_M50 GSP-EG003.1 Hennighausen C 13 06-10-08_Hennighausen_1PK_Mouse430_2_4038WT GSP-EG003.2 Hennighausen C 14 06-10-08_Hennighausen_2PK_Mouse430_2_4060WT GSP-EG003.2 Hennighausen C 15 06-10-08_Hennighausen_3PK_Mouse430_2_4063WT GSP-EG003.2 Hennighausen C 16 06-10-08_Hennighausen_4PK_Mouse430_2_4035KO GSP-EG003.2 Hennighausen C 17 06-10-08_Hennighausen_5PK_Mouse430_2_4036KO GSP-EG003.2 Hennighausen C 18 06-10-08_Hennighausen_6PK_Mouse430_2_4042KO GSP-EG003.2 Hennighausen Gene Property Filtering 18 arrays and 45101 genes in the input dataset 18 arrays and 76 genes in the output dataset. 45025 genes excluded for Well ID not being in local list 'EG3-1-test-1-FC'. A A A A A A B B B B B B C C C C C C 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M42 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M43 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M44 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M47 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M48 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M50 GSP-EG003.1 Hennighausen 06-10-08_Hennighausen_1PK_Mouse430_2_4038WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_2PK_Mouse430_2_4060WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_3PK_Mouse430_2_4063WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_4PK_Mouse430_2_4035KO GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_5PK_Mouse430_2_4036KO GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_6PK_Mouse430_2_4042KO GSP-EG003.2 Hennighausen Well ID Feature ID Map mgB37_Probe Chr:Start-Stop mgB37_Probe Cytoband mgB37_RefSeq Chr:Start-Stop mgB37_RefSeq Cytoband Annotation_Src UniGene RefSeq Refseqs_Hit geneIDS_Hit Entrez GeneID Locus Tag Gene Description BioCarta Pathways KEGG Pathways Gene Ontology Terms GO Tier2 Component GO Tier3 Component GO Tier2 Function GO Tier3 Function GO Tier2 Process GO Tier3 Process 60.0895 89.6449 61.6450 66.4106 61.3588 49.9231 407.9903 406.7446 942.3607 894.1517 386.8004 921.0368 436.3086 403.7933 481.0253 406.5774 395.0082 303.9622 1343360 1416708_a_at 7 13.0 cM chr7:31915193-31917633 7 B1 chr7:31915145-31936069 7 B1 RSQ Mm.27366 NM_027898 1 1 52857 Gramd1a GRAM domain containing 1A (Gramd1a), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 1267.2908 1151.6519 944.1697 954.9052 782.3186 938.7876 2995.0112 2961.6519 6635.0619 6660.7491 3045.5934 6634.2451 10791.4896 8811.8216 10037.3329 5381.3538 4402.9422 5091.6732 1343385 1416835_s_at 10 25.0 cM chr10:40009199-40010422 10 B1 chr10:40007264-40021992 10 B1 RSQ Mm.253533 NM_009665 5 5 11702 Amd1 S-adenosylmethionine decarboxylase 1 (Amd1), mRNA. Arginine and proline metabolism;; Cysteine and methionine metabolism;; Metabolic pathways CLASS Metabolism; Amino Acid Metabolism; Cysteine and methionine metabolism [PATH:mmu00270] Metabolism; Amino Acid Metabolism; Methionine metabolism [PATH:mmu00271] Metabolism; Amino Acid Metabolism; Arginine and proline metabolism [PATH:mmu00330];; Methionine metabolism adenosylmethionine decarboxylase activity;; carboxy-lyase activity;; in utero embryonic development;; lyase activity;; polyamine biosynthetic process;; protein binding;; spermidine biosynthetic process;; spermine biosynthetic process binding;; catalytic activity lyase activity;; protein binding cellular process;; developmental process;; metabolic process;; multicellular organismal process biosynthetic process;; cellular metabolic process;; embryonic development;; multicellular organismal development;; nitrogen compound metabolic process;; primary metabolic process 53.9805 60.7781 50.3236 51.8402 50.3162 40.0145 76.3389 89.8983 262.7482 224.6651 88.4559 227.8496 157.9852 183.0014 287.4398 85.9731 78.4342 65.4170 1328794 1417312_at 7 chr7:119260710-119261088 7 F1 chr7:119259532-119302571 7 F1 RSQ Mm.55143 NM_015814 1 1 50781 Dkk3 dickkopf homolog 3 (Xenopus laevis) (Dkk3), mRNA. extracellular region;; extracellular space;; multicellular organismal development;; negative regulation of Wnt receptor signaling pathway;; Wnt receptor signaling pathway extracellular region;; extracellular region part extracellular region part;; extracellular space biological regulation;; cellular process;; developmental process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process cell communication;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; regulation of biological process;; regulation of cellular process 149.8882 162.5916 118.2641 144.7928 159.0788 92.4510 615.6347 623.0472 1620.7427 1626.4259 604.9297 1625.4179 2400.7707 1795.1549 2650.4324 1866.7552 2093.0708 1567.6395 1328966 1417522_at 15 chr15:58011931-58012223 15 D1 chr15:58011633-58046433 15 D1 RSQ Mm.292042 NM_026346 1 1 67731 Fbxo32 F-box protein 32 (Fbxo32), mRNA. modification-dependent protein catabolic process;; nucleus;; protein binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding protein binding cellular process;; metabolic process catabolic process;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 22.9933 21.2014 23.2580 23.9194 26.5585 26.6697 26.8275 24.5152 152.6904 106.3417 30.6207 92.1240 55.3328 113.4937 92.1606 32.1468 27.0840 25.6622 1329031 1417597_at 1 30.1 cM chr1:60826814-60827346 1 C2 chr1:60803231-60830203 1 C2 RSQ Mm.255003 NM_007642 2 2 12487 CH29-189K17.3 Cd28 CD28 antigen (Cd28), mRNA. Antigen Dependent B Cell Activation;; Bystander B Cell Activation;; HIV Induced T Cell Apoptosis;; Role of Tob in T-cell activation;; Selective expression of chemokine receptors during T-cell polarization;; T Cytotoxic Cell Surface Molecules;; T Helper Cell Surface Molecules;; Th1/Th2 Differentiation;; The Co-Stimulatory Signal During T-cell Activation Allograft rejection;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Immune System; T cell receptor signaling pathway [PATH:mmu04660] Human Diseases; Immune Disorders; Systemic lupus erythematosus [PATH:mmu05322] Human Diseases; Immune Disorders; Aut;; Systemic lupus erythematosus;; T cell receptor signaling pathway;; Type I diabetes mellitus external side of plasma membrane;; external side of plasma membrane;; external side of plasma membrane;; immune response;; induction of apoptosis by extracellular signals;; integral to membrane;; membrane;; negative thymic T cell selection;; plasma membrane;; positive regulation of alpha-beta T cell proliferation;; positive regulation of alpha-beta T cell proliferation;; positive regulation of inflammatory response to antigenic stimulus;; positive regulation of interleukin-2 biosynthetic process;; positive regulation of isotype switching to IgG isotypes;; positive regulation of T cell proliferation;; positive regulation of T cell proliferation;; T cell costimulation;; T cell costimulation cell;; cell part cell part;; cell surface;; membrane;; membrane part biological regulation;; cellular process;; death;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; biosynthetic process;; cell activation;; cell death;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; immune effector process;; immune response;; immune system development;; leukocyte activation;; lymphocyte costimulation;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; response to external stimulus;; response to stress;; somatic diversification of immune receptors;; T cell selection 164.1750 133.5957 190.0678 127.4434 176.0916 175.2583 246.7763 268.5551 630.5303 733.3004 233.2480 756.2393 131.8816 143.0271 185.3942 120.0337 121.7201 127.7511 1329298 1417929_at 14 chr14:55341124-55341626 14 C3 chr14:55341051-55400723 14 C3 RSQ Mm.276831 NM_016972 1 1 50934 Slc7a8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (Slc7a8), mRNA. amine transmembrane transporter activity;; amino acid transmembrane transporter activity;; amino acid transport;; cytoplasm;; integral to membrane;; L-amino acid transmembrane transporter activity;; L-amino acid transport;; membrane;; plasma membrane;; transport cell;; cell part cell part;; intracellular;; intracellular part;; membrane;; membrane part transporter activity substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization establishment of localization;; transmembrane transport;; transport 50.8392 50.2213 71.8814 57.9647 63.5955 56.6146 243.0805 216.2775 550.9603 512.3839 222.4566 535.1430 247.4181 210.7387 268.4159 190.8733 185.4139 196.6382 1329435 1418091_at 1 chr1:120581186-120581654 1 E2.3 chr1:120524521-120581745 1 E2.3 RSQ Mm.24621 NM_023755 1 1 81879 Tcfcp2l1 transcription factor CP2-like 1 (Tcfcp2l1), mRNA. cell morphogenesis;; cytoplasm;; cytoplasm organization;; determination of adult life span;; DNA binding;; epithelial cell maturation;; general transcriptional repressor activity;; membrane;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; positive regulation of growth;; regulation of transcription, DNA-dependent;; salivary gland development;; transcription;; transcription factor complex cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity nucleic acid binding;; transcription repressor activity biological regulation;; cellular component organization;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process aging;; anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cellular component morphogenesis;; cellular developmental process;; cellular metabolic process;; cytoplasm organization;; determination of adult life span;; developmental maturation;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of growth;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of growth;; regulation of metabolic process 17.8044 20.1361 18.3384 49.2846 28.3416 46.7672 248.9299 268.4852 653.5010 643.1115 246.2027 725.4607 255.1171 453.8417 590.9852 134.6512 73.0052 94.5830 1343687 1418507_s_at 10 C2|10 52.0 cM chr10:94874243-94874582 10 C2 UGA Mm.474283 216233 Socs2 Suppressor of cytokine signaling 2 (Socs2), mRNA Insulin signaling pathway;; Jak-STAT signaling pathway;; Type II diabetes mellitus CLASS Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] Human Diseases; Metabolic Disorders; Type II diabetes mellitus [PATH:mmu04930] growth hormone receptor binding;; intracellular signaling cascade;; lactation;; lactation;; mammary gland alveolus development;; mammary gland alveolus development;; modification-dependent protein catabolic process;; negative regulation of JAK-STAT cascade;; negative regulation of multicellular organism growth;; negative regulation of multicellular organism growth;; negative regulation of signal transduction;; positive regulation of neuron differentiation;; regulation of growth;; regulation of multicellular organism growth binding protein binding biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process anatomical structure development;; catabolic process;; cell communication;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organism growth;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of growth;; negative regulation of multicellular organismal process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of multicellular organismal process;; reproductive process;; reproductive process in a multicellular organism 42.1646 37.8794 50.0380 57.8193 76.5623 68.3550 164.7075 175.9609 413.8376 349.4793 184.0654 397.5633 502.3105 462.2016 605.9685 176.4864 150.8865 189.4122 1330166 1418981_at 9 1.11 cM chr9:5354642-5371964 9 A1 chr9:5345475-5373034 9 A1 RSQ Mm.42163 NM_009808 2 2 12364 Casp12 caspase 12 (Casp12), mRNA. Alzheimer's disease;; Amyotrophic lateral sclerosis (ALS);; Apoptosis;; Prion diseases CLASS Cellular Processes; Cell Growth and Death; Apoptosis [PATH:mmu04210] Human Diseases; Neurodegenerative Diseases; Alzheimer's disease [PATH:mmu05010] Human Diseases; Neurodegenerative Diseases; Amyotrophic lateral sclerosis (ALS) [PATH:mmu05014] Human Diseases; Neurodegenerative Diseases; Prion diseases [PATH:mmu05020] apoptosis;; apoptosis in response to endoplasmic reticulum stress;; cysteine-type endopeptidase activity;; cysteine-type peptidase activity;; endoplasmic reticulum;; endoplasmic reticulum unfolded protein response;; hydrolase activity;; induction of apoptosis;; intracellular;; peptidase activity;; protein binding;; proteolysis;; regulation of apoptosis;; virus-infected cell apoptosis cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; catalytic activity hydrolase activity;; protein binding biological regulation;; cellular process;; death;; developmental process;; metabolic process;; positive regulation of biological process;; regulation of biological process;; response to stimulus catabolic process;; cell communication;; cell death;; cellular response to stimulus;; macromolecule metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; response to biotic stimulus;; response to chemical stimulus;; response to stress 298.9698 252.2672 307.2753 254.8818 279.5633 255.2021 1486.8186 1408.2953 3208.6653 2981.0044 1430.5068 2903.3414 1686.3321 2029.6574 2549.8540 1858.6323 1499.8186 968.8041 1331338 1420657_at 7 50.0 cM chr7:107634360-107634874 7 E3 chr7:107621499-107634941 7 E3 RSQ Mm.6254 NM_009464 1 1 22229 Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) (Ucp3), nuclear gene encoding mitochondrial protein, mRNA. binding;; fatty acid metabolic process;; integral to membrane;; membrane;; mitochondrial inner membrane;; mitochondrial transport;; mitochondrion;; mitochondrion;; oxidative phosphorylation uncoupler activity;; response to superoxide;; transport cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding;; transporter activity transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process;; response to stimulus cellular localization;; cellular metabolic process;; establishment of localization;; establishment of localization in cell;; primary metabolic process;; response to chemical stimulus;; response to stress;; transport 214.4234 228.9297 176.0408 297.3186 279.9465 252.4171 200.1609 167.7075 560.8443 521.5580 174.5408 507.9575 700.2908 558.4112 649.1553 224.4297 204.4297 214.4663 1344533 1422102_a_at 11 60.5 cM chr11:100644325-100648678 11 D chr11:100642044-100711899 11 D RSQ Mm.34064 NM_001113563 2 1 20851 RP23-279L23.3 Stat5b signal transducer and activator of transcription 5B (Stat5b), mRNA. Acute myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; ErbB signaling pathway [PATH:mmu04012] Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Immune System; Chemokine signaling pathway [PATH:mmu04062] Human Diseases; Cancers; Pathways in cancer [PA;; Chemokine signaling pathway;; Chronic myeloid leukemia;; ErbB signaling pathway;; Jak-STAT signaling pathway;; Pathways in cancer calcium ion binding;; cytokine-mediated signaling pathway;; cytoplasm;; development of secondary female sexual characteristics;; development of secondary male sexual characteristics;; development of secondary male sexual characteristics;; DNA binding;; female pregnancy;; female pregnancy;; JAK-STAT cascade;; lactation;; lipid storage;; luteinization;; natural killer cell differentiation;; negative regulation of apoptosis;; negative regulation of erythrocyte differentiation;; nucleus;; Peyer's patch development;; positive regulation of activated T cell proliferation;; positive regulation of activated T cell proliferation;; positive regulation of B cell differentiation;; positive regulation of cell proliferation;; positive regulation of gamma-delta T cell differentiation;; positive regulation of inflammatory response;; positive regulation of interleukin-2 biosynthetic process;; positive regulation of lymphocyte differentiation;; positive regulation of mitotic cell cycle;; positive regulation of multicellular organism growth;; positive regulation of multicellular organism growth;; positive regulation of natural killer cell differentiation;; positive regulation of natural killer cell mediated cytotoxicity;; positive regulation of natural killer cell proliferation;; positive regulation of survival gene product expression;; positive regulation of transcription from RNA polymerase II promoter;; positive regulation of transcription from RNA polymerase II promoter;; progesterone metabolic process;; protein binding;; regulation of cell adhesion;; regulation of epithelial cell differentiation;; regulation of steroid metabolic process;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; response to interleukin-15;; response to interleukin-2;; response to interleukin-4;; sex differentiation;; signal transducer activity;; signal transduction;; T cell differentiation in the thymus;; T cell homeostasis;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; protein binding;; signal transducer activity;; transcription factor activity biological adhesion;; biological regulation;; cell killing;; cellular process;; death;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus;; rhythmic process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell activation;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; female pregnancy;; hormone metabolic process;; immune effector process;; immune response;; immune system development;; leukocyte activation;; leukocyte homeostasis;; leukocyte mediated cytotoxicity;; macromolecule localization;; macromolecule metabolic process;; multicellular organism growth;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; ovulation cycle;; ovulation cycle process;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of growth;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of homeostatic process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; reproductive developmental process;; reproductive process;; reproductive process in a multicellular organism;; response to chemical stimulus;; response to external stimulus;; response to stress 36.8179 32.6977 47.5826 137.0905 121.0724 106.5132 195.1879 183.1424 842.1944 887.5067 193.3896 963.3258 1420.4606 1362.1924 1505.7619 301.7720 176.5317 187.4154 1344534 1422103_a_at 11 60.5 cM chr11:100642207-100642625 11 D chr11:100642044-100711899 11 D RSQ Mm.34064 NM_001113563 2 1 20851 RP23-279L23.3 Stat5b signal transducer and activator of transcription 5B (Stat5b), mRNA. Acute myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; ErbB signaling pathway [PATH:mmu04012] Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Immune System; Chemokine signaling pathway [PATH:mmu04062] Human Diseases; Cancers; Pathways in cancer [PA;; Chemokine signaling pathway;; Chronic myeloid leukemia;; ErbB signaling pathway;; Jak-STAT signaling pathway;; Pathways in cancer calcium ion binding;; cytokine-mediated signaling pathway;; cytoplasm;; development of secondary female sexual characteristics;; development of secondary male sexual characteristics;; development of secondary male sexual characteristics;; DNA binding;; female pregnancy;; female pregnancy;; JAK-STAT cascade;; lactation;; lipid storage;; luteinization;; natural killer cell differentiation;; negative regulation of apoptosis;; negative regulation of erythrocyte differentiation;; nucleus;; Peyer's patch development;; positive regulation of activated T cell proliferation;; positive regulation of activated T cell proliferation;; positive regulation of B cell differentiation;; positive regulation of cell proliferation;; positive regulation of gamma-delta T cell differentiation;; positive regulation of inflammatory response;; positive regulation of interleukin-2 biosynthetic process;; positive regulation of lymphocyte differentiation;; positive regulation of mitotic cell cycle;; positive regulation of multicellular organism growth;; positive regulation of multicellular organism growth;; positive regulation of natural killer cell differentiation;; positive regulation of natural killer cell mediated cytotoxicity;; positive regulation of natural killer cell proliferation;; positive regulation of survival gene product expression;; positive regulation of transcription from RNA polymerase II promoter;; positive regulation of transcription from RNA polymerase II promoter;; progesterone metabolic process;; protein binding;; regulation of cell adhesion;; regulation of epithelial cell differentiation;; regulation of steroid metabolic process;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; response to interleukin-15;; response to interleukin-2;; response to interleukin-4;; sex differentiation;; signal transducer activity;; signal transduction;; T cell differentiation in the thymus;; T cell homeostasis;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; protein binding;; signal transducer activity;; transcription factor activity biological adhesion;; biological regulation;; cell killing;; cellular process;; death;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus;; rhythmic process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell activation;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; female pregnancy;; hormone metabolic process;; immune effector process;; immune response;; immune system development;; leukocyte activation;; leukocyte homeostasis;; leukocyte mediated cytotoxicity;; macromolecule localization;; macromolecule metabolic process;; multicellular organism growth;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; ovulation cycle;; ovulation cycle process;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of growth;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of homeostatic process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; reproductive developmental process;; reproductive process;; reproductive process in a multicellular organism;; response to chemical stimulus;; response to external stimulus;; response to stress 68.4044 70.4995 82.4082 57.7213 73.6600 66.9479 139.0409 144.9107 338.6226 318.3671 141.4038 281.5625 188.1201 171.1101 171.3201 122.4046 125.7445 136.5622 1333713 1423825_at 3 H4 chr3:159598126-159598647 3 H4 UGA Mm.6766 68151 Gpr177 G protein-coupled receptor 177 (Gpr177), mRNA integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 197.1894 215.9323 185.3704 247.6566 223.1626 187.5363 740.9057 722.6335 1643.5945 1548.8396 706.3995 1452.3215 623.4708 498.2980 630.0106 510.2520 464.9516 503.9633 1334205 1424457_at 18 B2 chr18:36830844-36834637 18 B2 UG5 Mm.89673 225372 Apbb3 Amyloid beta (A4) precursor protein-binding, family B, member 3 (Apbb3), mRNA negative regulation of apoptosis;; protein binding binding protein binding biological regulation;; cellular process;; death;; developmental process;; negative regulation of biological process;; regulation of biological process cell death;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process 404.1059 516.7383 449.4993 621.6116 596.6417 511.4949 953.5615 1016.9887 2841.0170 2711.1166 1015.2672 2667.8203 897.4399 939.4244 931.2811 1954.4339 1721.6484 1168.7522 1334422 1424735_at 2 chr2:32270714-32271132 2 B chr2:32270006-32306939 2 B RSQ Mm.37395 NM_146118 1 1 227731 RP23-255P20.1 Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 (Slc25a25), nuclear gene encoding mitochondrial protein, mRNA. binding;; calcium ion binding;; integral to membrane;; membrane;; mitochondrial inner membrane;; mitochondrion;; transport cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding ion binding establishment of localization;; localization establishment of localization;; transport 48.3118 50.5877 59.0861 49.5796 80.8323 49.3861 67.1359 51.3696 489.9384 431.6515 47.0724 377.0922 555.6433 734.1229 760.2554 124.9346 74.9565 80.3294 1345143 1424795_a_at 2 chr2:30651685-30653425 2 B chr2:30651082-30657227 2 B RSQ Mm.34166 NM_198000 1 1 73598 RP23-221O14.1 1700001O22Rik RIKEN cDNA 1700001O22 gene (1700001O22Rik), mRNA. 34.9231 32.1933 39.0085 34.1061 38.6470 36.7849 47.3997 39.6747 120.2125 113.8210 37.3176 120.0190 32.7201 35.2193 47.9810 39.4218 35.8014 30.6653 1334673 1425079_at 8 chr8:72602280-72603860 8 B3.3 chr8:72596830-72603951 8 B3.3 RSQ Mm.37974 NM_181540 1 1 107770 Tm6sf2 transmembrane 6 superfamily member 2 (Tm6sf2), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 1243.3540 707.5395 1030.4411 898.5519 459.3143 1726.1680 273.8139 269.4133 547.2341 557.8625 281.7780 554.3976 1059.5088 724.5477 970.8555 611.2543 630.1791 606.1168 1345355 1425400_a_at 4 D2.2|4 56.65 cM chr4:120339825-120340283 4 D2.2 UGA Mm.272646 56222 RP23-18M2.2 Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4, mRNA (cDNA clone IMAGE:3670674) cytoplasm;; nucleus;; positive regulation of transcription;; regulation of transcription;; regulation of transcription, DNA-dependent;; transcription;; transcription coactivator activity;; transcription coactivator activity;; transcription regulator activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity protein binding;; transcription activator activity;; transcription cofactor activity biological regulation;; cellular process;; metabolic process;; positive regulation of biological process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 141.7900 125.3745 122.2632 160.5860 160.9295 128.7504 73.1578 76.2143 269.5804 235.2393 75.9593 240.4633 109.2820 74.7242 79.8504 63.7484 67.8046 86.2546 1335161 1425965_at 5 chr5:125866334-125870928 5 G1.1 RSQ XM_001479835 1 1 100048105 LOC100048105 PREDICTED: similar to Ubc protein, transcript variant 2 (LOC100048105), mRNA. PPAR signaling pathway CLASS Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] 32.7911 29.9082 30.6245 28.4432 44.9766 29.5648 78.5539 87.4236 212.5964 191.2307 84.9827 177.5100 76.3944 76.2112 67.1412 93.7556 80.0893 73.9014 1335714 1426858_at 1 E2.3|1 64.1 cM chr1:121312137-121312619 1 E2.3 UGA Mm.3092 16324 Inhbb Inhibin beta-B subunit Cytokine-cytokine receptor interaction;; TGF-beta signaling pathway CLASS Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway [PATH:mmu04350] Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] extracellular region;; growth;; growth factor activity;; hormone activity;; negative regulation of insulin secretion extracellular region binding protein binding biological regulation;; cellular process;; establishment of localization;; growth;; localization;; negative regulation of biological process;; regulation of biological process cell communication;; cellular localization;; establishment of localization;; establishment of localization in cell;; generation of a signal involved in cell-cell signaling;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of transport;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of localization;; secretion by cell;; transport 67.5293 43.7639 39.9385 73.8273 86.1004 53.2431 65.4287 77.2778 153.1302 145.3725 72.9969 149.3902 292.8034 203.2252 127.3522 156.0278 145.0544 67.8311 1335795 1426959_at 16 chr16:31458401-31458555 16 B2 chr16:31422382-31458987 16 B2 RSQ Mm.293470 NM_175177 2 1 71911 Bdh1 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. Butanoate metabolism;; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Butanoate metabolism [PATH:mmu00650] Metabolism; Lipid Metabolism; Synthesis and degradation of ketone bodies [PATH:mmu00072];; Synthesis and degradation of ketone bodies 3-hydroxybutyrate dehydrogenase activity;; binding;; catalytic activity;; metabolic process;; mitochondrial inner membrane;; mitochondrion;; oxidation reduction;; oxidoreductase activity cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding;; catalytic activity oxidoreductase activity metabolic process oxidation reduction 16.7457 23.9955 18.2506 22.0354 22.0988 37.2792 92.0472 89.8266 191.7828 181.2917 85.0148 171.0661 178.8125 152.7356 192.1384 116.8197 74.4440 59.4200 1335963 1427167_at X E3 chrX:131230701-131230976 X E3 UGA Mm.31961 102910 Armcx4 Armadillo repeat containing, X-linked 4, mRNA (cDNA clone IMAGE:5374915) 106.4135 125.3745 103.5521 125.2260 157.2532 97.0008 1345.0827 1318.0969 3270.1303 3132.1231 1323.4778 3324.6294 4141.9650 3910.5902 3560.0473 3616.8186 1965.3796 6423.3900 1346052 1427329_a_at 12 F1-2|12 58.0 cM chr12:114659183-114659651 12 F1 UGA Mm.342177 16019 Igh-6 Immunoglobulin heavy chain complex, mRNA (cDNA clone MGC:28019 IMAGE:3660622) activation of MAPK activity;; antigen binding;; antigen processing and presentation;; B cell receptor complex;; B cell receptor signaling pathway;; early endosome to late endosome transport;; external side of plasma membrane;; extracellular region;; humoral immune response mediated by circulating immunoglobulin;; immunoglobulin complex, circulating;; immunoglobulin mediated immune response;; integral to membrane;; membrane;; perinuclear region of cytoplasm;; plasma membrane;; positive regulation of B cell activation;; positive regulation of B cell proliferation;; positive regulation of endocytosis;; positive regulation of MAPKKK cascade;; positive regulation of peptidyl-tyrosine phosphorylation;; protein binding;; transmembrane receptor activity cell;; cell part;; extracellular region;; extracellular region part;; macromolecular complex cell part;; cell surface;; extracellular region part;; extracellular space;; immunoglobulin complex, circulating;; intracellular;; intracellular part;; membrane;; membrane part;; protein complex binding;; molecular transducer activity antigen binding;; protein binding;; signal transducer activity biological regulation;; cellular component organization;; cellular process;; establishment of localization;; immune system process;; localization;; metabolic process;; positive regulation of biological process;; regulation of biological process;; response to stimulus activation of immune response;; antigen processing and presentation;; cell activation;; cell communication;; cell proliferation;; cellular localization;; cellular metabolic process;; establishment of localization;; establishment of localization in cell;; immune effector process;; immune response;; leukocyte activation;; macromolecule metabolic process;; membrane organization;; positive regulation of biological process;; positive regulation of cellular component organization;; positive regulation of cellular process;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of response to stimulus;; positive regulation of transport;; primary metabolic process;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of immune system process;; regulation of localization;; regulation of metabolic process;; regulation of molecular function;; regulation of response to stimulus;; transport;; vesicle-mediated transport 235.0361 245.3532 206.7069 256.9354 249.2300 228.7343 334.9651 362.4043 774.6081 726.0298 361.0147 784.7735 655.9574 717.4458 667.8830 701.1452 414.3117 1090.0621 1346060 1427351_s_at 12 F1-2|12 58.0 cM chr12:114659066-114659146 12 F1 UGA Mm.342177 16019 Igh-6 Immunoglobulin heavy chain complex, mRNA (cDNA clone MGC:28019 IMAGE:3660622) activation of MAPK activity;; antigen binding;; antigen processing and presentation;; B cell receptor complex;; B cell receptor signaling pathway;; early endosome to late endosome transport;; external side of plasma membrane;; extracellular region;; humoral immune response mediated by circulating immunoglobulin;; immunoglobulin complex, circulating;; immunoglobulin mediated immune response;; integral to membrane;; membrane;; perinuclear region of cytoplasm;; plasma membrane;; positive regulation of B cell activation;; positive regulation of B cell proliferation;; positive regulation of endocytosis;; positive regulation of MAPKKK cascade;; positive regulation of peptidyl-tyrosine phosphorylation;; protein binding;; transmembrane receptor activity cell;; cell part;; extracellular region;; extracellular region part;; macromolecular complex cell part;; cell surface;; extracellular region part;; extracellular space;; immunoglobulin complex, circulating;; intracellular;; intracellular part;; membrane;; membrane part;; protein complex binding;; molecular transducer activity antigen binding;; protein binding;; signal transducer activity biological regulation;; cellular component organization;; cellular process;; establishment of localization;; immune system process;; localization;; metabolic process;; positive regulation of biological process;; regulation of biological process;; response to stimulus activation of immune response;; antigen processing and presentation;; cell activation;; cell communication;; cell proliferation;; cellular localization;; cellular metabolic process;; establishment of localization;; establishment of localization in cell;; immune effector process;; immune response;; leukocyte activation;; macromolecule metabolic process;; membrane organization;; positive regulation of biological process;; positive regulation of cellular component organization;; positive regulation of cellular process;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of response to stimulus;; positive regulation of transport;; primary metabolic process;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of immune system process;; regulation of localization;; regulation of metabolic process;; regulation of molecular function;; regulation of response to stimulus;; transport;; vesicle-mediated transport 67.2103 61.6777 66.1078 53.6141 70.7729 67.5500 132.7359 136.8830 336.8695 369.3644 114.0280 424.8182 161.1338 155.0082 260.9169 124.1905 116.6953 107.3741 1336133 1427384_at 2 H2 chr2:160772766-160773158 2 H2 UGA Mm.122738 71389 RP23-384K10.1 Chd6 Chromodomain helicase DNA binding protein 6, mRNA (cDNA clone IMAGE:3597702) helicase activity;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle catalytic activity hydrolase activity 20.4691 19.6137 19.8437 20.8589 19.1393 20.3895 20.9009 20.5427 93.2300 94.2457 22.6625 122.9824 106.4931 42.3269 37.0779 16.8811 9.8637 23.7602 1336340 1427722_at 6 chr6:137932110-138021719 6 G1 RSQ Mm.269823 NM_177787 1 1 277898 Slc15a5 solute carrier family 15, member 5 (Slc15a5), mRNA. integral to membrane;; membrane;; oligopeptide transport;; peptide transport;; protein transport;; symporter activity;; transport;; transporter activity cell;; cell part cell part;; membrane;; membrane part transporter activity transmembrane transporter activity establishment of localization;; localization establishment of localization;; establishment of protein localization;; macromolecule localization;; transport 113.2984 145.5687 178.7431 160.1258 122.0618 85.1566 2022.3901 2068.3186 6563.1989 6610.9871 2083.5964 6908.7095 434.1351 562.1519 536.9156 313.0404 399.7279 277.0665 1336689 1428306_at 10 chr10:59412481-59412957 10 B4 chr10:59412422-59414518 10 B4 RSQ Mm.21697 NM_029083 1 1 74747 Ddit4 DNA-damage-inducible transcript 4 (Ddit4), mRNA. mTOR signaling pathway CLASS Environmental Information Processing; Signal Transduction; mTOR signaling pathway [PATH:mmu04150] apoptosis;; cytoplasm;; negative regulation of signal transduction cell;; cell part cell part;; intracellular;; intracellular part biological regulation;; cellular process;; death;; negative regulation of biological process;; regulation of biological process cell communication;; cell death;; negative regulation of biological process;; negative regulation of cellular process;; regulation of biological process;; regulation of cellular process 159.8594 96.5305 92.6462 130.8693 136.7388 238.5904 284.7408 257.7510 1491.9889 1412.7241 262.5376 1337.1505 511.9971 506.2394 595.2630 558.1104 471.4421 346.7177 1346626 1431213_a_at 8 UGA Mm.463370 Transcribed locus, weakly similar to XP_001379802.1 PREDICTED: similar to pol protein [Monodelphis domestica] 1443.0070 902.1295 1371.1218 1033.4406 904.3991 1158.2260 549.7658 560.6155 2143.1672 2100.7630 504.7480 2175.6269 509.3776 844.7421 1033.9999 646.8443 585.0293 306.0313 1347360 1436689_a_at 1 chr1:169298245-169298401 1 H2.3 chr1:169280121-169298661 1 H2.3 RSQ Mm.330055 NM_019993 1 1 56752 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA. 3-Chloroacrylic acid degradation;; Arginine and proline metabolism;; Ascorbate and aldarate metabolism;; beta-Alanine metabolism;; Butanoate metabolism;; Fatty acid metabolism;; Glycerolipid metabolism;; Glycolysis / Gluconeogenesis;; Histidine metabolism;; Limonene and pinene degradation;; Lysine degradation;; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Glycolysis / Gluconeogenesis [PATH:mmu00010] Metabolism; Carbohydrate Metabolism; Ascorbate and aldarate metabolism [PATH:mmu00053] Metabolism; Carbohydrate Metabolism; Pyruvate metabolism [PATH:mmu00620] Metabolism; Carbohydrate Metabolism; Propanoate metabolism [PATH:mmu00640] Metabolism; C;; Propanoate metabolism;; Pyruvate metabolism;; Tryptophan metabolism;; Valine, leucine and isoleucine degradation 4-trimethylammoniobutyraldehyde dehydrogenase activity;; aldehyde dehydrogenase (NAD) activity;; carnitine metabolic process;; cytoplasm;; cytosol;; metabolic process;; oxidation reduction;; oxidoreductase activity;; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor cell;; cell part cell part;; intracellular;; intracellular part catalytic activity oxidoreductase activity cellular process;; metabolic process cellular metabolic process;; nitrogen compound metabolic process;; oxidation reduction;; primary metabolic process 73.2476 81.6525 76.8405 75.1815 69.9325 81.7355 51.9557 61.4238 152.8239 135.7862 54.4551 146.7140 97.7738 115.4867 125.2645 53.7487 65.4406 66.3333 1338084 1437025_at 1 30.1 cM chr1:60829610-60829918 1 C2 chr1:60803231-60830203 1 C2 RSQ Mm.255003 NM_007642 2 2 12487 CH29-189K17.3 Cd28 CD28 antigen (Cd28), mRNA. Antigen Dependent B Cell Activation;; Bystander B Cell Activation;; HIV Induced T Cell Apoptosis;; Role of Tob in T-cell activation;; Selective expression of chemokine receptors during T-cell polarization;; T Cytotoxic Cell Surface Molecules;; T Helper Cell Surface Molecules;; Th1/Th2 Differentiation;; The Co-Stimulatory Signal During T-cell Activation Allograft rejection;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Immune System; T cell receptor signaling pathway [PATH:mmu04660] Human Diseases; Immune Disorders; Systemic lupus erythematosus [PATH:mmu05322] Human Diseases; Immune Disorders; Aut;; Systemic lupus erythematosus;; T cell receptor signaling pathway;; Type I diabetes mellitus external side of plasma membrane;; external side of plasma membrane;; external side of plasma membrane;; immune response;; induction of apoptosis by extracellular signals;; integral to membrane;; membrane;; negative thymic T cell selection;; plasma membrane;; positive regulation of alpha-beta T cell proliferation;; positive regulation of alpha-beta T cell proliferation;; positive regulation of inflammatory response to antigenic stimulus;; positive regulation of interleukin-2 biosynthetic process;; positive regulation of isotype switching to IgG isotypes;; positive regulation of T cell proliferation;; positive regulation of T cell proliferation;; T cell costimulation;; T cell costimulation cell;; cell part cell part;; cell surface;; membrane;; membrane part biological regulation;; cellular process;; death;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; biosynthetic process;; cell activation;; cell death;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; immune effector process;; immune response;; immune system development;; leukocyte activation;; lymphocyte costimulation;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; response to external stimulus;; response to stress;; somatic diversification of immune receptors;; T cell selection 677.6724 469.2906 609.6344 537.8606 471.5644 528.9066 237.6797 244.9858 1031.1579 993.4510 272.6434 956.7375 307.5396 393.4332 504.3200 313.3426 282.5293 251.0767 1347565 1437398_a_at 1 chr1:169297696-169298074 1 H2.3 chr1:169280121-169298661 1 H2.3 RSQ Mm.330055 NM_019993 1 1 56752 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA. 3-Chloroacrylic acid degradation;; Arginine and proline metabolism;; Ascorbate and aldarate metabolism;; beta-Alanine metabolism;; Butanoate metabolism;; Fatty acid metabolism;; Glycerolipid metabolism;; Glycolysis / Gluconeogenesis;; Histidine metabolism;; Limonene and pinene degradation;; Lysine degradation;; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Glycolysis / Gluconeogenesis [PATH:mmu00010] Metabolism; Carbohydrate Metabolism; Ascorbate and aldarate metabolism [PATH:mmu00053] Metabolism; Carbohydrate Metabolism; Pyruvate metabolism [PATH:mmu00620] Metabolism; Carbohydrate Metabolism; Propanoate metabolism [PATH:mmu00640] Metabolism; C;; Propanoate metabolism;; Pyruvate metabolism;; Tryptophan metabolism;; Valine, leucine and isoleucine degradation 4-trimethylammoniobutyraldehyde dehydrogenase activity;; aldehyde dehydrogenase (NAD) activity;; carnitine metabolic process;; cytoplasm;; cytosol;; metabolic process;; oxidation reduction;; oxidoreductase activity;; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor cell;; cell part cell part;; intracellular;; intracellular part catalytic activity oxidoreductase activity cellular process;; metabolic process cellular metabolic process;; nitrogen compound metabolic process;; oxidation reduction;; primary metabolic process 74.4192 48.7619 107.4835 107.5749 98.1812 95.1100 1050.2375 1121.8854 2694.9050 2752.8130 1151.9891 2685.5082 816.3741 930.9440 1011.2987 956.1259 893.9462 751.9297 1338746 1448181_at 6 chr6:90424643-90425023 6 D1 chr6:90412619-90425203 6 D1 RSQ Mm.41389 NM_023184 1 1 66277 Klf15 Kruppel-like factor 15 (Klf15), mRNA. DNA binding;; DNA binding;; glucose transport;; intracellular;; metal ion binding;; nucleic acid binding;; nucleus;; positive regulation of transcription, DNA-dependent;; protein binding;; regulation of transcription, DNA-dependent;; transcription;; transcription factor activity;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity ion binding;; nucleic acid binding;; protein binding;; transcription factor activity biological regulation;; cellular process;; establishment of localization;; localization;; metabolic process;; positive regulation of biological process;; regulation of biological process biosynthetic process;; cellular metabolic process;; establishment of localization;; macromolecule metabolic process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; transport 93.3259 97.7350 117.8024 134.2480 125.2634 117.3888 106.7986 110.3035 251.0973 183.4840 111.6506 241.8198 136.5065 213.7686 297.7688 104.7680 98.0654 77.5603 1339128 1448669_at 7 chr7:119259868-119260122 7 F1 chr7:119259532-119302571 7 F1 RSQ Mm.55143 NM_015814 1 1 50781 Dkk3 dickkopf homolog 3 (Xenopus laevis) (Dkk3), mRNA. extracellular region;; extracellular space;; multicellular organismal development;; negative regulation of Wnt receptor signaling pathway;; Wnt receptor signaling pathway extracellular region;; extracellular region part extracellular region part;; extracellular space biological regulation;; cellular process;; developmental process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process cell communication;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; regulation of biological process;; regulation of cellular process 605.4722 797.3774 241.9977 1044.7616 2713.7768 856.5815 60.0072 57.7634 126.2640 107.7231 56.7346 117.4833 35.0984 23.1433 29.4871 67.2878 68.1489 56.9569 1339138 1448680_at 12 51.0 cM chr12:105133323-105135281 12 E chr12:105133135-105143160 12 E RSQ Mm.439694 NM_009245 2 2 20702 Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C (Serpina1c), mRNA. endopeptidase inhibitor activity;; extracellular region;; protein amino acid N-linked glycosylation;; protein binding;; response to cytokine stimulus;; response to peptide hormone stimulus;; serine-type endopeptidase inhibitor activity extracellular region binding;; enzyme regulator activity enzyme inhibitor activity;; protein binding cellular process;; metabolic process;; response to stimulus biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process;; response to chemical stimulus;; response to endogenous stimulus 228.0238 398.3964 283.2197 495.2884 453.0797 551.0824 1230.2147 1169.5646 4293.6797 4113.7206 1136.2792 4409.4028 1080.4852 1721.8420 3238.0171 495.1049 180.4638 363.2432 1339177 1448724_at 9 59.0 cM chr9:107203813-107204254 9 F1 chr9:107199019-107204292 9 F1 RSQ Mm.4592 NM_009895 1 1 12700 Cish cytokine inducible SH2-containing protein (Cish), mRNA. Jak-STAT signaling pathway CLASS Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway;; intracellular signaling cascade;; modification-dependent protein catabolic process;; negative regulation of signal transduction;; plasma membrane;; protein binding;; regulation of growth cell;; cell part cell part;; membrane binding protein binding biological regulation;; cellular process;; growth;; metabolic process;; negative regulation of biological process;; regulation of biological process catabolic process;; cell communication;; cellular metabolic process;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of growth;; regulation of metabolic process;; regulation of molecular function 30.2436 49.5261 32.0600 33.6938 25.0206 42.9629 1240.6519 1217.0150 2674.5881 2442.3125 1208.5964 2562.1903 2591.0843 2066.9852 2712.4628 2006.5825 2318.7357 1830.7298 1339195 1448747_at 15 chr15:58012414-58012790 15 D1 chr15:58011633-58046433 15 D1 RSQ Mm.292042 NM_026346 1 1 67731 Fbxo32 F-box protein 32 (Fbxo32), mRNA. modification-dependent protein catabolic process;; nucleus;; protein binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding protein binding cellular process;; metabolic process catabolic process;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 38.4313 29.2628 32.6417 62.9996 52.0411 64.4851 472.4270 433.4186 1003.3441 981.8046 474.8078 934.7482 597.6048 845.6000 1011.9679 231.8657 185.9429 203.6540 1339494 1449109_at 10 52.0 cM chr10:94875126-94875560 10 C2 chr10:94874675-94879455 10 C2 RSQ Mm.474283 NM_007706 3 3 216233 Socs2 suppressor of cytokine signaling 2 (Socs2), mRNA. Insulin signaling pathway;; Jak-STAT signaling pathway;; Type II diabetes mellitus CLASS Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] Human Diseases; Metabolic Disorders; Type II diabetes mellitus [PATH:mmu04930] growth hormone receptor binding;; intracellular signaling cascade;; lactation;; lactation;; mammary gland alveolus development;; mammary gland alveolus development;; modification-dependent protein catabolic process;; negative regulation of JAK-STAT cascade;; negative regulation of multicellular organism growth;; negative regulation of multicellular organism growth;; negative regulation of signal transduction;; positive regulation of neuron differentiation;; regulation of growth;; regulation of multicellular organism growth binding protein binding biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process anatomical structure development;; catabolic process;; cell communication;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organism growth;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of growth;; negative regulation of multicellular organismal process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of multicellular organismal process;; reproductive process;; reproductive process in a multicellular organism 24.8068 23.7843 23.5432 29.1122 27.2175 25.4449 101.0482 111.2058 258.5023 239.1447 98.5324 253.1287 298.3186 317.9297 362.7039 116.8754 77.1682 97.8343 1339649 1449297_at 9 1.11 cM chr9:5372098-5372617 9 A1 chr9:5345475-5373034 9 A1 RSQ Mm.42163 NM_009808 2 2 12364 Casp12 caspase 12 (Casp12), mRNA. Alzheimer's disease;; Amyotrophic lateral sclerosis (ALS);; Apoptosis;; Prion diseases CLASS Cellular Processes; Cell Growth and Death; Apoptosis [PATH:mmu04210] Human Diseases; Neurodegenerative Diseases; Alzheimer's disease [PATH:mmu05010] Human Diseases; Neurodegenerative Diseases; Amyotrophic lateral sclerosis (ALS) [PATH:mmu05014] Human Diseases; Neurodegenerative Diseases; Prion diseases [PATH:mmu05020] apoptosis;; apoptosis in response to endoplasmic reticulum stress;; cysteine-type endopeptidase activity;; cysteine-type peptidase activity;; endoplasmic reticulum;; endoplasmic reticulum unfolded protein response;; hydrolase activity;; induction of apoptosis;; intracellular;; peptidase activity;; protein binding;; proteolysis;; regulation of apoptosis;; virus-infected cell apoptosis cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; catalytic activity hydrolase activity;; protein binding biological regulation;; cellular process;; death;; developmental process;; metabolic process;; positive regulation of biological process;; regulation of biological process;; response to stimulus catabolic process;; cell communication;; cell death;; cellular response to stimulus;; macromolecule metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; response to biotic stimulus;; response to chemical stimulus;; response to stress 136.5044 357.6715 241.1579 157.5509 151.5962 205.6194 69.0098 69.3379 393.3762 400.2617 65.9741 420.8046 59.3971 91.1739 62.6944 48.5173 88.2391 799.8730 1348421 1449526_a_at 7 chr7:133911136-133919078 7 F3 chr7:133909927-133919159 7 F3 RSQ Mm.246881 NM_024228 1 1 68616 Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 (Gdpd3), mRNA. glycerol metabolic process;; glycerophosphodiester phosphodiesterase activity;; hydrolase activity;; integral to membrane;; lipid metabolic process;; membrane;; phosphoric diester hydrolase activity cell;; cell part cell part;; membrane;; membrane part catalytic activity hydrolase activity cellular process;; metabolic process alcohol metabolic process;; cellular metabolic process;; primary metabolic process 51.8347 49.2401 60.5953 60.4990 69.0633 68.4838 108.9853 107.4891 311.8064 219.6831 98.8646 224.5103 108.7865 89.2876 119.3750 119.7721 103.2648 88.0379 1348434 1449590_a_at 9 chr9:99288490-99290204 9 E3.3 chr9:99285838-99337131 9 E3.3 RSQ Mm.2045 NM_008624 1 1 17532 Mras muscle and microspikes RAS (Mras), mRNA. MAPK signaling pathway;; Regulation of actin cytoskeleton CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Cellular Processes; Cell Motility; Regulation of actin cytoskeleton [PATH:mmu04810] Cellular Processes; Cell Communication; Tight junction [PATH:mmu04530];; Tight junction GTP binding;; intracellular;; membrane;; nucleotide binding;; plasma membrane;; small GTPase mediated signal transduction cell;; cell part cell part;; intracellular;; membrane binding nucleotide binding biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 13.8932 16.3582 22.5512 59.7969 39.8737 43.7828 25.8331 31.5116 82.9659 78.6861 31.5116 72.4687 166.3186 137.2517 149.8765 74.5429 65.4503 55.7989 1348627 1450259_a_at 11 60.5 cM chr11:100742343-100745240 11 D chr11:100720716-100746483 11 D RSQ Mm.277403 NM_011488 1 1 20850 RP23-279L23.4 Stat5a signal transducer and activator of transcription 5A (Stat5a), mRNA. EPO Signaling Pathway;; Growth Hormone Signaling Pathway;; IL 2 signaling pathway;; IL 3 signaling pathway;; IL-2 Receptor Beta Chain in T cell Activation;; IL-7 Signal Transduction;; IL22 Soluble Receptor Signaling Pathway;; Inhibition of Cellular Proliferation by Gleevec;; TPO Signaling Pathway Acute myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; ErbB signaling pathway [PATH:mmu04012] Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221] Hu;; Chronic myeloid leukemia;; ErbB signaling pathway;; Jak-STAT signaling pathway;; Pathways in cancer calcium ion binding;; cytokine-mediated signaling pathway;; cytoplasm;; development of secondary female sexual characteristics;; development of secondary male sexual characteristics;; development of secondary male sexual characteristics;; DNA binding;; epithelial cell differentiation involved in prostate gland development;; female pregnancy;; JAK-STAT cascade;; lactation;; lipid storage;; luteinization;; mammary gland development;; natural killer cell differentiation;; negative regulation of apoptosis;; negative regulation of erythrocyte differentiation;; negative regulation of mast cell apoptosis;; nucleus;; peptidyl-tyrosine phosphorylation;; Peyer's patch development;; positive regulation of activated T cell proliferation;; positive regulation of activated T cell proliferation;; positive regulation of B cell differentiation;; positive regulation of cell proliferation;; positive regulation of cell proliferation;; positive regulation of gamma-delta T cell differentiation;; positive regulation of inflammatory response;; positive regulation of interleukin-2 biosynthetic process;; positive regulation of lymphocyte differentiation;; positive regulation of mast cell differentiation;; positive regulation of mast cell proliferation;; positive regulation of mitotic cell cycle;; positive regulation of multicellular organism growth;; positive regulation of natural killer cell differentiation;; positive regulation of natural killer cell mediated cytotoxicity;; positive regulation of survival gene product expression;; positive regulation of transcription from RNA polymerase II promoter;; positive regulation of transcription from RNA polymerase II promoter;; prostate gland epithelium morphogenesis;; protein binding;; regulation of cell adhesion;; regulation of epithelial cell differentiation;; regulation of steroid metabolic process;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; response to peptide hormone stimulus;; signal transducer activity;; signal transduction;; T cell differentiation in the thymus;; T cell homeostasis;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; protein binding;; signal transducer activity;; transcription factor activity biological adhesion;; biological regulation;; cell killing;; cellular process;; death;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus;; rhythmic process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell activation;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; female pregnancy;; immune effector process;; immune response;; immune system development;; leukocyte activation;; leukocyte homeostasis;; leukocyte mediated cytotoxicity;; macromolecule localization;; macromolecule metabolic process;; multicellular organism growth;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; ovulation cycle;; ovulation cycle process;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of growth;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of homeostatic process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; reproductive developmental process;; reproductive process;; reproductive process in a multicellular organism;; response to chemical stimulus;; response to endogenous stimulus;; response to external stimulus;; response to stress 76.0049 79.1269 68.3399 83.7290 74.3432 73.9998 119.8420 114.0869 478.6041 582.4354 131.5029 535.5104 84.4673 87.3341 90.5160 69.5824 64.6864 79.0687 1340562 1450606_at 11 chr11:98248718-98249320 11 D chr11:98247945-98249411 11 D RSQ Mm.57030 NM_008890 1 1 18948 RP23-355L10.6 Pnmt phenylethanolamine-N-methyltransferase (Pnmt), mRNA. Metabolic pathways CLASS Metabolism; Amino Acid Metabolism; Tyrosine metabolism [PATH:mmu00350];; Tyrosine metabolism catecholamine biosynthetic process;; methyltransferase activity;; phenylethanolamine N-methyltransferase activity;; transferase activity catalytic activity transferase activity cellular process;; metabolic process alcohol metabolic process;; biosynthetic process;; cellular metabolic process;; nitrogen compound metabolic process;; primary metabolic process 55.6164 55.6164 58.3606 49.0425 52.2882 62.2736 351.4852 390.0426 1629.9509 1790.5964 342.2789 1860.1253 229.7631 276.4024 442.2075 129.3800 117.5628 98.9141 1341364 1451715_at 2 91.0 cM chr2:160191130-160191719 2 H2 chr2:160189412-160192801 2 H2 RSQ Mm.330745 NM_010658 1 1 16658 RP23-333A18.1 Mafb v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA. brain segmentation;; DNA binding;; inner ear morphogenesis;; nucleus;; positive regulation of transcription from RNA polymerase II promoter;; protein binding;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; respiratory gaseous exchange;; rhombomere 5 development;; rhombomere 6 development;; segment specification;; sequence-specific DNA binding;; transcription;; transcription factor activity;; transcription factor complex cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity nucleic acid binding;; protein binding;; transcription factor activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cellular metabolic process;; embryonic development;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; pattern specification process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; respiratory gaseous exchange 104.7092 115.8596 130.8743 90.6181 117.8875 143.2256 715.7394 690.2579 2766.2138 2808.5714 665.3594 2755.7235 652.5212 666.6209 1120.3174 341.1308 278.8834 265.8186 1341365 1451716_at 2 H2|2 91.0 cM chr2:160189869-160190403 2 H2 UG5 Mm.330745 16658 RP23-333A18.1 Mafb V-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA brain segmentation;; DNA binding;; inner ear morphogenesis;; nucleus;; positive regulation of transcription from RNA polymerase II promoter;; protein binding;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; respiratory gaseous exchange;; rhombomere 5 development;; rhombomere 6 development;; segment specification;; sequence-specific DNA binding;; transcription;; transcription factor activity;; transcription factor complex cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity nucleic acid binding;; protein binding;; transcription factor activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cellular metabolic process;; embryonic development;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; pattern specification process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; respiratory gaseous exchange 62.8092 86.4302 62.9574 80.5540 88.3045 65.1818 112.4378 108.5944 197.3820 258.9297 108.2185 255.3610 112.4359 103.9248 75.5867 111.6237 105.2096 113.8202 1341465 1451883_at 3 A2|3 chr3:19586092-19586509 3 A2 UGA Mm.450006 620316 BC002189 CDNA sequence BC002189, mRNA (cDNA clone MGC:7386 IMAGE:3487872) 395.9749 323.3935 468.5698 514.6855 596.5964 376.1519 429.9117 430.9946 967.9575 883.5241 451.3442 909.2381 1300.8780 1194.8214 787.6699 766.2231 753.5689 526.1922 1341716 1452257_at 16 chr16:31457009-31457556 16 B2 chr16:31422382-31458987 16 B2 RSQ Mm.293470 NM_175177 2 1 71911 Bdh1 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. Butanoate metabolism;; Metabolic pathways CLASS Metabolism; Carbohydrate Metabolism; Butanoate metabolism [PATH:mmu00650] Metabolism; Lipid Metabolism; Synthesis and degradation of ketone bodies [PATH:mmu00072];; Synthesis and degradation of ketone bodies 3-hydroxybutyrate dehydrogenase activity;; binding;; catalytic activity;; metabolic process;; mitochondrial inner membrane;; mitochondrion;; oxidation reduction;; oxidoreductase activity cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding;; catalytic activity oxidoreductase activity metabolic process oxidation reduction 4707.9487 4429.0510 5154.3189 5292.9181 7748.5524 4456.2118 22.9533 20.3788 57.4732 44.0718 18.4784 41.3349 16.1563 16.7283 11.7841 38.0734 41.0757 14.6605 1349572 1454608_x_at 18 7.0 cM chr18:20832268-20832377 18 A2 chr18:20823913-20832820 18 A2 RSQ Mm.2108 NM_013697 1 1 22139 Ttr transthyretin (Ttr), mRNA. extracellular region;; hormone activity;; thyroid hormone generation;; transport extracellular region binding protein binding biological regulation;; cellular process;; establishment of localization;; localization;; metabolic process cellular metabolic process;; establishment of localization;; hormone metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological quality;; transport 489.5551 358.4544 492.8005 286.3250 237.3763 280.4460 432.4445 449.9297 901.7931 860.0940 427.3303 908.3186 402.0770 429.9424 435.5353 409.6664 352.0807 358.9929 1342410 1455220_at 19 37.6 cM chr19:41920549-41921065 19 C3 chr19:41920467-41922622 19 C3 RSQ Mm.222723 NM_177603 1 1 212398 Frat2 frequently rearranged in advanced T-cell lymphomas 2 (Frat2), mRNA. Wnt signaling pathway CLASS Environmental Information Processing; Signal Transduction; Wnt signaling pathway [PATH:mmu04310] Wnt receptor signaling pathway;; Wnt receptor signaling pathway biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 180.0056 154.9201 168.4422 184.0496 205.6186 154.8569 323.9602 308.2770 1664.2896 1416.2154 321.4307 1466.3313 469.9297 420.6888 500.4297 485.9151 410.1359 355.7149 1342536 1455869_at 11 chr11:5908951-5909394 11 A1 UGA Mm.458283 Transcribed locus, moderately similar to XP_001477892.1 PREDICTED: hypothetical protein [Mus musculus] 3651.6992 3470.0276 4154.1246 4593.5087 6869.2908 3762.0437 10.0928 8.9278 24.0086 26.5427 11.9452 20.2236 10.4789 10.9173 8.7860 25.0619 18.3032 12.0530 1349780 1455913_x_at 18 7.0 cM chr18:20832283-20832379 18 A2 chr18:20823913-20832820 18 A2 RSQ Mm.2108 NM_013697 1 1 22139 Ttr transthyretin (Ttr), mRNA. extracellular region;; hormone activity;; thyroid hormone generation;; transport extracellular region binding protein binding biological regulation;; cellular process;; establishment of localization;; localization;; metabolic process cellular metabolic process;; establishment of localization;; hormone metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological quality;; transport 41.7678 33.8437 86.8471 37.5738 51.9935 39.9188 135.3742 125.2048 269.4157 288.4518 112.1038 260.9304 238.3257 301.5408 416.4719 194.9429 308.3438 245.5021 1342923 1460336_at 5 chr5:51849303-51854566 5 C1 chr5:51845487-51945160 5 C1 RSQ Mm.259072 NM_008904 2 1 19017 Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (Ppargc1a), transcript variant 1, mRNA. Regulation of PGC-1a;; Role of PPAR-gamma Coactivators in Obesity and Thermogenesis Adipocytokine signaling pathway;; Huntington's disease CLASS Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] Cellular Processes; Endocrine System; Adipocytokine signaling pathway [PATH:mmu04920] Human Diseases; Neurodegenerative Diseases; Huntington's disease [PATH:mmu05016];; Insulin signaling pathway DNA binding;; nucleic acid binding;; nucleotide binding;; nucleus;; positive regulation of transcription;; positive regulation of transcription from RNA polymerase II promoter;; protein binding;; receptor activity;; regulation of transcription, DNA-dependent;; respiratory electron transport chain;; RNA binding;; transcription;; transcription activator activity;; transcription coactivator activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity nucleic acid binding;; nucleotide binding;; protein binding;; signal transducer activity;; transcription activator activity;; transcription cofactor activity biological regulation;; cellular process;; metabolic process;; positive regulation of biological process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; oxidation reduction;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 162.6124 151.8905 163.9779 119.8749 97.5051 144.3770 721.2315 703.3000 1895.7038 1694.9889 714.5902 1660.2075 408.8358 536.3186 384.5423 243.2002 335.2188 213.8707 1350443 1428352_at 8 chr8:73359362-73359595 8 B3.3 chr8:73359036-73363619 8 B3.3 RSQ Mm.24215 NM_027560 1 1 70807 Arrdc2 arrestin domain containing 2 (Arrdc2), mRNA. 17.0275 16.9106 19.9746 17.9895 18.6048 21.7383 163.3294 172.5743 314.2027 376.0961 179.3186 358.6830 32.9315 33.8547 50.4968 58.2947 53.2984 30.0474 1351838 1430352_at 6 D1 chr6:92795416-92795850 6 D1 UGA Mm.257557 101401 mCG_142056 Adamts9 MKIAA1312 protein endopeptidase activity;; extracellular space;; metallopeptidase activity;; positive regulation of melanocyte differentiation;; proteinaceous extracellular matrix;; proteolysis;; proteolysis;; regulation of pigmentation during development extracellular region;; extracellular region part extracellular matrix;; extracellular region part;; extracellular space catalytic activity hydrolase activity biological regulation;; cellular process;; developmental process;; metabolic process;; pigmentation;; positive regulation of biological process;; regulation of biological process catabolic process;; cellular developmental process;; macromolecule metabolic process;; pigmentation during development;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process 39.1411 33.6537 31.4941 30.3688 33.7145 33.4306 24.0320 31.9706 74.0188 64.2147 25.7320 46.0115 32.6034 30.8262 27.9737 21.4393 22.1939 27.9959 1352872 1431869_at 1 chr1:78591732-78592181 1 C4 UGA Mm.462998 Transcribed locus 36.5669 34.1892 34.2516 41.4322 41.6775 34.9320 31.3186 35.9796 84.3463 74.2800 39.9359 84.2294 27.7300 22.3955 27.0462 21.7037 20.2123 32.8104 1353251 1432461_at 10 chr10:22889870-22905127 10 A3 UGA Mm.444786 Transcribed locus 106.3457 129.4261 137.7822 103.6289 127.4963 116.2633 157.8126 162.8186 380.3680 360.8920 169.7019 324.3706 173.6549 250.2903 273.6243 196.8169 191.8134 210.0363 1355034 1435188_at 3 chr3:95682590-95683010 3 F2.1 chr3:95682427-95686151 3 F2.1 RSQ Mm.331218 NM_001033302 1 1 229599 Gm129 predicted gene 129 (Gm129), mRNA. 43.1165 38.6592 45.2781 29.9397 41.5449 43.3398 30.9623 42.6913 94.6231 83.2493 44.5354 78.6205 128.8303 133.1761 157.9499 75.2886 49.8386 55.2788 1355746 1436309_at 8 chr8:88161038-88161540 8 C3 chr8:88160486-88214908 8 C3 RSQ Mm.126079 NM_001081324 1 1 74513 Neto2 neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), mRNA. integral to membrane;; membrane;; plasma membrane;; receptor activity cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity 20.6117 31.7894 22.5429 23.5381 26.0521 21.5602 29.1586 28.9029 63.2457 54.4033 28.0957 63.3116 21.4183 21.5015 23.5698 20.3494 25.7466 30.6803 1357927 1440016_at chr3:116216915-116217450 3 G1 IPA ESTs 131.1027 97.5409 115.2718 127.9043 149.3613 130.8655 686.9248 736.2371 1542.6583 1455.2829 726.0295 1414.9135 1441.8606 1229.6741 1426.0947 1350.7680 1318.5567 1358.7346 1358662 1440844_at 11 chr11:94072819-94072951 11 D chr11:94072767-94076809 11 D RSQ Mm.259673 NM_009427 1 1 22057 RP23-244C22.1 Tob1 transducer of ErbB-2.1 (Tob1), mRNA. Role of Tob in T-cell activation cytoplasm;; negative regulation of BMP signaling pathway;; negative regulation of osteoblast differentiation;; protein binding;; SMAD binding;; SMAD protein nuclear translocation;; transcription corepressor activity cell;; cell part cell part;; intracellular;; intracellular part binding;; transcription regulator activity protein binding;; transcription cofactor activity;; transcription repressor activity biological regulation;; cellular process;; developmental process;; establishment of localization;; localization;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process anatomical structure development;; cell communication;; cellular developmental process;; cellular localization;; establishment of localization;; establishment of localization in cell;; establishment of protein localization;; macromolecule localization;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; ossification;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process;; tissue remodeling;; transport 140.9122 129.9372 140.4589 160.0506 101.8413 172.6618 166.6573 176.0408 396.8003 359.5980 162.3692 355.7399 170.8752 110.9951 128.5818 200.7335 120.2462 193.5358 1359017 1441228_at 6 G1 chr6:134936253-134936706 6 G1 UG5 Mm.296104 381823 Apold1 Apolipoprotein L domain containing 1 (Apold1), mRNA 93.3358 102.5830 99.7480 101.9220 94.8237 105.2300 107.1100 91.2041 248.2030 229.3167 100.0896 268.3572 123.8972 130.6620 159.8440 105.3776 79.6263 97.5645 1359079 1441300_at 12 A1.1 chr12:17181256-17181600 12 A1.1 UGA Mm.40173 382571 Kcnf1 Potassium voltage-gated channel, subfamily F, member 1 (Kcnf1), mRNA integral to membrane;; ion channel activity;; ion transport;; membrane;; potassium channel activity;; potassium ion binding;; potassium ion transport;; protein binding;; transport;; voltage-gated ion channel activity;; voltage-gated potassium channel activity;; voltage-gated potassium channel complex cell;; cell part;; macromolecular complex cell part;; membrane;; membrane part;; protein complex binding;; transporter activity ion binding;; protein binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 49.2502 53.4814 51.5917 43.7548 43.0360 46.1209 114.4313 113.9699 304.5925 328.7047 113.0672 401.3536 458.4861 460.1643 620.7335 270.0419 105.7489 96.3556 1359154 1441384_at 9 F3 chr9:115984734-115985251 9 F3 UG5 Mm.29221 73748 Gadl1 Glutamate decarboxylase-like 1 (Gadl1), mRNA carboxy-lyase activity;; carboxylic acid metabolic process;; catalytic activity;; lyase activity;; pyridoxal phosphate binding binding;; catalytic activity cofactor binding;; lipid binding;; lyase activity;; vitamin binding cellular process;; metabolic process cellular metabolic process 29.5326 50.7203 28.4933 45.1224 40.6373 35.4435 140.4297 146.9383 364.9948 405.3497 125.8017 366.8801 118.7726 137.7341 120.9021 144.1744 167.6070 161.0341 1360668 1443100_at 14 chr14:18661754-18662090 14 A2 UGA Mm.406687 Transcribed locus 44.4352 50.0524 37.3470 45.3961 47.8865 39.9166 248.1519 219.4084 542.2619 507.4418 234.4187 462.3202 103.7687 115.7316 127.6573 104.4197 93.6171 96.9214 1362558 1445148_at chr1:55487728-55488266 1 C1.2 IPA Mus musculus 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230091K16 product:unknown EST, full insert sequence. 39.2034 38.4510 43.8003 49.8877 40.6373 35.7670 47.8348 51.0117 101.1707 101.9682 53.2824 106.6829 40.9233 32.8096 48.3425 40.2215 31.0515 39.3015 1363186 1445809_at 10 chr10:23067802-23068323 10 A3 UGA Mm.444891 Transcribed locus 27.2588 28.7282 24.6552 27.0689 25.1552 35.7810 22.3955 23.8650 48.0810 41.6238 20.6031 44.5490 17.5490 20.6898 18.4870 22.6002 17.3948 19.7262 1363507 1446134_at chr15:66989390-66989885 15 D2 IPA ESTs 95.5052 76.9258 69.9392 77.6037 68.6925 77.4155 71.0820 80.9267 173.5964 195.1596 72.7367 164.1151 73.2654 84.5402 58.3413 91.0637 86.2893 89.4989 1364374 1447023_at chr14:18606024-18606518 14 A2 IPA ESTs 13.9648 14.5341 16.1145 15.3991 12.3485 15.6880 13.8693 22.9534 28.9957 55.7832 14.2759 35.3177 13.7650 12.2680 10.6671 10.1603 12.0090 11.5744 1364676 1447360_at 14 D3|14 42.0 cM chr14:76821285-76821639 14 D3 UGA Mm.153272 21807 Tsc22d1 TSC22-related inducible leucine zipper 1b (Tilz1b) cytoplasm;; nucleus;; regulation of transcription, DNA-dependent;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; transcription factor activity biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 31.9917 32.2208 42.3948 34.2168 36.6746 37.2588 195.1244 198.8168 462.8211 440.0609 192.7568 415.9858 169.7343 138.0403 260.0653 177.5963 295.6453 124.1355 1372117 1447830_s_at 1 78.0 cM chr1:145847885-145847980 1 F chr1:145846467-145851279 1 F RSQ Mm.28262 NM_009061 1 1 19735 AL592303.1 Rgs2 regulator of G-protein signaling 2 (Rgs2), mRNA. brown fat cell differentiation;; cell cycle;; G-protein coupled receptor protein signaling pathway;; GTPase activator activity;; negative regulation of signal transduction;; nucleus;; signal transducer activity;; spermatogenesis cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle enzyme regulator activity;; molecular transducer activity enzyme activator activity;; nucleoside-triphosphatase regulator activity;; signal transducer activity biological regulation;; cellular process;; developmental process;; negative regulation of biological process;; regulation of biological process;; reproduction;; reproductive process cell communication;; cell cycle;; cellular developmental process;; gamete generation;; negative regulation of biological process;; negative regulation of cellular process;; regulation of biological process;; regulation of cellular process;; reproductive process;; sexual reproduction 86.1739 64.0624 91.3430 102.6487 106.3951 105.2779 163.2630 149.6342 431.9551 370.4974 160.3225 367.5856 282.7366 290.2828 441.2631 145.0960 98.2182 99.2781 1372229 1452771_s_at 1 24.1 cM chr1:78703065-78703322 1 C4 chr1:78654399-78704318 1 C4 RSQ Mm.276016 NM_001136222 3 1 74205 Acsl3 acyl-CoA synthetase long-chain family member 3 (Acsl3), transcript variant 3, mRNA. Adipocytokine signaling pathway CLASS Metabolism; Lipid Metabolism; Fatty acid metabolism [PATH:mmu00071] Environmental Information Processing; Membrane Transport; Other transporters Cellular Processes; Endocrine System; Adipocytokine signaling pathway [PATH:mmu04920] Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320];; Fatty acid metabolism;; Metabolic pathways;; PPAR signaling pathway ATP binding;; catalytic activity;; endoplasmic reticulum;; fatty acid metabolic process;; integral to membrane;; ligase activity;; lipid metabolic process;; long-chain-fatty-acid-CoA ligase activity;; magnesium ion binding;; membrane;; metabolic process;; microsome;; mitochondrial outer membrane;; mitochondrion;; nucleotide binding;; peroxisome cell;; cell part;; envelope;; organelle;; organelle part cell fraction;; cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding;; catalytic activity ion binding;; ligase activity;; nucleoside binding;; nucleotide binding cellular process;; metabolic process cellular metabolic process;; primary metabolic process 97.0200 100.5597 71.4778 109.9291 105.1672 84.5122 134.4837 144.7839 360.5110 306.5686 157.2401 345.4387 88.6647 110.6624 107.6649 98.9603 99.8188 112.5430 1365491 1453368_at 11 E2 chr11:120237523-120238045 11 E2 UGA Mm.476851 71885 RP23-82I5.4 2310003H01Rik RIKEN cDNA 2310003H01 gene, mRNA (cDNA clone MGC:37540 IMAGE:4986832) DNA binding;; DNA repair;; nucleus;; response to DNA damage stimulus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding nucleic acid binding cellular process;; metabolic process;; response to stimulus cellular metabolic process;; cellular response to stimulus;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; response to stress 18.4807 20.3811 22.2198 28.8419 17.5167 18.4864 56.6816 47.6452 379.9297 338.0776 57.2635 368.4297 68.6281 77.4844 179.4429 28.0236 16.7551 28.4394 1366492 1454768_at 12 chr12:17179290-17179470 12 A1.1 chr12:17178905-17183694 12 A1.1 RSQ Mm.40173 NM_201531 1 1 382571 Kcnf1 potassium voltage-gated channel, subfamily F, member 1 (Kcnf1), mRNA. integral to membrane;; ion channel activity;; ion transport;; membrane;; potassium channel activity;; potassium ion binding;; potassium ion transport;; protein binding;; transport;; voltage-gated ion channel activity;; voltage-gated potassium channel activity;; voltage-gated potassium channel complex cell;; cell part;; macromolecular complex cell part;; membrane;; membrane part;; protein complex binding;; transporter activity ion binding;; protein binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 10.4793 14.6916 18.3893 18.0748 11.9143 14.7118 72.7277 79.6896 165.3645 186.3418 84.3333 180.2684 73.0591 62.1333 88.4579 96.8324 123.7355 68.6730 1367622 1456789_at 4 chr4:55095838-55096382 4 B3 chr4:54960816-55096435 4 B3 RSQ Mm.102904 NM_172867 1 1 242466 RP23-281K3.2 Zfp462 zinc finger protein 462 (Zfp462), mRNA. negative regulation of DNA binding;; nucleus;; positive regulation of transcription from RNA polymerase II promoter cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle biological regulation;; cellular process;; metabolic process;; positive regulation of biological process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; regulation of molecular function 67.4383 71.8530 68.2470 75.3261 71.5535 54.9563 42.0233 40.3867 118.1431 94.5930 38.2933 80.9575 69.7181 70.0735 92.0686 34.4037 28.8514 51.9150 1368912 1458210_at 17 E1.1 chr17:66904670-66905148 17 E1.1 UG5 Mm.218634 74556 9130404H23Rik PREDICTED: Mus musculus RIKEN cDNA 9130404H23 gene (9130404H23Rik), mRNA 83.2874 100.3066 91.9279 101.5437 106.7119 112.5634 255.0898 229.1534 647.8549 746.7632 238.5366 809.0697 89.7467 99.4203 90.6606 76.0075 79.1880 92.4345 1369075 1458409_at chr14:55370840-55371308 14 C3 IPA ESTs 14.5734 17.6809 15.4216 14.1742 19.4558 20.4819 58.4382 71.7892 322.4894 345.6549 63.2632 374.7537 360.5964 474.3886 397.1148 422.5462 467.7425 558.3741 1369924 1459289_at chr13:110341530-110342088 13 D2.1 IPA Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630027C04 product:unknown EST, full insert sequence.