A 1 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen A 2 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen A 3 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen A 4 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen A 5 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen A 6 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen B 7 02-09-07_Hennighausen_PK_Mouse430_2_M42 GSP-EG003.1 Hennighausen B 8 02-09-07_Hennighausen_PK_Mouse430_2_M43 GSP-EG003.1 Hennighausen B 9 02-09-07_Hennighausen_PK_Mouse430_2_M44 GSP-EG003.1 Hennighausen B 10 02-09-07_Hennighausen_PK_Mouse430_2_M47 GSP-EG003.1 Hennighausen B 11 02-09-07_Hennighausen_PK_Mouse430_2_M48 GSP-EG003.1 Hennighausen B 12 02-09-07_Hennighausen_PK_Mouse430_2_M50 GSP-EG003.1 Hennighausen C 13 06-10-08_Hennighausen_1PK_Mouse430_2_4038WT GSP-EG003.2 Hennighausen C 14 06-10-08_Hennighausen_2PK_Mouse430_2_4060WT GSP-EG003.2 Hennighausen C 15 06-10-08_Hennighausen_3PK_Mouse430_2_4063WT GSP-EG003.2 Hennighausen C 16 06-10-08_Hennighausen_4PK_Mouse430_2_4035KO GSP-EG003.2 Hennighausen C 17 06-10-08_Hennighausen_5PK_Mouse430_2_4036KO GSP-EG003.2 Hennighausen C 18 06-10-08_Hennighausen_6PK_Mouse430_2_4042KO GSP-EG003.2 Hennighausen Gene Property Filtering 18 arrays and 45101 genes in the input dataset 18 arrays and 130 genes in the output dataset. 44971 genes excluded for Well ID not being in local list 'EG3-1-test-2-FC'. A A A A A A B B B B B B C C C C C C 06-08-04_Hennighausen_Mouse430_2_KO1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_KO3 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT1 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT2 GSP-EG001 Hennighausen 06-08-04_Hennighausen_Mouse430_2_WT3 GSP-EG001 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M42 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M43 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M44 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M47 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M48 GSP-EG003.1 Hennighausen 02-09-07_Hennighausen_PK_Mouse430_2_M50 GSP-EG003.1 Hennighausen 06-10-08_Hennighausen_1PK_Mouse430_2_4038WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_2PK_Mouse430_2_4060WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_3PK_Mouse430_2_4063WT GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_4PK_Mouse430_2_4035KO GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_5PK_Mouse430_2_4036KO GSP-EG003.2 Hennighausen 06-10-08_Hennighausen_6PK_Mouse430_2_4042KO GSP-EG003.2 Hennighausen Well ID Feature ID Map mgB37_Probe Chr:Start-Stop mgB37_Probe Cytoband mgB37_RefSeq Chr:Start-Stop mgB37_RefSeq Cytoband Annotation_Src UniGene RefSeq Refseqs_Hit geneIDS_Hit Entrez GeneID Locus Tag Gene Description BioCarta Pathways KEGG Pathways Gene Ontology Terms GO Tier2 Component GO Tier3 Component GO Tier2 Function GO Tier3 Function GO Tier2 Process GO Tier3 Process 243.9024 141.0206 152.3739 155.0520 179.9378 212.0503 384.7245 415.0575 749.4852 780.6997 418.5468 908.0809 923.5178 1296.0958 1739.7546 997.2867 862.9285 644.2630 1327726 1415965_at 19 43.0 cM chr19:44472274-44474760 19 C3 chr19:44468939-44482199 19 C3 RSQ Mm.267377 NM_009127 1 1 20249 Scd1 stearoyl-Coenzyme A desaturase 1 (Scd1), mRNA. Biosynthesis of unsaturated fatty acids;; PPAR signaling pathway CLASS Metabolism; Lipid Metabolism; Biosynthesis of unsaturated fatty acids [PATH:mmu01040] Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] brown fat cell differentiation;; endoplasmic reticulum;; fatty acid biosynthetic process;; integral to membrane;; iron ion binding;; lipid biosynthetic process;; lipid metabolic process;; membrane;; oxidation reduction;; oxidoreductase activity;; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;; stearoyl-CoA 9-desaturase activity;; white fat cell differentiation cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding;; catalytic activity ion binding;; oxidoreductase activity cellular process;; developmental process;; metabolic process biosynthetic process;; cellular developmental process;; cellular metabolic process;; oxidation reduction;; primary metabolic process 442.6437 495.1519 496.5210 376.2766 734.4557 569.8191 272.7580 282.5272 251.0264 256.1806 260.3645 254.3658 637.3946 542.8403 551.2780 595.2583 608.4431 497.4458 1327729 1415971_at 10 22.0 cM chr10:36854908-36855205 10 B1 chr10:36853048-36858732 10 B1 RSQ Mm.477725 NM_008538 1 1 17118 Marcks myristoylated alanine rich protein kinase C substrate (Marcks), mRNA. Effects of calcineurin in Keratinocyte Differentiation actin binding;; calmodulin binding;; cell cortex;; centrosome;; cytoplasm;; cytoskeleton;; germinal vesicle;; membrane;; protein kinase C binding cell;; cell part;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane-bounded organelle;; non-membrane-bounded organelle;; organelle part binding protein binding 93.8312 116.3330 114.3274 118.8291 105.2733 123.1567 61.6673 67.4182 58.1149 67.8136 67.0724 74.3360 124.4942 175.2179 152.0450 175.0784 125.3745 129.8743 1328142 1416515_at 5 86.0 cM chr5:143731618-143733619 5 G2 chr5:143722033-143734868 5 G2 RSQ Mm.289707 NM_007984 1 1 14086 Fscn1 fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) (Fscn1), mRNA. actin binding;; actin filament binding;; filopodium;; protein binding, bridging cell;; cell part cell part;; cell projection binding protein binding 50.7422 63.8374 56.7587 60.7169 54.4305 68.2139 70.8244 61.3450 78.4428 73.5792 61.1725 68.8450 98.1674 136.5536 119.2316 154.7761 127.3038 118.4420 1328143 1416516_at 5 86.0 cM chr5:143722346-143722870 5 G2 chr5:143722033-143734868 5 G2 RSQ Mm.289707 NM_007984 1 1 14086 Fscn1 fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) (Fscn1), mRNA. actin binding;; actin filament binding;; filopodium;; protein binding, bridging cell;; cell part cell part;; cell projection binding protein binding 1971.4204 1772.1900 2029.0843 1419.0408 995.6952 1564.1986 306.7430 350.6772 354.9930 337.8001 335.1519 337.8894 472.6103 350.4852 599.8741 748.4521 885.0931 504.5599 1328338 1416756_at 8 chr8:86134177-86134795 8 C2 chr8:86132091-86135802 8 C2 RSQ Mm.282092 NM_018808 1 1 81489 Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 (Dnajb1), mRNA. chaperone mediated protein folding requiring cofactor;; cytoplasm;; heat shock protein binding;; nucleus;; protein folding;; response to stress;; unfolded protein binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding protein binding cellular process;; metabolic process;; response to stimulus cellular metabolic process;; macromolecule metabolic process;; primary metabolic process;; response to stress 1104.7930 1130.9852 1273.8893 947.3741 862.0848 1494.8186 361.2927 343.3687 406.1542 358.6103 344.0687 365.4885 650.0898 688.1143 696.4480 710.5316 749.3700 703.8838 1328429 1416868_at 4 24.7 cM chr4:109333505-109334060 4 C7 chr4:109333480-109337977 4 C7 RSQ Mm.1912 NM_007671 1 1 12580 RP23-320F19.3 Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (Cdkn2c), mRNA. Cyclins and Cell Cycle Regulation Cell cycle CLASS Cellular Processes; Cell Growth and Death; Cell cycle [PATH:mmu04110] cell cycle;; kinase activity;; negative regulation of cell proliferation catalytic activity transferase activity biological regulation;; cellular process;; negative regulation of biological process;; regulation of biological process cell cycle;; cell proliferation;; negative regulation of biological process;; negative regulation of cellular process;; regulation of biological process;; regulation of cellular process 330.4221 342.3403 318.5219 361.6105 292.6987 338.5557 204.6095 203.3306 241.0903 244.4452 199.7921 221.8304 447.5221 291.7224 309.0661 482.4485 393.9240 394.5724 1328495 1416955_at 11 chr11:120358349-120359739 11 E2 chr11:120353185-120360480 11 E2 RSQ Mm.3991 NM_013770 1 1 27376 Slc25a10 solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 (Slc25a10), nuclear gene encoding mitochondrial protein, mRNA. binding;; integral to membrane;; membrane;; mitochondrial inner membrane;; mitochondrial transport;; mitochondrion;; secondary active transmembrane transporter activity;; transport cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding;; transporter activity transmembrane transporter activity cellular process;; establishment of localization;; localization cellular localization;; establishment of localization;; establishment of localization in cell;; transport 2326.1987 2312.3485 2925.5634 1435.6627 1871.0527 2435.2773 262.0308 264.8220 341.3328 310.3656 260.3557 358.8396 855.8505 551.7630 627.1321 552.5380 565.9334 593.5015 1328584 1417061_at 1 B chr1:45965073-45965478 1 C1.1 UG5 Mm.28756 53945 Slc40a1 Solute carrier family 40 (iron-regulated transporter), member 1, mRNA (cDNA clone MGC:6489 IMAGE:2647365) integral to membrane;; ion transport;; iron ion binding;; iron ion transmembrane transporter activity;; iron ion transport;; membrane;; plasma membrane;; synaptic vesicle;; transport cell;; cell part;; organelle;; synapse;; synapse part cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; synapse part;; synaptic vesicle;; vesicle binding;; transporter activity ion binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 458.2637 362.8102 636.7936 439.4229 623.2406 480.9654 170.8045 189.9838 210.2075 172.5739 198.2940 223.0868 285.9421 490.2564 564.1244 666.3463 516.9240 500.2075 1328880 1417420_at 7 72.3 cM chr7:152116598-152117027 7 F5 chr7:152115835-152125830 7 F5 RSQ Mm.273049 NM_007631 1 1 12443 Ccnd1 cyclin D1 (Ccnd1), mRNA. BTG family proteins and cell cycle regulation;; Cell Cycle: G1/S Check Point;; Cyclins and Cell Cycle Regulation;; Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages;; Influence of Ras and Rho proteins on G1 to S Transition;; p53 Signaling Pathway;; WNT Signaling Pathway Acute myeloid leukemia;; Bladder cancer;; Cell cycle;; Chronic myeloid leukemia;; Colorectal cancer;; Endometrial cancer;; Focal adhesion;; Glioma;; Jak-STAT signaling pathway;; Melanoma;; Non-small cell lung cancer CLASS Environmental Information Processing; Signal Transduction; Wnt signaling pathway [PATH:mmu04310] Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Cell Growth and Death; Cell cycle [PATH:mmu04110] Cellular Processes; Cell Growth and Death; p53 signal;; p53 signaling pathway;; Pancreatic cancer;; Pathways in cancer;; Prostate cancer;; Small cell lung cancer;; Thyroid cancer;; Wnt signaling pathway cell cycle;; cell division;; cyclin-dependent protein kinase holoenzyme complex;; cyclin-dependent protein kinase regulator activity;; cytosol;; endoplasmic reticulum unfolded protein response;; fat cell differentiation;; kinase activity;; lactation;; lactation;; mammary gland alveolus development;; mammary gland alveolus development;; mammary gland epithelial cell proliferation;; negative regulation of epithelial cell differentiation;; negative regulation of Wnt receptor signaling pathway;; nucleoplasm;; nucleus;; protein amino acid phosphorylation;; protein binding;; protein kinase activity;; re-entry into mitotic cell cycle;; regulation of cell cycle;; Wnt receptor signaling pathway through beta-catenin cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; catalytic activity;; enzyme regulator activity kinase regulator activity;; protein binding;; transferase activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; cell communication;; cell cycle;; cell cycle process;; cell division;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cellular response to stimulus;; macromolecule metabolic process;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process;; reproductive process;; reproductive process in a multicellular organism;; response to biotic stimulus;; response to chemical stimulus;; response to stress 149.8882 162.5916 118.2641 144.7928 159.0788 92.4510 615.6347 623.0472 1620.7427 1626.4259 604.9297 1625.4179 2400.7707 1795.1549 2650.4324 1866.7552 2093.0708 1567.6395 1328966 1417522_at 15 chr15:58011931-58012223 15 D1 chr15:58011633-58046433 15 D1 RSQ Mm.292042 NM_026346 1 1 67731 Fbxo32 F-box protein 32 (Fbxo32), mRNA. modification-dependent protein catabolic process;; nucleus;; protein binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding protein binding cellular process;; metabolic process catabolic process;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 55.4319 51.7790 62.6862 58.6000 68.4214 77.1084 200.7075 193.7650 255.7471 258.6284 223.7441 255.3044 428.6979 495.8657 559.7944 590.5408 506.1516 389.1916 1329061 1417634_at 5 31.0 cM chr5:52759403-52759968 5 C1 chr5:52755042-52760977 5 C1 RSQ Mm.2407 NM_011435 1 1 20657 Sod3 superoxide dismutase 3, extracellular (Sod3), mRNA. antioxidant activity;; copper ion binding;; extracellular region;; extracellular space;; metal ion binding;; oxidation reduction;; oxidoreductase activity;; protein binding;; response to hypoxia;; superoxide dismutase activity;; superoxide metabolic process;; trans-Golgi network;; zinc ion binding cell;; cell part;; extracellular region;; extracellular region part;; organelle;; organelle part cell part;; extracellular region part;; extracellular space;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle part antioxidant activity;; binding;; catalytic activity ion binding;; oxidoreductase activity;; protein binding cellular process;; metabolic process;; response to stimulus cellular metabolic process;; oxidation reduction;; response to chemical stimulus;; response to stress 33.1265 33.4343 28.1230 28.4022 44.4568 29.1756 34.6453 46.0859 44.7310 31.0854 30.0212 29.1012 54.1914 51.4691 77.9024 77.8044 97.2547 67.0928 1329760 1418486_at 10 A1-B2 chr10:23624644-23625114 10 A4 UGA Mm.27154 22361 Vnn1 Vanin 1, mRNA (cDNA clone MGC:29064 IMAGE:5041670) Pantothenate and CoA biosynthesis CLASS Metabolism; Metabolism of Cofactors and Vitamins; Pantothenate and CoA biosynthesis [PATH:mmu00770] acute inflammatory response;; anchored to membrane;; anti-apoptosis;; cell-cell adhesion;; chronic inflammatory response;; extracellular space;; GPI anchor binding;; hydrolase activity;; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;; innate immune response;; integral to membrane;; membrane;; nitrogen compound metabolic process;; pantetheine hydrolase activity;; plasma membrane;; positive regulation of T cell differentiation in the thymus cell;; cell part;; extracellular region;; extracellular region part cell part;; extracellular region part;; extracellular space;; membrane;; membrane part binding;; catalytic activity hydrolase activity;; lipid binding biological adhesion;; biological regulation;; cellular process;; death;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; cell activation;; cell adhesion;; cell death;; cellular developmental process;; immune response;; immune system development;; leukocyte activation;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of multicellular organismal process;; response to external stimulus;; response to stress 32.3332 34.6774 28.3329 30.9332 26.5910 28.3329 41.2584 47.7341 54.2586 49.5046 43.1524 59.8078 78.7277 113.5885 109.8749 103.6978 121.0189 76.6174 1329787 1418525_at 8 22.5 cM chr8:42417966-42418424 8 A4 chr8:42325112-42419441 8 A4 RSQ Mm.117896 NM_023662 1 1 18536 Pcm1 pericentriolar material 1 (Pcm1), mRNA. cytoplasm;; cytoskeleton cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; non-membrane-bounded organelle 65.5816 62.3299 65.6177 67.4182 72.5336 60.9309 139.3570 172.8583 219.1384 170.1015 155.2263 215.5945 380.5738 267.0408 384.3462 503.0964 318.8741 414.3186 1329881 1418645_at 10 51.0 cM chr10:92976777-92979211 10 C2 chr10:92951512-92979488 10 C2 RSQ Mm.13000 NM_010401 1 1 15109 Hal histidine ammonia lyase (Hal), mRNA. Histidine metabolism;; Metabolic pathways CLASS Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:mmu00910] Metabolism; Amino Acid Metabolism; Histidine metabolism [PATH:mmu00340];; Nitrogen metabolism ammonia ligase activity;; biosynthetic process;; cytoplasm;; histidine ammonia-lyase activity;; histidine catabolic process;; histidine metabolic process;; lyase activity;; soluble fraction cell;; cell part cell fraction;; cell part;; intracellular;; intracellular part catalytic activity ligase activity;; lyase activity cellular process;; metabolic process biosynthetic process;; catabolic process;; cellular metabolic process;; nitrogen compound metabolic process;; primary metabolic process 47.5626 43.1406 37.3736 57.4408 46.4590 53.2431 71.0839 70.1695 85.1768 64.2993 65.8150 72.1405 115.1344 185.4230 127.4017 153.6813 150.8221 121.8953 1330061 1418848_at 4 chr4:40981243-40982246 4 A5 chr4:40980106-40995169 4 A5 RSQ Mm.8728 NM_007473 1 1 11832 RP23-28I8.6 Aqp7 aquaporin 7 (Aqp7), mRNA. PPAR signaling pathway CLASS Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] integral to membrane;; integral to plasma membrane;; membrane;; transport;; transporter activity;; water channel activity;; water transport cell;; cell part cell part;; membrane;; membrane part transporter activity substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 408.4960 364.3741 400.3741 466.8766 636.6980 410.2014 776.8052 796.1330 713.0390 677.1720 787.7251 651.1900 2091.5578 2143.0032 2260.8741 3234.9852 2402.4730 1924.6148 1330167 1418982_at 7 12.0 cM chr7:35906421-35906839 7 B1 chr7:35904311-35906947 7 B1 RSQ Mm.349667 NM_007678 1 1 12606 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha (Cebpa), mRNA. Keratinocyte Differentiation;; MAPKinase Signaling Pathway Acute myeloid leukemia CLASS Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221];; Pathways in cancer brown fat cell differentiation;; cell maturation;; cytokine-mediated signaling pathway;; DNA binding;; embryonic placenta development;; fat cell differentiation;; liver development;; lung development;; macrophage differentiation;; mitochondrion organization;; myeloid cell differentiation;; negative regulation of cell proliferation;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; positive regulation of specific transcription from RNA polymerase II promoter;; positive regulation of transcription;; promoter binding;; protein binding;; protein dimerization activity;; protein homodimerization activity;; regulation of cell proliferation;; regulation of transcription, DNA-dependent;; RNA polymerase II transcription factor activity, enhancer binding;; sequence-specific DNA binding;; specific RNA polymerase II transcription factor activity;; transcription;; transcription factor activity;; transcription factor complex;; urea cycle cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; transcription regulator activity nucleic acid binding;; protein binding;; RNA polymerase II transcription factor activity;; transcription factor activity biological regulation;; cellular component organization;; cellular process;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process anatomical structure development;; biosynthetic process;; cell communication;; cell proliferation;; cellular developmental process;; cellular metabolic process;; developmental maturation;; embryonic development;; immune system development;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; organelle organization;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 157.8952 177.1785 157.3417 185.5964 145.6099 156.8227 123.6276 110.6696 142.7479 144.7451 127.9534 153.1519 355.0037 206.8725 352.0478 442.7344 221.0571 259.7794 1330720 1419684_at 11 47.0 cM chr11:81928740-81930259 11 C chr11:81928693-81930297 11 C RSQ Mm.42029 NM_021443 1 1 20307 RP23-446K18.1 Ccl8 chemokine (C-C motif) ligand 8 (Ccl8), mRNA. Chemokine signaling pathway CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] Cellular Processes; Immune System; Chemokine signaling pathway [PATH:mmu04062];; Cytokine-cytokine receptor interaction chemokine activity;; chemotaxis;; cytokine activity;; extracellular region;; extracellular space;; heparin binding;; immune response;; inflammatory response extracellular region;; extracellular region part extracellular region part;; extracellular space binding carbohydrate binding;; pattern binding;; protein binding immune system process;; locomotion;; response to stimulus behavior;; immune response;; response to chemical stimulus;; response to external stimulus;; response to stress;; taxis 40.0453 40.9138 43.4818 49.5780 56.7271 57.8220 167.7865 147.4773 145.6945 164.9446 157.1092 162.3797 361.2231 461.2620 475.8007 380.6723 492.9228 260.1455 1344152 1420715_a_at 6 52.7 cM chr6:115439974-115440254 6 E3 chr6:115372083-115440419 6 E3 RSQ Mm.3020 NM_011146 2 1 19016 Pparg peroxisome proliferator activated receptor gamma (Pparg), transcript variant 2, mRNA. Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression;; Nuclear Receptors in Lipid Metabolism and Toxicity;; Role of PPAR-gamma Coactivators in Obesity and Thermogenesis;; Visceral Fat Deposits and the Metabolic Syndrome Huntington's disease;; Pathways in cancer;; PPAR signaling pathway;; Thyroid cancer CLASS Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Thyroid Cancer [PATH:mmu05216] Human Diseases; Neurodegenerative Diseases; Huntington's disease [PATH:mmu05016] arachidonic acid binding;; brown fat cell differentiation;; cell fate commitment;; chromatin binding;; cytosol;; DNA binding;; DNA binding;; epithelial cell differentiation;; fat cell differentiation;; fat cell differentiation;; inflammatory response;; ligand-dependent nuclear receptor activity;; long-chain fatty acid transport;; metal ion binding;; negative regulation of cell proliferation;; negative regulation of cytokine production;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription, DNA-dependent;; nucleus;; placenta development;; positive regulation of fat cell differentiation;; positive regulation of fat cell differentiation;; positive regulation of transcription;; positive regulation of transcription from RNA polymerase II promoter;; protein binding;; receptor activity;; regulation of fat cell differentiation;; regulation of fat cell differentiation;; regulation of transcription;; regulation of transcription, DNA-dependent;; response to lipid;; sequence-specific DNA binding;; steroid hormone receptor activity;; transcription;; transcription activator activity;; transcription factor activity;; transcription repressor activity;; transcription repressor activity;; transcriptional repressor complex;; white fat cell differentiation;; white fat cell differentiation;; zinc ion binding cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; molecular transducer activity;; transcription regulator activity carboxylic acid binding;; chromatin binding;; ion binding;; lipid binding;; nucleic acid binding;; protein binding;; signal transducer activity;; transcription activator activity;; transcription factor activity;; transcription repressor activity biological regulation;; cellular process;; developmental process;; establishment of localization;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; establishment of localization;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; negative regulation of multicellular organismal process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; response to chemical stimulus;; response to external stimulus;; response to stress;; transport 51.1920 59.7151 46.5958 49.4246 66.8533 41.4296 125.8152 149.8666 133.1177 120.7424 147.7845 117.1975 191.5096 252.4297 332.6812 292.2765 305.8123 254.2576 1344266 1421149_a_at 6 60.21 cM chr6:124692719-124693272 6 F2 chr6:124692561-124706505 6 F2 RSQ Mm.333380 NM_007881 2 2 13498 Atn1 atrophin 1 (Atn1), mRNA. cytoplasm;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; nucleus;; protein binding;; toxin metabolic process;; toxin receptor binding;; transcription corepressor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity protein binding;; transcription cofactor activity;; transcription repressor activity biological regulation;; cellular process;; metabolic process;; negative regulation of biological process;; regulation of biological process;; response to stimulus biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; response to chemical stimulus;; secondary metabolic process 22.2420 21.7816 21.6642 25.8887 27.3112 24.6389 31.7706 33.1645 38.1509 32.4633 31.7687 33.6211 55.1718 62.6902 83.6432 79.6346 75.1855 56.2994 1331859 1421379_at 11 chr11:50735336-50735895 11 B1.3 chr11:50735287-50745137 11 B1.3 RSQ Mm.74670 NM_013744 1 1 27274 RP23-292E3.7 Zfp354b zinc finger protein 354B (Zfp354b), mRNA. DNA binding;; intracellular;; metal ion binding;; nucleic acid binding;; nucleus;; regulation of transcription, DNA-dependent;; transcription;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding ion binding;; nucleic acid binding biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 47.2927 40.7607 53.2892 57.4001 59.4762 52.8360 60.2403 64.1338 101.5482 113.9159 81.3877 109.7455 185.2001 150.2693 226.5313 216.8483 132.2123 135.1045 1344381 1421551_s_at 1 chr1:175892699-175912975 1 H3 RSQ Mm.218770 NM_011940 3 2 26388 Ifi202b interferon activated gene 202B (Ifi202b), transcript variant 2, mRNA. cytoplasm;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle 41.3713 40.9726 42.5488 50.9825 54.1880 33.1228 54.2888 51.1518 43.9413 49.2716 53.7399 55.1182 119.5417 124.2635 156.3065 166.3437 119.7170 138.9096 1331990 1421555_at 8 10.0 cM chr8:28337294-28338230 8 A2 chr8:28336247-28340060 8 A2 RSQ Mm.278475 NM_013462 1 1 11556 Adrb3 adrenergic receptor, beta 3 (Adrb3), mRNA. Calcium signaling pathway;; Endocytosis CLASS Environmental Information Processing; Signal Transduction; Calcium signaling pathway [PATH:mmu04020] Environmental Information Processing; Signaling Molecules and Interaction; Neuroactive ligand-receptor interaction [PATH:mmu04080] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144];; Neuroactive ligand-receptor interaction activation of adenylate cyclase activity by G-protein signaling pathway;; adrenoceptor activity;; beta-3 adrenergic receptor binding;; beta-adrenergic receptor activity;; brown fat cell differentiation;; diet induced thermogenesis;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; heat generation;; integral to membrane;; membrane;; membrane fraction;; negative regulation of multicellular organism growth;; plasma membrane;; receptor activity;; response to cold;; signal transducer activity;; signal transduction;; vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure cell;; cell part cell fraction;; cell part;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity biological regulation;; cellular process;; developmental process;; growth;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus biosynthetic process;; cell communication;; cellular developmental process;; cellular metabolic process;; multicellular organism growth;; multicellular organismal metabolic process;; negative regulation of biological process;; negative regulation of growth;; negative regulation of multicellular organismal process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of growth;; regulation of metabolic process;; regulation of molecular function;; regulation of multicellular organismal process;; response to abiotic stimulus;; response to dietary excess;; response to stress;; system process;; temperature homeostasis 36.8887 33.7820 33.4435 46.6734 40.6512 45.6915 108.5243 89.0018 62.6017 69.2477 85.3186 64.4220 130.6714 199.6548 222.0753 227.7912 189.1142 172.9099 1332082 1421681_at 9 chr9:55069139-55090023 9 B chr9:55068028-55131432 9 B RSQ Mm.443874 NM_032002 1 1 83961 Nrg4 neuregulin 4 (Nrg4), mRNA. g-Secretase mediated ErbB4 Signaling Pathway ErbB signaling pathway CLASS Environmental Information Processing; Signal Transduction; ErbB signaling pathway [PATH:mmu04012] extracellular region;; growth factor activity;; integral to membrane;; membrane;; plasma membrane cell;; cell part;; extracellular region cell part;; membrane;; membrane part binding protein binding 291.6817 217.4220 332.6520 215.6481 246.5698 301.4006 225.8039 230.3638 238.7650 240.0570 217.9269 217.1702 504.0869 512.8958 551.5580 609.0543 542.5672 371.5695 1332679 1422508_at 16 chr16:44085965-44086095 16 B4 chr16:44085516-44139132 16 B4 RSQ Mm.217787 NM_007508 1 1 11964 Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A (Atp6v1a), mRNA. Metabolic pathways CLASS Metabolism; Energy Metabolism; Oxidative phosphorylation [PATH:mmu00190];; Oxidative phosphorylation ATP binding;; ATP metabolic process;; ATP synthesis coupled proton transport;; cytosol;; hydrogen ion transmembrane transporter activity;; hydrogen ion transporting ATP synthase activity, rotational mechanism;; hydrolase activity;; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;; ion transport;; mitochondrion;; nucleotide binding;; plasma membrane;; proton transport;; proton-transporting ATPase activity, rotational mechanism;; proton-transporting two-sector ATPase complex;; proton-transporting two-sector ATPase complex, catalytic domain;; proton-transporting V-type ATPase, V1 domain;; transport cell;; cell part;; macromolecular complex;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; protein complex binding;; catalytic activity;; transporter activity hydrolase activity;; nucleoside binding;; nucleotide binding;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process biosynthetic process;; cellular metabolic process;; establishment of localization;; nitrogen compound metabolic process;; primary metabolic process;; transmembrane transport;; transport 136.3287 192.5470 141.9204 128.8051 163.7045 177.1898 1133.9571 1169.8142 1210.6099 1268.8846 1137.8251 1251.0922 1984.5654 2567.0337 2545.4361 2996.2075 2343.5261 1741.9297 1332932 1422820_at 7 5.5 cM chr7:26165082-26165863 7 A3 chr7:26164545-26175125 7 A3 RSQ Mm.333679 NM_001039507 2 1 16890 mCG_147818 Lipe lipase, hormone sensitive (Lipe), transcript variant 2, mRNA. Insulin signaling pathway CLASS Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] cholesterol metabolic process;; cytosol;; diacylglycerol catabolic process;; hormone-sensitive lipase activity;; hydrolase activity;; lipase activity;; lipid catabolic process;; lipid metabolic process;; membrane;; metabolic process;; plasma membrane;; steroid metabolic process;; triacylglycerol lipase activity;; triglyceride catabolic process cell;; cell part cell part;; intracellular;; intracellular part;; membrane catalytic activity hydrolase activity cellular process;; metabolic process alcohol metabolic process;; biosynthetic process;; catabolic process;; cellular metabolic process;; organic ether metabolic process;; primary metabolic process 22.4061 22.8564 22.5481 23.6571 24.4103 24.1054 502.2074 489.4766 589.8502 605.4739 507.4237 618.3404 938.9297 1270.4965 1019.7040 1338.1593 1095.0474 777.7562 1333421 1423439_at 2 103.0 cM chr2:172984188-172984580 2 H3 chr2:172978573-172984755 2 H3 RSQ Mm.477474 NM_011044 1 1 18534 RP23-44L6.3 Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic (Pck1), mRNA. Adipocytokine signaling pathway CLASS Metabolism; Carbohydrate Metabolism; Glycolysis / Gluconeogenesis [PATH:mmu00010] Metabolism; Carbohydrate Metabolism; Citrate cycle (TCA cycle) [PATH:mmu00020] Metabolism; Carbohydrate Metabolism; Pyruvate metabolism [PATH:mmu00620] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] Cel;; Citrate cycle (TCA cycle);; Glycolysis / Gluconeogenesis;; Insulin signaling pathway;; Metabolic pathways;; PPAR signaling pathway;; Pyruvate metabolism carboxy-lyase activity;; cytoplasm;; gluconeogenesis;; glycerol biosynthetic process from pyruvate;; GTP binding;; kinase activity;; lipid metabolic process;; lyase activity;; manganese ion binding;; metal ion binding;; nucleotide binding;; phosphoenolpyruvate carboxykinase (GTP) activity;; phosphoenolpyruvate carboxykinase activity;; purine nucleotide binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; lyase activity;; nucleotide binding;; transferase activity cellular process;; metabolic process alcohol metabolic process;; biosynthetic process;; cellular metabolic process;; organic ether metabolic process;; primary metabolic process 101.4994 97.0605 123.9014 134.8187 119.0697 115.2748 430.9837 461.9510 491.7432 463.1621 451.1126 482.0518 1215.1582 1098.1363 1109.8630 1429.3547 1241.7630 943.0829 1333463 1423488_at 11 chr11:90138754-90139257 11 C chr11:90110789-90139887 11 C RSQ Mm.277518 NM_026178 2 2 67468 RP23-220F20.1 Mmd monocyte to macrophage differentiation-associated (Mmd), mRNA. cytolysis;; endosome;; integral to membrane;; lysosome;; membrane;; receptor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle molecular transducer activity signal transducer activity cellular process;; death cell death 74.1885 76.6516 84.3829 147.3703 118.1957 139.5693 731.6965 677.8186 843.3732 796.3962 697.7075 784.2800 1854.2693 1607.5960 1746.0964 2053.1093 1748.9408 1418.2271 1333464 1423489_at 11 chr11:90139426-90139743 11 C chr11:90110789-90139887 11 C RSQ Mm.277518 NM_026178 2 2 67468 RP23-220F20.1 Mmd monocyte to macrophage differentiation-associated (Mmd), mRNA. cytolysis;; endosome;; integral to membrane;; lysosome;; membrane;; receptor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle molecular transducer activity signal transducer activity cellular process;; death cell death 90.5353 100.3679 90.1303 79.2850 84.6895 84.3689 116.3642 110.1091 118.7933 128.3783 99.9177 144.7965 117.8057 145.4297 210.9297 257.0370 231.7937 222.9436 1333567 1423619_at 11 chr11:59776968-59777397 11 B1.3 chr11:59776682-59778444 11 B1.3 RSQ Mm.3903 NM_009026 1 1 19416 RP23-247B13.6 Rasd1 RAS, dexamethasone-induced 1 (Rasd1), mRNA. cytoplasm;; GTP binding;; intracellular;; membrane;; nucleotide binding;; nucleus;; plasma membrane;; small GTPase mediated signal transduction cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane-bounded organelle binding nucleotide binding biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 123.2483 149.2484 159.2152 95.0278 130.8837 153.2086 109.8662 137.8947 129.3978 121.8748 116.5868 123.7635 210.8890 225.1398 326.9466 318.8293 250.2378 226.3515 1333644 1423726_at 11 chr11:101320219-101320582 11 D chr11:101320061-101327513 11 D RSQ Mm.29210 NM_012037 1 1 26949 RP23-328K2.5 Vat1 vesicle amine transport protein 1 homolog (T californica) (Vat1), mRNA. binding;; catalytic activity;; metabolic process;; oxidation reduction;; oxidoreductase activity;; zinc ion binding binding;; catalytic activity ion binding;; oxidoreductase activity metabolic process oxidation reduction 597.3471 536.6259 648.2379 344.4637 307.7104 368.7197 298.9244 295.5625 302.4900 263.0497 309.9131 290.3726 612.7475 607.2283 535.0130 698.1968 705.3741 527.4491 1333913 1424086_at 9 23.0 cM chr9:43030228-43030494 9 A5.1 chr9:43029360-43047899 9 A5.1 RSQ Mm.246479 NM_178644 1 1 102644 Oaf OAF homolog (Drosophila) (Oaf), mRNA. 61.9388 50.6878 53.1926 61.0757 54.5137 43.7053 636.0408 623.4816 787.0829 722.9852 628.5408 702.2073 983.5547 1092.6241 978.9370 1454.8496 1337.7251 1062.7387 1333965 1424155_at 3 A1|3 13.9 cM chr3:10204593-10204909 3 A1 UGA Mm.582 11770 Fabp4 Fatty acid binding protein 4, adipocyte (Fabp4), mRNA PPAR signaling pathway CLASS Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] binding;; brown fat cell differentiation;; cholesterol homeostasis;; cytokine production;; cytoplasm;; lipid binding;; negative regulation of protein kinase activity;; negative regulation of transcription;; nucleus;; positive regulation of inflammatory response;; transcription repressor activity;; transport;; transporter activity;; white fat cell differentiation cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity;; transporter activity lipid binding;; transcription repressor activity biological regulation;; cellular process;; developmental process;; establishment of localization;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus biosynthetic process;; cellular developmental process;; cellular metabolic process;; cytokine production;; establishment of localization;; macromolecule metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of metabolic process;; regulation of molecular function;; regulation of response to stimulus;; response to external stimulus;; response to stress;; transport 170.2747 153.1697 180.5408 281.1828 192.9606 133.0409 418.2227 431.9268 579.7830 553.0904 423.1519 530.0941 1348.9521 1126.1295 1110.0311 1808.6801 1451.1741 1111.9595 1334125 1424357_at 9 chr9:31233861-31234366 9 A4 chr9:31233780-31271823 9 A4 RSQ Mm.390134 NM_144936 1 1 235135 Tmem45b transmembrane protein 45b (Tmem45b), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 267.0544 228.8362 238.8843 203.5744 175.8186 222.4058 358.7701 351.8302 410.6519 385.6970 340.5467 381.6293 700.5926 632.7639 701.0206 806.0848 834.9297 578.2402 1334159 1424399_at 2 chr2:32110569-32111113 2 B chr2:32110521-32115625 2 B RSQ Mm.425076 NM_011675 3 3 22245 RP23-161B9.4 Uck1 uridine-cytidine kinase 1 (Uck1), mRNA. Drug metabolism - other enzymes;; Metabolic pathways CLASS Metabolism; Nucleotide Metabolism; Pyrimidine metabolism [PATH:mmu00240] Metabolism; Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes [PATH:mmu00983];; Pyrimidine metabolism ATP binding;; kinase activity;; metabolic process;; nucleotide binding;; phosphotransferase activity, alcohol group as acceptor;; transferase activity;; uridine kinase activity binding;; catalytic activity nucleoside binding;; nucleotide binding;; transferase activity metabolic process 171.7887 158.6519 153.2948 221.5408 225.6826 224.0984 280.9998 282.8741 291.0388 291.3361 271.3463 283.2577 501.2783 575.5090 627.2381 764.3651 501.9373 457.4389 1345117 1424667_a_at 5 78.0 cM chr5:136724440-136724601 5 G2 chr5:136724004-137043275 5 G2 RSQ Mm.320317 NM_198602 1 1 13047 Cux1 cut-like homeobox 1 (Cux1), transcript variant 2, mRNA. auditory receptor cell differentiation;; chromatin binding;; DNA binding;; Golgi apparatus;; integral to Golgi membrane;; integral to membrane;; intra-Golgi vesicle-mediated transport;; lung development;; membrane;; multicellular organismal development;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; regulation of transcription;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; transcription;; transcription factor activity;; transcription regulator activity;; transcription repressor activity;; transport cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part binding;; transcription regulator activity chromatin binding;; nucleic acid binding;; transcription factor activity;; transcription repressor activity biological regulation;; cellular process;; developmental process;; establishment of localization;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process anatomical structure development;; biosynthetic process;; cellular developmental process;; cellular localization;; cellular metabolic process;; establishment of localization;; establishment of localization in cell;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; transport;; vesicle-mediated transport 189.6004 124.4826 105.3736 196.7640 94.1117 110.6966 364.1001 354.1012 353.2630 356.2427 357.5293 388.5157 916.5180 626.8934 740.6832 1079.8715 711.2379 950.1731 1345191 1424948_x_at 17 B1|17 18.44 cM chr17:34133284-34134088 17 B1 UG5 Mm.422886 14972 H2-K1 Histocompatibility 2, K1, K region, mRNA (cDNA clone MGC:7052 IMAGE:3156482) Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class I;; antigen processing and presentation of peptide antigen via MHC class I;; defense response to bacterium;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; peptide antigen binding;; positive regulation of T cell mediated cytotoxicity cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding antigen binding;; peptide binding biological regulation;; cell killing;; cellular process;; death;; developmental process;; immune system process;; multi-organism process;; positive regulation of biological process;; regulation of biological process;; response to stimulus antigen processing and presentation;; cell death;; immune effector process;; immune response;; leukocyte mediated cytotoxicity;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of response to stimulus;; regulation of biological process;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of response to stimulus;; response to biotic stimulus;; response to other organism;; response to stress 104.2819 131.0210 116.2087 133.0063 136.9960 110.0955 98.0831 98.5815 105.9053 87.6530 93.6892 87.3277 156.9155 126.6023 160.0234 260.2630 174.9636 159.9021 1334755 1425215_at 7 chr7:31604072-31604574 7 B1 chr7:31603375-31608794 7 B1 RSQ Mm.97338 NM_146187 1 1 233079 Ffar2 free fatty acid receptor 2 (Ffar2), mRNA. G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; integral to membrane;; lipid binding;; membrane;; plasma membrane;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity lipid binding;; signal transducer activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 94.2148 106.2434 95.5878 135.9853 108.9330 110.0957 106.9119 114.7452 86.5724 113.9313 102.7695 95.1100 182.9297 193.0831 218.4320 363.0408 241.3464 198.1519 1334756 1425216_at 7 chr7:31603441-31603954 7 B1 chr7:31603375-31608794 7 B1 RSQ Mm.97338 NM_146187 1 1 233079 Ffar2 free fatty acid receptor 2 (Ffar2), mRNA. G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; integral to membrane;; lipid binding;; membrane;; plasma membrane;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity lipid binding;; signal transducer activity biological regulation;; cellular process;; regulation of biological process cell communication;; regulation of biological process;; regulation of cellular process 1324.9834 1103.3679 1389.0342 1335.5408 1339.0415 916.1124 3404.4275 3339.7406 3843.7613 3594.5270 3289.8861 3573.3205 7018.3004 4854.9973 5880.8359 7541.0047 5583.6519 8057.1376 1345328 1425336_x_at 17 18.44 cM chr17:34132956-34137278 17 B1 RSQ Mm.422886 NM_001001892 1 1 14972 H2-K1 histocompatibility 2, K1, K region (H2-K1), transcript variant 1, mRNA. Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class I;; antigen processing and presentation of peptide antigen via MHC class I;; defense response to bacterium;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; peptide antigen binding;; positive regulation of T cell mediated cytotoxicity cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding antigen binding;; peptide binding biological regulation;; cell killing;; cellular process;; death;; developmental process;; immune system process;; multi-organism process;; positive regulation of biological process;; regulation of biological process;; response to stimulus antigen processing and presentation;; cell death;; immune effector process;; immune response;; leukocyte mediated cytotoxicity;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of response to stimulus;; regulation of biological process;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of response to stimulus;; response to biotic stimulus;; response to other organism;; response to stress 1243.3540 707.5395 1030.4411 898.5519 459.3143 1726.1680 273.8139 269.4133 547.2341 557.8625 281.7780 554.3976 1059.5088 724.5477 970.8555 611.2543 630.1791 606.1168 1345355 1425400_a_at 4 D2.2|4 56.65 cM chr4:120339825-120340283 4 D2.2 UGA Mm.272646 56222 RP23-18M2.2 Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4, mRNA (cDNA clone IMAGE:3670674) cytoplasm;; nucleus;; positive regulation of transcription;; regulation of transcription;; regulation of transcription, DNA-dependent;; transcription;; transcription coactivator activity;; transcription coactivator activity;; transcription regulator activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity protein binding;; transcription activator activity;; transcription cofactor activity biological regulation;; cellular process;; metabolic process;; positive regulation of biological process;; regulation of biological process biosynthetic process;; cellular metabolic process;; macromolecule metabolic process;; nitrogen compound metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 150.2630 143.6542 150.1506 170.7959 164.7851 150.0141 37.1927 51.5099 62.8204 65.2644 58.8237 55.5615 187.8805 189.8574 131.0361 129.8743 181.8186 86.3434 1345371 1425436_x_at 6 62.69 cM chr6:130128783-130128874 6 F3 chr6:130128699-130143130 6 F3 RSQ Mm.457996 NM_010651 2 2 16640 Klra9 killer cell lectin-like receptor subfamily A, member 9 (Klra9), mRNA. Graft-versus-host disease CLASS Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Human Diseases; Immune Disorders; Graft-versus-host disease [PATH:mmu05332];; Natural killer cell mediated cytotoxicity plasma membrane;; receptor activity;; sugar binding cell;; cell part cell part;; membrane binding;; molecular transducer activity carbohydrate binding;; signal transducer activity 62.5129 51.0376 45.2336 63.6684 47.9478 43.5173 107.9864 115.8312 123.8346 107.5586 111.0735 104.3988 241.5908 228.4367 251.2003 362.3639 255.8382 281.1665 1345392 1425477_x_at 17 B1|17 18.64 cM UG5 Mm.254067 14961 H2-Ab1 Histocompatibility 2, class II antigen A, beta 1, mRNA (cDNA clone MGC:6297 IMAGE:2651058) Allograft rejection;; Antigen processing and presentation;; Asthma;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Immune System; Antigen processing and presentation [PATH:mmu04612] Human Diseases; Immune Disorders; Asthma [PATH:mmu05310] Human Diseases; Immune Disorders; Systemic lupus erythema;; Systemic lupus erythematosus;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class II;; antigen processing and presentation of peptide antigen;; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;; early endosome;; external side of plasma membrane;; Golgi apparatus;; immune response;; integral to membrane;; intracellular;; membrane;; MHC class II protein complex;; multivesicular body;; peptide antigen binding;; plasma membrane;; protein binding cell;; cell part;; macromolecular complex;; organelle cell part;; cell surface;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; protein complex binding antigen binding;; peptide binding;; protein binding immune system process;; response to stimulus antigen processing and presentation;; immune response 105.9246 91.1126 81.7356 134.9744 99.5136 86.6249 760.5655 738.2776 831.1004 771.4788 776.9735 776.3932 1441.7902 1547.4986 1889.1281 1860.8291 1657.7775 1883.9420 1345403 1425519_a_at 18 32.0 cM chr18:60963502-60972306 18 E1 RSQ Mm.439737 NM_010545 2 1 16149 Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), transcript variant 2, mRNA. Antigen processing and presentation CLASS Cellular Processes; Immune System; Antigen processing and presentation [PATH:mmu04612] antigen processing and presentation;; antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class II;; chaperone mediated protein folding requiring cofactor;; chaperone mediated protein folding requiring cofactor;; defense response;; endoplasmic reticulum;; external side of plasma membrane;; Golgi apparatus;; immune response;; immunoglobulin mediated immune response;; integral to membrane;; integral to plasma membrane;; intracellular protein transport;; intracellular protein transport;; late endosome;; lysosome;; membrane;; MHC class II protein binding;; multivesicular body;; negative regulation of T cell differentiation;; negative thymic T cell selection;; plasma membrane;; plasma membrane;; positive regulation of T cell differentiation;; positive thymic T cell selection;; protein binding;; protein complex assembly cell;; cell part;; organelle cell part;; cell surface;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding protein binding anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; developmental process;; establishment of localization;; immune system process;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; antigen processing and presentation;; cell activation;; cellular component assembly;; cellular developmental process;; cellular localization;; cellular metabolic process;; establishment of localization;; establishment of localization in cell;; establishment of protein localization;; immune effector process;; immune response;; immune system development;; leukocyte activation;; macromolecular complex subunit organization;; macromolecule localization;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; negative regulation of immune system process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; primary metabolic process;; protein complex biogenesis;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of multicellular organismal process;; response to stress;; T cell selection;; transport 801.6771 657.0363 1137.0124 600.9767 542.1292 592.5544 2595.0729 2703.9113 2723.2379 2734.1156 2612.1242 2776.7309 5807.8741 4157.6850 4761.7075 6835.6684 4668.1183 8367.8736 1345415 1425545_x_at 17 19.09 cM chr17:35403151-35403941 17 B1 chr17:35400038-35404442 17 B1 RSQ NM_010380 1 1 14964 H2-D1 histocompatibility 2, D region locus 1 (H2-D1), mRNA. Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of peptide antigen via MHC class I;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; plasma membrane;; protein binding cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding protein binding immune system process;; response to stimulus antigen processing and presentation;; immune response 5309.2547 3956.9852 4473.9309 7516.4008 10060.6083 6105.5723 472.1008 492.4752 542.9663 512.1519 496.8186 555.7075 1151.6535 881.9404 1191.9837 1390.2340 1037.9056 835.2374 1345416 1425546_a_at 9 56.0 cM chr9:103112884-103118269 9 F1 chr9:103111205-103132616 9 F1 RSQ Mm.37214 NM_133977 1 1 22041 Trf transferrin (Trf), mRNA. The role of FYVE-finger proteins in vesicle transport cellular iron ion homeostasis;; endocytic vesicle;; endocytic vesicle;; endosome;; extracellular region;; ferric iron binding;; ion transport;; iron ion binding;; iron ion transport;; metal ion binding;; recycling endosome;; transport cell;; cell part;; extracellular region;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle;; vesicle binding ion binding biological regulation;; cellular process;; establishment of localization;; localization cellular homeostasis;; establishment of localization;; regulation of biological quality;; transport 19.5852 22.2607 20.8496 23.7345 19.0876 22.3843 15.3757 14.8625 17.1823 15.2861 15.9410 14.2511 25.6359 31.7010 35.6932 56.3035 33.3184 34.8540 1345474 1425681_a_at 2 75.0 cM chr2:131781086-131781563 2 F2 chr2:131776596-131781866 2 F2 RSQ Mm.180750 NM_001126338 2 1 26434 RP23-401J24.2 Prnd prion protein dublet (Prnd), transcript variant 2, mRNA. anchored to membrane;; cellular copper ion homeostasis;; copper ion binding;; membrane;; plasma membrane;; protein homooligomerization cell;; cell part cell part;; membrane;; membrane part binding ion binding anatomical structure formation;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process cellular component assembly;; cellular homeostasis;; macromolecular complex subunit organization;; protein complex biogenesis;; regulation of biological quality 86.7559 69.0739 95.1605 79.4258 117.8322 64.2243 128.7077 151.9846 160.7587 153.6721 136.2452 155.9015 294.7990 264.5478 270.2950 302.0697 271.3060 279.3816 1345481 1425702_a_at 17 23.5 cM chr17:44222705-44223013 17 B3 chr17:44215817-44223508 17 B3 RSQ Mm.30145 NM_032003 1 1 83965 Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (Enpp5), mRNA. catalytic activity;; extracellular region;; hydrolase activity;; integral to membrane;; integral to plasma membrane;; membrane;; metabolic process;; nucleotide catabolic process;; nucleotide diphosphatase activity cell;; cell part;; extracellular region cell part;; membrane;; membrane part catalytic activity hydrolase activity cellular process;; metabolic process catabolic process;; cellular metabolic process;; nitrogen compound metabolic process;; primary metabolic process 60.9293 60.6860 59.6738 76.3424 56.6700 79.7858 50.8361 57.4924 66.9541 66.4316 54.0144 51.6114 103.2325 97.8553 109.7047 142.7075 154.8023 118.0419 1345489 1425716_s_at 17 chr17:27157931-27159823 17 A3.3 chr17:27156756-27165571 17 A3.3 RSQ Mm.2443 NM_007523 1 1 12018 Bak1 BCL2-antagonist/killer 1 (Bak1), mRNA. Role of Mitochondria in Apoptotic Signaling activation of caspase activity;; activation of caspase activity;; activation of caspase activity by cytochrome c;; apoptosis;; apoptosis;; apoptosis in response to endoplasmic reticulum stress;; B cell apoptosis;; B cell homeostasis;; B cell homeostasis;; B cell negative selection;; blood vessel remodeling;; cell proliferation;; cytosol;; endoplasmic reticulum;; homeostasis of number of cells;; integral to membrane;; intracellular;; leukocyte homeostasis;; limb morphogenesis;; membrane;; metal ion binding;; mitochondrial fusion;; mitochondrial membrane;; mitochondrion;; myeloid cell homeostasis;; negative regulation of peptidyl-serine phosphorylation;; positive regulation of apoptosis;; positive regulation of apoptosis;; positive regulation of calcium ion transport into cytosol;; post-embryonic camera-type eye morphogenesis;; reduction of endoplasmic reticulum calcium ion concentration;; regulation of apoptosis;; regulation of cell cycle;; response to fungus;; response to gamma radiation;; response to mycotoxin;; vagina development;; zinc ion binding cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding ion binding biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; establishment of localization;; immune system process;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; B cell selection;; cell activation;; cell cycle;; cell death;; cell proliferation;; cellular component morphogenesis;; cellular developmental process;; cellular homeostasis;; cellular metabolic process;; establishment of localization;; immune system development;; leukocyte activation;; leukocyte homeostasis;; macromolecule metabolic process;; membrane organization;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; organelle organization;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of homeostatic process;; positive regulation of transport;; post-embryonic camera-type eye development;; post-embryonic development;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of homeostatic process;; regulation of localization;; regulation of metabolic process;; regulation of molecular function;; reproductive developmental process;; reproductive process;; response to abiotic stimulus;; response to biotic stimulus;; response to chemical stimulus;; response to other organism;; tissue remodeling;; transport 218.4880 234.7680 382.3166 241.6148 229.0091 225.6262 694.8017 668.6737 612.4733 558.8084 700.0055 565.5954 1082.4667 1094.3968 1269.2635 1872.3067 1536.0464 1665.5079 1345585 1425895_a_at 2 84.0 cM chr2:152562239-152562793 2 H1 chr2:152562009-152563146 2 H1 RSQ Mm.444 NM_010495 1 1 15901 RP23-106A3.1 Id1 inhibitor of DNA binding 1 (Id1), mRNA. TGF-beta signaling pathway CLASS Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway [PATH:mmu04350] apoptosis;; BMP signaling pathway;; collagen metabolic process;; endothelial cell morphogenesis;; heart development;; lung morphogenesis;; lung vasculature development;; multicellular organismal development;; negative regulation of transcription from RNA polymerase II promoter;; nucleus;; protein binding;; regulation of angiogenesis;; regulation of MAPKKK cascade;; regulation of transcription;; response to antibiotic;; response to protein stimulus;; soluble fraction;; transcription regulator activity cell;; cell part;; organelle cell fraction;; cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity protein binding anatomical structure formation;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; biosynthetic process;; cell communication;; cell death;; cellular component morphogenesis;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal development;; multicellular organismal metabolic process;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; response to chemical stimulus 54.7268 58.8042 60.5520 52.3582 63.7786 49.4040 127.6109 123.7621 105.8898 111.8599 131.2870 130.1395 279.6696 248.2999 360.8186 311.3841 275.3032 274.3376 1345622 1425967_a_at 14 20.0 cM chr14:56679515-56680545 14 C3 chr14:56678580-56681147 14 C3 RSQ Mm.439684 NM_010779 1 1 17227 Mcpt4 mast cell protease 4 (Mcpt4), mRNA. hydrolase activity;; intracellular;; peptidase activity;; proteolysis;; serine-type endopeptidase activity;; serine-type peptidase activity cell;; cell part cell part;; intracellular catalytic activity hydrolase activity metabolic process catabolic process;; macromolecule metabolic process;; primary metabolic process 48.4314 43.4709 56.4800 49.6834 74.7569 46.5359 90.4629 95.7936 123.6554 111.0989 96.6187 104.6030 147.5569 144.4853 150.2371 246.6519 187.4297 171.9785 1335211 1426116_at 1 chr1:91849291-91864852 1 D chr1:91849252-91911152 1 D RSQ Mm.215164 NM_139152 1 1 208372 Asb18 ankyrin repeat and SOCS box-containing 18 (Asb18), mRNA. intracellular signaling cascade;; modification-dependent protein catabolic process biological regulation;; cellular process;; metabolic process;; regulation of biological process catabolic process;; cell communication;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process 71.9599 88.8369 71.6569 67.4542 78.1300 85.2611 79.9148 75.6334 110.7395 90.0473 77.6026 92.6102 153.8445 129.8156 133.2646 167.3042 153.4081 190.3108 1345747 1426157_a_at 8 chr8:3918669-3922069 8 A1.1 chr8:3918643-3926798 8 A1.1 RSQ Mm.175163 NM_001037800 2 1 69165 Cd209b CD209b antigen (Cd209b), transcript variant 2, mRNA. binding;; calcium ion binding;; detection of bacterium;; detection of yeast;; endocytosis;; external side of plasma membrane;; integral to membrane;; mannose binding;; membrane;; metal ion binding;; phagocytosis, recognition;; polysaccharide binding;; positive regulation of phagocytosis;; positive regulation of tumor necrosis factor biosynthetic process;; receptor activity;; sugar binding;; zymosan binding cell;; cell part cell part;; cell surface;; membrane;; membrane part binding;; molecular transducer activity carbohydrate binding;; ion binding;; pattern binding;; signal transducer activity biological regulation;; cellular component organization;; cellular process;; establishment of localization;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus biosynthetic process;; cell recognition;; cellular metabolic process;; cytokine production;; detection of stimulus;; establishment of localization;; macromolecule metabolic process;; membrane organization;; positive regulation of biological process;; positive regulation of cellular component organization;; positive regulation of cellular process;; positive regulation of metabolic process;; positive regulation of transport;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of localization;; regulation of metabolic process;; regulation of multicellular organismal process;; response to biotic stimulus;; response to external stimulus;; response to other organism;; transport;; vesicle-mediated transport 98.6709 124.1259 159.2744 107.6643 125.7886 157.7992 360.3781 353.1627 399.7425 357.0171 319.1639 380.8431 784.2030 643.3230 700.2106 1058.7961 657.1425 1302.9549 1335336 1426324_at 17 B1|17 18.44 cM chr17:35403699-35403794 17 B1 UGA Mm.439675 14972 H2-K1 MRNA similar to histocompatibility 2, D region locus 1 (cDNA clone MGC:25703 IMAGE:3675316) Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class I;; antigen processing and presentation of peptide antigen via MHC class I;; defense response to bacterium;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; peptide antigen binding;; positive regulation of T cell mediated cytotoxicity cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding antigen binding;; peptide binding biological regulation;; cell killing;; cellular process;; death;; developmental process;; immune system process;; multi-organism process;; positive regulation of biological process;; regulation of biological process;; response to stimulus antigen processing and presentation;; cell death;; immune effector process;; immune response;; leukocyte mediated cytotoxicity;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of response to stimulus;; regulation of biological process;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of response to stimulus;; response to biotic stimulus;; response to other organism;; response to stress 18.6375 28.1476 24.1307 25.3642 22.2049 22.3780 27.3614 33.7180 30.2736 23.3141 31.5978 24.0641 54.8253 86.5457 82.5615 64.8568 69.6521 69.6668 1335414 1426433_at 10 chr10:4739751-4752813 10 A1 RSQ Mm.338242 NM_026793 1 1 68632 Myct1 myc target 1 (Myct1), mRNA. integral to membrane;; membrane;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle 219.9349 200.8214 233.7962 280.6139 228.2809 211.8808 409.4345 390.2151 726.4197 716.0649 379.0538 686.5129 1384.7015 1458.9940 1471.5683 1921.9176 1727.5791 1434.1089 1335439 1426464_at 11 chr11:98629636-98631067 11 D chr11:98629248-98636556 11 D RSQ Mm.390397 NM_145434 1 1 217166 RP23-395E10.7 Nr1d1 nuclear receptor subfamily 1, group D, member 1 (Nr1d1), mRNA. Circadian rhythm - mammal CLASS Cellular Processes; Behavior; Circadian rhythm - mammal [PATH:mmu04710] circadian rhythm;; DNA binding;; ligand-dependent nuclear receptor activity;; metal ion binding;; nucleus;; receptor activity;; regulation of transcription, DNA-dependent;; sequence-specific DNA binding;; steroid hormone receptor activity;; transcription;; transcription factor activity;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; signal transducer activity;; transcription factor activity biological regulation;; cellular process;; metabolic process;; regulation of biological process;; rhythmic process biosynthetic process;; cellular metabolic process;; circadian rhythm;; macromolecule metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 67.6781 69.2316 103.5210 51.1385 64.7516 74.4164 34.5471 36.4241 33.3882 27.1549 34.6428 37.2293 88.1138 73.8195 84.3237 97.6690 84.5894 66.6934 1336073 1427301_at 1 93.3 cM chr1:173629579-173629781 1 H3 chr1:173612185-173635388 1 H3 RSQ Mm.1738 NM_007649 1 1 12506 Cd48 CD48 antigen (Cd48), mRNA. Natural killer cell mediated cytotoxicity CLASS Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] anchored to membrane;; eukaryotic cell surface binding;; external side of plasma membrane;; membrane;; plasma membrane;; protein binding;; response to protein stimulus;; signal transduction;; T cell activation cell;; cell part cell part;; cell surface;; membrane;; membrane part binding cell surface binding;; protein binding biological regulation;; cellular process;; immune system process;; regulation of biological process;; response to stimulus cell activation;; cell communication;; leukocyte activation;; regulation of biological process;; regulation of cellular process;; response to chemical stimulus 189.9950 227.1694 161.3251 204.7630 208.9297 177.3937 139.3123 146.8561 82.3272 86.3048 159.1842 97.0230 555.4214 205.7242 292.5824 355.1519 424.9447 274.6168 1336105 1427343_at 8 C1 chr8:77747442-77747638 8 C1 UG5 Mm.179267 75141 Rasd2 RASD family, member 2, mRNA (cDNA clone IMAGE:4988981) GTP binding;; intracellular;; locomotory behavior;; membrane;; nucleotide binding;; small GTPase mediated signal transduction cell;; cell part cell part;; intracellular;; membrane binding nucleotide binding biological regulation;; cellular process;; regulation of biological process;; response to stimulus behavior;; cell communication;; regulation of biological process;; regulation of cellular process 3745.3357 3877.3524 3957.9849 1607.2075 1164.8137 2113.9588 314.9876 300.3467 354.9774 328.8318 280.0321 340.1580 606.3516 529.8788 698.4297 846.0903 625.1551 515.1727 1346686 1431609_a_at 9 6.0 cM chr9:21931170-21935042 9 A3 RSQ Mm.46354 NM_007388 3 1 11433 Acp5 acid phosphatase 5, tartrate resistant (Acp5), transcript variant 3, mRNA. gamma-Hexachlorocyclohexane degradation;; Lysosome CLASS Metabolism; Metabolism of Cofactors and Vitamins; Riboflavin metabolism [PATH:mmu00740] Metabolism; Xenobiotics Biodegradation and Metabolism; gamma-Hexachlorocyclohexane degradation [PATH:mmu00361] Cellular Processes; Transport and Catabolism; Lysosome [PATH:mmu04142];; Riboflavin metabolism acid phosphatase activity;; acid phosphatase activity;; bone morphogenesis;; bone resorption;; dephosphorylation;; hydrolase activity;; immune response;; iron ion binding;; lysosome;; metal ion binding;; response to cytokine stimulus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; catalytic activity hydrolase activity;; ion binding biological regulation;; cellular process;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; cellular metabolic process;; immune response;; multicellular organismal development;; multicellular organismal homeostasis;; regulation of biological quality;; response to chemical stimulus;; tissue remodeling 119.2512 116.4326 65.4153 128.9913 92.3403 85.4145 580.9299 546.4297 888.8382 813.7706 586.3542 841.9954 2348.5575 2883.4864 2884.6519 2902.7281 2711.3186 1294.5176 1337510 1434340_at 11 A1 UGA Mm.269736 66152 RP23-280J3.4 1110020P15Rik RIKEN cDNA 1110020P15 gene, mRNA (cDNA clone MGC:37480 IMAGE:4984172) Alzheimer's disease;; Cardiac muscle contraction;; Huntington's disease CLASS Metabolism; Energy Metabolism; Oxidative phosphorylation [PATH:mmu00190] Cellular Processes; Circulatory System; Cardiac muscle contraction [PATH:mmu04260] Human Diseases; Neurodegenerative Diseases; Alzheimer's disease [PATH:mmu05010] Human Diseases; Neurodegenerative Diseases; Parkinson's disease [PATH:mmu05012] Human Diseas;; Metabolic pathways;; Oxidative phosphorylation;; Parkinson's disease electron transport chain;; membrane;; mitochondrial electron transport, ubiquinol to cytochrome c;; mitochondrial envelope;; mitochondrial inner membrane;; mitochondrion;; respiratory chain;; transport;; ubiquinol-cytochrome-c reductase activity cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part catalytic activity;; transporter activity oxidoreductase activity;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process cellular metabolic process;; establishment of localization;; oxidation reduction;; transport 220.2867 189.0393 209.8279 202.5118 166.5932 203.8637 859.9223 744.9613 1146.2013 1059.3887 843.5532 1048.0854 2212.6519 2347.4852 2083.9050 2190.5964 2002.7089 1345.5922 1347039 1434341_x_at 11 A1 chr11:4602128-4604281 11 A1 UGA Mm.269736 66152 RP23-280J3.4 1110020P15Rik RIKEN cDNA 1110020P15 gene, mRNA (cDNA clone MGC:37480 IMAGE:4984172) Alzheimer's disease;; Cardiac muscle contraction;; Huntington's disease CLASS Metabolism; Energy Metabolism; Oxidative phosphorylation [PATH:mmu00190] Cellular Processes; Circulatory System; Cardiac muscle contraction [PATH:mmu04260] Human Diseases; Neurodegenerative Diseases; Alzheimer's disease [PATH:mmu05010] Human Diseases; Neurodegenerative Diseases; Parkinson's disease [PATH:mmu05012] Human Diseas;; Metabolic pathways;; Oxidative phosphorylation;; Parkinson's disease electron transport chain;; membrane;; mitochondrial electron transport, ubiquinol to cytochrome c;; mitochondrial envelope;; mitochondrial inner membrane;; mitochondrion;; respiratory chain;; transport;; ubiquinol-cytochrome-c reductase activity cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part catalytic activity;; transporter activity oxidoreductase activity;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process cellular metabolic process;; establishment of localization;; oxidation reduction;; transport 41.2790 37.3164 33.8673 46.5436 41.7553 42.7167 43.1577 49.6012 25.3176 42.1655 40.8113 34.4581 56.1811 65.8569 50.6283 77.8018 112.2458 125.8238 1347450 1436989_s_at 2 E3 UGA Mm.46449 107723 RP23-208E23.1 Slc12a6 Solute carrier family 12, member 6, mRNA (cDNA clone IMAGE:5359319) apical plasma membrane;; axon;; basolateral plasma membrane;; cation:chloride symporter activity;; chloride transport;; integral to membrane;; ion transport;; membrane;; potassium ion binding;; potassium ion transport;; protein binding;; sodium ion transport;; symporter activity;; transport;; transporter activity cell;; cell part apical part of cell;; cell part;; cell projection;; membrane;; membrane part binding;; transporter activity ion binding;; protein binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 58.8360 56.3439 57.3667 72.7084 75.4655 61.0574 93.9920 90.8617 89.1426 84.4225 103.1523 82.0318 160.4229 113.6398 162.2812 196.0983 271.3365 190.7871 1338720 1448147_at 14 chr14:61583106-61583261 14 D1 chr14:61582872-61665306 14 D1 RSQ Mm.281356 NM_013869 1 1 29820 Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 (Tnfrsf19), mRNA. Cytokine-cytokine receptor interaction CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] extracellular region;; hair follicle development;; integral to membrane;; membrane;; plasma membrane;; receptor activity cell;; cell part;; extracellular region cell part;; membrane;; membrane part molecular transducer activity signal transducer activity developmental process;; multicellular organismal process anatomical structure development;; molting cycle;; multicellular organismal development 53.0054 48.4751 38.9348 48.4171 33.3155 33.1101 82.0365 94.6227 125.2912 125.7983 83.9711 110.5522 364.1519 246.6005 358.7981 266.7688 249.7060 162.2068 1338760 1448201_at 3 38.5 cM chr3:83577660-83577987 3 E3 chr3:83570242-83578236 3 E3 RSQ Mm.19155 NM_009144 1 1 20319 Sfrp2 secreted frizzled-related protein 2 (Sfrp2), mRNA. Wnt signaling pathway CLASS Environmental Information Processing; Signal Transduction; Wnt signaling pathway [PATH:mmu04310] anterior/posterior pattern formation;; cell differentiation;; cellular response to extracellular stimulus;; extracellular region;; multicellular organismal development;; somitogenesis;; Wnt receptor signaling pathway extracellular region biological regulation;; cellular process;; developmental process;; multicellular organismal process;; regulation of biological process;; response to stimulus cell communication;; cellular developmental process;; cellular response to stimulus;; embryonic development;; multicellular organismal development;; pattern specification process;; regulation of biological process;; regulation of cellular process;; response to external stimulus 70.3510 72.9219 68.4044 62.6213 75.5634 63.3622 141.4692 139.7701 198.9852 174.2487 164.5932 180.8634 425.2079 343.8897 423.5509 399.0937 417.4943 272.0202 1338998 1448507_at 1 chr1:89206841-89207235 1 D chr1:89160938-89207366 1 D RSQ Mm.247951 NM_028889 1 1 98363 Efhd1 EF hand domain containing 1 (Efhd1), mRNA. calcium ion binding;; mitochondrial inner membrane;; neuron projection development cell;; cell part;; envelope;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane-bounded organelle;; organelle envelope;; organelle membrane;; organelle part binding ion binding cellular component organization;; cellular process;; developmental process;; multicellular organismal process anatomical structure development;; cell projection organization;; cellular developmental process;; multicellular organismal development 3043.4308 2494.3395 3426.3036 1800.0778 2135.5080 2733.8868 140.9502 168.8049 275.6097 232.5485 157.0554 227.8649 575.3896 371.3847 423.0962 346.3424 378.8162 435.2894 1339046 1448566_at 1 chr1:45966177-45967900 1 C1.1 chr1:45964914-45982439 1 C1.1 RSQ Mm.28756 NM_016917 1 1 53945 Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1), mRNA. integral to membrane;; ion transport;; iron ion binding;; iron ion transmembrane transporter activity;; iron ion transport;; membrane;; plasma membrane;; synaptic vesicle;; transport cell;; cell part;; organelle;; synapse;; synapse part cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; synapse part;; synaptic vesicle;; vesicle binding;; transporter activity ion binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 377.3177 318.8181 599.3763 414.0630 568.5634 404.6972 231.4852 224.4994 289.5408 291.9983 231.4396 269.4759 365.1774 510.9069 559.3372 675.6031 553.2279 513.6138 1339155 1448698_at 7 72.3 cM chr7:152115900-152116415 7 F5 chr7:152115835-152125830 7 F5 RSQ Mm.273049 NM_007631 1 1 12443 Ccnd1 cyclin D1 (Ccnd1), mRNA. BTG family proteins and cell cycle regulation;; Cell Cycle: G1/S Check Point;; Cyclins and Cell Cycle Regulation;; Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages;; Influence of Ras and Rho proteins on G1 to S Transition;; p53 Signaling Pathway;; WNT Signaling Pathway Acute myeloid leukemia;; Bladder cancer;; Cell cycle;; Chronic myeloid leukemia;; Colorectal cancer;; Endometrial cancer;; Focal adhesion;; Glioma;; Jak-STAT signaling pathway;; Melanoma;; Non-small cell lung cancer CLASS Environmental Information Processing; Signal Transduction; Wnt signaling pathway [PATH:mmu04310] Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Cellular Processes; Cell Growth and Death; Cell cycle [PATH:mmu04110] Cellular Processes; Cell Growth and Death; p53 signal;; p53 signaling pathway;; Pancreatic cancer;; Pathways in cancer;; Prostate cancer;; Small cell lung cancer;; Thyroid cancer;; Wnt signaling pathway cell cycle;; cell division;; cyclin-dependent protein kinase holoenzyme complex;; cyclin-dependent protein kinase regulator activity;; cytosol;; endoplasmic reticulum unfolded protein response;; fat cell differentiation;; kinase activity;; lactation;; lactation;; mammary gland alveolus development;; mammary gland alveolus development;; mammary gland epithelial cell proliferation;; negative regulation of epithelial cell differentiation;; negative regulation of Wnt receptor signaling pathway;; nucleoplasm;; nucleus;; protein amino acid phosphorylation;; protein binding;; protein kinase activity;; re-entry into mitotic cell cycle;; regulation of cell cycle;; Wnt receptor signaling pathway through beta-catenin cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; catalytic activity;; enzyme regulator activity kinase regulator activity;; protein binding;; transferase activity biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; cell communication;; cell cycle;; cell cycle process;; cell division;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cellular response to stimulus;; macromolecule metabolic process;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of multicellular organismal process;; reproductive process;; reproductive process in a multicellular organism;; response to biotic stimulus;; response to chemical stimulus;; response to stress 27.0208 25.6126 20.0667 26.9888 29.0471 20.8333 32.9122 39.8214 41.1549 37.0941 33.4596 38.7050 87.9308 108.7108 137.4182 124.7565 89.9551 77.7158 1339165 1448710_at 1 67.4 cM chr1:130485067-130485335 1 E4 chr1:130484775-130488876 1 E4 RSQ Mm.1401 NM_009911 1 1 12767 Cxcr4 chemokine (C-X-C motif) receptor 4 (Cxcr4), mRNA. CXCR4 Signaling Pathway;; Pertussis toxin-insensitive CCR5 Signaling in Macrophage;; Selective expression of chemokine receptors during T-cell polarization Axon guidance;; Chemokine signaling pathway;; Cytokine-cytokine receptor interaction;; Endocytosis;; Leukocyte transendothelial migration CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu04060] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Leukocyte transendothelial migration [PATH:mmu04670] Cellular Processes; ameboidal cell migration;; brain development;; C-C chemokine receptor activity;; C-X-C chemokine receptor activity;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; germ cell development;; germ cell migration;; growth cone;; integral to membrane;; membrane;; motor axon guidance;; nervous system development;; neuron migration;; organ morphogenesis;; patterning of blood vessels;; plasma membrane;; receptor activity;; regulation of cell migration;; regulation of cell migration;; signal transducer activity;; signal transduction;; T cell proliferation cell;; cell part cell part;; cell projection;; membrane;; membrane part;; site of polarized growth binding;; molecular transducer activity peptide binding;; protein binding;; signal transducer activity anatomical structure formation;; biological regulation;; cellular component organization;; cellular process;; developmental process;; immune system process;; localization;; locomotion;; multicellular organismal process;; regulation of biological process;; reproduction;; reproductive process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; cell activation;; cell communication;; cell motility;; cell motion;; cell projection organization;; cell proliferation;; cellular component morphogenesis;; cellular developmental process;; gamete generation;; leukocyte activation;; localization of cell;; multicellular organismal development;; pattern specification process;; regulation of biological process;; regulation of cellular process;; regulation of localization;; regulation of locomotion;; reproductive process;; sexual reproduction 336.5107 265.5324 254.9800 312.4020 294.8403 259.2164 1555.8117 1495.8398 1398.3183 1424.3730 1482.3883 1359.0964 2605.0688 3613.9115 4098.4646 5533.2047 3669.5042 3767.4064 1339421 1449015_at 16 B5|16 32.6 cM chr16:48842672-48844529 16 B5 UGA Mm.441868 57262 Retnla Resistin like alpha, mRNA (cDNA clone MGC:35890 IMAGE:4189285) extracellular region;; hormone activity extracellular region binding protein binding 34.2524 25.9040 25.3818 34.4490 24.3122 33.3592 87.0576 79.3429 76.5943 75.1611 84.2687 80.4106 94.9022 126.9803 144.5088 216.2075 175.4274 158.4009 1348342 1449070_x_at 18 E1 chr18:63112987-63113316 18 E1 UGA Mm.391102 494504 Apcdd1 Adenomatosis polyposis coli down-regulated 1 (Apcdd1), mRNA integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 150.7879 220.5041 256.5993 225.1770 247.7991 381.4441 449.5478 444.4970 441.7566 405.5964 463.9825 364.7840 664.5258 885.3742 1041.5601 1127.9783 1337.0408 798.6034 1339514 1449135_at 2 96.0 cM chr2:181404769-181405114 2 H4 chr2:181404541-181406345 2 H4 RSQ Mm.264904 NM_009236 1 1 20672 Sox18 SRY-box containing gene 18 (Sox18), mRNA. angiogenesis;; DNA binding;; nucleus;; regulation of transcription, DNA-dependent;; transcription;; transcription factor activity;; vasculogenesis cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; transcription factor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; regulation of biological process anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; biosynthetic process;; cellular developmental process;; cellular metabolic process;; macromolecule metabolic process;; multicellular organismal development;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 87.7158 88.8376 93.1275 95.3777 116.0027 65.4573 187.0391 208.3156 178.8339 177.2192 187.1516 177.4457 369.8286 370.8415 350.7776 494.7371 397.4913 348.9612 1339524 1449147_at 2 chr2:92454920-92455309 2 E1 chr2:92439863-92455409 2 E1 RSQ Mm.38021 NM_023850 1 1 76969 RP23-165L23.5 Chst1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (Chst1), mRNA. Keratan sulfate biosynthesis;; Metabolic pathways CLASS Metabolism; Glycan Biosynthesis and Metabolism; Keratan sulfate biosynthesis [PATH:mmu00533] carbohydrate metabolic process;; Golgi apparatus;; Golgi membrane;; inflammatory response;; integral to membrane;; keratan sulfotransferase activity;; membrane;; sulfotransferase activity;; transferase activity cell;; cell part;; organelle;; organelle part cell part;; endomembrane system;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; organelle membrane;; organelle part catalytic activity transferase activity metabolic process;; response to stimulus primary metabolic process;; response to external stimulus;; response to stress 309.2827 343.7846 345.6714 373.0288 417.2775 315.9305 735.0315 720.5078 727.5071 698.5505 738.1761 712.7230 1188.9852 1065.5581 1122.9786 2383.9250 1708.9555 1448.1651 1339555 1449182_at 8 0.37 cM chr8:3655809-3659742 8 A1.1 chr8:3655788-3658096 8 A1.1 RSQ Mm.1181 NM_022984 1 1 57264 Retn resistin (Retn), mRNA. extracellular region;; hormone activity extracellular region binding protein binding 84.3235 61.1323 67.9024 77.0656 106.4749 78.2709 120.4960 135.3124 105.0715 98.6059 126.0537 100.4643 243.4689 263.4501 262.9191 246.6519 306.4654 218.4156 1339578 1449211_at 1 chr1:187181209-187181563 1 H5 chr1:187156037-187181648 1 H5 RSQ Mm.227549 NM_011794 1 1 23827 Bpnt1 bisphosphate 3'-nucleotidase 1 (Bpnt1), mRNA. Sulfur metabolism CLASS Metabolism; Energy Metabolism; Sulfur metabolism [PATH:mmu00920] 3'(2'),5'-bisphosphate nucleotidase activity;; hydrolase activity;; inositol or phosphatidylinositol phosphatase activity;; lithium ion binding;; magnesium ion binding;; metal ion binding binding;; catalytic activity hydrolase activity;; ion binding 85.9458 108.3219 94.2228 70.3351 67.4182 68.4010 60.5250 70.2196 73.5858 72.4736 68.2558 73.4358 143.3363 174.3599 156.7431 164.5877 134.1586 136.2064 1339828 1449514_at 19 55.0 cM chr19:61166433-61168180 19 D3 chr19:60965651-61168459 19 D3 RSQ Mm.279400 NM_018869 1 1 14773 Grk5 G protein-coupled receptor kinase 5 (Grk5), mRNA. Chemokine signaling pathway;; Endocytosis CLASS Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Chemokine signaling pathway [PATH:mmu04062] ATP binding;; G-protein coupled receptor kinase activity;; kinase activity;; nucleotide binding;; protein amino acid phosphorylation;; protein kinase activity;; protein serine/threonine kinase activity;; signal transducer activity;; signal transduction;; transferase activity binding;; catalytic activity;; molecular transducer activity nucleoside binding;; nucleotide binding;; signal transducer activity;; transferase activity biological regulation;; cellular process;; metabolic process;; regulation of biological process cell communication;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process 119.3891 86.1920 163.5004 140.6539 157.2103 118.9554 30.8332 40.0068 64.1276 58.2037 47.8191 48.1419 98.5178 76.8334 90.3629 111.9151 83.5840 71.5843 1339874 1449568_at 5 chr5:65774651-65775180 5 C3.1 chr5:65739649-65775242 5 C3.1 RSQ Mm.45274 NM_031180 1 1 83379 Klb klotho beta (Klb), mRNA. carbohydrate metabolic process;; catalytic activity;; cation binding;; hydrolase activity, hydrolyzing O-glycosyl compounds;; integral to membrane;; membrane;; plasma membrane cell;; cell part cell part;; membrane;; membrane part binding;; catalytic activity hydrolase activity;; ion binding metabolic process primary metabolic process 55.2462 60.5614 44.2123 55.7385 58.7242 63.8055 92.4788 97.7903 89.0266 85.9540 100.0781 84.4725 168.7150 199.3186 213.6166 229.0526 202.8142 255.7643 1340086 1449918_at 8 chr8:4136365-4137667 8 A1.1 chr8:4134245-4137707 8 A1.1 RSQ Mm.390006 XM_284376 2 1 70192 Cd209g PREDICTED: CD209g antigen (Cd209g), mRNA. integral to membrane;; membrane;; sugar binding cell;; cell part cell part;; membrane;; membrane part binding carbohydrate binding 105.7091 79.8201 102.1115 41.6861 43.0829 35.1840 230.7630 242.3235 167.7622 180.9728 241.0001 191.8741 414.8807 401.2452 324.6121 520.1367 550.0026 458.3301 1340171 1450044_at 1 30.1 cM chr1:59543258-59543780 1 C1.3 chr1:59538990-59543799 1 C1.3 RSQ Mm.297906 NM_008057 1 1 14369 Fzd7 frizzled homolog 7 (Drosophila) (Fzd7), mRNA. Basal cell carcinoma CLASS Environmental Information Processing; Signal Transduction; Wnt signaling pathway [PATH:mmu04310] Cellular Processes; Endocrine System; Melanogenesis [PATH:mmu04916] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Colorectal cancer [PATH:mmu05210] Human Diseases; Cancers; Basal cell carcinom;; Colorectal cancer;; Melanogenesis;; Pathways in cancer;; Wnt signaling pathway cell surface receptor linked signal transduction;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; integral to membrane;; membrane;; multicellular organismal development;; non-G-protein coupled 7TM receptor activity;; receptor activity;; signal transducer activity;; signal transduction;; transmembrane receptor activity;; Wnt receptor signaling pathway cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity biological regulation;; cellular process;; developmental process;; multicellular organismal process;; regulation of biological process cell communication;; multicellular organismal development;; regulation of biological process;; regulation of cellular process 513.4762 356.8073 412.0435 139.1363 78.0887 147.5433 17.5503 17.4648 18.6625 20.5990 21.3868 19.4384 51.5856 40.7220 43.1129 54.3777 41.1417 31.2346 1340189 1450065_at 8 40.0 cM chr8:90853286-90853457 8 C3 chr8:90806890-90853861 8 C3 RSQ Mm.288206 NM_001109756 4 1 11513 Adcy7 adenylate cyclase 7 (Adcy7), transcript variant 4, mRNA. Calcium signaling pathway;; Chemokine signaling pathway;; Gap junction;; GnRH signaling pathway;; Melanogenesis CLASS Metabolism; Nucleotide Metabolism; Purine metabolism [PATH:mmu00230] Environmental Information Processing; Signal Transduction; Calcium signaling pathway [PATH:mmu04020] Cellular Processes; Cell Communication; Gap junction [PATH:mmu04540] Cellular Processes; Circulatory System; Vascular smooth muscle contraction [PATH:mmu04270] Cellu;; Purine metabolism;; Vascular smooth muscle contraction activation of adenylate cyclase activity;; adenylate cyclase activity;; ATP binding;; cAMP biosynthetic process;; cyclic nucleotide biosynthetic process;; integral to membrane;; intracellular signaling cascade;; lyase activity;; magnesium ion binding;; membrane;; metal ion binding;; nucleotide binding;; phosphorus-oxygen lyase activity;; plasma membrane cell;; cell part cell part;; membrane;; membrane part binding;; catalytic activity cyclase activity;; ion binding;; lyase activity;; nucleoside binding;; nucleotide binding biological regulation;; cellular process;; metabolic process;; regulation of biological process biosynthetic process;; cell communication;; cellular metabolic process;; nitrogen compound metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; regulation of molecular function 95.7308 90.1043 96.1439 112.1050 99.1985 102.6012 114.6100 105.5720 116.9665 117.9322 117.5526 117.8219 247.1964 253.1895 284.3426 357.0918 268.9733 326.9686 1340228 1450130_at 1 81.6 cM chr1:157126726-157127275 1 G3 chr1:157122786-157264574 1 G3 RSQ Mm.266215 NM_011273 1 1 19775 Xpr1 xenotropic and polytropic retrovirus receptor 1 (Xpr1), mRNA. integral to membrane;; membrane;; plasma membrane;; receptor activity;; response to virus;; response to virus cell;; cell part cell part;; membrane;; membrane part molecular transducer activity signal transducer activity multi-organism process;; response to stimulus response to biotic stimulus;; response to other organism 80.6420 99.7018 122.8120 61.0042 91.8994 94.0006 74.7081 72.6452 58.8742 61.2051 72.1458 70.7522 165.0964 155.4819 153.3741 207.8186 160.4300 119.2498 1348619 1450241_a_at 11 46.13 cM chr11:79340425-79340856 11 B5 chr11:79340061-79344111 11 B5 RSQ Mm.439665 NM_010161 2 1 14017 RP23-271B20.1 Evi2a ecotropic viral integration site 2a (Evi2a), transcript variant 2, mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 13.8932 16.3582 22.5512 59.7969 39.8737 43.7828 25.8331 31.5116 82.9659 78.6861 31.5116 72.4687 166.3186 137.2517 149.8765 74.5429 65.4503 55.7989 1348627 1450259_a_at 11 60.5 cM chr11:100742343-100745240 11 D chr11:100720716-100746483 11 D RSQ Mm.277403 NM_011488 1 1 20850 RP23-279L23.4 Stat5a signal transducer and activator of transcription 5A (Stat5a), mRNA. EPO Signaling Pathway;; Growth Hormone Signaling Pathway;; IL 2 signaling pathway;; IL 3 signaling pathway;; IL-2 Receptor Beta Chain in T cell Activation;; IL-7 Signal Transduction;; IL22 Soluble Receptor Signaling Pathway;; Inhibition of Cellular Proliferation by Gleevec;; TPO Signaling Pathway Acute myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; ErbB signaling pathway [PATH:mmu04012] Environmental Information Processing; Signal Transduction; Jak-STAT signaling pathway [PATH:mmu04630] Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200] Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221] Hu;; Chronic myeloid leukemia;; ErbB signaling pathway;; Jak-STAT signaling pathway;; Pathways in cancer calcium ion binding;; cytokine-mediated signaling pathway;; cytoplasm;; development of secondary female sexual characteristics;; development of secondary male sexual characteristics;; development of secondary male sexual characteristics;; DNA binding;; epithelial cell differentiation involved in prostate gland development;; female pregnancy;; JAK-STAT cascade;; lactation;; lipid storage;; luteinization;; mammary gland development;; natural killer cell differentiation;; negative regulation of apoptosis;; negative regulation of erythrocyte differentiation;; negative regulation of mast cell apoptosis;; nucleus;; peptidyl-tyrosine phosphorylation;; Peyer's patch development;; positive regulation of activated T cell proliferation;; positive regulation of activated T cell proliferation;; positive regulation of B cell differentiation;; positive regulation of cell proliferation;; positive regulation of cell proliferation;; positive regulation of gamma-delta T cell differentiation;; positive regulation of inflammatory response;; positive regulation of interleukin-2 biosynthetic process;; positive regulation of lymphocyte differentiation;; positive regulation of mast cell differentiation;; positive regulation of mast cell proliferation;; positive regulation of mitotic cell cycle;; positive regulation of multicellular organism growth;; positive regulation of natural killer cell differentiation;; positive regulation of natural killer cell mediated cytotoxicity;; positive regulation of survival gene product expression;; positive regulation of transcription from RNA polymerase II promoter;; positive regulation of transcription from RNA polymerase II promoter;; prostate gland epithelium morphogenesis;; protein binding;; regulation of cell adhesion;; regulation of epithelial cell differentiation;; regulation of steroid metabolic process;; regulation of transcription from RNA polymerase II promoter;; regulation of transcription, DNA-dependent;; response to peptide hormone stimulus;; signal transducer activity;; signal transduction;; T cell differentiation in the thymus;; T cell homeostasis;; transcription;; transcription factor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; molecular transducer activity;; transcription regulator activity ion binding;; nucleic acid binding;; protein binding;; signal transducer activity;; transcription factor activity biological adhesion;; biological regulation;; cell killing;; cellular process;; death;; developmental process;; growth;; immune system process;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus;; rhythmic process anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell activation;; cell adhesion;; cell communication;; cell cycle;; cell death;; cell proliferation;; cellular developmental process;; cellular metabolic process;; cytokine production;; female pregnancy;; immune effector process;; immune response;; immune system development;; leukocyte activation;; leukocyte homeostasis;; leukocyte mediated cytotoxicity;; macromolecule localization;; macromolecule metabolic process;; multicellular organism growth;; multicellular organism reproduction;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; nitrogen compound metabolic process;; ovulation cycle;; ovulation cycle process;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of growth;; positive regulation of immune system process;; positive regulation of metabolic process;; positive regulation of multicellular organismal process;; positive regulation of response to stimulus;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of homeostatic process;; regulation of immune system process;; regulation of metabolic process;; regulation of multicellular organismal process;; regulation of response to stimulus;; reproductive developmental process;; reproductive process;; reproductive process in a multicellular organism;; response to chemical stimulus;; response to endogenous stimulus;; response to external stimulus;; response to stress 16.0762 14.6973 13.8208 17.1377 15.7443 16.0506 34.0331 35.0447 37.7950 28.2764 35.2623 33.1230 90.4048 83.3322 128.0871 115.8169 103.5314 81.5511 1348652 1450344_a_at 3 82.0 cM chr3:157307126-157307682 3 H4 chr3:157229855-157307722 3 H4 RSQ Mm.30424 NM_011196 1 1 19218 Ptger3 prostaglandin E receptor 3 (subtype EP3) (Ptger3), mRNA. Eicosanoid Metabolism Calcium signaling pathway;; Neuroactive ligand-receptor interaction CLASS Environmental Information Processing; Signal Transduction; Calcium signaling pathway [PATH:mmu04020] Environmental Information Processing; Signaling Molecules and Interaction; Neuroactive ligand-receptor interaction [PATH:mmu04080] activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger;; bicarbonate transport;; diuresis;; elevation of cytosolic calcium ion concentration;; fever;; fever;; G-protein coupled receptor activity;; G-protein coupled receptor protein signaling pathway;; G-protein signaling, coupled to cAMP nucleotide second messenger;; integral to membrane;; membrane;; plasma membrane;; prostaglandin E receptor activity;; prostaglandin E receptor activity;; prostaglandin receptor activity;; protein binding;; receptor activity;; signal transducer activity;; signal transduction cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity protein binding;; signal transducer activity biological regulation;; cellular process;; establishment of localization;; localization;; multicellular organismal process;; regulation of biological process;; response to stimulus cell communication;; cellular homeostasis;; establishment of localization;; regulation of biological process;; regulation of biological quality;; regulation of body fluid levels;; regulation of cellular process;; regulation of molecular function;; response to external stimulus;; response to stress;; system process;; temperature homeostasis;; transport 125.3745 135.1520 115.2457 156.0408 154.2765 115.3375 273.1625 264.8792 438.9728 441.2854 265.0371 397.7630 698.4523 736.3306 440.6302 516.0759 870.2358 664.2246 1348662 1450381_a_at 16 13.9 cM chr16:23968165-23968505 16 B1 chr16:23965137-23988698 16 B1 RSQ Mm.347398 NM_009744 1 1 12053 Bcl6 B-cell leukemia/lymphoma 6 (Bcl6), mRNA. actin cytoskeleton organization;; B cell differentiation;; cell morphogenesis;; cell morphogenesis;; chromatin binding;; chromatin binding;; chromatin DNA binding;; DNA binding;; erythrocyte development;; germinal center formation;; intracellular;; metal ion binding;; negative regulation of apoptosis;; negative regulation of apoptosis;; negative regulation of cell differentiation;; negative regulation of cell proliferation;; negative regulation of cell-matrix adhesion;; negative regulation of isotype switching to IgE isotypes;; negative regulation of isotype switching to IgE isotypes;; negative regulation of mast cell cytokine production;; negative regulation of Rho protein signal transduction;; negative regulation of T-helper 2 cell differentiation;; negative regulation of T-helper 2 type immune response;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription from RNA polymerase II promoter;; nucleic acid binding;; nucleus;; nucleus;; positive regulation of B cell proliferation;; positive regulation of cell motion;; protein binding;; protein binding;; protein localization;; regulation of cell proliferation;; regulation of inflammatory response;; regulation of memory T cell differentiation;; regulation of Rho GTPase activity;; regulation of transcription, DNA-dependent;; Rho protein signal transduction;; sequence-specific DNA binding;; spermatogenesis;; T-helper 2 type immune response;; transcription;; transcription repressor activity;; transcription repressor activity;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity chromatin binding;; ion binding;; nucleic acid binding;; protein binding;; transcription repressor activity biological adhesion;; biological regulation;; cellular component organization;; cellular process;; death;; developmental process;; immune system process;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; reproduction;; reproductive process;; response to stimulus actin filament-based process;; anatomical structure development;; anatomical structure morphogenesis;; biosynthetic process;; cell activation;; cell adhesion;; cell communication;; cell death;; cell motion;; cell proliferation;; cellular component morphogenesis;; cellular developmental process;; cellular metabolic process;; cytokine production;; gamete generation;; immune effector process;; immune response;; immune system development;; leukocyte activation;; localization of cell;; macromolecule localization;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; negative regulation of immune system process;; negative regulation of metabolic process;; negative regulation of multicellular organismal process;; negative regulation of response to stimulus;; nitrogen compound metabolic process;; organelle organization;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of immune system process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of localization;; regulation of metabolic process;; regulation of molecular function;; regulation of multicellular organismal process;; regulation of response to stimulus;; reproductive process;; response to external stimulus;; response to stress;; sexual reproduction;; somatic diversification of immune receptors 55.4172 64.1543 43.7559 49.2277 65.0095 46.7495 192.5017 194.1384 210.2064 223.5557 195.0952 212.5426 399.6710 420.9770 401.4890 473.6784 385.5695 352.1978 1340496 1450515_at 7 41.0 cM chr7:53354049-53354582 7 B4 chr7:53352531-53355607 7 B4 RSQ Mm.333863 NM_010602 1 1 16514 Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 (Kcnj11), mRNA. Type II diabetes mellitus CLASS Human Diseases; Metabolic Disorders; Type II diabetes mellitus [PATH:mmu04930] ATP binding;; ATP-activated inward rectifier potassium channel activity;; integral to membrane;; inward rectifier potassium channel activity;; ion channel activity;; ion transport;; membrane;; plasma membrane;; potassium ion binding;; potassium ion import;; potassium ion transport;; transport;; voltage-gated ion channel activity cell;; cell part cell part;; membrane;; membrane part binding;; transporter activity ion binding;; nucleoside binding;; nucleotide binding;; substrate-specific transporter activity;; transmembrane transporter activity establishment of localization;; localization establishment of localization;; transport 37.2715 31.5728 44.0034 44.1588 45.7841 44.1055 164.8873 164.3553 155.2630 149.5299 160.9589 160.7205 303.0379 284.2098 270.7630 336.6168 421.0807 274.6070 1340585 1450639_at 2 chr2:122310676-122353776 2 E5 RSQ Mm.29510 NM_001085518 2 2 381417 RP23-357I14.1 Rp23-357i14.1 novel protein similar to solute carrier family 28 (sodium-coupled nucleoside transporter) member 2 (Slc28a2) (Rp23-357i14.1), mRNA. 55.4337 75.1908 90.7747 75.1148 78.0652 70.9847 491.3778 500.4250 579.6459 580.0727 490.5525 563.6427 1028.0408 729.4287 1152.9904 959.8060 966.2075 1182.6789 1340713 1450798_at 17 18.74 cM chr17:34855796-34856551 17 B1 chr17:34807479-34856170 17 B1 RSQ Mm.290527 NM_031176 1 1 81877 Tnxb tenascin XB (Tnxb), mRNA. ECM-receptor interaction CLASS Environmental Information Processing; Signaling Molecules and Interaction; ECM-receptor interaction [PATH:mmu04512] Cellular Processes; Cell Communication; Focal adhesion [PATH:mmu04510];; Focal adhesion cell-cell adhesion;; cell-matrix adhesion;; collagen binding;; collagen fibril organization;; collagen metabolic process;; elastic fiber assembly;; extracellular matrix organization;; extracellular region;; extracellular space;; fatty acid metabolic process;; fibril organization;; fibrillar collagen;; heparin binding;; intracellular;; lipid metabolic process;; phospholipid metabolic process;; positive regulation of cell adhesion;; proteinaceous extracellular matrix;; regulation of JUN kinase activity;; triglyceride metabolic process cell;; cell part;; extracellular region;; extracellular region part cell part;; extracellular matrix;; extracellular matrix part;; extracellular region part;; extracellular space;; intracellular binding carbohydrate binding;; pattern binding;; protein binding anatomical structure formation;; biological adhesion;; biological regulation;; cellular component biogenesis;; cellular component organization;; cellular process;; metabolic process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus cell adhesion;; cell communication;; cellular component assembly;; cellular metabolic process;; cellular response to stimulus;; extracellular structure organization;; macromolecule metabolic process;; multicellular organismal metabolic process;; organic ether metabolic process;; organophosphate metabolic process;; positive regulation of biological process;; positive regulation of cellular process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process;; regulation of molecular function;; regulation of response to stimulus;; response to stress 67.6767 69.1694 85.6233 70.0928 105.4587 82.4959 70.5197 72.6250 57.6680 62.2610 65.6650 78.6925 120.6347 169.9424 195.6806 198.1038 140.5059 109.2421 1341346 1451679_at X chrX:132568984-132569483 X F1 chrX:132567905-132569483 X F1 RSQ NR_003641 1 1 76219 6530401D17Rik RIKEN cDNA 6530401D17 gene (6530401D17Rik), non-coding RNA. 164.1317 107.6868 190.2088 83.8730 82.1665 121.4835 363.0902 416.5964 327.9297 381.4167 403.1389 391.3918 858.9852 657.3160 727.5383 1039.9632 729.0964 1088.6519 1349018 1451683_x_at 17 B1|17 18.44 cM UG5 Mm.439675 14972 H2-K1 MRNA similar to histocompatibility 2, D region locus 1 (cDNA clone MGC:25703 IMAGE:3675316) Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class I;; antigen processing and presentation of peptide antigen via MHC class I;; defense response to bacterium;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; peptide antigen binding;; positive regulation of T cell mediated cytotoxicity cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding antigen binding;; peptide binding biological regulation;; cell killing;; cellular process;; death;; developmental process;; immune system process;; multi-organism process;; positive regulation of biological process;; regulation of biological process;; response to stimulus antigen processing and presentation;; cell death;; immune effector process;; immune response;; leukocyte mediated cytotoxicity;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of response to stimulus;; regulation of biological process;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of response to stimulus;; response to biotic stimulus;; response to other organism;; response to stress 53.6444 51.4517 44.8551 55.8890 56.6751 40.8058 173.8887 166.4177 186.6710 183.5686 165.3542 194.4439 309.8791 330.8072 405.2568 409.7542 369.2357 398.4282 1349037 1451721_a_at 17 B1|17 18.64 cM UG5 Mm.254067 14961 H2-Ab1 Histocompatibility 2, class II antigen A, beta 1, mRNA (cDNA clone MGC:6297 IMAGE:2651058) Allograft rejection;; Antigen processing and presentation;; Asthma;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Immune System; Antigen processing and presentation [PATH:mmu04612] Human Diseases; Immune Disorders; Asthma [PATH:mmu05310] Human Diseases; Immune Disorders; Systemic lupus erythema;; Systemic lupus erythematosus;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class II;; antigen processing and presentation of peptide antigen;; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;; early endosome;; external side of plasma membrane;; Golgi apparatus;; immune response;; integral to membrane;; intracellular;; membrane;; MHC class II protein complex;; multivesicular body;; peptide antigen binding;; plasma membrane;; protein binding cell;; cell part;; macromolecular complex;; organelle cell part;; cell surface;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; protein complex binding antigen binding;; peptide binding;; protein binding immune system process;; response to stimulus antigen processing and presentation;; immune response 1076.0811 658.2393 1290.5454 539.9742 724.7679 626.1727 2608.4160 2661.5858 2738.2194 2772.7818 2631.3775 2831.7435 5963.3806 4157.8399 4849.6595 6679.7630 4796.8948 7731.0583 1349062 1451784_x_at 17 19.09 cM chr17:35403151-35403945 17 B1 chr17:35400038-35404442 17 B1 RSQ NM_010380 1 1 14964 H2-D1 histocompatibility 2, D region locus 1 (H2-D1), mRNA. Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of peptide antigen via MHC class I;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; plasma membrane;; protein binding cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding protein binding immune system process;; response to stimulus antigen processing and presentation;; immune response 755.0634 691.3421 1004.7680 512.7077 505.8453 635.5013 1893.9210 2090.5408 2065.4374 2043.9019 2012.6703 2102.7828 4413.4852 3394.2857 3566.5220 5335.9297 3538.8359 5631.3416 1349133 1451931_x_at 17 B1|17 18.44 cM UGA Mm.439675 14972 H2-K1 MRNA similar to histocompatibility 2, D region locus 1 (cDNA clone MGC:25703 IMAGE:3675316) Allograft rejection;; Antigen processing and presentation;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Endocytosis;; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Transport and Catabolism; Endocytosis [PATH:mmu04144] Cellular Processes; Immune System; Natural killer cell mediated cytotoxicity [PATH:mmu04650] Cellular Processes; Immune System;;; Natural killer cell mediated cytotoxicity;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class I;; antigen processing and presentation of peptide antigen via MHC class I;; defense response to bacterium;; external side of plasma membrane;; immune response;; integral to membrane;; membrane;; MHC class I protein complex;; peptide antigen binding;; positive regulation of T cell mediated cytotoxicity cell;; cell part;; macromolecular complex cell part;; cell surface;; membrane;; membrane part;; protein complex binding antigen binding;; peptide binding biological regulation;; cell killing;; cellular process;; death;; developmental process;; immune system process;; multi-organism process;; positive regulation of biological process;; regulation of biological process;; response to stimulus antigen processing and presentation;; cell death;; immune effector process;; immune response;; leukocyte mediated cytotoxicity;; positive regulation of biological process;; positive regulation of cell killing;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; positive regulation of response to stimulus;; regulation of biological process;; regulation of cell killing;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of response to stimulus;; response to biotic stimulus;; response to other organism;; response to stress 1221.3782 681.2041 1159.7546 724.7925 1044.7360 671.9647 782.7702 747.6665 1170.2803 1025.6796 741.3321 1004.8186 1601.8713 3039.6844 2725.6312 1668.6856 1546.5644 1361.1412 1349251 1452406_x_at RSQ Mm.391385 NM_133362 1 1 170942 Erdr1 erythroid differentiation regulator 1 (Erdr1), mRNA. 124.8385 100.2431 98.0736 119.8471 120.4317 111.1593 214.6368 226.5161 261.2908 217.2031 223.7999 246.6519 939.6733 724.9297 829.1106 1419.6960 859.9257 1380.3186 1349261 1452431_s_at 17 B1|17 18.65 cM UGA Mm.235338 14960 H2-Aa Histocompatibility 2, class II antigen A, alpha, mRNA (cDNA clone MGC:25391 IMAGE:3670758) Allograft rejection;; Antigen processing and presentation;; Asthma;; Autoimmune thyroid disease;; Cell adhesion molecules (CAMs);; Graft-versus-host disease CLASS Environmental Information Processing; Signaling Molecules and Interaction; Cell adhesion molecules (CAMs) [PATH:mmu04514] Cellular Processes; Immune System; Antigen processing and presentation [PATH:mmu04612] Human Diseases; Immune Disorders; Asthma [PATH:mmu05310] Human Diseases; Immune Disorders; Systemic lupus erythema;; Systemic lupus erythematosus;; Type I diabetes mellitus antigen processing and presentation;; antigen processing and presentation of exogenous peptide antigen via MHC class II;; antigen processing and presentation of peptide antigen;; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;; external side of plasma membrane;; immune response;; integral to membrane;; lysosome;; membrane;; MHC class II protein complex;; peptide antigen binding;; plasma membrane;; positive regulation of T cell differentiation;; protein binding cell;; cell part;; macromolecular complex;; organelle cell part;; cell surface;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle;; protein complex binding antigen binding;; peptide binding;; protein binding biological regulation;; cellular process;; developmental process;; immune system process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; antigen processing and presentation;; cell activation;; cellular developmental process;; immune response;; immune system development;; leukocyte activation;; multicellular organismal development;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; positive regulation of immune system process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of immune system process;; regulation of multicellular organismal process 212.3416 233.6865 212.5293 277.2907 249.8870 263.8306 161.2777 159.8468 231.5412 214.5839 158.9996 223.7728 430.7320 329.8741 455.5408 298.5790 397.7630 600.7351 1349566 1454373_x_at 5 G1.1|5 64.0 cM UG5 Mm.331 22190 Ubc Ubiquitin C, mRNA (cDNA clone IMAGE:2645223) PPAR signaling pathway CLASS Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] cytoplasm;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle 70.3646 95.6575 59.8008 62.1087 79.6220 63.8157 176.5201 192.0631 140.5245 139.6971 172.9784 127.6174 625.5690 704.2230 826.8130 1153.4187 783.4692 523.2278 1342546 1455918_at 8 10.0 cM chr8:28336344-28336821 8 A2 IPA Adrb3 adrenergic receptor, beta 3 120.5971 106.9891 94.2228 132.1419 140.3186 100.8211 520.3902 505.8652 526.5408 545.4004 554.6801 553.0658 1091.2918 1637.4404 1664.8059 1550.7658 1140.0075 894.9635 1350720 1428821_at 2 A3 chr2:26448641-26449174 2 A3 UGA Mm.24244 67512 RP23-125H15.1 Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (Agpat2), mRNA Ether lipid metabolism;; Glycerolipid metabolism;; Glycerophospholipid metabolism;; Metabolic pathways CLASS Metabolism; Lipid Metabolism; Glycerolipid metabolism [PATH:mmu00561] Metabolism; Lipid Metabolism; Glycerophospholipid metabolism [PATH:mmu00564] Metabolism; Lipid Metabolism; Ether lipid metabolism [PATH:mmu00565] 1-acylglycerol-3-phosphate O-acyltransferase activity;; acyltransferase activity;; endoplasmic reticulum;; integral to membrane;; membrane;; metabolic process;; phospholipid biosynthetic process;; transferase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle catalytic activity transferase activity cellular process;; metabolic process biosynthetic process;; cellular metabolic process;; organophosphate metabolic process;; primary metabolic process 32.3646 27.7300 32.1555 36.4215 44.0806 33.2701 39.2721 52.8590 55.8762 46.1494 43.3827 42.4205 75.5563 104.5280 70.0845 95.0608 85.0225 95.5554 1350915 1429120_at 2 chr2:74357913-74358343 2 C3 chr2:74352893-74417005 2 C3 RSQ Mm.156113 NM_027133 2 1 69605 RP23-313J15.1 Lnp limb and neural patterns (Lnp), transcript variant 1, mRNA. blood coagulation;; embryonic digit morphogenesis;; embryonic forelimb morphogenesis;; integral to membrane;; membrane;; multicellular organismal development cell;; cell part cell part;; membrane;; membrane part biological regulation;; developmental process;; multicellular organismal process;; response to stimulus anatomical structure development;; anatomical structure morphogenesis;; coagulation;; embryonic development;; multicellular organismal development;; regulation of biological quality;; regulation of body fluid levels;; response to external stimulus;; response to stress 34.1932 31.5363 31.1925 45.2684 40.1620 35.6289 72.5825 69.4762 83.4715 77.0000 71.8190 72.4800 173.2064 154.9167 172.0175 181.6473 162.1715 141.3742 1351306 1429679_at 5 chr5:21080798-21081258 5 A3 chr5:21049344-21081729 5 A3 RSQ Mm.439963 NM_028977 1 1 74511 Lrrc17 leucine rich repeat containing 17 (Lrrc17), mRNA. protein binding binding protein binding 62.9027 64.6006 91.9871 40.4775 71.9532 76.8953 32.7652 33.0183 35.5440 31.2393 30.8769 35.1483 92.3557 67.4359 70.8265 76.4882 66.6538 67.4182 1351521 1429954_at 6 chr6:122917515-122919822 6 F2 chr6:122902661-122919892 6 F2 RSQ Mm.25684 NM_153197 1 1 73149 Clec4a3 C-type lectin domain family 4, member a3 (Clec4a3), mRNA. integral to membrane;; membrane;; receptor activity;; sugar binding cell;; cell part cell part;; membrane;; membrane part binding;; molecular transducer activity carbohydrate binding;; signal transducer activity 77.2439 66.8769 80.2440 59.8078 99.2277 57.3331 678.4476 670.4325 295.5887 322.3900 601.6635 337.6717 837.8303 1440.6726 1744.2968 2267.7608 1755.8989 1723.4822 1370950 1430584_s_at 3 A2|3 11.7 cM chr3:14865376-14865506 3 A1 UGA Mm.300 12350 Car3 Carbonic anhydrase 3, mRNA (cDNA clone MGC:18583 IMAGE:4195712) Nitrogen metabolism CLASS Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:mmu00910] carbonate dehydratase activity;; cytoplasm;; lyase activity;; metal ion binding;; nickel ion binding;; one-carbon metabolic process;; zinc ion binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; lyase activity cellular process;; metabolic process cellular metabolic process 78.5246 72.0006 67.1761 77.6311 50.3412 69.3224 70.4277 72.2671 95.2206 74.5342 75.1252 80.9407 130.5938 183.7836 207.7039 146.0130 202.0696 143.5506 1371114 1432489_a_at 15 chr15:57979902-57985205 15 D1 chr15:57972990-57990209 15 D1 RSQ Mm.26771 NM_029734 1 1 76773 Wdyhv1 WDYHV motif containing 1 (Wdyhv1), mRNA. cytosol;; nucleus;; protein catabolic process;; protein modification process;; protein N-terminal glutamine amidohydrolase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle catalytic activity hydrolase activity cellular process;; metabolic process catabolic process;; cellular metabolic process;; macromolecule metabolic process;; primary metabolic process 195.5574 201.3360 177.2936 104.5322 87.4100 117.7885 59.2237 53.1875 62.8862 56.7542 44.6727 69.2559 106.1008 96.8572 90.1249 151.6957 114.8758 78.1668 1371134 1433465_a_at 7 chr7:134237344-134237486 7 F3 chr7:134234949-134237563 7 F3 RSQ Mm.478036 NM_178901 1 1 101602 AI467606 expressed sequence AI467606 (AI467606), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 31.4721 33.1490 35.8108 22.8940 29.1114 35.4126 28.4144 28.9029 27.9580 32.1816 33.4472 30.3142 43.1201 63.2484 58.9215 104.8319 73.8819 71.3221 1354695 1434572_at 12 A3 chr12:35056459-35056774 12 A3 UG5 Mm.310551 79221 Hdac9 Histone deacetylase-related protein A (Hdrpa) mRNA, complete cds, alternatively spliced Signal Dependent Regulation of Myogenesis by Corepressor MITR;; Sumoylation by RanBP2 Regulates Transcriptional Repression B cell differentiation;; chromatin modification;; cytoplasm;; heart development;; histone deacetylase activity;; histone deacetylase activity;; histone deacetylase complex;; hydrolase activity;; inflammatory response;; negative regulation of striated muscle development;; negative regulation of transcription;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription from RNA polymerase II promoter;; negative regulation of transcription, DNA-dependent;; nervous system development;; nucleus;; protein binding;; regulation of transcription, DNA-dependent;; specific transcriptional repressor activity;; transcription;; transcription corepressor activity;; transcription factor binding;; transcription repressor activity cell;; cell part;; macromolecular complex;; membrane-enclosed lumen;; organelle;; organelle part cell part;; intracellular;; intracellular organelle;; intracellular organelle part;; intracellular part;; membrane-bounded organelle;; organelle lumen;; organelle part;; protein complex binding;; catalytic activity;; transcription regulator activity hydrolase activity;; protein binding;; transcription cofactor activity;; transcription repressor activity biological regulation;; cellular component organization;; cellular process;; developmental process;; immune system process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; biosynthetic process;; cell activation;; cellular developmental process;; cellular metabolic process;; immune system development;; leukocyte activation;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of developmental process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; organelle organization;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of developmental process;; regulation of metabolic process;; regulation of multicellular organismal process;; response to external stimulus;; response to stress 88.6179 64.7775 56.9769 80.7653 57.9102 74.5947 321.3168 319.6575 435.5772 416.2460 321.3260 414.8585 664.1929 596.3478 627.2335 781.6778 726.0103 535.3994 1354746 1434671_at 1 chr1:121549196-121549508 1 E2.3 UGA Mm.130344 Transcribed locus 44.2843 50.7526 51.3302 38.6980 57.9486 56.1546 83.2590 82.8258 123.0100 101.2528 87.4206 108.1155 176.3548 192.7513 202.0815 219.6509 189.4050 145.2075 1354966 1435075_at 6 chr6:13036755-13036914 6 A1 chr6:13019758-13039269 6 A1 RSQ Mm.27742 NM_027992 1 1 71900 Tmem106b transmembrane protein 106B (Tmem106b), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 73.5243 81.8254 52.9742 60.8516 75.5634 76.9689 75.3092 84.8967 86.4714 73.1070 81.4272 81.9134 130.0828 119.8165 169.8212 194.4718 164.0964 144.9401 1355605 1436101_at 2 74.0 cM chr2:131124400-131124749 2 F1 chr2:131124223-131178561 2 F1 RSQ Mm.477523 NM_178607 1 1 51902 RP23-387C21.6 Rnf24 ring finger protein 24 (Rnf24), mRNA. Golgi apparatus;; integral to membrane;; membrane;; metal ion binding;; protein binding;; zinc ion binding cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding ion binding;; protein binding 11.8948 15.8571 14.7005 15.3028 13.3762 16.5494 306.3826 283.6565 325.3591 277.5195 305.7593 281.5648 347.9297 780.9139 714.4056 817.7173 706.6174 470.8713 1355838 1436453_at 7 D3 chr7:86865110-86865282 7 D3 UGA Mm.254917 103968 Plin Perilipin (Plin), transcript variant 2, mRNA PPAR signaling pathway CLASS Cellular Processes; Endocrine System; PPAR signaling pathway [PATH:mmu03320] lipid catabolic process;; lipid metabolic process;; lipid particle;; protein binding cell;; cell part cell part;; intracellular;; intracellular part binding protein binding metabolic process catabolic process;; primary metabolic process 87.6041 64.6707 83.4437 74.3321 100.5191 94.6485 41.6413 39.8215 44.4701 36.4406 58.4072 38.4622 113.6123 82.3965 102.5717 107.7774 89.8428 93.8447 1356037 1436779_at X chrX:9013285-9013716 X A1.1 chrX:9012377-9046450 X A1.1 RSQ Mm.200362 NM_007807 1 1 13058 RP23-243O4.1 Cybb cytochrome b-245, beta polypeptide (Cybb), mRNA. Leukocyte transendothelial migration CLASS Cellular Processes; Immune System; Leukocyte transendothelial migration [PATH:mmu04670] cytoplasm;; electron carrier activity;; electron transport chain;; FAD binding;; hydrogen peroxide biosynthetic process;; integral to membrane;; ion channel activity;; ion transport;; iron ion binding;; membrane;; metal ion binding;; mitochondrion;; oxidation reduction;; oxidoreductase activity;; plasma membrane;; transport;; voltage-gated ion channel activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle binding;; catalytic activity;; electron carrier activity;; transporter activity cofactor binding;; ion binding;; nucleoside binding;; nucleotide binding;; oxidoreductase activity;; substrate-specific transporter activity;; transmembrane transporter activity cellular process;; establishment of localization;; localization;; metabolic process biosynthetic process;; cellular metabolic process;; establishment of localization;; oxidation reduction;; transport 35.1895 36.3663 37.1285 33.0210 39.4357 28.8077 68.3821 78.6239 68.5479 59.5045 80.1455 63.3984 121.9304 136.0256 201.8644 177.3186 226.7170 185.6567 1371329 1437479_x_at 5 65.0 cM chr5:120134159-120134242 5 F chr5:120120677-120134610 5 F RSQ Mm.219139 NM_198052 2 1 21386 Tbx3 T-box 3 (Tbx3), transcript variant 2, mRNA. blood vessel development;; branching involved in mammary gland duct morphogenesis;; cell aging;; DNA binding;; forelimb morphogenesis;; heart looping;; heart morphogenesis;; in utero embryonic development;; limb morphogenesis;; limbic system development;; mammary gland development;; mammary placode formation;; mammary placode formation;; multicellular organismal development;; negative regulation of transcription;; negative regulation of transcription, DNA-dependent;; nucleus;; organ morphogenesis;; positive regulation of transcription, DNA-dependent;; regulation of cell proliferation;; regulation of transcription, DNA-dependent;; specification of organ position;; transcription;; transcription factor activity;; transcription repressor activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle binding;; transcription regulator activity nucleic acid binding;; transcription factor activity;; transcription repressor activity anatomical structure formation;; biological regulation;; cellular process;; developmental process;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process aging;; anatomical structure development;; anatomical structure formation involved in morphogenesis;; anatomical structure morphogenesis;; biosynthetic process;; cell aging;; cell proliferation;; cellular metabolic process;; embryonic development;; macromolecule metabolic process;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of metabolic process;; nitrogen compound metabolic process;; pattern specification process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of metabolic process;; primary metabolic process;; regulation of biological process;; regulation of cellular process;; regulation of metabolic process 67.3314 70.6102 67.5713 76.3401 74.6426 72.5730 65.3448 75.5567 144.8742 136.0798 79.1647 136.7798 164.1441 148.2827 290.7075 312.5774 272.3150 145.4537 1356683 1438055_at 3 chr3:67282929-67283407 3 E1 chr3:67282813-67319535 3 E1 RSQ Mm.38002 XM_001475793 2 1 109222 Rarres1 PREDICTED: retinoic acid receptor responder (tazarotene induced) 1 (Rarres1), mRNA. 87.2932 106.9891 71.4332 59.8199 104.6569 62.1052 178.7950 177.0408 219.4476 189.3013 174.1481 182.7630 501.5173 602.0631 612.3131 559.0248 596.4027 311.3603 1356810 1438285_at 11 A1 chr11:5681352-5681850 11 A1 UGA Mm.260203 76508 2210015D19Rik PREDICTED: Mus musculus RIKEN cDNA 2210015D19 gene, transcript variant 2 (2210015D19Rik), mRNA 12.8698 10.0902 12.7866 10.2657 11.3753 10.0578 20.0888 21.5472 17.9538 18.2423 20.1267 20.8772 31.6523 45.1828 46.2399 58.8077 46.4092 31.7372 1356824 1438309_at 2 C1.1 chr2:58120038-58120425 2 C1.1 UG5 Mm.77751 269275 RP23-100B18.1 Acvr1c Activin A receptor, type IC, mRNA (cDNA clone IMAGE:1196242) Adherens junction;; Chronic myeloid leukemia CLASS Environmental Information Processing; Signal Transduction; MAPK signaling pathway [PATH:mmu04010] Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway [PATH:mmu04350] Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction [PATH:mmu0;; Colorectal cancer;; Endocytosis;; MAPK signaling pathway;; Pancreatic cancer;; Pathways in cancer;; TGF-beta signaling pathway activin binding;; apoptosis;; ATP binding;; cell surface;; determination of left/right symmetry;; in utero embryonic development;; integral to membrane;; kinase activity;; lipid storage;; magnesium ion binding;; manganese ion binding;; membrane;; metal ion binding;; negative regulation of insulin secretion;; nucleotide binding;; positive regulation of apoptosis;; protein amino acid phosphorylation;; protein kinase activity;; protein serine/threonine kinase activity;; receptor activity;; response to dietary excess;; response to glucose stimulus;; response to insulin stimulus;; transferase activity;; transforming growth factor beta receptor activity;; transmembrane receptor protein serine/threonine kinase activity;; trophectodermal cell proliferation cell;; cell part cell part;; cell surface;; membrane;; membrane part binding;; catalytic activity;; molecular transducer activity ion binding;; nucleoside binding;; nucleotide binding;; protein binding;; signal transducer activity;; transferase activity biological regulation;; cellular process;; death;; developmental process;; establishment of localization;; growth;; localization;; metabolic process;; multicellular organismal process;; negative regulation of biological process;; positive regulation of biological process;; regulation of biological process;; response to stimulus anatomical structure development;; cell communication;; cell death;; cell proliferation;; cellular localization;; cellular metabolic process;; developmental growth;; embryonic development;; establishment of localization;; establishment of localization in cell;; generation of a signal involved in cell-cell signaling;; macromolecule localization;; macromolecule metabolic process;; multicellular organism growth;; multicellular organismal development;; negative regulation of biological process;; negative regulation of cellular process;; negative regulation of transport;; pattern specification process;; positive regulation of biological process;; positive regulation of cellular process;; positive regulation of developmental process;; primary metabolic process;; regulation of biological process;; regulation of biological quality;; regulation of cellular process;; regulation of developmental process;; regulation of growth;; regulation of localization;; regulation of multicellular organismal process;; response to chemical stimulus;; response to dietary excess;; response to endogenous stimulus;; secretion by cell;; transport 42.9154 42.7486 41.5104 47.5794 45.3061 41.5104 93.0273 94.5577 106.3928 109.4516 91.4119 109.5074 313.2228 238.8955 280.8846 289.8741 355.7855 368.1383 1357038 1438720_at 10 chr10:28949419-28949955 10 A4 UG5 Mm.379334 Transcribed locus 31.4402 49.4625 43.6299 48.7520 42.9246 31.5551 451.2741 398.6261 511.7858 484.5408 422.2897 476.4412 924.7325 980.8851 742.1196 1093.4855 875.0291 970.9587 1371433 1439087_a_at 11 chr11:3233342-3233587 11 A1 chr11:3230733-3242974 11 A1 RSQ Mm.390323 NM_178149 1 1 216505 RP23-191E3.6 Pik3ip1 phosphoinositide-3-kinase interacting protein 1 (Pik3ip1), mRNA. integral to membrane;; membrane cell;; cell part cell part;; membrane;; membrane part 55.3016 87.6133 54.0427 90.6230 74.5709 44.4937 342.2140 351.6430 545.7029 468.4125 349.4883 477.3954 747.2694 904.0125 805.0935 1097.5599 860.2380 658.7183 1371469 1439617_s_at 2 C1-qter|2 103.0 cM chr2:172980730-172981559 2 H3 UGA Mm.477474 18534 RP23-44L6.3 Pck1 Phosphoenolpyruvate carboxykinase 1, cytosolic, mRNA (cDNA clone MGC:46881 IMAGE:4973187) Adipocytokine signaling pathway CLASS Metabolism; Carbohydrate Metabolism; Glycolysis / Gluconeogenesis [PATH:mmu00010] Metabolism; Carbohydrate Metabolism; Citrate cycle (TCA cycle) [PATH:mmu00020] Metabolism; Carbohydrate Metabolism; Pyruvate metabolism [PATH:mmu00620] Cellular Processes; Endocrine System; Insulin signaling pathway [PATH:mmu04910] Cel;; Citrate cycle (TCA cycle);; Glycolysis / Gluconeogenesis;; Insulin signaling pathway;; Metabolic pathways;; PPAR signaling pathway;; Pyruvate metabolism carboxy-lyase activity;; cytoplasm;; gluconeogenesis;; glycerol biosynthetic process from pyruvate;; GTP binding;; kinase activity;; lipid metabolic process;; lyase activity;; manganese ion binding;; metal ion binding;; nucleotide binding;; phosphoenolpyruvate carboxykinase (GTP) activity;; phosphoenolpyruvate carboxykinase activity;; purine nucleotide binding cell;; cell part cell part;; intracellular;; intracellular part binding;; catalytic activity ion binding;; lyase activity;; nucleotide binding;; transferase activity cellular process;; metabolic process alcohol metabolic process;; biosynthetic process;; cellular metabolic process;; organic ether metabolic process;; primary metabolic process 23.1772 25.1969 19.3721 21.5145 27.6557 22.6325 436.1894 444.1576 556.9391 549.7219 456.1765 553.4852 1556.7029 1156.1628 1112.1309 1277.4385 1184.3762 985.9630 1357783 1439859_at 6 chr6:127035208-127035696 6 F3 chr6:127035139-127059554 6 F3 RSQ Mm.101836 NM_177003 2 2 319801 9630033F20Rik RIKEN cDNA 9630033F20 gene (9630033F20Rik), mRNA. catalytic activity;; fructose-2,6-bisphosphate 2-phosphatase activity;; hydrolase activity;; metabolic process catalytic activity hydrolase activity metabolic process 8.3541 8.2004 8.2560 8.7619 7.4253 7.5327 13.9926 11.8322 17.0626 12.4226 12.0626 16.1221 19.9740 30.1968 25.4789 37.0564 33.0070 26.4618 1371519 1440172_s_at 10 C2 chr10:86693258-86693302 10 C1 UGA Mm.78423 76640 1700113H08Rik PREDICTED: Mus musculus RIKEN cDNA 1700113H08 gene (1700113H08Rik), mRNA 42.6322 52.5959 57.2313 48.5342 44.9461 37.5364 185.8055 205.8552 186.1101 193.3616 201.8787 192.3153 416.1203 548.2478 539.1323 510.0122 511.6171 437.9437 1358895 1441096_at 11 chr11:76511606-76512085 11 B5 chr11:76493374-76512164 11 B5 RSQ Mm.127006 NM_177709 1 1 237858 RP23-343C18.2 Tusc5 tumor suppressor candidate 5 (Tusc5), mRNA. integral to membrane;; membrane;; response to biotic stimulus cell;; cell part cell part;; membrane;; membrane part response to stimulus response to biotic stimulus 20.1669 35.0523 21.1417 22.5224 25.3991 25.2820 46.5674 53.5703 39.8910 44.8186 46.6734 46.0292 58.3944 109.8771 142.5652 138.9007 121.9025 74.1708 1359928 1442294_at 6 chr6:60347246-60353601 6 B3 chr6:60346342-60353692 6 B3 RSQ XR_035290 2 1 208079 A530053G22Rik PREDICTED: RIKEN cDNA A530053G22 gene (A530053G22Rik), misc RNA. 71.3120 95.4687 90.7770 95.9602 115.3932 82.9297 45.7746 37.1615 53.5491 46.9962 40.2949 50.7743 66.8930 64.2993 83.1294 102.3995 109.2162 77.8591 1360549 1442977_at chr1:45373406-45373830 1 C1.1 IPA ESTs, Weakly similar to phosphatase [Caenorhabditis elegans] [C.elegans] 3261.2630 3579.5130 2532.8741 2735.2075 1644.0513 2481.0846 30.1843 32.1608 28.4405 42.8404 39.6438 49.7581 67.3071 50.5638 46.7304 63.2368 103.1472 75.8263 1366052 1454193_at 12 chr12:32781628-32782060 12 A3 UGA Mm.383841 Transcribed locus 23.7665 16.9779 20.4442 25.5326 23.8401 16.9640 28.9793 33.0981 34.7437 34.7814 32.1509 33.3871 59.3213 84.3573 61.8591 112.5430 89.8428 70.0030 1366465 1454720_at 10 B1 chr10:36553604-36554025 10 B1 UG5 Mm.332442 319415 Hs3st5 Heparan sulfate (glucosamine) 3-O-sulfotransferase 5, mRNA (cDNA clone MGC:182415 IMAGE:9056309) Heparan sulfate biosynthesis CLASS Metabolism; Glycan Biosynthesis and Metabolism; Heparan sulfate biosynthesis [PATH:mmu00534] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity;; Golgi apparatus;; integral to membrane;; membrane;; sulfotransferase activity;; transferase activity cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane;; membrane part;; membrane-bounded organelle catalytic activity transferase activity 17.5669 16.1162 14.2134 20.9689 34.5109 20.7271 57.6233 55.0794 46.1979 36.3080 49.8583 43.9885 123.3106 117.1716 126.1256 145.7923 156.1046 129.0346 1366550 1454877_at 1 chr1:194670735-194671190 1 H6 chr1:194670681-194681915 1 H6 RSQ Mm.22806 NM_198247 1 1 214791 RP23-381K21.1 Sertad4 SERTA domain containing 4 (Sertad4), mRNA. 24.7658 26.4524 23.1683 28.0964 33.1401 26.0401 74.1278 65.9586 60.6943 57.8184 74.1526 57.7339 145.9714 90.4430 106.9015 145.2427 160.9739 152.9183 1366754 1455238_at X chrX:135772327-135772833 X F1 chrX:135769523-135772871 X F1 RSQ Mm.478157 NM_175541 1 1 245631 Mum1l1 melanoma associated antigen (mutated) 1-like 1 (Mum1l1), mRNA. 22.8297 19.3211 30.4573 54.7045 22.9444 28.3437 38.7231 38.5595 33.7612 45.8962 40.3211 37.9257 62.8164 70.5993 72.4249 85.2324 65.3387 90.1634 1367719 1456895_at 8 chr8:3917912-3918187 8 A1.1 chr8:3917656-3926814 8 A1.1 RSQ Mm.175163 NM_026972 1 1 69165 Cd209b CD209b antigen (Cd209b), transcript variant 1, mRNA. binding;; calcium ion binding;; detection of bacterium;; detection of yeast;; endocytosis;; external side of plasma membrane;; integral to membrane;; mannose binding;; membrane;; metal ion binding;; phagocytosis, recognition;; polysaccharide binding;; positive regulation of phagocytosis;; positive regulation of tumor necrosis factor biosynthetic process;; receptor activity;; sugar binding;; zymosan binding cell;; cell part cell part;; cell surface;; membrane;; membrane part binding;; molecular transducer activity carbohydrate binding;; ion binding;; pattern binding;; signal transducer activity biological regulation;; cellular component organization;; cellular process;; establishment of localization;; localization;; metabolic process;; multi-organism process;; multicellular organismal process;; positive regulation of biological process;; regulation of biological process;; response to stimulus biosynthetic process;; cell recognition;; cellular metabolic process;; cytokine production;; detection of stimulus;; establishment of localization;; macromolecule metabolic process;; membrane organization;; positive regulation of biological process;; positive regulation of cellular component organization;; positive regulation of cellular process;; positive regulation of metabolic process;; positive regulation of transport;; regulation of biological process;; regulation of cellular component organization;; regulation of cellular process;; regulation of localization;; regulation of metabolic process;; regulation of multicellular organismal process;; response to biotic stimulus;; response to external stimulus;; response to other organism;; transport;; vesicle-mediated transport 56.9843 51.1179 53.7367 62.7476 55.2265 55.1888 80.3621 93.2247 99.7970 79.2927 81.0504 93.5868 195.5695 138.2218 161.4077 393.0408 457.7161 322.8464 1367914 1457102_at 18 chr18:68501510-68501988 18 E2 UGA Mm.95774 Transcribed locus 39.1411 38.0211 51.0103 55.6637 62.6636 40.5081 50.5394 56.9933 82.1429 88.8944 53.3356 88.5048 153.0206 106.6594 213.5858 195.1865 143.2591 106.9627 1372506 1457666_s_at 1 H3 chr1:175892797-175892865 1 H3 UGA Mm.218770 26388 Ifi202b Interferon activated gene 202B, mRNA (cDNA clone MGC:18552 IMAGE:3990226) cytoplasm;; nucleus cell;; cell part;; organelle cell part;; intracellular;; intracellular organelle;; intracellular part;; membrane-bounded organelle 25.0159 23.8403 24.5887 28.1928 41.7640 18.6378 34.4944 35.3807 48.2518 48.3650 33.6339 42.9072 46.2099 57.4041 54.6436 68.7361 92.1638 52.7968 1368565 1457843_at 2 chr2:50047002-50047501 2 C1.1 chr2:49983888-50049084 2 C1.1 RSQ Mm.130607 NM_177139 1 1 320343 RP23-343I2.1 Lypd6 LY6/PLAUR domain containing 6 (Lypd6), mRNA. extracellular region extracellular region 65.2184 60.0845 59.9820 70.3081 83.6936 72.0392 71.3279 76.1458 67.4694 81.8275 75.0932 72.7446 183.5943 170.8214 134.1250 205.5359 163.9676 155.2833 1369047 1458379_at 10 A4 chr10:28947684-28948074 10 A4 UGA Mm.132789 212448 9330159F19Rik RIKEN cDNA 9330159F19 gene, mRNA (cDNA clone IMAGE:8861298) 14.5734 17.6809 15.4216 14.1742 19.4558 20.4819 58.4382 71.7892 322.4894 345.6549 63.2632 374.7537 360.5964 474.3886 397.1148 422.5462 467.7425 558.3741 1369924 1459289_at chr13:110341530-110342088 13 D2.1 IPA Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630027C04 product:unknown EST, full insert sequence.